Abstract：
OBJECTIVES:It has been shown that combined rehabilitation and pharmacological treatment reduce pain in subjects with osteoarthritis (OA), although the efficacy of either therapy alone may be limited. We studied the effects of a comprehensive rehabilitation programme alone and together with pharmacological treatment in relatively young OA patients awaiting total joint replacement (TJR). METHODS:Forty-four OA patients randomly divided into two groups underwent three weeks of comprehensive day hospital rehabilitation treatment alone (group A) or in combination with acetaminophen 1g three times a day. Pain intensity was measured using a visual analogue scale (VAS) before and during treatment, and for four weeks afterwards, and compared between the groups using Student's t-test for unpaired data. RESULTS:In group A, pain intensity was not reduced after the first week of treatment (T0 vs. T1: p=0.739), but was significantly reduced from the end of the second week to the end of the observation period (p<0.01). In group B, pain intensity was significantly reduced (p<0.01) from the first week of treatment to the end of the observation period. The differences in the VAS score variations from T0 between the two groups were statistically significant throughout the study period (T0-T1: p=0.004, T0-T2: p=0.041, T0-T3: p=0.035, T0-T4: p=0.009, T0-T5: p=0.011, T0-T6: p=0.014 T0-T7: p=0.015). CONCLUSIONS:Rehabilitation is effective in reducing pain even in patients with severe OA on a waiting list for TJR, but its efficacy is boosted by adding appropriate pharmacological treatment.
journal_name
Clin Exp Rheumatoljournal_title
Clinical and experimental rheumatologyauthors
Casale R,Damiani C,Rosati V,Atzeni F,Sarzi-Puttini P,Nica ASsubject
Has Abstractpub_date
2012-03-01 00:00:00pages
233-9issue
2eissn
0392-856Xissn
1593-098Xpii
4775journal_volume
30pub_type
杂志文章,随机对照试验abstract：OBJECTIVES:To assess the extent of coexistence of inflammatory back pain (IBP) with fibromyalgia (FM) features in patients with spondyloarthritis (SpA), and to assess the degree of overlap of FM tender points (TeP) and enthesitis sites (ES) in patients with SpA. METHODS:We evaluated 61 consecutive patients who present...
journal_title：Clinical and experimental rheumatology
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journal_title：Clinical and experimental rheumatology
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journal_title：Clinical and experimental rheumatology
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journal_title：Clinical and experimental rheumatology
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journal_title：Clinical and experimental rheumatology
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journal_title：Clinical and experimental rheumatology
pub_type： 临床试验,杂志文章
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2018-01-01 00:00:00
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：1983-07-01 00:00:00
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：1984-01-01 00:00:00
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pub_type： 杂志文章,随机对照试验
doi：
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章,评审
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更新日期：2006-03-01 00:00:00
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journal_title：Clinical and experimental rheumatology
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journal_title：Clinical and experimental rheumatology
pub_type： 临床试验,杂志文章
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journal_title：Clinical and experimental rheumatology
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pub_type： 杂志文章
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pub_type： 杂志文章
doi：
更新日期：2019-11-01 00:00:00
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：1999-05-01 00:00:00
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2012-05-01 00:00:00
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2002-07-01 00:00:00
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doi：
更新日期：2017-01-01 00:00:00
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更新日期：2015-11-01 00:00:00
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journal_title：Clinical and experimental rheumatology
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doi：
更新日期：2012-01-01 00:00:00
