Abstract：
BACKGROUND:FDG-PET in ALS most typically demonstrates a primary (and sometimes also supplementary) motor cortex hypometabolism, often associated with more diffuse cortical hypometabolism involving mostly the dorsolateral prefrontal cortex, the medial and lateral premotor cortices, and the bilateral insular cortex involvement. In ALS-FTD, extensive temporal hypometabolism is seen in addition to severe diffuse frontal hypometabolism. METHODS:This study analyses FDG-PET findings in 6 ALS patients and 4 ALS-FTD patients. RESULTS:In addition to earlier described areas of hypometabolism in ALS, we found also reduced FDG-PET metabolism in the medial frontal cortex, the orbitofrontal cortex, and the anterior temporal lobe in our ALS patients. The anterolateral area was the best preserved part of the frontal lobe in ALS patients. In ALS-FTD, frontal and temporal hypometabolism was severe (and parietal hypometabolism was often also present) with relatively preserved perirolandic metabolism. CONCLUSION:In ALS, more diffuse frontal and temporal FDG-PET hypometabolism was seen than earlier reported, with the anterolateral area as the best preserved part of the frontal lobe. In ALS-FTD, relatively preserved perirolandic metabolism was seen, associated with severe frontal and temporal hypometabolism.
journal_name
Acta Neurol Belgjournal_title
Acta neurologica Belgicaauthors
Renard D,Collombier L,Castelnovo G,Fourcade G,Kotzki PO,LaBauge Psubject
Has Abstractpub_date
2011-12-01 00:00:00pages
306-9issue
4eissn
0300-9009issn
2240-2993journal_volume
111pub_type
杂志文章abstract：:The EEG of 48 patients suffering from either an unilateral or a bilateral thrombosis of the carotid artery are compared, and the most discriminative data of the recordings in these two conditions are stressed. ...
journal_title：Acta neurologica Belgica
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journal_title：Acta neurologica Belgica
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pub_type： 杂志文章
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