Abstract:
:A 48-year-old woman underwent total abdominal hysterectomy with conservation of the ovaries and tubes. Histology showed a well-circumscribed smooth muscle tumor with foci of degeneration (including infarct-type necrosis) but no coagulative tumor cell necrosis and only mild focal cytological atypia. She presented, 24 years later with shortness of breath and abdominal distension and underwent bilateral salpingo-oophorectomy, appendectomy, omental biopsy and para-aortic lymph node sampling. Histology showed bilateral ovarian smooth muscle tumors with no coagulative tumor cell necrosis or significant cellular atypia. The cells were mitotically active. The tumors in both ovaries were most likely secondary to the previous uterine smooth muscle neoplasm. To our knowledge, this case is the first in the literature to describe a benign cellular leiomyoma that subsequently behaved as a smooth muscle tumor of uncertain malignant potential, which recurred 24 years after the initial diagnosis.
journal_name
J Gynecol Oncoljournal_title
Journal of gynecologic oncologyauthors
Canciani GN,Burbos N,Duncan TJ,Lonsdale R,Nieto JJdoi
10.3802/jgo.2012.23.1.69subject
Has Abstractpub_date
2012-01-01 00:00:00pages
69-71issue
1eissn
2005-0380issn
2005-0399journal_volume
23pub_type
杂志文章abstract:OBJECTIVE:We evaluated the human papillomavirus (HPV) DNA load for the diagnosis and prediction of persistent vaginal intraepithelial neoplasia (VAIN). METHODS:A retrospective review of the medical records of patients with a pathological diagnosis of VAIN was performed. Eligible women (N=48) were followed for cytology...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2009.20.4.232
更新日期:2009-12-01 00:00:00
abstract:OBJECTIVE:Accumulating evidence support that complete cytoreduction (CC) at the time of secondary cytoreductive surgery (SCS) improves survival in patients affected by recurrent ovarian cancer (ROC). Here, we aimed to determine whether artificial intelligence (AI) might be useful in weighting the importance of clinical...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2018.29.e66
更新日期:2018-09-01 00:00:00
abstract:OBJECTIVE:Synchronous occurrence of endometrial and ovarian tumors is uncommon, and they affect less than 10% of women with endometrial or ovarian cancers. The aim of this study is to describe the epidemiological and clinical factors; and survival outcomes of women with these cancers. METHODS:This is a retrospective c...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2011.22.4.239
更新日期:2011-12-01 00:00:00
abstract:OBJECTIVE:Hypermethylation of CpG island is a common mechanism for the inactivation of tumor suppressor genes. Hypermethylation of the E-cadherin promoter region has been rarely studied in endometrial carcinoma of Korean women. The purpose of this study is to investigate methylation status of E-cadherin promoter region...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2008.19.4.241
更新日期:2008-12-01 00:00:00
abstract:OBJECTIVE:To show noninferiority of a limited-excision (resection of the dysplastic lesion only) vs. classical Large Loop Excision of the Transformation Zone (LLETZ). METHODS:In this prospective, randomized, multicenter trial, women with human papillomavirus (HPV) positive cervical intraepithelial neoplasia grade 3 we...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.3802/jgo.2019.30.e42
更新日期:2019-05-01 00:00:00
abstract::The most common form of malignant transformation developing from a mature cystic teratoma is squamous cell carcinoma, representing 80% of malignant transformations, while adenocarcinoma accounts for approximately 5%. Because of this rarity, few reports exist of preoperative diagnosis of this tumor by magnetic resonanc...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2012.23.2.125
更新日期:2012-04-01 00:00:00
abstract::The incidence rate of cervical cancer in Korea is still higher than in other developed countries, notwithstanding the national mass-screening program. Furthermore, a new method has been introduced in cervical cancer screening. Therefore, the committee for cervical cancer screening in Korea updated the recommendation s...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章,实务指引
doi:10.3802/jgo.2015.26.3.232
更新日期:2015-07-01 00:00:00
abstract::All surgery performed in an epicenter of the coronavirus disease 2019 (COVID-19) pandemic, irrespective of the known or suspected severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) status of the patient, should be regarded as high risk and protection of the surgical team at the bedside should be at the highe...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章,评审
doi:10.3802/jgo.2020.31.e59
更新日期:2020-05-01 00:00:00
abstract:OBJECTIVE:To describe metastatic pattern of uterine leiomyosarcomas (ULMS) and correlate it with clinical and histopathologic parameters. METHODS:We included 113 women (mean age, 53 years; range, 29 to 72 years) with histopathology-confirmed ULMS from 2000 to 2012. Distribution of metastases was noted from imaging by ...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2014.25.4.306
更新日期:2014-10-01 00:00:00
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journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2014.25.1.43
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:To compare peri- and postoperative outcomes and complications of laparoscopic vs. robotic-assisted surgical staging for women with endometrial cancer at two established academic institutions. METHODS:Retrospective chart review of all women that underwent total hysterectomy with pelvic and para-aortic lymphad...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2013.24.1.21
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:As cancer stem cells (CSCs) are considered as the origin of tumor development, recurrence, and drug resistance, we aimed to explore the mechanism related to modulating stemness in CSCs, thus facilitating to search for new therapeutic strategy for ovarian cancer. METHODS:In this study, ovarian cancer stem cel...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2020.31.e46
更新日期:2020-07-01 00:00:00
abstract:OBJECTIVE:This study was to investigate the synergistic growth inhibitory effect by combination of adenovirus mediated p53 gene transfer and cisplatin in ovarian cancer cell lines with different p53 gene mutation patterns. METHODS:Three ovarian cancer cell lines, p53 deleted SKOV3, p53 mutated OVCAR-3, and PA-1 with w...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2009.20.1.48
更新日期:2009-03-01 00:00:00
abstract:OBJECTIVE:To assess the association between condom use and oral contraceptive consumption and the risk of cervical intraepithelial neoplasia (CIN). METHODS:A cross-sectional study was conducted in Perth clinics. A total of 348 women responded to the structured questionnaire. Information sought included demographic and...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章,多中心研究
doi:10.3802/jgo.2014.25.3.183
更新日期:2014-07-01 00:00:00
abstract:OBJECTIVE:Uterine leiomyomas are the most common tumor of the uterus. But the molecular causes of uterine leiomyoma remain unclear. We conducted the current investigation in order to elucidate the molecular mechanisms in the development of uterine leiomyoma. METHODS:We employed a new and accurate reverse transcription...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2008.19.2.139
更新日期:2008-06-01 00:00:00
abstract::Fertility-sparing surgery was optimal to patients with tumor diameter smaller than 2 cm. For patients with larger tumors, neoadjuvant chemotherapy can debulk the tumor and offer the chance of surgery. We report 2 cases of stage IB1 cervical cancer treated by neoadjuvant chemotherapy and fertility-sparing surgery. Rele...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2013.24.3.287
更新日期:2013-07-01 00:00:00
abstract:OBJECTIVE:Although radiation therapy (RT) and concurrent chemoradiotherapy (CCRT) are the global standards for adjuvant therapy treatment in cervical cancer, many Japanese institutions choose chemotherapy (CT) because of the low frequency of irreversible adverse events. In this study, we aimed to clarify the trends of ...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2016.27.e29
更新日期:2016-05-01 00:00:00
abstract:OBJECTIVES:Two randomized, controlled studies comparing outcomes in patients treated with direct oral anticoagulants or low-molecular weight heparin for cancer-associated venous thromboembolism (VTE) have previously been performed. However, gynecologic cancers accounted for approximately 10% of the study populations. W...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2020.31.e10
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:To investigate the relationship between the precursors of high grade serous ovarian cancer (HGSOC) and the characteristics of patients with a low HGSOC risk in terms of the effects of pregnancy. METHODS:We prospectively examined consecutive cases in which the bilateral fallopian tubes were removed during ben...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2019.30.e96
更新日期:2019-11-01 00:00:00
abstract:OBJECTIVE:Primary sarcoma of the cervix is rare and is associated with worse outcomes as compared to other histologies. The purpose of this study was to identify national treatment patterns and outcomes based on histological subtype using the National Cancer Database (NCDB). METHODS:The NCDB was queried for patients w...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2020.31.e25
更新日期:2020-05-01 00:00:00
abstract:OBJECTIVE:The standard dose for pegylated liposomal doxorubicin (PLD) is 50 mg/m² every 4 weeks. While 40 mg/m² has recently been used in clinical practice, evidence supporting this use remains lacking. METHODS:This phase III randomized, non-inferiority study compared progression-free survival (PFS) for patients with ...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2021.32.e9
更新日期:2021-01-01 00:00:00
abstract:OBJECTIVE:'The Endometrial Cancer Conservative Treatment (E.C.Co.). A multicentre archive' is a worldwide project endorsed by the Gynecologic Cancer Inter-Group, aimed at registering conservatively treated endometrial cancer (EC) patients. This paper reports the oncological and reproductive outcomes of intramucous, G2,...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2020.31.e74
更新日期:2020-09-01 00:00:00
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journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2017.28.e38
更新日期:2017-07-01 00:00:00
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journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2014.25.4.282
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVE:To determine whether preoperative platelets to lymphocyte ratio (PLR) could predict disease stage, surgical outcome, and survival in patients with epithelial ovarian cancer (EOC). METHODS:Medical records of EOC patients who had surgery between January 2004 and December 2010 were reviewed. Clinicopathological...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2012.23.4.265
更新日期:2012-10-01 00:00:00
abstract:OBJECTIVE:To evaluate the efficacy of modified Swede Colposcopic Index (MSCI) to predict high-grade lesion and cancer of cervix (CIN2+, cervical intraepithelial neoplasia grade 2 or worse) in women with abnormal cervical cytology who underwent a colposcopy. METHODS:We conducted a retrospective study and MSCI using 5 f...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2019.30.e78
更新日期:2019-09-01 00:00:00
abstract:OBJECTIVE:Our previous study showed that insulin resistance (IR) was related to endometrial hyperplasia as well as endometrial cancer. But the exact impact of IR on fertility-sparing treatment in endometrial hyperplasic disease is unclear. This study investigated how IR affects fertility-sparing treatment in endometria...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2018.29.e35
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVE:Neoadjuvant chemotherapy (NACT) for the treatment of epithelial ovarian cancer (EOC) has remained controversial. This meta-analysis was performed to systematically assess the efficacy and safety of NACT versus primary debulking surgery (PDS) in patients with EOC. METHODS:PubMed, Embase, ClinicalTrials.gov, a...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2020.31.e12
更新日期:2020-03-01 00:00:00
abstract:OBJECTIVE:Impaired local cellular immunity contributes to persistent human papillomavirus (HPV) infection and development of cervical intraepithelial neoplasia (CIN). Programmed death-1 (PD-1) and its ligands PD-ligand-1 (L1) and PD-L2 are negative regulators of T cell activity in various cancers, but few studies exist...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2018.29.e27
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the feasibility and the safety of robotic single-site radical hysterectomy (RSSRH) plus pelvic lymphadenectomy (PL) in endometrial or cervical cancer. METHODS:Patients with endometrial cancer (EC) International Federation of Gynecology and Obstetrics (FIGO) stage II, early cervical cancer (ECC) F...
journal_title:Journal of gynecologic oncology
pub_type: 临床试验,杂志文章
doi:10.3802/jgo.2018.29.e2
更新日期:2018-01-01 00:00:00