Potentiation of anti-cancer treatment by modulators of energy metabolism.

abstract：:Tryparedoxin peroxidase (TryP) is a key enzyme of the trypanothione-dependent metabolism for removal of oxidative stress in leishmania. These enzymes function as antioxidants through their peroxidase and peroxynitrite reductase activities. Inhibitors of this enzyme are presumed to be antilesihmania drugs and structura...

journal_title：Current pharmaceutical biotechnology

authors： Singh BK,Dubey VK

更新日期：2009-09-01 00:00:00

abstract：:Active or passive immunotherapy is expected to slow or stop the pathological process of Alzheimer's disease (AD). Immunotherapy for AD has demonstrated that targeting beta-amyloid (Aβ) or tau protein with vaccines or antibodies can reduce AD pathologies. Active anti-Aβ immunization for AD includes using AN1792 and sec...

journal_title：Current pharmaceutical biotechnology

authors： Yang C,Xiao S

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Worldwide, the progress in reducing neonatal mortality has been very slow. The rate of preterm birth has increased over the last 20 years in low-income and middle-income countries. Its association with increased mortality and morbidity is based on experimental studies and neonatal outcomes from countries wit...

journal_title：Current pharmaceutical biotechnology

authors： Muñoz-Pérez VM,Ortiz MI,Cariño-Cortés R,Fernández-Martínez E,Rocha-Zavaleta L,Bautista-Ávila M

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Vulvar Lichen Sclerosus (VLS) is a chronic inflammatory disease with a huge impact on a person's quality of life. A correct therapy is required for relieving symptoms, reversing signs and preventing further anatomical changes. OBJECTIVE:The main objective of the present paper is to provide suggestions for t...

journal_title：Current pharmaceutical biotechnology

authors： Borghi A,Corazza M

更新日期：2021-01-01 00:00:00

abstract：:It is now widely believed that tumors originate from normal cells as a result of accumulated genetic/epigenetic changes. These alterations affect the signaling pathways at transcriptional and post-transcriptional level that drive cells into uncontrolled cell division, growth, and migration. Recent advancement of molec...

journal_title：Current pharmaceutical biotechnology

authors： Yamashita T,Honda M,Kaneko S

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:Connexin (Cx) proteins are the building blocks of gap junctions. Among these, Cx37 and Cx40 are expressed on vascular system and reported to have cardioprotective role. Linking polymorphisms in genes coding for Cx and coronary artery disease (CAD) risk showed conflicting results in different populations. Non...

journal_title：Current pharmaceutical biotechnology

authors： El Tahry FA,Hashad IM,Abdel Rahman MF,Gad MZ

更新日期：2017-11-10 00:00:00

abstract：:The most challenging and fruitful biomedical research endeavor of this decade will be the mapping of cell signaling systems and establishing their linkages to normal and disease-related processes. Amongst other things, the Human Genome Sequencing Project has greatly facilitated MALDI-TOF mass spectrometry identificati...

journal_title：Current pharmaceutical biotechnology

authors： Pelech S

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND:Despite the extended laboratory and clinical study of sepsis, its diagnosis remains a clinical challenge. The initiation of sepsis activates many different biochemical and immunological pathways being expressed by alterations of various molecules in human tissues. The detection and measurement of the concent...

journal_title：Current pharmaceutical biotechnology

authors： Giannakopoulos K,Hoffmann U,Ansari U,Bertsch T,Borggrefe M,Akin I,Behnes M

更新日期：2017-01-01 00:00:00

abstract：:Ivermectin is a broad spectrum antiparasitic veterinary drug introduced in human medicine in 1987. It is considered the drug of choice in onchocerciasis and strongyloidiasis infections, and remains as a therapeutic option for mass treatment in lymphatic filariasis, for which it has widely proved its efficacy. While re...

journal_title：Current pharmaceutical biotechnology

authors： González P,González FA,Ueno K

更新日期：2012-05-01 00:00:00

abstract：:Tinospora cordifolia (Giloy) is a medicinal plant used in folk and Ayurvedic medicines throughout India since ancient times. All the parts of the plant are immensely useful due to the presence of different compounds of pharmaceutical importance belonging to various groups as alkaloids, diterpenoid lactones, glycosides...

journal_title：Current pharmaceutical biotechnology

authors： Kumar P,Kamle M,Mahato DK,Bora H,Sharma B,Rasane P,Bajpai VK

更新日期：2020-01-01 00:00:00

abstract：:Malignant glioma is a primary tumor of the central nervous system, representing a major cause of mortality in a young, productive subset of population. The management of this neoplasm requires aggressive treatments, including radiotherapy. Accurate imaging plays a central role in treatment planning process with curati...

journal_title：Current pharmaceutical biotechnology

authors： Marvaso G,Barone A,Amodio N,Cascini GL,Scotti V,Bianco C

更新日期：2014-01-01 00:00:00

abstract：:Positron emission tomography (PET) is a powerful and rapidly developing area of molecular imaging that is used to study and visualize human physiology by the detection of positron-emitting radiopharmaceuticals. Information about metabolism, receptor/enzyme function, and biochemical mechanisms in living tissue can be o...

journal_title：Current pharmaceutical biotechnology

authors： Wu Z,Kandeel F

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Nanotechnology involves the synthesis of materials that are in nanometre sizes (1 to 100 nm). Nanotechnology has appeared as a new area of fundamental science and is getting worldwide consideration due to its extensive applications. They have exceptional physicochemical properties due to their unique size, s...

journal_title：Current pharmaceutical biotechnology

authors： Roy A

更新日期：2020-10-27 00:00:00

abstract：:Chitin and chitosan derivatives are used as excipients and drug carriers in the pharmaceutical field. Their derivatization contributed to expansion of application and decrease toxicity. Chitosan is used as an excipient in oral dosage form. Chitosan tablet can exhibit a sustained drug release compared to commercial pro...

journal_title：Current pharmaceutical biotechnology

authors： Kato Y,Onishi H,Machida Y

更新日期：2003-10-01 00:00:00

abstract：:Carbon nanotubes are nano sized cylindrical chicken wire like structures made of carbon atoms. Carbon nanotubes have applications in electronics, energy storage, electromagnetic devices, environmental remediation and in medicine as well. The biomedical applications of carbon nanotubes can be owed to features like low ...

journal_title：Current pharmaceutical biotechnology

authors： Wani TU,Mohi-Ud-Din R,Wani TA,Hassan R,Itoo AM,Sheikh FA,Khan NA,Pottoo FH

更新日期：2020-11-10 00:00:00

abstract：:Beta-lactams and glycopeptides antibiotics directed against enzymes involved in bacterial cell wall synthesis have generated bacterial resistance. Search for new antibiotic molecules is widely focused on bifunctional Penicillin-Binding Proteins (PBPs), with particular emphasis on their glycosyltransferase activity. Th...

journal_title：Current pharmaceutical biotechnology

authors： Di Guilmi AM,Dessen A,Dideberg O,Vernet T

更新日期：2002-06-01 00:00:00

abstract：:Ribotoxins constitute a family of toxic extracellular fungal RNases that exert a highly specific activity on a conserved region of the larger molecule of rRNA, known as the sarcin-ricin loop. This cleavage of a single phosphodiester bond inactivates the ribosome and leads to protein synthesis inhibition and cell death...

journal_title：Current pharmaceutical biotechnology

authors： Carreras-Sangrà N,Alvarez-García E,Herrero-Galán E,Tomé J,Lacadena J,Alegre-Cebollada J,Oñaderra M,Gavilanes JG,Martínez-Del-Pozo A

更新日期：2008-06-01 00:00:00

abstract：:Over the last 50 years, evidence for central involvement of glutamatergic neurotransmission in the pathophysiology of schizophrenia has accumulated. Recent advances in neuroimaging technology now allow several components of glutamatergic neurotransmission to be assessed in the living human brain. Positron emission tom...

journal_title：Current pharmaceutical biotechnology

authors： Egerton A,Stone JM

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Although Semaphorin 3A (Sema3A)/ Neuropilin-1(NRP1)/Plexin A1 is one of the important targets in bone metabolism, few studies are done on this target in the glucocorticoids-induced osteoporosis. Luteolin is a chemical component of Honeysuckle and it has various bioactivities. The effect and study of Luteolin...

journal_title：Current pharmaceutical biotechnology

authors： Zheng L

更新日期：2020-12-16 00:00:00

abstract：BACKGROUND:Bacterial lipases especially Pseudomonas lipases are extensively used for different biotechnological applications. OBJECTIVES:With the better understanding and progressive needs for improving its activity in accordance with the growing market demand, we aimed in this study to improve the recombinant product...

journal_title：Current pharmaceutical biotechnology

authors： El-Aziz AMA,Shaker MA,Shaaban MI

更新日期：2019-01-01 00:00:00

abstract：:Whole-cell bio-chips for functional sensing integrate living cells on miniaturized platforms made by micro-system-technologies (MST). The cells are integrated, deposited or immersed in a media which is in contact with the chip. The cells behavior is monitored via electrical, electrochemical or optical methods. In this...

journal_title：Current pharmaceutical biotechnology

authors： Shacham-Diamand Y,Belkin S,Rishpon J,Elad T,Melamed S,Biran A,Yagur-Kroll S,Almog R,Daniel R,Ben-Yoav H,Rabner A,Vernick S,Elman N,Popovtzer R

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Up to 25% of diabetic patients will develop a diabetic foot ulcer. Chronic wounds such as diabetic foot ulcers often fail to heal with conventional therapies. In recent years, it has been identified that chronic wounds are usually associated with elevated level of matrix metalloproteinases (MMPs). Doxycyclin...

journal_title：Current pharmaceutical biotechnology

authors： Xu DH,Zhu Z,Fang Y

更新日期：2017-01-01 00:00:00

abstract：:The interaction between reactive oxygen species (ROS) and inflammation plays an important role in the pathogenesis of endothelial dysfunction and cardiovascular disease, cancer and other diseases. Thus, antioxidant strategies may be important in immune regulation and in limiting inflammation. Surprisingly, large clini...

journal_title：Current pharmaceutical biotechnology

authors： Spychalowicz A,Wilk G,Śliwa T,Ludew D,Guzik TJ

更新日期：2012-10-01 00:00:00

abstract：:Interleukin (IL)-7 is a cytokine inducing the Janus Kinase (JAK)/Signal Transducer and Activator of Transcription (STAT) pathway. As a consequence of IL-7 activating this pathway, STAT5 is phosphorylated. In pharmaceutical quality control, the potency of biopharmaceuticals is commonly assessed by proliferation assays....

journal_title：Current pharmaceutical biotechnology

authors： Zumpe C,Engel K,Wiedemann N,Metzger AU,Pischetsrieder M,Bachmann CL

更新日期：2011-10-01 00:00:00

abstract：:Currently dengue is a serious disease which has become a global burden in the last decade. Unfortunately, there are no effective drugs and vaccines against this disease. DENV non-structural protein (NS) 3, which is viral protease which is a potential target for antiviral therapy. Targeting this we performed homology m...

journal_title：Current pharmaceutical biotechnology

authors： Parida P,Yadav RN,Sarma K,Nainwal LM

更新日期：2013-01-01 00:00:00

abstract：:Pathophysiological changes are common in critically ill patients, and can alter the time course of drug concentrations following dosing. The latter is termed pharmacokinetics (PK), and describes the relationship between dose administered and drug concentrations in plasma. Thus, modifications in PK necessitate dose adj...

journal_title：Current pharmaceutical biotechnology

authors： Patel K,Kirkpatrick CM

更新日期：2011-12-01 00:00:00

abstract：:TGF-β isoforms (TGF-β1, -β2, and -β3) are secreted signaling ligands that stimulate the expression of protein components of the extracellular matrix, regulate the growth and differentiation of epithelial cells, modulate immune cell function, and play roles in the development of several essential organs, including the ...

journal_title：Current pharmaceutical biotechnology

authors： Hinck AP,O'Connor-McCourt MD

更新日期：2011-12-01 00:00:00

abstract：:Until recently, most research efforts aimed at developing anti-cancer tools were focusing on small molecules. Alternative compounds are now being increasingly assessed for their potential anti-cancer properties, including peptides and their derivatives. One earlier limitation to the use of peptides was their limited c...

journal_title：Current pharmaceutical biotechnology

authors： Barras D,Widmann C

更新日期：2011-08-01 00:00:00

abstract：:Foods and nutrients play a vital role in normal functioning of the body. They are helpful in maintaining the health of the individual and in reducing the risk of various diseases. Worldwide acceptance of this fact formed a recognition link between "nutrition" and "health" and the concept of "nutraceuticals" was evolve...

journal_title：Current pharmaceutical biotechnology

authors： Ramaa CS,Shirode AR,Mundada AS,Kadam VJ

更新日期：2006-02-01 00:00:00

abstract：:Most cancer patients will experience moderate to severe pain and/or neuropathy during the course of their disease. Recent improvements in the primary treatment of cancer have increased the life span of cancer patients, but not necessarily their quality of life (QoL). The pain and suffering cancer patients experience m...

journal_title：Current pharmaceutical biotechnology

authors： Knopp KL,Nisenbaum ES,Arneric SP

更新日期：2011-10-01 00:00:00