Genomics and pharmacogenomics of brain disorders.

abstract：:X-ray is a non-thermal technology that has shown good efficacy in reducing pathogenic and spoilage bacteria, viruses and parasites. X-ray hygiene technology resulted in a high microbial loss in numerous food products, such as dairy products, ready-to-eat shrimp, oysters, fresh products, strawberries, shredded iceberg ...

journal_title：Current pharmaceutical biotechnology

authors： Zehi ZB,Afshari A,Noori SMA,Jannat B,Hashemi M

更新日期：2020-01-01 00:00:00

abstract：:Momordica balsamina, African pumpkin (Cucurbitaceae), is a tendril-bearing, wild climber containing wide spectrum of medicinal and nutritional values and has been used as a traditional folk medicine in many countries. The leaves, fruits, seeds, and bark of the plant contains resins, alkaloids, flavonoids, glycosides, ...

journal_title：Current pharmaceutical biotechnology

authors： Thakur GS,Bag M,Sanodiya BS,Bhadouriya P,Debnath M,Prasad GB,Bisen PS

更新日期：2009-11-01 00:00:00

abstract：:The blood-brain barrier (BBB), which impedes drug penetration into the central nervous system, is composed of specific structures formed by brain capillary endothelial cells and sheathed by astrocytic end-feet through basement membrane. Many brain drug delivery strategies have focused on adsorptive-mediated transcytos...

journal_title：Current pharmaceutical biotechnology

authors： Lu W

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:To date, an increasing number of pet owners, especially in the USA, are using cannabis-derived products containing generally delta 9-tetrahydrocannabinol (THC) and cannabidiol (CBD) to help their animals' health. Unfortunately, studies on the clinical use of cannabinoids in veterinary medicine are still limi...

journal_title：Current pharmaceutical biotechnology

authors： Rotolo MC,Graziano S,Pellegrini M,Corlazzoli D,Antinori L,Porcarelli L,Pichini S

更新日期：2017-01-01 00:00:00

abstract：:Signals relayed through G protein-coupled receptors (GPCR) play pivotal roles in human physiology and are important drug targets. About 40% of all GPCRs couple to the heterotrimeric G protein Gq. Biochemical studies as well as crystallography have improved our understanding of GqPCRs and their downstream partners. Her...

journal_title：Current pharmaceutical biotechnology

authors： Jalink K,Adjobo-Hermans MJ

更新日期：2014-01-01 00:00:00

abstract：:We aim to determine the regulation of apoptosis by paclitaxel-induced and understand cancer dynamics to treatment targets for HeLa cells by identifying decrease/increase genes expression on HeLa cells. In this study, the anti-tumor effects of Paclitaxel (PAC) on HeLa cells have been studied in order to determine the c...

journal_title：Current pharmaceutical biotechnology

authors： Serbes U,Ozsoylemez OD,Ozcan G

更新日期：2016-01-01 00:00:00

abstract：PURPOSE:Previous studies in humans concluded that a multigenic model including specific FSHR, ESR1 and ESR2 genotype patterns may partially explain the poor response to FSH. The aim of our study is to analyse three different loci -polymorphisms in ESR1 Pvu II, ESR2 Rsa I and Ser680Asn FSH receptor gene- in a Greek popu...

journal_title：Current pharmaceutical biotechnology

authors： Anagnostou E,Mavrogianni D,Theofanakis C,Drakakis P,Bletsa R,Demirol A,Gurgan T,Antsaklis A,Loutradis D

更新日期：2012-03-01 00:00:00

abstract：:One of the most surprising aspects of neural development is that cells do not remain in their birthplace but actively migrate along a variety of routes to their final destinations. This review traces past, present, and future techniques used to analyze progenitor cell migration in the brain, and also discusses their r...

journal_title：Current pharmaceutical biotechnology

authors： Comte I,Tran PB,Szele FG

更新日期：2007-06-01 00:00:00

abstract：:Xylitol is an important polyalcohol suitable for use in odontological, medical and pharmaceutical products and as an additive in food. The first studies on the efficacy of xylitol in the control and treatment of infections started in the late 1970s and it is still applied for this purpose, with safety and very little ...

journal_title：Current pharmaceutical biotechnology

authors： Ferreira AS,Silva-Paes-Leme AF,Raposo NR,da Silva SS

更新日期：2015-01-01 00:00:00

abstract：:3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (also known as statins) are drugs active in the blockade of cholesterol synthesis and thus lowering cholesterol serum levels. Since their discovery, experimental evidence showed that statins strongly reduced atherogenesis and the risk of acute ischem...

journal_title：Current pharmaceutical biotechnology

authors： Montecucco F,Quercioli A,Mirabelli-Badenier M,Viviani GL,Mach F

更新日期：2012-01-01 00:00:00

abstract：:Medical applications of ultrasound were first investigated about seventy years ago. It has rapidly evolved since then, becoming an essential tool in medical imaging. Ultrasound ability to provide real time images with frame rates exceeding several hundred frames per second allows one to view rapid anatomical changes a...

journal_title：Current pharmaceutical biotechnology

authors： Azhari H

更新日期：2012-09-01 00:00:00

abstract：:Understanding and consequently treating neuropathic pain effectively is a challenge for modern medicine, as unlike inflammation, which can be controlled relatively well, chronic pain due to nerve injury is refractory to most current therapeutics. Here we define a target pathway for a new class of analgesics, tetrahydr...

journal_title：Current pharmaceutical biotechnology

authors： Latremoliere A,Costigan M

更新日期：2011-10-01 00:00:00

abstract：:The aim of the present article was to review the role of the placenta function in the transfer of immunosuppressants and monoclonal antibodies used for the treatment of inflammatory bowel disease, as well as the available data regarding the safety of these therapies during pregnancy. Methotrexate can cause congenital ...

journal_title：Current pharmaceutical biotechnology

authors： Chaparro M,Gisbert JP

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:Up to 25% of diabetic patients will develop a diabetic foot ulcer. Chronic wounds such as diabetic foot ulcers often fail to heal with conventional therapies. In recent years, it has been identified that chronic wounds are usually associated with elevated level of matrix metalloproteinases (MMPs). Doxycyclin...

journal_title：Current pharmaceutical biotechnology

authors： Xu DH,Zhu Z,Fang Y

更新日期：2017-01-01 00:00:00

abstract：:The interaction between reactive oxygen species (ROS) and inflammation plays an important role in the pathogenesis of endothelial dysfunction and cardiovascular disease, cancer and other diseases. Thus, antioxidant strategies may be important in immune regulation and in limiting inflammation. Surprisingly, large clini...

journal_title：Current pharmaceutical biotechnology

authors： Spychalowicz A,Wilk G,Śliwa T,Ludew D,Guzik TJ

更新日期：2012-10-01 00:00:00

abstract：:Fc-based therapeutics including therapeutic full-size monoclonal antibodies (mAbs) and Fcfusion proteins represent fastest-growing market in biopharmaceutical industrial. However, one major challenge during development of Fc-based therapeutics is how to maintain their efficacy in clinic use. Many factors may lead to f...

journal_title：Current pharmaceutical biotechnology

authors： Chen X,Zeng F,Huang T,Cheng L,Liu H,Gong R

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:In this study, local sustainable enzyme sources involving excised digestive juice of African land snail and yeast were utilized to achieve the simultaneous saccharification (SSF) and fermentation (SSF) of plantain pseudostem (PPS) waste, and afterwards their effects on terpenoids using gas chromatography cou...

journal_title：Current pharmaceutical biotechnology

authors： Uchenna AP,Charity ON,Abbey B

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:Frequent administrations for DPPIV-resistant GLP-1 analogs are necessary to maintain the blood concentrations due to the short half-life of less than 5 minutes. However, most delivery systems that possess the ability of sustainable release of GLP-1 have drawbacks such as low yield, high cost and undesirable s...

journal_title：Current pharmaceutical biotechnology

authors： Fan L,Fan Y,Fan H,Huang K

更新日期：2020-01-01 00:00:00

abstract：:Bone grafts are widely used for augmentation procedures in oral and maxillofacial surgery, with autogenous bone being the gold standard. Recently, the focus of research has shifted towards synthetic bone substitutes, as no second surgery is needed and large quantities of graft can easily be provided. Within the broad ...

journal_title：Current pharmaceutical biotechnology

authors： Gotz W,Papageorgiou SN

更新日期：2017-01-01 00:00:00

abstract：:Lipid nanocapsules with their unique composition represent a promising biocompatible drug delivery platform in nanometer range with narrow size distribution. They are highly stable in comparison to other nano-vectors and were found to impart very desirable characteristics to the therapeutic molecule being delivered wi...

journal_title：Current pharmaceutical biotechnology

authors： Nasr M,Abdel-Hamid S

更新日期：2015-01-01 00:00:00

abstract：:Better understanding of protein higher order structures (HOS) is of major interest to researchers in the field of biotechnology and biopharmaceutics. Monitoring a protein's HOS is crucial towards understanding the impact of molecular conformation on the biotechnological application. In addition, maintaining the HOS is...

journal_title：Current pharmaceutical biotechnology

authors： Nagarkar RP,Murphy BM,Yu X,Manning MC,Al-Azzam WA

更新日期：2013-01-01 00:00:00

abstract：:Calcium-sensing receptor (CaSR), a member of family C of the G protein-coupled receptors, is expressed most abundantly in the parathyroid glands and kidney. It plays key role in these two organs because it senses changes in extracellular calcium and regulates PTH secretion and calcium reabsorption to suit the extracel...

journal_title：Current pharmaceutical biotechnology

authors： Vezzoli G,Soldati L,Gambaro G

更新日期：2009-04-01 00:00:00

abstract：:Interstitial lung disease (ILD) is one of the most common complications of polymyositis (PM) and dermatomyositis (DM). It is always progressive and does not respond to conventional immunosuppressive agent treatment. Biologics are commonly used in treatment of rheumatic diseases. They are also used in polymyositis and ...

journal_title：Current pharmaceutical biotechnology

authors： Sun Y,He Y,Liu Y,Shi G

更新日期：2014-01-01 00:00:00

abstract：:Oncogene-driven proliferative signaling in tumor cells requires comprehensive upregulation of cellular energy metabolism and macromolecule syntheses. These alterations are now known to include not only upregulated glycolysis, but also increased fatty acid metabolism, glutaminolysis, deregulated mitochondrial function ...

journal_title：Current pharmaceutical biotechnology

authors： Shoshan MC

更新日期：2013-01-01 00:00:00

abstract：:In many signaling pathways, various factors have been isolated by molecular genetic studies and wholegenome analysis. Understanding the interactions among these factors is crucial to understanding the signaling process as a whole. Recent studies on auxin signaling in the regulation of plant growth and development have...

journal_title：Current pharmaceutical biotechnology

authors： Muto H,Kinjo M

更新日期：2012-11-01 00:00:00

abstract：:Spirulina, a filamentous cyanobacterium, possesses diverse biological activities and nutritional significance due to high concentration of natural nutrients, having bio-modulatory and immuno-modulatory functions. Different Spirulina preparations influence immune system viz. increase phagocytic activity of macrophages,...

journal_title：Current pharmaceutical biotechnology

authors： Khan Z,Bhadouria P,Bisen PS

更新日期：2005-10-01 00:00:00

abstract：:To better identify patients at high risk for cardiovascular events, several markers of risk have been proposed for use in screening. Recently, oxidative stress and inflammation have been evaluated as potential tools for prediction of the risk of cardiovascular events. Among them, we have measured reactive oxygen speci...

journal_title：Current pharmaceutical biotechnology

authors： Yasunari K,Watanabe T,Nakamura M

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND:Sexual dysfunction and infertility are conditions with high prevalence in the general population. Nutritional factors have been reported to have an impact on sexual and reproductive health. OBJECTIVE:The aim of this review is to summarize the data on nutritional factors that have influence on male and femal...

journal_title：Current pharmaceutical biotechnology

authors： Silva T,Jesus M,Cagigal C,Silva C

更新日期：2019-01-01 00:00:00

abstract：:Many theoretical models of molecular interactions, biochemical and chemical reactions are described on the single-molecule level, although our knowledge about the biochemical/chemical structure and dynamics primarily originates from the investigation of many-molecule systems. At present, there are four experimental pl...

journal_title：Current pharmaceutical biotechnology

authors： Földes-Papp Z,Baumann G,Demel U,Tilz GP

更新日期：2004-04-01 00:00:00

abstract：:Long-term increase of blood pressure represents one of the most important risk factors triggering many cardiovascular diseases, and via counter-regulatory mechanisms it is itself modulated by them. Adequate perfusion of the respective areas with nutrients requires appropriate production of vasodilatory and vasoconstri...

journal_title：Current pharmaceutical biotechnology

authors： Kristek F

更新日期：2011-09-01 00:00:00