Abstract：
AIM:To analyze the demography, presenting clinical features, spread of the disease of retinoblastoma in patients who were treated in two tertiary hospitals in Malaysia. METHODS:In this retrospective study, information of gender, age, race, presenting clinical features, findings of CT scan orbits and brain, lumbar puncture and bone marrow aspiration results were collected from the medical records of retinoblastoma patients diagnosed in Hospital of Universiti Sains Malaysia and General Hospital of Kuala Lumpur over a period of ten years. The data were collected in the same type of proforma from both hospitals. RESULTS:A total of 64 patients were treated in both hospitals together, of whom boys and girls were almost equally affected. The mean age of children at presentation was 24.2 (range 3-84) months, 53 (82.8%) children were under 36 months old. The disease was unilateral in 39 (60.9%) patients. The most common presenting signs were leukocoria in 46 (71.8%), followed by proptosis in 21 (32.8%) patients. Routine screening of the siblings of affected children revealed retinoblastoma in 2 patients. There was intracranial extension in 8 (12.5%) and metastasis in bone marrow in 6 (9.3%) patients. CONCLUSION:Leukocoria is the most common presentation of retinoblastoma in Malaysia. However, the disease was intraocular in 40 (62.5%) and extraocular (orbital involvement, intracranial and distant metastasis) in 24 (37.5%) patients.
journal_name
Int J Ophthalmoljournal_title
International journal of ophthalmologyauthors
Reddy SC,Anusya Sdoi
10.3980/j.issn.2222-3959.2010.01.15subject
Has Abstractpub_date
2010-01-01 00:00:00pages
64-8issue
1eissn
2222-3959issn
2227-4898pii
ijo-03-01-064journal_volume
3pub_type
杂志文章abstract：AIM:To analyze and identify the proteomic differences between liquefied after-cataracts and normal lenses by means of liquefied chromatography-tandem mass spectrometry (LC-MS/MS). METHODS:Three normal lenses and three liquefied after-cataracts were exposed to depolymerizing reagents to extract the total proteins. Prot...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2017.09.02
更新日期：2017-09-18 00:00:00
abstract：AIM:To investigate the incidence and the predisposing factors of anterior chamber (AC) gas bubbles during femtosecond laser (FS) flap creation for laser in situ keratomileusis (LASIK). METHODS:All patients who underwent FS-LASIK surgery at CMU LASIK Center between January 2013 and May 2016 were retrospective reviewed....
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2020.08.22
更新日期：2020-08-18 00:00:00
abstract：AIM:To evaluate the thickness and volume changes of the choroidal, outer retinal layers (ORL) and retinal pigment epithelium (RPE) in patients with diabetic retinopathy (DR) using optical coherence tomography (OCT) and correlate them with visual acuity. METHODS:We carried out a retrospective observational case series....
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2018.12.14
更新日期：2018-12-18 00:00:00
abstract：AIM:To investigate the effect of Bak Foong Pills (BFP) on the expression of β-amyloid (Aβ) in rats retina with optic nerve transection, and its roles and possible mechanisms in protecting optic nerve damage. METHODS:Seventy-two healthy, Sprague-Dawley, adult rats were randomly assigned to three groups: negative contro...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.3980/j.issn.2222-3959.2011.01.13
更新日期：2011-01-01 00:00:00
abstract：AIM:To study the effects of curcumin on the secretion of interleukin (IL)-6 and IL-8 by corneal limbus epithelial cells. METHODS:Human corneal limbus epithelial cells were isolated and cultured from donor eyes and irradiated by UVB at different dosages with or without curcumin. MTT test was used for studying the effec...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2017.06.01
更新日期：2017-06-18 00:00:00
abstract：AIM:To assess the biosafety of a poly(acrylamide-co-sodium acrylate) hydrogel (PAH) as a 3D-printed intraocular lens (IOL) material. METHODS:The biosafety of PAH was first evaluated in vitro using human lens epithelial cells (LECs) and the ARPE19 cell line, and a cell counting kit-8 (CCK-8) assay was performed to inve...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2020.10.03
更新日期：2020-10-18 00:00:00
abstract：AIM:To examine the association between the single nucleotide polymorphisms (SNPs) of matrix metalloprotease-9 (MMP-9) gene and primary angle-closure glaucoma (PACG) in a Chinese Han population. METHODS:DNA samples were extracted from peripheral-blood mononuclear cells of 214 PACG patients and 224 healthy controls. Gen...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.3980/j.issn.2222-3959.2014.03.02
更新日期：2014-06-18 00:00:00
abstract：:Non-simulator-based examination methods of the fundal examination have shown to be cost-effective. We reviewed different non-simulator-based direct fundoscopy examination methods used in undergraduate curricula and their outcomes. PubMed (MEDLINE) and Cochrane Database of Systematic Reviews were searched using standar...
journal_title：International journal of ophthalmology
pub_type： 杂志文章,评审
doi：10.18240/ijo.2020.04.20
更新日期：2020-04-18 00:00:00
abstract：AIM:To report the outcomes of patients undergoing anterior segment optical coherence tomography-guided transepithelial phototherapeutic keratectomy (ASOCT T-PTK) for central corneal scarring after pterygium excision. METHODS:The charts of 11 eyes of 10 patients that underwent ASOCT T-PTK following excision of visual a...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2020.03.20
更新日期：2020-03-18 00:00:00
abstract：AIM:To investigate whether the enhanced green fluorescent protein (EGFP) reporter gene could be transferred into human trabecular meshwork (HTM) cells by a HIV-based lentivirus both in vitro and ex vivo. METHODS:The HIV-based lentivirus that contains an EF1-α promoter driving EGFP expression cassette was constructed f...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.3980/j.issn.2222-3959.2014.06.02
更新日期：2014-12-18 00:00:00
abstract：AIM:To investigate microRNA-143 expression and effect on suppression of retinoblastoma (RB) cells. METHODS:The expression of microRNA-143 was investigated and compared in normal human retina tissue samples and in RB cell lines of Y79 and Weri1. The microRNA-143 mimics were transfected into the RB cell lines separately...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2016.11.08
更新日期：2016-11-18 00:00:00
abstract：AIM:To construct functional human full-thickness corneal replacements. METHODS:Acellular porcine corneal matrix (APCM) was developed from porcine cornea by decellulariztion. The biomechanical properties of anterior-APCM (AAPCM) and posterior-APCM (PAPCM) were checked using uniaxial tensile testing. Human corneal cells...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2019.03.01
更新日期：2019-03-18 00:00:00
abstract：AIM:To describe the clinical characteristics and late results of patients with retinopathy of prematurity (ROP) treated with "6h cryotherapy". METHODS:Out of 1252 infants screened for ROP, 52 patients were treated with temporal 6h cryotherapy from 1997 to 2005 were recalled to our clinic. Among these 23 patients were ...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2016.04.15
更新日期：2016-04-18 00:00:00
abstract：AIM:To evalaute the effect of fixed-combination latanoprost 0.005%/timolol maleate 0.5% and dorzolamide hydrochloride 2%/timolol maleate 0.5% on postoperative intraocular pressure after phacoemulsification cataract surgery. METHODS:This study is a prospective, randomized, double-masked and placebo-controlled. The stud...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.3980/j.issn.2222-3959.2011.02.17
更新日期：2011-01-01 00:00:00
abstract：AIM:To evaluate the impact of 4 different intraocular lenses (IOLs) on posterior capsule opacification (PCO) by comparing the neodymium: yttrium-aluminum-garnet (Nd:YAG) laser capsulotomy rates. METHODS:This retrospective study included 4970 eyes of 4013 cataract patients who underwent phacoemulsification and IOL impl...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.3980/j.issn.2222-3959.2015.01.22
更新日期：2015-02-18 00:00:00
abstract：AIM:To observe and characterize imaging features of macular and optic disc areas in less than 60-year-old patients with early primary open angle glaucoma (POAG) by optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA), and to evaluate the diagnostic value of OCT and OCTA. METHODS:Total...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2020.12.11
更新日期：2020-12-18 00:00:00
abstract：AIM:To investigate the ocular hemodynamic effects of applying a hot compress to the eye. METHODS:The right eyes of five New Zealand white rabbits, both male and female, were hot-compressed for 18min. An independently designed novel ocular contact-type temperature measuring device was used to measure the ocular surface...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2018.12.04
更新日期：2018-12-18 00:00:00
abstract：AIM:To compare the efficacy of prophylactic vitrectomy for acute retinal necrosis syndrome(ARN) with routine treatment in Chinese patients, thereby investigate the necessity of prophylactic vitrectomy for ARN. METHODS:Thirty patients (37 eyes) were retrospectively included in this study. The eyes were divided into 2 g...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.3980/j.issn.2222-3959.2012.04.15
更新日期：2012-01-01 00:00:00
abstract：AIM:To identify risk factors for an atherothrombotic event (ATE) among patients who were treated for diabetic macular edema (DME) with intravitreal bevacizumab injections. METHODS:This retrospective study enrolled all consecutive patients with DME who were treated by intravitreal bevacizumab from 2009 through 2016 in ...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2020.09.12
更新日期：2020-09-18 00:00:00
abstract：AIM:To assess and compare the impact of a daily disposable contact lens (CL) with high water content on the ocular surface and comfort of the presbyopic and non-presbyopic population after one day of use. METHODS:Totally 20 presbyopes and 30 non-presbyopes non-contact wearers were fitted with nesofilcon A CLs. CL thic...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2019.04.19
更新日期：2019-04-18 00:00:00
abstract：:Experts lack knowledge of periocular tuberculosis (TB) in China. Nested polymerase chain reaction (PCR) shows advantages in diagnosis of extrapulmonary TB. Our study aims to explore the clinical and laboratory features of PCR-confirmed periocular TB. We retrospectively reviewed medical records of presumptive periocula...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2018.11.20
更新日期：2018-11-18 00:00:00
abstract：AIM:To evaluate the neuroprotective effect of rosuvastatin, in a rat experimental glaucoma model. METHODS:Ocular hypertension was induced in right eyes of Long-Evans rats (n=30) by cauterization of three episcleral veins. Left eyes were defined as controls. Rats were divided into five groups: oral rosuvastatin, intrav...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2016.03.03
更新日期：2016-03-18 00:00:00
abstract：AIM:To determine the association between cigarettes smoking, body mass index (BMI) and the risk of age-related cataract (ARC) in middle-aged and elderly men in Northeast China. METHODS:A hospital-based case control study was conducted. Cases (n =362) were men who had surgically treated ARC, 45-85 years old; controls f...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.3980/j.issn.2222-3959.2012.03.13
更新日期：2012-01-01 00:00:00
abstract：AIM:To evaluate the rotational stability and visual outcomes of a single-piece hydrophilic acrylic toric intraocular lenses (IOL) over a 1.5-year follow-up period. Data from the 6-month follow-up study have been previously reported. METHODS:Forty eyes of 26 cataract patients (mean age: 72.8±7.9y) with pre-existing cor...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2017.04.12
更新日期：2017-04-18 00:00:00
abstract：AIM:To evaluate the visual outcomes and patient satisfaction of two multifocal intraocular lens implantation patterns, with the decision between the two patterns being guided by the patients' choice of visual zones that best suited their lifestyle, or lifestyle zones. METHODS:This is a prospective non-randomized compa...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.3980/j.issn.2222-3959.2012.01.16
更新日期：2012-01-01 00:00:00
abstract：AIM:To describe and compare the corneal endothelial cell density and morphology in young, low and moderate myopic Chinese adults in Malaysian Chinese population. METHODS:Non-contact specular microscopy (Topcon SP3000P, Tokyo, Japan) was performed in low (n=78; 21.22±1.51 years) and moderate (n=78; 21.82±1.40 years) my...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.3980/j.issn.2222-3959.2013.04.11
更新日期：2013-08-18 00:00:00
abstract：AIM:To compare conventional slow equilibrium cooling and directional freezing (DF) by gauze package for cryopreservation of human umbilical vein endothelial cells (HUVECs). METHODS:HUVECs were randomly assigned to conventional freezing (CF) and DF by gauze package group. The two groups of HUVECs were incubated with a ...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.3980/j.issn.2222-3959.2014.05.05
更新日期：2014-10-18 00:00:00
abstract：AIM:To estimate the adult reference values for measured deviations by a computerized diplopia test and testify the validity. METHODS:Totally 391 participants were recruited and taken the computerized diplopia test. The plots and amplitude of deviations were recorded. The differences in different gender, age and visual...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2016.11.18
更新日期：2016-11-18 00:00:00
abstract：AIM:To compare the best corrected visual acuity (BCVA) between Verteporfin with photodynamic therapy (PDT) and intravitreal anti-vascular endothelial growth factor (anti-VEGF) in patients with myopic choroidal neovascularization (CNV). METHOD:Published literature from Medline, Premedline, Embase and the Cochrane Libra...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.3980/j.issn.2222-3959.2014.04.25
更新日期：2014-08-18 00:00:00
abstract：AIM:To investigate the effect of protein kinase C (PKC) on transforming growth factor-β(2) (TGFβ(2)) and dopamine in retinal Müller cells of guinea pig myopic eye. METHODS:Myopia was induced by translucent goggles in guinea pig, whose retinal Müller cells were cultured using the enzyme-digesting method. Retinal Müller...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.3980/j.issn.2222-3959.2011.04.06
更新日期：2011-01-01 00:00:00
