Abstract：
AIM:To study plasma levels of vascular endothelial growth factor (VEGF), endothelin-1(ET-1) and nitric oxide (NO) in patients with proliferative diabetic retinopathy (PDR) before and after pan-retinal photocoagulation (PRP). METHODS:Forty patients (23 females and 17 males, mean age 48.5±12.2 years) with PDR without previous PRP therapy were studied. Blood samples were obtained before and 3 months after the last PRP session. Baseline (prelaser) plasma levels of VEGF, ET-1 and NO were compared with their levels in 30 healthy age- and sex- matched controls and also with plasma levels 3 months post-PRP. RESULTS:Patients with PDR had significantly raised plasma VEGF (375±89ng/L), ET-1(20±5ng/L) and NO (135±53µmol/L) when compared with healthy control group (P<0.01). After PRP, there was a significant reduction in plasma VEGF (179±66ng/L), ET-1 (11±5ng/L) and NO (91±49µmol/L) levels at 3 months' follow-up but still significantly higher than healthy controls. CONCLUSION:Patients with PDR demonstrate elevated VEGF, ET-1 and NO, which decrease after successful laser treatment.
journal_name
Int J Ophthalmoljournal_title
International journal of ophthalmologyauthors
Mohamed TA,Mohamed Sel-Ddoi
10.3980/j.issn.2222-3959.2010.01.05subject
Has Abstractpub_date
2010-01-01 00:00:00pages
19-22issue
1eissn
2222-3959issn
2227-4898pii
ijo-03-01-019journal_volume
3pub_type
杂志文章abstract：AIM:To explore the correlation between several blood cell-associated inflammatory indices including mean platelet volume (MPV), platelet distribution width (PDW), neutrophil to lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR), and the presence and severity of diabetic retinopathy (DR). METHODS:We searched fo...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2019.02.20
更新日期：2019-02-18 00:00:00
abstract：AIM:To evaluate clinical outcomes of unilateral implantation of a diffractive multifocal intraocular lens (IOL) in patients with contralateral monofocal IOL. METHODS:Twenty-two patients who already had implantation of a monofocal IOL in unilateral eye underwent implantation of a diffractive multifocal IOL in contralat...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2020.05.07
更新日期：2020-05-18 00:00:00
abstract：:Corneal neovascularization (CNV) is a global important cause of visual impairment. The immune mechanisms leading to corneal heme- and lymphangiogenesis have been extensively studied over the past years as more attempts were made to develop better prophylactic and therapeutic measures. This article aims to discuss immu...
journal_title：International journal of ophthalmology
pub_type： 杂志文章,评审
doi：10.18240/ijo.2016.04.25
更新日期：2016-04-18 00:00:00
abstract：AIM:To evaluate the real-life clinical outcomes of intravitreal injection of conbercept combined rescue therapy for polypoidal choroidal vasculopathy (PCV). METHODS:This was an open label, single center, and interventional study. All enrolled patients were treated initially with three consecutive monthly intravitreal ...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2019.01.08
更新日期：2019-01-18 00:00:00
abstract：AIM:To describe the clinical features of congenital double elevator palsy (CDEP) and to evaluate various surgical outcomes between the standard Knapp and augmented Knapp procedures, based on improvements in primary eye position and ocular motility. METHODS:Twenty-two patients with CDEP at Shanghai Children's Hospital ...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2018.08.16
更新日期：2018-08-18 00:00:00
abstract：AIM:To investigate extent and nature of visual pathways involvement in children with clinically isolated syndrome (CIS). METHODS:Forty-seven patients (age 11-17y) with CIS, which later proved to be multiple sclerosis (MS) onset, and 30 controls underwent visual evoked potentials (VEP) investigation within 12d from the...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.3980/j.issn.2222-3959.2015.02.30
更新日期：2015-04-18 00:00:00
abstract：AIM:To analyze the efficacy of ultraviolet (UV) light initiating corneal cross-linking (CXL). METHODS:The time-dependent absorption of UV light due to the depletion of the initiator (riboflavin) was calculated. The effective dose of CXL with corneal surface covered by a thin layer of riboflavin was derived analyticall...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2016.08.01
更新日期：2016-08-18 00:00:00
abstract：:Myopia, a worldwide condition, is a multifactorial disease resulting in many ocular complications. Early onset of myopia has a great tendency to develop high myopia and pathological myopia later in life. The pathophysiology and progression of myopia is still unclear. Owing to its involving in visual function, optic di...
journal_title：International journal of ophthalmology
pub_type： 杂志文章,评审
doi：10.18240/ijo.2018.05.25
更新日期：2018-05-18 00:00:00
abstract：AIM:To evaluate the efficacy and safety of orbital decomposition (OD) surgery in combination with horse chestnut seed extract (HCSE), as compared to OD alone, in patients with thyroid-associated ophthalmopathy (TAO). METHODS:Sixty-two orbits from 62 TAO patients were randomly assigned to OD or OD+HCSE at 1:1 ratio (31...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2016.06.14
更新日期：2016-06-18 00:00:00
abstract：AIM:To study the effects of gender, eye side and age on anterior chamber measurements; To compare the anterior chamber parameters between glaucoma and normal subjects. METHODS:A total of 169 patients (299 eyes), of which 122 normal subjects (218 eyes), 24 cases (39 eyes) with primary angle-closure glaucoma (PACG) and ...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.3980/j.issn.2222-3959.2010.04.17
更新日期：2010-01-01 00:00:00
abstract：AIM:To describe the clinical and imaging characteristics associated with focal choroidal excavation (FCE), analyze the possible complication, and interpret its probable etiopathogenesis. METHODS:Retrospective descriptive case series of 37 eyes of 32 patients with FCE. Findings of spectral-domain optical coherence tomo...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.3980/j.issn.2222-3959.2015.03.14
更新日期：2015-06-18 00:00:00
abstract：:[This retracts the article DOI: 10.3980/j.issn.2222-3959.2015.01.27.]. ...
journal_title：International journal of ophthalmology
pub_type： 撤回出版物
doi：
更新日期：2017-07-18 00:00:00
abstract：AIM:To evaluate chorioretinal responses to intravitreal aflibercept injection (IAI) in patients with acute central serous chorioretinopathy (CSC). METHODS:Seventy-one eyes from 71 patients with symptomatic CSC for less than six months were included. Thirty-five eyes received a single IAI and 36 eyes were observed with...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2019.12.08
更新日期：2019-12-18 00:00:00
abstract：AIM:To evaluate the efficacy of prophylactic administration of topical non-steroidal anti-inflammatory drugs (NSAIDs) on macular edema following cataract surgery in diabetic patients, and to compare between types of NSAIDs (ketorolac tromethamine 0.4% and nepafenac 0.1%). METHODS:Group 1 (control) received artificial ...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2018.04.13
更新日期：2018-04-18 00:00:00
abstract：AIM:To study the effects of curcumin on the secretion of interleukin (IL)-6 and IL-8 by corneal limbus epithelial cells. METHODS:Human corneal limbus epithelial cells were isolated and cultured from donor eyes and irradiated by UVB at different dosages with or without curcumin. MTT test was used for studying the effec...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2017.06.01
更新日期：2017-06-18 00:00:00
abstract：AIM:To explore the effect of saturated hydrogen saline on blue light-induced retinal damage in rats. METHODS:The retinal damage of rats was induced by blue light exposure for 6 hours and examined 8 hours, 16 hours and 24 hours after the exposure. One hundred female Sprague-Dawley rats were randomly divided into four g...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.3980/j.issn.2222-3959.2012.02.07
更新日期：2012-01-01 00:00:00
abstract：AIM:To investigate the cross-talk between oxidative stress and the epidermal growth factor receptor (EGFR)/AKT signaling pathway in retinal pigment epithelial (RPE) cells. METHODS:Human RPE cell lines (ARPE-19 cell) were treated with different doses of epidermal growth factor (EGF) and hydrogen peroxide (H2O2). Cell v...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2017.04.02
更新日期：2017-04-18 00:00:00
abstract：AIM:To report various ocular injuries caused by durian fruit. METHODS:Three cases of ocular injuries were described in young patients, due to accidental fall of durian fruit on the forehead and face, while they were taking rest/sleeping /playing under the durian tree. RESULTS:The ocular injuries observed were lacerat...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.3980/j.issn.2222-3959.2012.04.25
更新日期：2012-01-01 00:00:00
abstract：AIM:To investigate whether the enhanced green fluorescent protein (EGFP) reporter gene could be transferred into human trabecular meshwork (HTM) cells by a HIV-based lentivirus both in vitro and ex vivo. METHODS:The HIV-based lentivirus that contains an EF1-α promoter driving EGFP expression cassette was constructed f...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.3980/j.issn.2222-3959.2014.06.02
更新日期：2014-12-18 00:00:00
abstract：AIM:To compare the clinical results of femtosecond (FS) laser in situ keratomileusis (LASIK) in high myopic patients and low myopic patients. METHODS:This study included 212 myopic eyes undergoing LASIK using a VisuMax 500kHz FS laser. All treated eyes were assigned to one of two groups according to preoperative manif...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2020.11.15
更新日期：2020-11-18 00:00:00
abstract：AIM:To investigate the relationship between C-reactive protein (CRP) and diabetic retinopathy (DR) in a cohort of Chinese patients with type 2 diabetes mellitus (T2DM). METHODS:Community-based observational cohort study. There were 1131 participants recruited from November 2009 to September 2011 in Desheng community i...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2016.01.19
更新日期：2016-01-18 00:00:00
abstract：AIM:To investigate the effect of age on reading acuity and reading speed in attaining text information in healthy eyes. METHODS:Reading acuity, critical print size, reading speed and maximum reading speed were measured in groups of 40 children (8 to 12 years old), 40 teenagers (13 to 19 years old), 40 young adults (20...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2019.07.19
更新日期：2019-07-18 00:00:00
abstract：AIM:To evaluate the long-term response to the fixed combination of dorzolamide/timolol in patients with primary open angle glaucoma (POAG) and the addition of other intraocular pressure (IOP) lowering medications such as prostaglandin analogs and brimonidine. METHODS:A retrospective, non-randomized, and descriptive cl...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.3980/j.issn.2222-3959.2014.02.25
更新日期：2014-04-18 00:00:00
abstract：AIM:To elucidate the associations of iris color with major eye diseases. METHODS:A systematic search on Medline with coverage up to August 2013 was conducted. Assessment of the quality of studies based on their levels of evidence was in accordance with the Centre for Evidence-Based Medicine, Oxford, United Kingdom. R...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.3980/j.issn.2222-3959.2014.05.25
更新日期：2014-10-18 00:00:00
abstract：AIM:To investigate the expression of the v-raf-1 murine leukemia viral oncogene homolog 1 (Raf-1) and its role in the innate immune response of human corneal epithelial cells (HCECs) infected by Aspergillus fumigatus. METHODS:HCECs were cultured in vitro. They were randomly divided into 4 groups, including control gro...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2016.10.01
更新日期：2016-10-18 00:00:00
abstract：:This study is to investigate the characteristic features of Acanthamoeba keratitis (AK) that differentiating it from herpetic epithelial keratitis (HEK) using anterior segment optical coherence tomography (AS-OCT). Medical records of three eyes of each AK and herpetic keratitis who had AS-OCT examination were reviewed...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2018.08.26
更新日期：2018-08-18 00:00:00
abstract：AIM:To analyze the lab diagnosis and etiology of infectious endophthalmitis. METHODS:The medical and microbial records of 36 patients diagnosed with infectious endophthalmitis and 8 patients diagnosed with intraocular lens (IOL)-related inflammation between Nov. 1999 and Dec. 2009 were retrospectively reviewed for lab...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.3980/j.issn.2222-3959.2011.01.23
更新日期：2011-01-01 00:00:00
abstract：AIM:To investigate the proportion and characteristic of emmetropia in schoolchildren aged 6-11, especially estimate the normal value of ocular biometric parameters of emmetropia. METHODS:A population-based cross-sectional study was conducted on children aged 6-11y in Shenzhen. Totally, 2386 schoolchildren from two pri...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2020.12.21
更新日期：2020-12-18 00:00:00
abstract：:Retinal diseases, including age-related macular degeneration (AMD) and diabetic retinopathy (DR) are the leading causes of blindness in adults over the age of 50 years in the US. While most of those conditions do not have a cure, currently available treatment options attempt to prevent further vision loss. For many op...
journal_title：International journal of ophthalmology
pub_type： 杂志文章,评审
doi：10.18240/ijo.2018.06.23
更新日期：2018-06-18 00:00:00
abstract：AIM:To evaluate the effects of femtosecond laser-assisted in situ keratomileusis (FS-LASIK) and small-incision lenticule extraction (SMILE) to correct high myopic anisometropic amblyopia in juvenile patients. METHODS:From November 2013 to January 2015, 33 amblyopic patients with high myopic anisometropic amblyopia wer...
journal_title：International journal of ophthalmology
pub_type： 杂志文章
doi：10.18240/ijo.2017.11.07
更新日期：2017-11-18 00:00:00
