Abstract：
:The objective of this study was to evaluate the tolerability and efficacy of lacosamide (LCM) in residential patients at our epilepsy centre. We assessed retrospectively 80 patients (mean age 36.2 years, range 18-63 years; 29 female) with intellectual disability (ID) and drug-resistant epilepsy using an industry-independent, non-interventional study design based on standardised seizure records. Evaluation, including calculation of retention rate, was carried out for the intervals 3-6, 9-12 and 21-24 months after LCM initiation. The Clinical Global Impression scale (CGI) was used to allow assessment of qualitative changes in seizure severity and clinical status. CGI improved for 61% of the patients. The responder rate was 48%; ten patients (13%) became seizure free. The response was not related to the degree of ID. The retention rates after 12 and 24 months were 71% and 65%, and were significantly lower in patients taking other sodium-channel blockers (SCBs; 76% vs. 55%). The occurrence of adverse events (AEs) was related to the administration of concomitant SCBs (48% with SCBs vs. 26% without). Sedation (15%), ataxia (13%), vertigo (11%), and nausea (9%) were the commonest AEs. While 60% of our patients had concomitant psychiatric diagnosis, we found no relevant effect of this on challenging behaviour. Adjunctive LCM may provide an antiepileptic treatment option for patients with ID with or without additional psychiatric diagnosis. The occurrence of AEs and the LCM retention rate were affected by concomitant SCB use but not by psychiatric comorbidity.
journal_name
Acta Neurol Belgjournal_title
Acta neurologica Belgicaauthors
Kleist A,Kerling F,Hamer H,Winterholler Mdoi
10.1007/s13760-019-01098-3subject
Has Abstractpub_date
2019-09-01 00:00:00pages
423-430issue
3eissn
0300-9009issn
2240-2993pii
10.1007/s13760-019-01098-3journal_volume
119pub_type
杂志文章abstract：:A 47-year-old female developed proximal limb weakness after hysterectomy for uterine fibromatosis. Muscle strength slowly improved, but relapse occurred at age 52. She presented with progressive gait difficulty, proximal limb weakness, and painful calves. Family history was not contributory. Cranial nerves, deep tendo...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：
更新日期：2000-03-01 00:00:00
abstract：:Functional brain imaging studies, such as positron emission tomography and functional nuclear magnetic resonance imaging, are based on the regional increases in cerebral blood flow, glucose consumption and oxygen consumption that are associated with regional increases in neuronal activity. The cellular basis of the si...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章,评审
doi：
更新日期：2002-12-01 00:00:00
abstract：:The authors report the case of a 17 year-old female patient who presented acute ascending polyneuritis of the Landry-Guillain-Barré type extending to all cranial nerve pairs during the abatement of hepatitis of unspecified etiology. The patient remained in a state of coma vigil for five days prior to gradual but full ...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：
更新日期：1980-07-01 00:00:00
abstract：:The gastrocnemius and quadriceps muscles findings in 18 patients with chronic arterial insufficiency were reviewed with regard to mitochondrial changes. Prominent mitochondrial alterations were present in eight out of 18 patients. The comparison of clinical data between patients with and without mitochondrial changes ...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：
更新日期：1986-11-01 00:00:00
abstract：:A 54-year-old female patient presented acute hallucinatory psychotic episodes with irritative EEG for seven years before an initial state of complex partial mal. A single convulsive episode occurred 14 years after the beginning of the psychiatric symptoms. The intercritical EEG showed independent temporal lobe foci pr...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：: ...
journal_title：Acta neurologica Belgica
pub_type： 新闻
doi：10.1007/s13760-019-01097-4
更新日期：2019-03-01 00:00:00
abstract：:Similar alterations in the neuronal cytoskeleton (paired helical filaments) and modifications in the molecular forms of acetylcholinesterase (specific decrease in the G4 form) have been detected in the elderly rat as well as in patients suffering from SDAT. These observations challenge the specificity of some manifest...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：
更新日期：1989-05-01 00:00:00
abstract：AIM:The aim of this study was to determine the correlations among hippocampal damage, spontaneous recurrent seizures (SRS), and mossy fiber sprouting (MFS) using pentylenetetrazole (PTZ) kindling model. METHODS:Chronic epileptic model was established by administration of PTZ. Behaviour and EEG seizure activity were re...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：
更新日期：2009-12-01 00:00:00
abstract：:Genistein (4',5,7-trihydroxyisoflavone) is the most abundant isoflavone found in the soybean that exhibits an anti-inflammatory effect. The present study was designed to examine the effects of genistein on expression levels of hemolysate-induced proinflammatory and adhesion molecules in SD rat brain microvascular endo...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：
更新日期：2009-03-01 00:00:00
abstract：:Sleep and sleep deprivation are often used for EEG activation in epilepsy. We compared postprandial naps and day-long sleep deprived EEGs in 36 patients with generalized seizures, 57 complex partial seizure patients, and 7 individuals with mixed seizure disorders. Ten of 36 generalized seizure patients had normal slee...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章,评审
doi：
更新日期：1990-01-01 00:00:00
abstract：:Although migraine is a neurological disorder known for its long, physiopathology remains unclear. The aim of this study was to investigate the levels of hematological parameters and neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), lymphocyte/monocyte ratio (LMR) and neutrophil/monocyte ratio (NMR) u...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：10.1007/s13760-020-01362-x
更新日期：2020-04-28 00:00:00
abstract：:Previous studies of multiple sclerosis (MS) patients have reported an inverse correlation between disability, the number of relapses and vitamin D levels in mostly white patients. It is unclear if this relationship has the same behavior in individuals with Hispanic backgrounds. To determine the relationship between vi...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：10.1007/s13760-017-0834-3
更新日期：2018-03-01 00:00:00
abstract：:Needle insertion during electromyography (EMG) may cause varying levels of pain that could lead to inaccurate assessment and premature termination of the procedure. The aim of this study is to compare paracetamol 325 mg/tramadol 37.5 mg with placebo in relieving pain before EMG. This is a randomized, crossover, placeb...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章,随机对照试验
doi：10.1007/s13760-016-0621-6
更新日期：2016-12-01 00:00:00
abstract：:A 60-year-old man was admitted with slowly progressive dizziness. Cranial nerve evaluation found no abnormalities. Magnetic resonance imaging revealed a well-circumscribed mass with homogeneous enhancement located in the fourth ventricle. The patient underwent surgery for the removal of the tumor via the bilateral sub...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章,评审
doi：10.1007/s13760-012-0040-2
更新日期：2012-03-01 00:00:00
abstract：:The EEG of 48 patients suffering from either an unilateral or a bilateral thrombosis of the carotid artery are compared, and the most discriminative data of the recordings in these two conditions are stressed. ...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：
更新日期：1976-01-01 00:00:00
abstract：:Intravenous tissue plasminogen activator is the only approved medical treatment for patients with acute ischemic stroke. While it is associated with excellent clinical outcome in about 30 %, even with timely thrombolysis administration, certain strokes continue to evolve and lead to poor outcomes. Several studies have...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章,评审
doi：10.1007/s13760-013-0270-y
更新日期：2014-06-01 00:00:00
abstract：:Psychiatric comorbidity in patients with headache contributes to poorer prognosis, chronification of disease, poor response to treatment, increased cost of treatment, and decreased quality of life. The purpose of the present study was to evaluate the depressive symptoms in adolescents with chronic and episodic migrain...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：10.1007/s13760-012-0135-9
更新日期：2013-03-01 00:00:00
abstract：:We aimed to examine the sensitivity and specificity of the Ankara University Cerebral Dominance Inventory (AUCDI) in determining left cerebral dominance compared with the Wada test. The AUCDI and Wada test were applied to 49 patients referred to Ankara University for epilepsy surgery. Hand, foot and 'total' preference...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：10.1007/s13760-013-0212-8
更新日期：2014-03-01 00:00:00
abstract：:Social media is a powerful tool in providing information and support for minority groups such as patients with chronic diseases. We aimed to assess the link between using online social media and depression in a sample population of Iranian Multiple Sclerosis (MS) patients. In this cross-sectional study, a number of MS...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：10.1007/s13760-020-01407-1
更新日期：2020-12-01 00:00:00
abstract：:Eighteen patients (11 male, 7 female) with left thalamic haemorrhage confirmed by CT-scan of the brain were investigated for their language function. Aphasia Test for Turkish Citizens modified from Mayo Clinic Aphasia Test and Boston Diagnostic Aphasia Examination were given for evaluating the language modalities. Flu...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：:The purpose of the study was to evaluate the relationship between sympathetic skin responses (SSR), electrodiagnostic reflex activities (F wave, H reflex), and functional capacity in post-stroke patients. The study comprised 40 hemiplegia patients (mean age 57.8 ± 10.9 years) and 40 healthy volunteers (mean age 557 ± ...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：10.1007/s13760-014-0397-5
更新日期：2015-09-01 00:00:00
abstract：:123Iodo-Amphetamine (IAMP) brain distribution was studied with a specially dedicated multilevel tomographic system in 30 patients with vascular ischemic (18) or hemorrhagic (12) disorders. Results were compared with clinical data, CT scan and rCBF measurement obtained by the 133Xe continuous inhalation method. Abnorma...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：
更新日期：1987-05-01 00:00:00
abstract：:Although cerebral palsy (CP), which affects the quality of life of many children and their families, is the most common cause of motor dysfunction in children, no comprehensive bibliometric study has holistically evaluated the publications on CP. This study aimed to analyze the scientific outputs published on CP in pe...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：10.1007/s13760-020-01549-2
更新日期：2020-11-23 00:00:00
abstract：:Blood circulating endothelial cells and circulating hematopoietic progenitor cells (CPCs) are two cell populations that are thought to play important role in angiogenesis. In the present study, we investigated the role of CPCs in patients with brain tumors. We prospectively studied 19 brain tumor patients. Ten healthy...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：10.1007/s13760-012-0097-y
更新日期：2013-03-01 00:00:00
abstract：:The first applications of positron emission tomography (PET) for the study of brain tumours appeared early in the development of this technology. New trends in these particular PET applications tend to take into account the histological heterogeneity of these tumours and the necessity to integrate PET data in their su...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章,评审
doi：
更新日期：1997-09-01 00:00:00
abstract：:The aim of this study is to investigate the frequency of unilateral cranial autonomic symptoms during migraine attacks, and to compare the clinical characteristics of migraine patients with and without unilateral cranial autonomic symptoms. One hundred and eighty-six consecutive patients with episodic migraine attacks...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：10.1007/s13760-012-0164-4
更新日期：2013-09-01 00:00:00
abstract：:High resolution MRI is very important in the evaluations of patients with intractable temporal lobe epilepsy in preoperative investigations. Morphologic abnormalities on cranial MRI usually indicate the epileptogenic focus. Intractable TLE patients who have normal cranial MRI or bilateral hippocampal atrophy may have ...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：
更新日期：2006-03-01 00:00:00
abstract：:We describe an additional case of spastic paretic hemifacial contracture, an uncommon condition characterized by sustained unilateral contraction of the facial muscles associated with mild ipsilateral facial paresis. This entity has only rarely been associated with multiple sclerosis (MS) and can be mistaken for hemif...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：10.1007/s13760-017-0817-4
更新日期：2017-12-01 00:00:00
abstract：:Self-reporting scales are commonly utilized in determining appropriate treatment strategies and follow-up in hand-related disorders. Responsiveness is described as the ability of a scale to detect clinically significant changes. We aimed to evaluate responsiveness of Michigan Hand Outcomes Questionnaire (MHQ), Duruöz ...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：10.1007/s13760-020-01443-x
更新日期：2020-07-15 00:00:00
abstract：BACKGROUND:In carotid artery dissections, local and ischemic manifestations usually occur within days or weeks. In some cases, persistent extracranial aneurysms cause thromboembolic complications even years after the initial event. The management of these aneurysms is still controversial. CASE DESCRIPTION:We report th...
journal_title：Acta neurologica Belgica
pub_type： 杂志文章
doi：
更新日期：2003-09-01 00:00:00
