Abstract:
OBJECTIVE:This study was conducted to examine the effects of front-line chemotherapy on overall survival (OS) and postrecurrence survival (PRS) of patients with recurrent ovarian cancer, when stratifying the histologic type. METHODS:Five hundred and seventy-four patients with recurrent ovarian cancer with sufficient clinical information, including front-line chemotherapy, were analyzed. The pathologic slides were evaluated by central pathologic review. The patients were divided into two groups: group A (n=261), who underwent taxane plus platinum, and group B (n=313), who underwent conventional platinum-based chemotherapy without taxanes. RESULTS:The median age was 54 years (range, 14 to 89 years). Group A had significantly better median OS (45.0 months vs. 30.3 months, p<0.001) and PRS (23.0 months vs. 13.0 months, p<0.001) compared to group B. The OS and PRS were similar between the groups in patients with clear cell or mucinous histology. In contrast, among patients with non-clear cell, non-mucinous histologies, the OS and PRS of group A were significantly better than those of group B (OS, p<0.001; PRS, p<0.001). Multivariable analyses revealed that, among patients with non-clear cell, non-mucinous histologies, chemotherapy including taxane and platinum was an independent predictor of favorable survival outcomes. Conversely, in patients with clear cell or mucinous histology, taxane-including platinum-based combination chemotherapy did not improve the OS and PRS compared to a conventional platinum-based regimen which did not include taxanes. CONCLUSION:Since the emergence of taxane plus platinum, the prognosis of patients with recurrent ovarian cancer has improved. However, we here demonstrate that this improvement is limited to patients with non-clear cell, non-mucinous histologies.
journal_name
J Gynecol Oncoljournal_title
Journal of gynecologic oncologyauthors
Kajiyama H,Shibata K,Mizuno M,Umezu T,Suzuki S,Sekiya R,Niimi K,Mitsui H,Yamamoto E,Kawai M,Nagasaka T,Kikkawa Fdoi
10.3802/jgo.2014.25.1.43subject
Has Abstractpub_date
2014-01-01 00:00:00pages
43-50issue
1eissn
2005-0380issn
2005-0399journal_volume
25pub_type
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journal_title:Journal of gynecologic oncology
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更新日期:2011-12-01 00:00:00
abstract::This corrects the article on p. e43 in vol. 29, PMID: 29770616. ...
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pub_type: 杂志文章,已发布勘误
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更新日期:2018-09-01 00:00:00
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更新日期:2018-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-04-01 00:00:00
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journal_title:Journal of gynecologic oncology
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更新日期:2010-03-01 00:00:00
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更新日期:2017-09-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2017-09-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2018-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2012-10-01 00:00:00
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journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2018.29.e12
更新日期:2018-01-01 00:00:00
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journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2017.28.e38
更新日期:2017-07-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2018-01-01 00:00:00
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journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2008.19.2.139
更新日期:2008-06-01 00:00:00
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journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
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更新日期:2018-05-01 00:00:00
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doi:10.3802/jgo.2019.30.e78
更新日期:2019-09-01 00:00:00
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journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2017.28.e82
更新日期:2017-11-01 00:00:00
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journal_title:Journal of gynecologic oncology
pub_type: 杂志文章,评审
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更新日期:2020-05-01 00:00:00
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更新日期:2020-07-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2019-05-01 00:00:00
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更新日期:2018-07-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2014-07-01 00:00:00