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Active axial stress in mouse aorta.

Abstract：

:The study verifies the development of active axial stress in the wall of mouse aorta over a range of physiological loads when the smooth muscle cells are stimulated to contract. The results obtained show that the active axial stress is virtually independent of the magnitude of pressure, but depends predominately on the longitudinal stretch ratio. The dependence is non-monotonic and is similar to the active stress-stretch dependence in the circumferential direction reported in the literature. The expression for the active axial stress fitted to the experimental data shows that the maximum active stress is developed at longitudinal stretch ratio 1.81, and 1.56 is the longitudinal stretch ratio below which the stimulation does not generate active stress. The study shows that the magnitude of active axial stress is smaller than the active circumferential stress. There is need for more experimental investigations on the active response of different types of arteries from different species and pathological conditions. The results of these studies can promote building of refined constrictive models in vascular rheology.

journal_name

J Biomech

journal_title

Journal of biomechanics

authors

Agianniotis A,Rachev A,Stergiopulos N

doi

10.1016/j.jbiomech.2012.05.025

subject

Has Abstract

pub_date

2012-07-26 00:00:00

pages

1924-7

issue

11

eissn

0021-9290

issn

1873-2380

pii

S0021-9290(12)00294-1

journal_volume

45

pub_type

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