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Cross-reactivity and expansion of dengue-specific T cells during acute primary and secondary infections in humans.

Abstract：

:Serotype-cross-reactive memory T cells responding to secondary dengue virus (DENV) infection are thought to contribute to disease. However, epitope-specific T cell responses have not been thoroughly compared between subjects with primary versus secondary DENV infection. We studied CD8(+) T cells specific for the HLA-A*1101-restricted NS3(133) epitope in a cohort of A11(+) DENV-infected patients throughout acute illness and convalescence. We compared the expansion, serotype-cross-reactivity, and activation of these cells in PBMC from patients experiencing primary or secondary infection and mild or severe disease by flow cytometry. Our results show expansion and activation of DENV-specific CD8(+) T cells during acute infection, which are predominantly serotype-cross-reactive regardless of DENV infection history. These data confirm marked T cell activation and serotype-cross-reactivity during the febrile phase of dengue; however, A11-NS3(133)-specific responses did not correlate with prior antigenic exposure or current disease severity.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Friberg H,Bashyam H,Toyosaki-Maeda T,Potts JA,Greenough T,Kalayanarooj S,Gibbons RV,Nisalak A,Srikiatkhachorn A,Green S,Stephens HA,Rothman AL,Mathew A

doi

10.1038/srep00051

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

51

issn

2045-2322

journal_volume

1

pub_type

杂志文章

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