Abstract：
BACKGROUND:Opioids have been shown to impair psychomotor and cognitive functioning in healthy volunteers with no history of opioid abuse. Few or no significant effects have been found in opioid-dependant patients in experimental or driving simulation studies. The risk of road traffic crash among patients under buprenorphine or methadone has not been subject to epidemiological investigation so far. The objective was to investigate the association between the risk of being responsible for a road traffic crash and the use of buprenorphine and methadone. METHODS:Data from three French national databases were extracted and matched: the national health care insurance database, police reports, and the national police database of injurious crashes. Case-control analysis comparing responsible versus non responsible drivers was conducted. RESULTS:72,685 drivers involved in an injurious crash in France over the July 2005-May 2008 period, were identified by their national health care number. The 196 drivers exposed to buprenorphine or methadone on the day of crash were young, essentially males, with an important co-consumption of other substances (alcohol and benzodiazepines). Injured drivers exposed to buprenorphine or methadone on the day of crash, had an increased risk of being responsible for the crash (odds ratio (OR)=2.02, 95% confidence interval (CI): 1.40 and 2.91). CONCLUSIONS:Users of methadone and buprenorphine were at increased risk of being responsible for injurious road traffic crashes. The increased risk could be explained by the combined effect of risky behaviors and treatments.
journal_name
Drug Alcohol Dependjournal_title
Drug and alcohol dependenceauthors
Corsenac P,Lagarde E,Gadegbeku B,Delorme B,Tricotel A,Castot A,Moore N,Philip P,Laumon B,Orriols Ldoi
10.1016/j.drugalcdep.2011.10.022subject
Has Abstractpub_date
2012-06-01 00:00:00pages
91-7issue
1-3eissn
0376-8716issn
1879-0046pii
S0376-8716(11)00473-Xjournal_volume
123pub_type
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pub_type： 杂志文章
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更新日期：2018-08-01 00:00:00
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