Bypassing the Greatwall-Endosulfine pathway: plasticity of a pivotal cell-cycle regulatory module in Drosophila melanogaster and Caenorhabditis elegans.

abstract：:The mak7-1 mutant loses the killer toxin-encoding M1 dsRNA. MAK7 is RPL4A, one of two genes encoding ribosomal protein L4. KRB1 is a dominant suppressor of mak7-1 that is tightly centromerelinked, but not linked to centromere markers of chromosomes I-XVI. Our orthogonal field agarose gel electrophoresis analysis of ch...

journal_title：Genetics

authors： Ohtake Y,Wickner RB

更新日期：1995-05-01 00:00:00

abstract：:The concept of haplotype blocks has been shown to be useful in genetics. Fields of application range from the detection of regions under positive selection to statistical methods that make use of dimension reduction. We propose a novel approach ("HaploBlocker") for defining and inferring haplotype blocks that focuses ...

journal_title：Genetics

authors： Pook T,Schlather M,de Los Campos G,Mayer M,Schoen CC,Simianer H

更新日期：2019-08-01 00:00:00

abstract：:We show by molecular analysis of behavioral and physiological mutants that the Drosophila Dmca1A calcium-channel alpha1 subunit is encoded by the cacophony (cac) gene and that nightblind-A and lethal(1)L13 mutations are allelic to cac with respect to an expanded array of behavioral and physiological phenotypes associa...

journal_title：Genetics

authors： Smith LA,Peixoto AA,Kramer EM,Villella A,Hall JC

更新日期：1998-07-01 00:00:00

abstract：:Circadian ( approximately 24 hr) rhythms of behavior and physiology are driven by molecular clocks that are endogenous to most organisms. The mechanisms underlying these clocks are remarkably conserved across evolution and typically consist of auto-regulatory loops in which specific proteins (clock proteins) rhythmica...

journal_title：Genetics

authors： Zheng X,Sehgal A

更新日期：2008-03-01 00:00:00

abstract：:DNA repair of single-strand breaks (produced by ionizing radiation) and of base damage (produced by ultraviolet (UV) light) are two repair mechanisms that most mammalian cells possess. Genetic defects in these repair mechanisms are exemplified by cells from the human premature-aging disease, progeria, which fail to re...

journal_title：Genetics

authors： Cleaver JE,Bootsma D,Friedberg E

更新日期：1975-06-01 00:00:00

abstract：:The extent of conservation of synteny and gene order in the Lepidoptera has been investigated previously only by comparing a small subset of linkage groups between the moth Bombyx mori and the butterfly Heliconius melpomene. Here we report the mapping of 64 additional conserved genes in H. melpomene, which contributed...

journal_title：Genetics

authors： Pringle EG,Baxter SW,Webster CL,Papanicolaou A,Lee SF,Jiggins CD

更新日期：2007-09-01 00:00:00

abstract：:The type of variegation of eyes of white-mottled mutants of D. hydei, either small-spotted or large-spotted, depends on the specific chromosome rearrangement involved. This distinction between mutants, though handsome, is not absolute because very seldomly small-spotted types do show a larger pigment aggregate and som...

journal_title：Genetics

authors： van Breugel FM

更新日期：1973-10-01 00:00:00

abstract：:Florida teosinte from Honduras and Guanajuato teosinte have most of their knobs internally located and a common inversion in the short arm of chromosome 8. Teosintes from northern Guatemala, Huixta and Monajil, have all their knobs terminally located and do not have any inversions. Therefore, Florida teosinte from Hon...

journal_title：Genetics

authors： Ting YC

更新日期：1976-08-01 00:00:00

abstract：:Among a large number of homologous gene clusters in C. elegans, two gene families that appear to undergo concerted evolution were studied in detail. Both gene families are nematode specific and encode small secreted proteins of unknown function. For both families in three Caenorhabditis species, concerted groups of ge...

journal_title：Genetics

authors： Thomas JH

更新日期：2006-04-01 00:00:00

abstract：:The genetics of phenotypic variation in inbred mice has for nearly a century provided a primary weapon in the medical research arsenal. A catalog of the genetic variation among inbred mouse strains, however, is required to enable powerful positional cloning and association techniques. A recent whole-genome resequencin...

journal_title：Genetics

authors： Kirby A,Kang HM,Wade CM,Cotsapas C,Kostem E,Han B,Furlotte N,Kang EY,Rivas M,Bogue MA,Frazer KA,Johnson FM,Beilharz EJ,Cox DR,Eskin E,Daly MJ

更新日期：2010-07-01 00:00:00

abstract：:Resident gut bacteria are constantly influencing the immune system, yet the role of the immune system in shaping microbiota composition during an organism's life span has remained unclear. Experiments in mice have been inconclusive due to differences in husbandry schemes that led to conflicting results. We used Drosop...

journal_title：Genetics

authors： Mistry R,Kounatidis I,Ligoxygakis P

更新日期：2017-06-01 00:00:00

abstract：:RecQ helicases function in the maintenance of genome stability in many organisms. The filamentous fungus Neurospora crassa has two RecQ homologs, QDE3 and RECQ2. We found that the qde-3 recQ2 double mutant showed a severe growth defect. The growth defect was alleviated by mutation in mei-3, the homolog of yeast RAD51,...

journal_title：Genetics

authors： Kato A,Inoue H

更新日期：2006-01-01 00:00:00

abstract：:Resolving the mechanistic and genetic bases of reproductive barriers between species is essential to understanding the evolutionary forces that shape speciation. Intrinsic hybrid incompatibilities are often treated as fixed between species, yet there can be considerable variation in the strength of reproductive isolat...

journal_title：Genetics

authors： Larson EL,Vanderpool D,Sarver BAJ,Callahan C,Keeble S,Provencio LL,Kessler MD,Stewart V,Nordquist E,Dean MD,Good JM

更新日期：2018-07-01 00:00:00

abstract：:To identify the callipyge mutation, we have resequenced 184 kb spanning the DLK1-, GTL2-, PEG11-, and MEG8-imprinted domain and have identified an A-to-G transition in a highly conserved dodecamer motif between DLK1 and GTL2. This was the only difference found between the callipyge (CLPG) allele and a phylogenetically...

journal_title：Genetics

authors： Smit M,Segers K,Carrascosa LG,Shay T,Baraldi F,Gyapay G,Snowder G,Georges M,Cockett N,Charlier C

更新日期：2003-01-01 00:00:00

abstract：:We have characterized the MPH1 gene from Saccharomyces cerevisiae. mph1 mutants display a spontaneous mutator phenotype. Homologs were found in archaea and in the EST libraries of Drosophila, mouse, and man. Mph1 carries the signature motifs of the DEAH family of helicases. Selected motifs were shown to be necessary f...

journal_title：Genetics

authors： Scheller J,Schürer A,Rudolph C,Hettwer S,Kramer W

更新日期：2000-07-01 00:00:00

abstract：:The gastrulation defective (gd) locus encodes a novel serine protease that is involved in specifying the dorsal-ventral axis during embryonic development. Mutant alleles of gd have been classified into three complementation groups, two of which exhibit strong interallelic (intragenic) complementation. To understand th...

journal_title：Genetics

authors： Ponomareff G,Giordano H,DeLotto Y,DeLotto R

更新日期：2001-10-01 00:00:00

abstract：:We have isolated and characterized deletions arising within a P transposon, P[hswa], in the presence of P transposase. P[hswa] carries white-apricot (wa) sequences, including a complete copia element, under the control of an hsp70 promoter, and resembles the original wa allele in eye color phenotype. In the presence o...

journal_title：Genetics

authors： Kurkulos M,Weinberg JM,Roy D,Mount SM

更新日期：1994-03-01 00:00:00

abstract：:Chromatin organization and structure are crucial for transcriptional regulation, DNA replication, and damage repair. Although initially characterized in remodeling cell wall glucans, the β-1,3-glucanosyltransferase Gas1 was recently discovered to regulate transcriptional silencing in a manner separable from its activi...

journal_title：Genetics

authors： Eustice M,Pillus L

更新日期：2014-04-01 00:00:00

abstract：:Constitutive transport of cellular materials is essential for cell survival. Although multiple small GTPase Rab proteins are required for the process, few regulators of Rabs are known. Here we report that EAT-17, a novel GTPase-activating protein (GAP), regulates RAB-6.2 function in grinder formation in Caenorhabditis...

journal_title：Genetics

authors： Straud S,Lee I,Song B,Avery L,You YJ

更新日期：2013-09-01 00:00:00

abstract：:The Caenorhabditis elegans pRb ortholog, LIN-35, functions in a wide range of cellular and developmental processes. This includes a role of LIN-35 in nutrient utilization by the intestine, which it carries out redundantly with SLR-2, a zinc-finger protein. This and other redundant functions of LIN-35 were identified i...

journal_title：Genetics

authors： Polley SR,Fay DS

更新日期：2012-08-01 00:00:00

abstract：:Many of the transcription factors and target genes that pattern the developing adult remain unknown. In the present study, we find that an ortholog of the poorly understood transcription factor, glucose transporter (GLUT4) enhancer factor (Glut4EF, GEF) [also known as the Huntington's disease gene regulatory region-bi...

journal_title：Genetics

authors： Yazdani U,Huang Z,Terman JR

更新日期：2008-02-01 00:00:00

abstract：:Septin proteins bind GTP and heterooligomerize into filaments with conserved functions across a wide range of eukaryotes. Most septins hydrolyze GTP, altering the oligomerization interfaces; yet mutations designed to abolish nucleotide binding or hydrolysis by yeast septins perturb function only at high temperatures. ...

journal_title：Genetics

authors： Weems AD,Johnson CR,Argueso JL,McMurray MA

更新日期：2014-03-01 00:00:00

abstract：:Heritable silencing effects are gene suppression phenomena that can persist for generations after induction. In the majority of RNAi experiments conducted in Caenorhabditis elegans, the silencing response results in a hypomorphic phenotype where the effects recede after the F1 generation. F2 and subsequent generations...

journal_title：Genetics

authors： Alcazar RM,Lin R,Fire AZ

更新日期：2008-11-01 00:00:00

abstract：:Aimed at investigating the recovery of a specific mutant allele of the mating type locus (MAT) by switching a defective MAT allele, these experiments provide information bearing on several models proposed for MAT interconversion in bakers yeast, Saccharomyces cerevisiae. Hybrids between heterothallic (ho) cells carryi...

journal_title：Genetics

authors： Klar AJ,Fogel S,Radin DN

更新日期：1979-07-01 00:00:00

abstract：:The T-complex protein 1, TCP1, gene codes for the CCT-alpha subunit of the group II chaperonins. The gene was first described in the house mouse, in which it is closely linked to the T locus at a distance of approximately 11 cM from the Mhc. In the zebrafish, Danio rerio, in which the T homolog is linked to the class ...

journal_title：Genetics

authors： Takami K,Figueroa F,Mayer WE,Klein J

更新日期：2000-01-01 00:00:00

abstract：:During development signaling pathways coordinate cell fates and regulate the choice between cell survival or programmed cell death. The well-conserved Wingless/Wnt pathway is required for many developmental decisions in all animals. One transducer of the Wingless/Wnt signal is Armadillo/beta-catenin. Drosophila Armadi...

journal_title：Genetics

authors： Cox RT,McEwen DG,Myster DL,Duronio RJ,Loureiro J,Peifer M

更新日期：2000-08-01 00:00:00

abstract：:A specific host-pathogen interaction exists between Caenorhabditis elegans and the gram-positive bacterium Microbacterium nematophilum. This bacterium is able to colonize the rectum of susceptible worms and induces a defensive tail-swelling response in the host. Previous mutant screens have identified multiple loci th...

journal_title：Genetics

authors： Yook K,Hodgkin J

更新日期：2007-02-01 00:00:00

abstract：:There has been considerable debate on the geographic origin of the human Y chromosome Alu polymorphism (YAP). Here we report a new, very rare deep-rooting haplogroup within the YAP clade, together with data on other deep-rooting YAP clades. The new haplogroup, found so far in only five Nigerians, is the least-derived ...

journal_title：Genetics

authors： Weale ME,Shah T,Jones AL,Greenhalgh J,Wilson JF,Nymadawa P,Zeitlin D,Connell BA,Bradman N,Thomas MG

更新日期：2003-09-01 00:00:00

abstract：:A method for estimating the average level of gene flow among populations is introduced. The method provides an estimate of Nm, where N is the size of each local population in an island model and m is the migration rate. This method depends on knowing the phylogeny of the nonrecombining segments of DNA that are sampled...

journal_title：Genetics

authors： Slatkin M,Maddison WP

更新日期：1989-11-01 00:00:00

abstract：:While mitochondria are renowned for their role in energy production, they also perform several other integral functions within the cell. Thus, it is not surprising that mitochondrial dysfunction can negatively impact cell viability. Although mitochondria have received an increasing amount of attention in recent years,...

journal_title：Genetics

authors： Kato A,Kurashima K,Chae M,Sawada S,Hatakeyama S,Tanaka S,Inoue H

更新日期：2010-08-01 00:00:00