Abstract:
AIM:To study the effects of curcumin on the secretion of interleukin (IL)-6 and IL-8 by corneal limbus epithelial cells. METHODS:Human corneal limbus epithelial cells were isolated and cultured from donor eyes and irradiated by UVB at different dosages with or without curcumin. MTT test was used for studying the effects of UVB and curcumin on the cell viability. The role of mitogen-activated protein kinase (MAPK) and nuclear factor-kappa B (NF-κB) pathways on the UVB-induced secretion of IL-6 and IL-8 were tested by addition of their inhibitors to the culture with or without UVB-radiation. Levels of various signal pathways, IL-6 and IL-8 in the cells and in the conditioned culture medium were measured by ELISA analysis. RESULTS:UVB at 20 mJ/cm2 or less and curcumin at 20 µmol/L or less did not affect the cell viability of cultured limbus epithelial cells (P>0.05). UVB irradiation at 10 and 20 mJ/cm2 induced a significant increase of secretion of IL-6 and IL-8 and upregulated NF-κB and phosphorylated MAPK pathways of cultured limbus epithelial cells (P<0.05). Various signal pathway inhibitors, including SP600125 (JNK inhibitor), SB203580 (p38 MAPK inhibitor) and BAY11-7082 (NF-κB inhibitor) significantly decreased the UVB-induced secretion of IL-6 and IL-8 secretion (P<0.05). Curcumin at 5-20 µmol/L significantly inhibited UVB-induced secretion of IL-6 and IL-8 by limbus epithelial cells in a dose-dependent manner; while curcumin alone did not affect the secretion of IL-6 and IL-8. The upregulation of NF-κB and MAPK pathways induced by UVB treatment was significantly inhibited by curcumin, suggesting that NF-κB and MAPK pathways are involved in the inhibitory effect of curcumin on UVB-induced production of IL-6 and IL-8. CONCLUSION:Curcumin may be a promising agent to be explored for the prevention and treatment of pterygium.
journal_name
Int J Ophthalmoljournal_title
International journal of ophthalmologyauthors
Chao SC,Hu DN,Roberts J,Shen X,Lee CY,Nien CW,Lin HYdoi
10.18240/ijo.2017.06.01subject
Has Abstractpub_date
2017-06-18 00:00:00pages
827-833issue
6eissn
2222-3959issn
2227-4898pii
ijo-10-06-827journal_volume
10pub_type
杂志文章abstract:AIM:To investigate the effect of protein kinase C (PKC) on transforming growth factor-β(2) (TGFβ(2)) and dopamine in retinal Müller cells of guinea pig myopic eye. METHODS:Myopia was induced by translucent goggles in guinea pig, whose retinal Müller cells were cultured using the enzyme-digesting method. Retinal Müller...
journal_title:International journal of ophthalmology
pub_type: 杂志文章
doi:10.3980/j.issn.2222-3959.2011.04.06
更新日期:2011-01-01 00:00:00
abstract:AIM:To compare refractive results, higher-order aberrations (HOAs), contrast sensitivity and dry eye after laser in situ keratomileusis (LASIK) performed with a femtosecond laser versus a mechanical microkeratome for myopia and astigmatism. METHODS:In this prospective, non-randomized study, 120 eyes with myopia receiv...
journal_title:International journal of ophthalmology
pub_type: 杂志文章
doi:10.3980/j.issn.2222-3959.2015.04.25
更新日期:2015-08-18 00:00:00
abstract::Retinoblastoma (RB) is the most common intraocular cancer of infancy and childhood. This cancer is initiated by mutation on RB1, the tumor suppressor gene that is responsible for the regulation of both cell cycle and gnome stability in retinal cells. Patients with a constitutional mutation on RB1 can be inherited. RB ...
journal_title:International journal of ophthalmology
pub_type: 杂志文章
doi:10.3980/j.issn.2222-3959.2013.03.26
更新日期:2013-06-18 00:00:00
abstract:AIM:To evaluate the fractal feature of the retinal vasculature of normal eyes on a stereographic projected and montaged ultra-wide field (UWF) fluorescein angiography (FA). METHODS:Prospective, observational, cross-sectional study. Totally 59 eyes of 31 normal subjects were imaged using the Optos 200Tx. Images obtaine...
journal_title:International journal of ophthalmology
pub_type: 杂志文章
doi:10.18240/ijo.2020.07.15
更新日期:2020-07-18 00:00:00
abstract:AIM:To evaluate postoperative visual acuity and contrast sensitivity results following deep anterior lamellar keratoplasty (DALK) and penetrating keratoplasty (PK) in patients with keratoconus (KC). METHODS:All the patients' records with KC who had PK or DALK surgery between May 2010 and May 2011 were retrospectively ...
journal_title:International journal of ophthalmology
pub_type: 杂志文章
doi:10.3980/j.issn.2222-3959.2012.06.16
更新日期:2012-01-01 00:00:00
abstract:AIM:To conduct a systematic review and quantitative Meta-analysis of the efficacy and safety of combined surgery for the eyes with coexisting cataract and open angle glaucoma. METHODS:We performed a systematic search of the related literature in the Cochrane Library, PubMed, EMBASE, Web of Science databases, CNKI, CBM...
journal_title:International journal of ophthalmology
pub_type: 杂志文章
doi:10.18240/ijo.2018.02.17
更新日期:2018-02-18 00:00:00
abstract::We report a case of syndromic gingival fibromatosis with notable ocular lesions, bilateral congenital cataracts, esotropia, and high myopia of a 21-year-old male patient from China. The patient was diagnosed with gingival fibromatosis based on his massive gingival overgrowth and histological findings that were consist...
journal_title:International journal of ophthalmology
pub_type: 杂志文章
doi:10.3980/j.issn.2222-3959.2014.03.32
更新日期:2014-06-18 00:00:00
abstract:AIM:To compare the clinical performance of two types of silicon hydrogel contact lenses used as bandage lenses after LASEK surgery. METHODS:A prospective, double-masked study was conducted on 42 eyes of 21 patients who received binocular LASEK surgeries. The interocular difference in spherical equivalent power was les...
journal_title:International journal of ophthalmology
pub_type: 杂志文章
doi:10.3980/j.issn.2222-3959.2011.03.22
更新日期:2011-01-01 00:00:00
abstract::There are many vision threatening diseases of the eye affecting millions of people worldwide. In this article, we are summarizing potential role of various matrix metalloproteinases (MMPs); the Zn (2+)-dependent endoproteases in eye health along with pathogenesis of prominent ocular diseases such as macular degenerati...
journal_title:International journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.18240/ijo.2017.08.20
更新日期:2017-08-18 00:00:00
abstract:AIM:To investigate the association of Manganese superoxide dismutase (MnSOD) Val16Ala polymorphism with diabetic retinopathy (DR). METHODS:PubMed, Embase, China National Knowledge Infrastructure, and Wanfang databases were searched. The pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to eva...
journal_title:International journal of ophthalmology
pub_type: 杂志文章
doi:10.18240/ijo.2017.04.22
更新日期:2017-04-18 00:00:00
abstract:AIM:To investigate the protective effect and its mechanism of lycium barbarum polysaccharides (LBP) against oxidative stress-induced apoptosis in human retinal pigment epithelial cells. METHODS:ARPE-19 cells, a human retinal pigment epithelial cell lines, were exposed to different concentrations of H2O2 for 24h, then ...
journal_title:International journal of ophthalmology
pub_type: 杂志文章
doi:10.3980/j.issn.2222-3959.2015.01.02
更新日期:2015-02-18 00:00:00
abstract:AIM:To evaluate the clinical presentations and visual outcomes of non-arteritic anterior ischaemic optic neuropathy (NAION). METHODS:A retrospective study was conducted involving 18 consecutive patients (20 eyes) with NAION attending Hospital Universiti Sains Malaysia from January 2005 until December 2009. RESULTS:Mo...
journal_title:International journal of ophthalmology
pub_type: 杂志文章
doi:10.3980/j.issn.2222-3959.2011.03.12
更新日期:2011-01-01 00:00:00
abstract:AIM:To establish an untransfected human corneal epithelial (HCEP) cell line and characterize its biocompatibility with denuded amniotic membrane (dAM). METHODS:The torn HCEP pieces were primarily cultured in DMEM/F12 media (pH 7.2) supplemented with 20% fetal bovine serum and other necessary factors, yielding an HCEP ...
journal_title:International journal of ophthalmology
pub_type: 杂志文章
doi:10.3980/j.issn.2222-3959.2011.03.02
更新日期:2011-01-01 00:00:00
abstract:AIM:To examine the cytotoxic effect of pilocarpine, an anti-glaucoma drug, on human corneal stromal (HCS) cells and its underlying cytotoxic mechanisms using an in vitro model of non-transfected HCS cells. METHODS:After HCS cells were treated with pilocarpine at a concentration from 0.15625 g/L to 20.0 g/L, their morp...
journal_title:International journal of ophthalmology
pub_type: 杂志文章
doi:10.18240/ijo.2016.04.05
更新日期:2016-04-18 00:00:00
abstract:AIM:To investigate the effects of the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 on retinal neovascularization (RNV) in the oxygen-induced retinopathy (OIR) mouse model and human umbilical vein endothelial cells (HUVECs). METHODS:C57BL/6J mice were randomly divided into normoxia-control, OIR-control and L...
journal_title:International journal of ophthalmology
pub_type: 杂志文章
doi:10.18240/ijo.2018.08.06
更新日期:2018-08-18 00:00:00
abstract::Valsalva retinopathy was described as a particular form of retinopathy, pre-retinal and subinternal limiting membrane haemorrhages in nature that rarely may break through and become subhyloid or intravitreal, secondary to a sudden increase in intrathoracic pressure. We reported a new way that Nd:YAG laser for ILM hyal...
journal_title:International journal of ophthalmology
pub_type: 杂志文章
doi:10.3980/j.issn.2222-3959.2013.02.25
更新日期:2013-04-18 00:00:00
abstract:AIM:To explore the effects of αA-crystallin in astrocyte gliosis after optic nerve crush (ONC) and the mechanism of α-crystallin in neuroprotection and axon regeneration. METHODS:ONC was established on the Sprague-Dawley rat model and αA-crystallin (10(-4) g/L, 4 µL) was intravitreously injected into the rat model. Fl...
journal_title:International journal of ophthalmology
pub_type: 杂志文章
doi:10.18240/ijo.2016.07.04
更新日期:2016-07-18 00:00:00
abstract:AIM:To investigate the published papers of ophthalmology in past ten years and explore the development of ophthalmology. METHORDS:The data of this study retrieved from Science Citation Index Expanded and downloaded online in November 2017, including all the papers with publication year from 2007-2016 were analyzed. Th...
journal_title:International journal of ophthalmology
pub_type: 杂志文章
doi:10.18240/ijo.2017.12.17
更新日期:2017-12-18 00:00:00
abstract:AIM:To assess strabismus control and motor ocular alignment for basic exotropia surgery at 5y follow-up. METHODS:The medical records of 80 consecutive patients aged less than 17 years of age, who underwent surgery for basic exotropia by a single surgeon between years 2000 to 2009 and completed a minimum of 5y follow-u...
journal_title:International journal of ophthalmology
pub_type: 杂志文章
doi:10.18240/ijo.2016.07.13
更新日期:2016-07-18 00:00:00
abstract:AIM:To compare the efficacy of prophylactic vitrectomy for acute retinal necrosis syndrome(ARN) with routine treatment in Chinese patients, thereby investigate the necessity of prophylactic vitrectomy for ARN. METHODS:Thirty patients (37 eyes) were retrospectively included in this study. The eyes were divided into 2 g...
journal_title:International journal of ophthalmology
pub_type: 杂志文章
doi:10.3980/j.issn.2222-3959.2012.04.15
更新日期:2012-01-01 00:00:00
abstract::Phacoemulsification is the main gold standard for cataract operation in the developed world together with foldable intraocular lens (IOL) implantation by injection, allowing for stable wound construction and less postoperative astigmatism. It is a safe procedure with high success rate with the advancement in machines,...
journal_title:International journal of ophthalmology
pub_type: 杂志文章
doi:10.3980/j.issn.2222-3959.2015.03.34
更新日期:2015-06-18 00:00:00
abstract::As a non-penetrating glaucoma surgery (NPGS), canaloplasty aims to reconstruct the physiological outflow of aqueous humor by dilating the Schlemm's canal. Ab interno canaloplasty (ABiC), which can reconstruct the natural outflow pathways of aqueous humor in mild-to-moderate primary open angle glaucoma (POAG) patients,...
journal_title:International journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.18240/ijo.2019.10.16
更新日期:2019-10-18 00:00:00
abstract:AIM:Tono-pen measurement of intraocular pressure (IOP) under topical anaesthesia in full term normal newborns. METHODS:The IOP measurements were taken using Tono-pen XL tonometer under topical anaesthesia in 150 newborns (300 eyes) within 24h after birth, over a period of three months, in a university hospital. Gender...
journal_title:International journal of ophthalmology
pub_type: 杂志文章
doi:10.3980/j.issn.2222-3959.2014.01.16
更新日期:2014-02-18 00:00:00
abstract:AIM:To investigate the expression of complement factors in the posterior scleral fibroblasts of guinea pigs with negative lens-defocused myopia. METHODS:Eighteen guinea pigs were assigned randomly to two groups: the negative lens-defocused group (NLD group, n=9) and the normal control without treatment group (NC group,...
journal_title:International journal of ophthalmology
pub_type: 杂志文章
doi:10.3980/j.issn.2222-3959.2015.04.06
更新日期:2015-08-18 00:00:00
abstract:AIM:To investigate mitochondrial factors associated with Leber hereditary optic neuropathy (LHON) through complete sequencing and analysis of the mitochondrial genome of Chinese patients with this disease. METHODS:Two unrelated southern Chinese families with LHON and 10 matched healthy controls were recruited, and the...
journal_title:International journal of ophthalmology
pub_type: 杂志文章
doi:10.3980/j.issn.2222-3959.2012.01.06
更新日期:2012-01-01 00:00:00
abstract:AIM:To investigate the effect of broccoli sprouts juice in preventing lens protein aggregation in diabetic rat model. METHODS:Totally 25 male Wistar rats were divided into negative control group, diabetic group without juice treatment as positive control and diabetic group given broccoli sprouts juice 0.25, 0.5 and 1 ...
journal_title:International journal of ophthalmology
pub_type: 杂志文章
doi:10.18240/ijo.2019.09.02
更新日期:2019-09-18 00:00:00
abstract:AIM:To analyze the risk factors, ophthalmological features, treatment modalities and their effect on the visual outcome in patients with endogenous fungal endophthalmitis (EFE). METHODS:Data retrieved from the medical files included age at presentation to the uveitis clinic, gender, ocular symptoms and their duration ...
journal_title:International journal of ophthalmology
pub_type: 杂志文章
doi:10.18240/ijo.2021.01.14
更新日期:2021-01-18 00:00:00
abstract:AIM:To identify the 100 most cited papers in cataract surgery, we performed a comprehensive bibliometric analysis basing on the literature search on the Thomson Reuters Web of Knowledge. METHODS:The number of citations, including the total citations, latest 5y citations and average citation number per year (ACY), auth...
journal_title:International journal of ophthalmology
pub_type: 杂志文章
doi:10.18240/ijo.2017.10.17
更新日期:2017-10-18 00:00:00
abstract:AIM:To report the surgical technique and efficacy of the tiled transplantation internal limiting membrane (ILM) pedicle flap technique after vitrectomy for 33 patients with large macular hole (MH). METHODS:This study was a prospective noncontrolled interventional study. All patients were treated by vitrectomy, the til...
journal_title:International journal of ophthalmology
pub_type: 杂志文章
doi:10.18240/ijo.2019.02.10
更新日期:2019-02-18 00:00:00
abstract::Diabetic retinopathy (DR) is one of the most common and challenging ocular complications of diabetes mellitus. As a chronic, progressive ocular disease that poses a serious threat to vision, DR has gradually become a leading cause of blindness worldwide. Emerging evidence points to an important role of endoplasmic ret...
journal_title:International journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.18240/ijo.2018.10.20
更新日期:2018-10-18 00:00:00