Abstract：
BACKGROUND:We report two cases of drug-facilitated sexual assault which presented with CNS depression rendering the victims vulnerable to sexual assault and unable to recall the events surrounding the crimes. In each tetrahydrozoline (THZ) was quantified. CASE REPORT:Case #1 ingested an unknown amount of eye drops containing THZ mixed with alcoholic beverages. Case #1 presented to the emergency department (ED) approximately 7h after reportedly being sexually assaulted and was without symptoms in the ED. Earlier reports from individuals who saw her indicated the victim to be "heavily intoxicated". Case #2 also ingested an unknown amount of eye drops containing THZ mixed with alcoholic beverages. Case #2 presented to an ED without symptoms approximately 23h after reportedly being sexually assaulted. Urine obtained from both cases was assessed for THZ concentrations using gas-chromatography-mass spectrometry. CASE DISCUSSION:Case #1 had a 0.15g% (by weight by volume) urine ethanol concentration and a urinary THZ concentration of 1.481ng/ml, approximately 7h after ingestion. Case #2 was negative for ethanol but had a urine THZ concentration of 108ng/ml at 23h post-ingestion. Few case reports have been published documenting the use of THZ to facilitate sexual assault. CONCLUSION:We report two cases of drug-facilitated sexual assault involving the use of THZ where alcoholic beverages were concomitantly consumed. This is the first paper to our knowledge which discusses pharmacology of THZ ingestion and the significance of alcohol being present.
journal_name
Forensic Sci Intjournal_title
Forensic science internationalauthors
Stillwell ME,Saady JJdoi
10.1016/j.forsciint.2012.04.004subject
Has Abstractpub_date
2012-09-10 00:00:00pages
e12-6issue
1-3eissn
0379-0738issn
1872-6283pii
S0379-0738(12)00167-3journal_volume
221pub_type
杂志文章abstract：:The objective of this study was to evaluate the applicability of human identification parameters, established by Tatlisumak et al. (2007), by means of cone-beam computed tomography and extraoral radiographs of the frontal sinus region. From a total of 58 dry skulls, 26 were selected. Posteroanterior, profile cephalome...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2016.03.030
更新日期：2016-05-01 00:00:00
abstract：:Ethyl glucuronide (EtG) and fatty acid ethyl esters (FAEE), non-volatile, direct metabolites of ethanol have been shown to be suitable markers for the evaluation of social and chronic excessive alcohol consumption. Previous investigations have shown that the regular use of hair-care products with high alcohol content ...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2011.10.015
更新日期：2012-05-10 00:00:00
abstract：:The effect of population subdivision on the determination of kinship of any two persons is investigated in this paper. Expressions of the joint genotype probabilities and likelihood ratios on kinship testing are reported. Two real cases are analysed using the Hong Kong Chinese population data and the Spanish data. Var...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/s0379-0738(03)00168-3
更新日期：2003-08-12 00:00:00
abstract：:5F-MDMB-PICA has been detected in products sold on the internet as well as in biological samples since 2016. It is associated with serious adverse health and behavioral effects and even death. Herein we report on twelve cases with proven 5F-MDMB-PICA consumption, including three fatalities, four cases of driving under...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2020.110410
更新日期：2020-09-01 00:00:00
abstract：:This study was undertaken for the purpose of analysing under the aspect of legal medicine, fatal accidents due to train surfing in the local transport system of Berlin (S-Bahn and underground). The period of investigation was from 1989 through 1995, with 41 train surfing accidents, among them 18 with fatal outcome. Ev...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/s0379-0738(98)00064-4
更新日期：1998-06-08 00:00:00
abstract：:Of the 110 species of genus Papaver, only Papaver somniferum and P. setigerum are controlled poppies in Korea. All poppy samples share similar morphology therefore it is important to check if they contain controlled substances such as morphine and codeine for forensic purpose. Since the alkaloid content of Papaver pla...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2012.08.002
更新日期：2012-10-10 00:00:00
abstract：:We investigated 40 patients who had died following open heart surgery between January 1990 and May 1992. Between this time, 703 open heart procedures were carried out at the University Medical School of Debrecen, 2nd Department of Surgery's Cardiac Surgery Unit with a mortality rate of 8.3%. We studied each individual...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(96)01896-8
更新日期：1996-05-31 00:00:00
abstract：:Some of the most polymorphic short tandem repeats (STRs) have alleles differing in size by as little as one basepair. Since sizing precision with commercially available internal standards ordinarily does not allow safe discrimination at this level, typing is accomplished through comparisons with allelic ladders run on...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/s0379-0738(97)02137-3
更新日期：1997-05-05 00:00:00
abstract：:DNA typing of 15 short tandem repeat (STR) loci included in the AmpFlSTR Identifiler PCR amplification kit (Applied Biosystems), was carried out in three Egyptian populations of different ethnic groups: the Berbers from the Siwa oasis (in the North-Western Egyptian desert), the Muslims and the Copts from Adaima (Upper...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2006.03.017
更新日期：2007-07-04 00:00:00
abstract：:Site and temporal changes in tranylcypromine (TCP) and lithium concentrations in blood were studied in a human poisoning case. Blood samples from peripheral vessels and six central vessels were obtained at 0, 6, 24, 48 and 72 h after starting the autopsy. Nine tissue samples were obtained on completion. TCP showed pre...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(93)90157-6
更新日期：1993-05-01 00:00:00
abstract：:In vitro evaluation of the effect of five insecticidal phosphoric and 11 thiophosphoric acid esters on different, non-specific human leukocytes esterases indicated that most of the organic phosphor compounds studied inhibited the activity of neutral alpha-naphthylacetate esterase, alpha-naphthylbutyryl esterase, and n...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(84)90192-0
更新日期：1984-07-01 00:00:00
abstract：:In Dunedin (South Island, New Zealand), a sexual assault is reported to police approximately once every two to three weeks, with some reports fictitious. Identifying a fictitious claim is difficult, and damage to apparel, especially knickers, may be the only form of evidence. In this paper, the tear behaviour of three...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2011.10.029
更新日期：2012-04-10 00:00:00
abstract：:Four novel alkyl 2-cyanoacrylate monomers (alkyl=1-cyanoethyl, 2-cyanoethyl, trideuteromethyl and pentadeuteroethyl) have been tested for their ability to develop latent fingermarks that can then be visualized using mid-infrared spectral (chemical) imaging. Each of the four monomers was chosen for its potential to pro...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2010.10.012
更新日期：2011-04-15 00:00:00
abstract：:A population study on thirteen short tandem repeat (STR) loci was performed on 223 unrelated Italian Caucasians. The DNA was amplified by PCR. Separation and detection of the amplified STR fragments was carried out by use of 377 automated system (Applied Biosystems Division/Perkin Elmer). All loci meet Hardy-Weinberg ...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/s0379-0738(98)00132-7
更新日期：1998-10-12 00:00:00
abstract：:In a recent technical note in this Journal, de Faria et al., 2017 [1] reported the Raman spectrum of authentic Indian yellow artists' pigment, correcting a decades old reference spectrum that has led to the misidentification of this pigment in artworks that actually contained tartrazine yellow. The present communicati...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2017.04.013
更新日期：2017-07-01 00:00:00
abstract：:Allele frequencies for the 19 STRs loci, D3S1358, D5S818, D7S820, D8S1179, D13S317, D16S539, D18S51, D21S11, CSF1PO, F13A01, F13B, FESFPS, FGA, LPL, Penta D, Penta E, TH01, TPOX and VWA were obtained from a sample of 203-1188 unrelated individuals living in the area of south-east Poland. ...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2003.10.001
更新日期：2004-01-06 00:00:00
abstract：:The assessment of sex is crucial to the establishment of a biological profile of an unidentified skeletal individual. The best methods currently available for the sexual diagnosis of human skeletal remains generally rely on the presence of well-preserved pelvic bones, which is not always the case. Postcranial elements...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2016.06.011
更新日期：2016-09-01 00:00:00
abstract：:Determination of the synthetic route in methamphetamine profiling relies on the identification of key, route specific marker impurity compounds. Impurity profiling of recent crystalline methamphetamine ('ice'), seized by the Australian Federal Police at the Australian border in 2003-2004, identified route specific mar...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2006.08.016
更新日期：2007-07-04 00:00:00
abstract：:This is a preliminary report on significant alterations in the DNA profile caused by toxic substances which potentially has profound implications for the use of DNA techniques in identification. Acute DNA changes in the globus pallidus of the brain in man caused by carbon monoxide poisoning were detected by DNA profil...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(95)01879-4
更新日期：1996-04-23 00:00:00
abstract：:The analysis of condom traces has recently been added to the standard forensic examination protocol of sexual assault and rape cases. Several recent studies have thus focussed on the detection of condom components and classification of the chemical profiles using statistics, obtaining very promising results. The purpo...
journal_title：Forensic science international
pub_type： 杂志文章,评审
doi：10.1016/j.forsciint.2020.110255
更新日期：2020-05-01 00:00:00
abstract：:It is important to have accurate and reliable measurements of soft tissue thickness for specific landmarks of the face and scalp when producing a facial reconstruction. In the past several methods have been created to measure facial soft tissue thickness (FSTT) in cadavers and in the living. The conventional spiral CT...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2010.02.018
更新日期：2010-06-15 00:00:00
abstract：:We have developed a triplex PCR method for D3S1359, HumTH01 and HumTPO tetranucleotide loci and a duplex PCR method for HumFES/FPS and HumvWA31A tetranucleotide loci using high resolution polyacrylamide gel electrophoresis and silver staining. The methods were evaluated for paternity testing and individual identificat...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/s0379-0738(96)02002-6
更新日期：1996-10-25 00:00:00
abstract：:Restriction fragment length polymorphism analysis (RFLP-analysis) was carried out on blood samples from 616 unrelated Danish Caucasians. DNA was restricted with Hinf I and analyzed with the single locus variable number tandem repeats (VNTR) probes MS1, MS31, MS43a and YNH24. The effect of the sample size on the estima...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(94)90275-5
更新日期：1994-05-13 00:00:00
abstract：:A new solid-phase extraction procedure for the determination of cocaine and some of its metabolites in brain tissue, using high-flow co-polymeric sorbents is reported as a substantial improvement on our recently reported procedure. The recovery of cocaine, norcocaine and cocaethylene was excellent as was the reproduci...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(92)90197-5
更新日期：1992-03-01 00:00:00
abstract：:Databases have been used to record data in forensic science, such as fingerprints, shoeprints, and photos. In traditional databases, we use "text" as the "keyword" for retrieving data (text-keyword retrieval); however, in some applications, "text" is not proper to describe the searching target, and in this case, "imag...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2004.11.006
更新日期：2005-12-01 00:00:00
abstract：:Forensic pathologists are often involved in the identification of unknown bodies. It is imperative, therefore, that they become aware of a national computerized identification system (NCIC) administered by the FBI. There is also a state system in California which has resulted in the identification of 59 individuals. T...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(86)90013-7
更新日期：1986-02-01 00:00:00
abstract：AIM:To highlight some problems that may occur when investigating clozapine-associated deaths including (i) that death may be related to gastrointestinal hypomotility and (ii) that post-mortem blood clozapine and norclozapine concentrations may not reflect ante-mortem concentrations. CASE REPORTS:A 41-year-old male die...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2010.07.021
更新日期：2011-03-20 00:00:00
abstract：:An improved cleanup method has been developed for the recovery of trace levels of 12 nitro-organic explosives in soil, which is important not only for the forensic community, but also has environmental implications. A wide variety of explosives or explosive-related compounds were evaluated, including nitramines, nitra...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2017.12.018
更新日期：2018-03-01 00:00:00
abstract：:It is a requirement that forensic DNA profiling evidence be accompanied by an estimation of its weight, in order that the court can assign an appropriate probative value to it during legal proceedings. There are various models by which this estimation can be made, but each relies on approximations of the allele freque...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2007.04.221
更新日期：2008-03-05 00:00:00
abstract：:Ten X-chromosomal STRs from two multiplex PCR approaches (DXS9898, DXS6807, HPRTB, DXS101, and androgen receptor (ARA); DXS7133, DXS10011, DXS7424, DXS8377, and DXS8378) have been typed in a Latvian population sample. ...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2005.04.006
更新日期：2006-03-10 00:00:00
