Heat-shock protein 70 from plant biofactories of recombinant antigens activate multiepitope-targeted immune responses.

Abstract:

:Although a physiological role of heat-shock proteins (HSP) in antigen presentation and immune response activation has not been directly demonstrated, their use as vaccine components is under clinical trial. We have previously demonstrated that the structure of plant-derived HSP70 (pHSP70) can be superimposed to the mammalian homologue and similarly to the mammalian counterpart, pHSP70-polypeptide complexes can activate the immune system. It is here shown that pHSP70 purified from plant tissues transiently expressing the influenza virus nucleoprotein are able to induce both the activation of major histocompatibility complex class I-restricted polyclonal T-cell responses and antibody production in mice of different haplotypes without the need of adjuvant co-delivery. These results indicate that pHSP70 derived from plants producing recombinant antigens may be used to formulate multiepitope vaccines.

journal_name

Plant Biotechnol J

authors

Buriani G,Mancini C,Benvenuto E,Baschieri S

doi

10.1111/j.1467-7652.2011.00673.x

subject

Has Abstract

pub_date

2012-04-01 00:00:00

pages

363-71

issue

3

eissn

1467-7644

issn

1467-7652

journal_volume

10

pub_type

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