Hypermethylation of E-cadherin in endometrial carcinoma.

Abstract:

OBJECTIVE:Hypermethylation of CpG island is a common mechanism for the inactivation of tumor suppressor genes. Hypermethylation of the E-cadherin promoter region has been rarely studied in endometrial carcinoma of Korean women. The purpose of this study is to investigate methylation status of E-cadherin promoter region in endometrial carcinomas and endometrial hyperplasias, and analyze the correlation with clinicopathologic variables in endometrial carcinomas. METHODS:We examined the methylation status of the E-cadherin promoter region using methylation specific polymerase chain reaction and immunohistochemical expression (IHC) of E-cadherin in 30 endometrioid endometrial carcinomas and 20 endometrial hyperplasias, and correlated these results with various clinicopathological factors of endometrial carcinomas. RESULTS:Decreased expression of E-cadherin was detected in 13 of 30 (43.3%) endometrial carcinomas and in 1 of 20 (5%) endometrial hyperplasias (p=0.009). Promoter hypermethylation was detected in 12 of 30 (40%) endometrial carcinomas and 2 of 20 (10%) endometrial hyperplasias (p=0.015). Methylation status did not have a significant influence on the tumor grade and lymph node metastasis. However, the hypermethylation rate was significantly higher in stage above Ic (p=0.025). Decreased expression of E-cadherin was associated with tumor grade, tumor stage, and lymph node metastasis in endometrial carcinomas (p=0.01, p=0.02, p=0.03). There was no correlation between DNA hypermethylation and decreased expression of E-cadherin in endometrial carcinomas (p>0.05). CONCLUSION:These results indicate that hypermethylation of E-cadherin promoter region is a frequent event in endometrial carcinoma, which may play an important role in the progression of carcinogenesis. Also, the promoter methylation of E-cadherin in endometrial carcinoma was found to be significantly associated with higher stage above Ic.

journal_name

J Gynecol Oncol

authors

Park JH,Lee BI,Song ES,Whang SO,Lee WY,Cho SJ

doi

10.3802/jgo.2008.19.4.241

subject

Has Abstract

pub_date

2008-12-01 00:00:00

pages

241-5

issue

4

eissn

2005-0380

issn

2005-0399

journal_volume

19

pub_type

杂志文章
  • Primary sarcoma of the cervix: an analysis of patient and tumor characteristics, treatment patterns, and outcomes.

    abstract:OBJECTIVE:Primary sarcoma of the cervix is rare and is associated with worse outcomes as compared to other histologies. The purpose of this study was to identify national treatment patterns and outcomes based on histological subtype using the National Cancer Database (NCDB). METHODS:The NCDB was queried for patients w...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2020.31.e25

    authors: Albert A,Lee A,Allbright R,Vijayakumar S

    更新日期:2020-05-01 00:00:00

  • Randomized phase III trial comparing pegylated liposomal doxorubicin (PLD) at 50 mg/m² versus 40 mg/m² in patients with platinum-refractory and -resistant ovarian carcinoma: the JGOG 3018 Trial.

    abstract:OBJECTIVE:The standard dose for pegylated liposomal doxorubicin (PLD) is 50 mg/m² every 4 weeks. While 40 mg/m² has recently been used in clinical practice, evidence supporting this use remains lacking. METHODS:This phase III randomized, non-inferiority study compared progression-free survival (PFS) for patients with ...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2021.32.e9

    authors: Motohashi T,Yabuno A,Michimae H,Ohishi T,Nonaka M,Takano M,Nishio S,Fujiwara H,Fujiwara K,Kondo E,Sugiyama T,Tabata T

    更新日期:2021-01-01 00:00:00

  • Practice patterns of adjuvant therapy for intermediate/high recurrence risk cervical cancer patients in Japan.

    abstract:OBJECTIVE:Although radiation therapy (RT) and concurrent chemoradiotherapy (CCRT) are the global standards for adjuvant therapy treatment in cervical cancer, many Japanese institutions choose chemotherapy (CT) because of the low frequency of irreversible adverse events. In this study, we aimed to clarify the trends of ...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2016.27.e29

    authors: Ikeda Y,Furusawa A,Kitagawa R,Tokinaga A,Ito F,Ukita M,Nomura H,Yamagami W,Tanabe H,Mikami M,Takeshima N,Yaegashi N

    更新日期:2016-05-01 00:00:00

  • Survival outcome of women with synchronous cancers of endometrium and ovary: a 10 year retrospective cohort study.

    abstract:OBJECTIVE:Synchronous occurrence of endometrial and ovarian tumors is uncommon, and they affect less than 10% of women with endometrial or ovarian cancers. The aim of this study is to describe the epidemiological and clinical factors; and survival outcomes of women with these cancers. METHODS:This is a retrospective c...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2011.22.4.239

    authors: Lim YK,Padma R,Foo L,Chia YN,Yam P,Chia J,Khoo-Tan H,Yap SP,Yeo R

    更新日期:2011-12-01 00:00:00

  • Incidence of metastasis in circumflex iliac nodes distal to the external iliac nodes in cervical cancer.

    abstract:OBJECTIVE:A causal relationship between removal of circumflex iliac nodes distal to the external iliac nodes (CINDEIN) and lower leg edema has been recently suggested. The aim of this study was to elucidate the incidence of CINDEIN metastasis in cervical cancer. METHODS:A retrospective chart review was carried out for...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2016.27.e42

    authors: Takeshita S,Todo Y,Okamoto K,Sudo S,Yamashiro K,Kato H

    更新日期:2016-07-01 00:00:00

  • p16(INK4a) immunohistochemistry is a promising biomarker to predict the outcome of low grade cervical intraepithelial neoplasia: comparison study with HPV genotyping.

    abstract:OBJECTIVE:In cervical intraepithelial neoplasia (CIN), p16(INK4a) immunohistochemistry has been reported to be a useful diagnostic biomarker. However, limited information is available about the association between the p16(INK4a) immunohistochemistry and the outcomes of CIN. Here, we report p16(INK4a) immunohistochemist...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2013.24.3.215

    authors: Nishio S,Fujii T,Nishio H,Kameyama K,Saito M,Iwata T,Kubushiro K,Aoki D

    更新日期:2013-07-01 00:00:00

  • Value of combined adjuvant chemotherapy and radiation on survival for stage III uterine cancer: is less radiation equal to more?

    abstract:OBJECTIVE:Locally advanced endometrioid adenocarcinoma (LA-EAC) accounts for the majority of deaths for this cancer, yet there is no consensus on adjuvant treatment after surgery. Past studies suggest that combined modality treatment (CMT) may improve outcomes over treatment with chemotherapy (CT) or radiation therapy ...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2018.29.e49

    authors: Wang CJ,Christie A,Folkert MR,Xie XJ,Albuquerque K

    更新日期:2018-07-01 00:00:00

  • The efficacy of modified Swede Colposcopic Index in prediction of high-grade lesion and cancer of cervix.

    abstract:OBJECTIVE:To evaluate the efficacy of modified Swede Colposcopic Index (MSCI) to predict high-grade lesion and cancer of cervix (CIN2+, cervical intraepithelial neoplasia grade 2 or worse) in women with abnormal cervical cytology who underwent a colposcopy. METHODS:We conducted a retrospective study and MSCI using 5 f...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2019.30.e78

    authors: Rodpenpear N,Pataradool K

    更新日期:2019-09-01 00:00:00

  • Surgical and oncologic outcomes after robotic radical hysterectomy as compared to open radical hysterectomy in the treatment of early cervical cancer.

    abstract:OBJECTIVE:The use of robotic radical hysterectomy has greatly increased in the treatment of early stage cervical cancer. We sought to compare surgical and oncologic outcomes of women undergoing robotic radical hysterectomy compared to open radical hysterectomy. METHODS:The clinic-pathologic, treatment, and recurrence ...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2017.28.e82

    authors: Shah CA,Beck T,Liao JB,Giannakopoulos NV,Veljovich D,Paley P

    更新日期:2017-11-01 00:00:00

  • Comparison of four malignancy risk indices in the detection of malignant ovarian masses.

    abstract:OBJECTIVE:The aim of this study was to evaluate the ability of four risk of malignancy indices (RMI) to detect malignant ovarian tumors. METHODS:This is a prospective study of 100 women admitted to the Department of Obstetrics and Gynecology of Gulhane Military Medicine Academy for surgical exploration of pelvic masse...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2011.22.3.177

    authors: Aktürk E,Karaca RE,Alanbay I,Dede M,Karaşahin E,Yenen MC,Başer I

    更新日期:2011-09-01 00:00:00

  • The utility of the human papillomavirus DNA load for the diagnosis and prediction of persistent vaginal intraepithelial neoplasia.

    abstract:OBJECTIVE:We evaluated the human papillomavirus (HPV) DNA load for the diagnosis and prediction of persistent vaginal intraepithelial neoplasia (VAIN). METHODS:A retrospective review of the medical records of patients with a pathological diagnosis of VAIN was performed. Eligible women (N=48) were followed for cytology...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2009.20.4.232

    authors: So KA,Hong JH,Hwang JH,Song SH,Lee JK,Lee NW,Lee KW

    更新日期:2009-12-01 00:00:00

  • Early diagnosis of malignant-transformed ovarian mature cystic teratoma: fat-suppressed MRI findings.

    abstract::The most common form of malignant transformation developing from a mature cystic teratoma is squamous cell carcinoma, representing 80% of malignant transformations, while adenocarcinoma accounts for approximately 5%. Because of this rarity, few reports exist of preoperative diagnosis of this tumor by magnetic resonanc...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2012.23.2.125

    authors: Takagi H,Ichigo S,Murase T,Ikeda T,Imai A

    更新日期:2012-04-01 00:00:00

  • Insulin resistance and overweight prolonged fertility-sparing treatment duration in endometrial atypical hyperplasia patients.

    abstract:OBJECTIVE:Our previous study showed that insulin resistance (IR) was related to endometrial hyperplasia as well as endometrial cancer. But the exact impact of IR on fertility-sparing treatment in endometrial hyperplasic disease is unclear. This study investigated how IR affects fertility-sparing treatment in endometria...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2018.29.e35

    authors: Yang B,Xie L,Zhang H,Zhu Q,Du Y,Luo X,Chen X

    更新日期:2018-05-01 00:00:00

  • Combined panel of serum human tissue kallikreins and CA-125 for the detection of epithelial ovarian cancer.

    abstract:OBJECTIVE:To determine the predictive accuracy of the combined panels of serum human tissue kallikreins (hKs) and CA-125 for the detection of epithelial ovarian cancer. METHODS:Serum specimens collected from 5 Indonesian centers and 1 Vietnamese center were analyzed for CA-125, hK6, and hK10 levels. A total of 375 spe...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2012.23.3.175

    authors: Koh SC,Huak CY,Lutan D,Marpuang J,Ketut S,Budiana NG,Saleh AZ,Aziz MF,Winarto H,Pradjatmo H,Hoan NK,Thanh PV,Choolani M

    更新日期:2012-07-01 00:00:00

  • Comparison of modified Cherney incision and vertical midline incision for management of early stage cervical cancer.

    abstract:OBJECTIVE:The aim of this study was to compare operative feasibility and surgical outcome of the modified Cherney incision and vertical midline incision in patients undergoing radical hysterectomy and pelvic lymphadenectomy. METHODS:Between March 2005 and December 2007, retrospective data of 78 patients (n=17; modifie...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2008.19.4.246

    authors: Lee SH,Yim GW,Lee DW,Kim SW,Kim S,Kim JW,Kim YT

    更新日期:2008-12-01 00:00:00

  • Fertility-sparing treatment for intramucous, moderately differentiated, endometrioid endometrial cancer: a Gynecologic Cancer Inter-Group (GCIG) study.

    abstract:OBJECTIVE:'The Endometrial Cancer Conservative Treatment (E.C.Co.). A multicentre archive' is a worldwide project endorsed by the Gynecologic Cancer Inter-Group, aimed at registering conservatively treated endometrial cancer (EC) patients. This paper reports the oncological and reproductive outcomes of intramucous, G2,...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2020.31.e74

    authors: Falcone F,Leone Roberti Maggiore U,Di Donato V,Perrone AM,Frigerio L,Bifulco G,Polterauer S,Casadio P,Cormio G,Masciullo V,Malzoni M,Greggi S

    更新日期:2020-09-01 00:00:00

  • Metastasis to the ovaries from transitional cell carcinoma of the bladder and renal pelvis: a report of two cases.

    abstract::Ovarian metastases from a primary urinary tract carcinoma are extremely rare. This can be difficult to distinguish from transitional cell carcinomas (TCC) of ovarian origin because of histologic similarity. A 65-year-old woman who was diagnosed with renal pelvis TCC 4 months prior was referred for evaluation of a left...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2010.21.1.59

    authors: Lee M,Jung YW,Kim SW,Kim SH,Kim YT

    更新日期:2010-03-01 00:00:00

  • SURF4 maintains stem-like properties via BIRC3 in ovarian cancer cells.

    abstract:OBJECTIVE:As cancer stem cells (CSCs) are considered as the origin of tumor development, recurrence, and drug resistance, we aimed to explore the mechanism related to modulating stemness in CSCs, thus facilitating to search for new therapeutic strategy for ovarian cancer. METHODS:In this study, ovarian cancer stem cel...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2020.31.e46

    authors: Yue Y,Xia L,Xu S,Wang C,Wang X,Lu W,Xie X

    更新日期:2020-07-01 00:00:00

  • Programmed death-1 (PD-1) expression in cervical intraepithelial neoplasia and its relationship with recurrence after conization.

    abstract:OBJECTIVE:Impaired local cellular immunity contributes to persistent human papillomavirus (HPV) infection and development of cervical intraepithelial neoplasia (CIN). Programmed death-1 (PD-1) and its ligands PD-ligand-1 (L1) and PD-L2 are negative regulators of T cell activity in various cancers, but few studies exist...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2018.29.e27

    authors: Chang H,Hong JH,Lee JK,Cho HW,Ouh YT,Min KJ,So KA

    更新日期:2018-05-01 00:00:00

  • Does adenocarcinoma have a worse prognosis than squamous cell carcinoma in patients with cervical cancer? A real-world study with a propensity score matching analysis.

    abstract:OBJECTIVE:To compare survival outcomes between cervical adenocarcinoma (ADC) and squamous cell carcinoma (SCC) using a propensity score matching (PSM) analysis based on the Surveillance, Epidemiology, and End Results (SEER) Program. METHODS:Patients diagnosed with cervical cancer between 1998 and 2016 were identified ...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2020.31.e80

    authors: Pan X,Yang W,Wen Z,Li F,Tong L,Tang W

    更新日期:2020-11-01 00:00:00

  • Cost effectiveness analysis of HPV primary screening and dual stain cytology triage compared with cervical cytology.

    abstract:OBJECTIVES:To assess the clinical and cost-effectiveness of human papillomavirus (HPV) primary screening triage with p16/Ki-67 dual stain cytology compared to cytology. METHODS:We conducted an Excel®-based budget impact model to estimate the preinvasive and invasive cervical cancer cases identified, mortality rate, di...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2019.30.e17

    authors: Termrungruanglert W,Khemapech N,Tantitamit T,Havanond P

    更新日期:2019-03-01 00:00:00

  • Metastatic pattern of uterine leiomyosarcoma: retrospective analysis of the predictors and outcome in 113 patients.

    abstract:OBJECTIVE:To describe metastatic pattern of uterine leiomyosarcomas (ULMS) and correlate it with clinical and histopathologic parameters. METHODS:We included 113 women (mean age, 53 years; range, 29 to 72 years) with histopathology-confirmed ULMS from 2000 to 2012. Distribution of metastases was noted from imaging by ...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2014.25.4.306

    authors: Tirumani SH,Deaver P,Shinagare AB,Tirumani H,Hornick JL,George S,Ramaiya NH

    更新日期:2014-10-01 00:00:00

  • Trends in incidence and survival outcome of epithelial ovarian cancer: 30-year national population-based registry in Taiwan.

    abstract:OBJECTIVE:To investigate the changes of incidence and prognosis of epithelial ovarian cancer in thirty years in Taiwan. METHODS:The databases of women with epithelial ovarian cancer during the period from 1979 to 2008 were retrieved from the National Cancer Registration System of Taiwan. The incidence and prognosis of...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2013.24.4.342

    authors: Chiang YC,Chen CA,Chiang CJ,Hsu TH,Lin MC,You SL,Cheng WF,Lai MS

    更新日期:2013-10-01 00:00:00

  • Robotic single site radical hysterectomy plus pelvic lymphadenectomy in gynecological cancers.

    abstract:OBJECTIVE:To evaluate the feasibility and the safety of robotic single-site radical hysterectomy (RSSRH) plus pelvic lymphadenectomy (PL) in endometrial or cervical cancer. METHODS:Patients with endometrial cancer (EC) International Federation of Gynecology and Obstetrics (FIGO) stage II, early cervical cancer (ECC) F...

    journal_title:Journal of gynecologic oncology

    pub_type: 临床试验,杂志文章

    doi:10.3802/jgo.2018.29.e2

    authors: Vizza E,Chiofalo B,Cutillo G,Mancini E,Baiocco E,Zampa A,Bufalo A,Corrado G

    更新日期:2018-01-01 00:00:00

  • Creating and field-testing the questionnaire for the assessment of knowledge about cervical cancer and its prevention among schoolgirls and female students.

    abstract:OBJECTIVE:The aim of this study was to develop and validate a questionnaire used to assess the level of general knowledge about cervical cancer, its primary and secondary prevention, and to identify sources of information about the disease among schoolgirls and female students. METHODS:THE QUESTIONNAIRE DEVELOPMENT PR...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2014.25.2.81

    authors: Jaglarz K,Tomaszewski KA,Kamzol W,Puskulluoglu M,Krzemieniecki K

    更新日期:2014-04-01 00:00:00

  • Neoadjuvant chemotherapy followed by surgery has no therapeutic advantages over concurrent chemoradiotherapy in International Federation of Gynecology and Obstetrics stage IB-IIB cervical cancer.

    abstract:OBJECTIVE:We aimed to assess the efficacy of neoadjuvant chemotherapy followed by surgery (NACT+S), and compared the clinical outcome with that of concurrent chemoradiotherapy (CCRT) in patients with International Federation of Gynecology and Obstetrics (FIGO) IB-IIB cervical cancer. METHODS:We reviewed 85 patients wi...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2016.27.e52

    authors: Lee J,Kim TH,Kim GE,Keum KC,Kim YB

    更新日期:2016-09-01 00:00:00

  • Efficacy and fertility outcomes of levonorgestrel-releasing intra-uterine system treatment for patients with atypical complex hyperplasia or endometrial cancer: a retrospective study.

    abstract:OBJECTIVE:To investigate the efficacy of levonorgestrel-releasing intra-uterine system (LNG-IUS) treatment in patients affected by atypical complex hyperplasia/endometrial cancer (ACH/EC) wishing to preserve their fertility and to present fertility outcomes of those patients who actively tried to conceive. METHODS:Dat...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2019.30.e57

    authors: Leone Roberti Maggiore U,Martinelli F,Dondi G,Bogani G,Chiappa V,Evangelista MT,Liberale V,Ditto A,Ferrero S,Raspagliesi F

    更新日期:2019-07-01 00:00:00

  • The age-adjusted Charlson comorbidity index as a predictor of survival in surgically treated vulvar cancer patients.

    abstract:OBJECTIVE:To evaluate the impact of age-adjusted Charlson comorbidity index (ACCI) in predicting disease-free survival (DFS), overall survival (OS), and cancer-specific survival (CSS) among surgically treated patients with vulvar carcinoma. The secondary aim is to evaluate its impact as a predictor of the pattern of re...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2019.30.e6

    authors: Di Donato V,Page Z,Bracchi C,Tomao F,Musella A,Perniola G,Panici PB

    更新日期:2019-01-01 00:00:00

  • Universal tolerance of nab-paclitaxel for gynecologic malignancies in patients with prior taxane hypersensitivity reactions.

    abstract:OBJECTIVE:To report on the incidence of nab-paclitaxel hypersensitivity reactions (HSRs) in patients with prior taxane HSR. METHODS:From 2005 to 2015, all patients who received nab-paclitaxel for a gynecologic malignancy were identified. Chart abstraction included pathology, prior therapy, indication for nab-paclitaxe...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2017.28.e38

    authors: Maurer K,Michener C,Mahdi H,Rose PG

    更新日期:2017-07-01 00:00:00

  • Artificial intelligence weights the importance of factors predicting complete cytoreduction at secondary cytoreductive surgery for recurrent ovarian cancer.

    abstract:OBJECTIVE:Accumulating evidence support that complete cytoreduction (CC) at the time of secondary cytoreductive surgery (SCS) improves survival in patients affected by recurrent ovarian cancer (ROC). Here, we aimed to determine whether artificial intelligence (AI) might be useful in weighting the importance of clinical...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2018.29.e66

    authors: Bogani G,Rossetti D,Ditto A,Martinelli F,Chiappa V,Mosca L,Leone Roberti Maggiore U,Ferla S,Lorusso D,Raspagliesi F

    更新日期:2018-09-01 00:00:00