Abstract:
:An in vivo model of hub-related catheter sepsis in rabbits is reported. The model was used to investigate the protection offered by a new hub design against external contamination by Pseudomonas aeruginosa or Staphylococcus epidermidis and to reassess the diagnostic value of the semiquantitative culture method in bacteremia of endoluminal origin. Contamination of conventional Luer-Lock connectors was followed by clinical sepsis, positive catheter segment cultures, or both, whereas contamination of the new hub was followed by complete protection. Clinical and bacteriological discrepancies observed between contamination with P. aeruginosa and S. epidermidis suggest that the virulence of microorganisms may account for differences in the natural history of hub-originated catheter sepsis. The semiquantitative extraluminal method for catheter culture yielded less than 15 CFU in three animals with proven bacteremia and should not be used as the "gold standard" to define catheter-related bacteremia.
journal_name
J Clin Microbioljournal_title
Journal of clinical microbiologyauthors
Segura M,Alía C,Valverde J,Franch G,Torres Rodríguez JM,Sitges-Serra Adoi
10.1128/JCM.28.11.2551-2554.1990subject
Has Abstractpub_date
1990-11-01 00:00:00pages
2551-4issue
11eissn
0095-1137issn
1098-660Xjournal_volume
28pub_type
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