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Vesicoureteral reflux: current trends in diagnosis, screening, and treatment.

Abstract：

CONTEXT:Vesicoureteral reflux (VUR) is present in approximately 1% of children in North America and Europe and is associated with an increased risk of pyelonephritis and renal scarring. Despite its prevalence and potential morbidity, however, many aspects of VUR management are controversial. OBJECTIVE:Review the evidence surrounding current controversies in VUR diagnosis, screening, and treatment. EVIDENCE ACQUISITION:A systematic review was performed of Medline, Embase, Prospero, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, clinicaltrials.gov, and the most recent guidelines of relevant medical specialty organizations. EVIDENCE SYNTHESIS:We objectively assessed and summarized the published data, focusing on recent areas of controversy relating to VUR screening, diagnosis, and treatment. CONCLUSIONS:The evidence base for many current management patterns in VUR is limited. Areas that could significantly benefit from additional future research include improved identification of children who are at risk for VUR-related renal morbidity, improved stratification tools for determining which children would benefit most from which VUR treatment option, and improved reporting of long-term outcomes of VUR treatments.

journal_name

Eur Urol

journal_title

European urology

authors

Routh JC,Bogaert GA,Kaefer M,Manzoni G,Park JM,Retik AB,Rushton HG,Snodgrass WT,Wilcox DT

doi

10.1016/j.eururo.2012.01.002

subject

Has Abstract

pub_date

2012-04-01 00:00:00

pages

773-82

issue

4

eissn

0302-2838

issn

1873-7560

pii

S0302-2838(12)00004-8

journal_volume

61

pub_type

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