Metalloproteinases as mediators of inflammation and the eyes: molecular genetic underpinnings governing ocular pathophysiology.

Abstract:

:There are many vision threatening diseases of the eye affecting millions of people worldwide. In this article, we are summarizing potential role of various matrix metalloproteinases (MMPs); the Zn (2+)-dependent endoproteases in eye health along with pathogenesis of prominent ocular diseases such as macular degeneration, diabetic retinopathy, and glaucoma via understanding MMPs regulation in affected patients, interactions of MMPs with their substrate molecules, and key regulatory functions of tissue inhibitor of metalloproteinases (TIMPs) towards maintaining overall homeostasis.

journal_name

Int J Ophthalmol

authors

Singh M,Tyagi SC

doi

10.18240/ijo.2017.08.20

subject

Has Abstract

pub_date

2017-08-18 00:00:00

pages

1308-1318

issue

8

eissn

2222-3959

issn

2227-4898

pii

ijo-10-08-1308

journal_volume

10

pub_type

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