Abstract：
BACKGROUND:Better prognostic markers are needed for pancreatic endocrine tumors. Survivin is an apoptosis inhibitor that is suggested to have a negative prognostic impact in several tumor types. Contradictory data exist, especially regarding the significance of a nuclear versus cytoplasmic location of survivin. The prognostic relevance of nuclear and cytoplasmic survivin expression in pancreatic endocrine tumors-controlled for the tumor Ki-67 index, World Health Organization classification, and TNM stage-was investigated. METHODS:A total of 111 patients treated at a tertiary referral center were retrospectively evaluated. Clinical data were gathered from medical records. Immunohistochemistry for survivin and Ki-67 was performed on paraffin-embedded tissue. Univariate and multivariate Cox analyses were performed. RESULTS:Patients with tumors that had <5% survivin-positive nuclei had a mean survival of 225 months [95% confidence interval (CI) 168-281]. The corresponding figure for patients with 5 to 50% survivin-positive tumor cell nuclei was 101 months [95% CI 61-140; hazard ratio (HR) 2.4; P < 0.01) and with >50% survivin-positive nuclei 47 months (95% CI 24-71; HR 4.9; P < 0.001). Nuclear survivin expression in >50% of the tumor cells was an independent marker of a poor prognosis (HR 5.7; P < 0.01). Cytoplasmic survivin was not a significant prognostic factor in the multivariate analysis (HR 0.94; P = 0.90). CONCLUSIONS:High expression of nuclear survivin is a significant marker of a poor prognosis in patients with a pancreatic endocrine tumor.
journal_name
World J Surgjournal_title
World journal of surgeryauthors
Ekeblad S,Lejonklou MH,Stålberg P,Skogseid Bdoi
10.1007/s00268-011-1345-7subject
Has Abstractpub_date
2012-06-01 00:00:00pages
1411-8issue
6eissn
0364-2313issn
1432-2323journal_volume
36pub_type
杂志文章abstract：:There are now excellent data that patients with stage III colon cancer or stage II and III rectal cancer live longer if they receive, respectively, systemic or regional and systemic therapy after surgery. In addition, disease-free survival, particularly freedom from the symptoms of regional recurrence, in the high ris...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/BF00308633
更新日期：1995-03-01 00:00:00
abstract：BACKGROUND:Congenital diaphragmatic hernia (CDH) continues to be associated with significant mortality and morbidity rates despite advances in neonatal care. Fetal intervention for CDH has been studied for 25 years. After initial difficulties encountered with open fetal repair, attention has turned to tracheal occlusio...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-007-9074-7
更新日期：2007-08-01 00:00:00
abstract：BACKGROUND:The extent to which obesity and genetics determine postoperative complications is incompletely understood. METHODS:We performed a retrospective study using two population cohorts with electronic health record (EHR) data. The first included 736,726 adults with body mass index (BMI) recorded between 1990 and ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-019-05202-9
更新日期：2020-01-01 00:00:00
abstract：:The geographic distribution of duodenal ulcer and its characteristics in rural areas of high incidence in developing countries are reviewed. The choice of surgical procedures is discussed in light of the bulky diet and nutritional problems of these countries. A vagotomy procedure is advised for duodenal ulcer and a B...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF01654731
更新日期：1977-01-01 00:00:00
abstract：:Congenital short colon (CSC) is a condition in which the colon is replaced, wholly or partially, by a dilated pouch together with anorectal malformation and a colourinary fistula. Most of the reported series have been from northern India where this malformation is frequent. This paper details the management of 108 pat...
journal_title：World journal of surgery
pub_type： 临床试验,杂志文章
doi：10.1007/s002689900019
更新日期：1996-01-01 00:00:00
abstract：:A review of the literature describing the management of hepatic and splenic injuries indicates that as many as 67% of exploratory celiotomies for blunt trauma are reported as nontherapeutic. Avoiding unnecessary surgery through nonoperative management offers an attractive alternative. Nonetheless, nonoperative managem...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s00268-001-0138-9
更新日期：2001-11-01 00:00:00
abstract：BACKGROUND:The profile and management of self-inflicted abdominal stab wounds (SI-ASW) patients is still obscure. METHODS:The National Trauma Data Bank (2012) was queried for adults with abdominal stab wounds (n = 9544). Patients with SI-ASW (n = 1724) and non-SI-ASW (n = 7820) were compared. Predictors for non-therap...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-017-4083-7
更新日期：2017-11-01 00:00:00
abstract：:There is a need for relevant, valid, and practical metrics to better quantify both need and progress in global pediatric surgery and for monitoring systems performance. There are several existing surgical metrics in use, including disability-adjusted life years (DALYs), surgical backlog, effective coverage, cost-effec...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s00268-018-4868-3
更新日期：2019-06-01 00:00:00
abstract：:Although widely practiced, laparoscopic appendectomy (LA) has not met with universal approval. Several controlled trials have been conducted, some in favor, others not. The goal of this review was to ascertain (1) if laparoscopy was capable of improving the diagnostic and therapeutic difficulties encountered during op...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s002689900587
更新日期：1999-08-01 00:00:00
abstract：BACKGROUND:Significant barriers limit the safe and timely provision of surgical and anaesthetic care in low- and middle-income countries. Nearly one-half of Mongolia's population resides in rural areas where the austere geography makes travel for adequate surgical care very difficult. Our goal was to characterize the a...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-010-0904-7
更新日期：2011-02-01 00:00:00
abstract：:Parathyroid carcinoma is a rare cause of primary hyperparathyroidism. However, to our best knowledge, at least 163 cases of functioning parathyroid carcinoma appeared in the English literature from 1981 to 1989. We summarize the available information obtained from the reports of those patients and compare it with prev...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/BF01665308
更新日期：1991-11-01 00:00:00
abstract：BACKGROUND:Enhanced recovery after surgery (ERAS(®)) pathways have reduced morbidity and length of hospital stay (LOS) in orthopedics, bariatric, and colorectal surgery. New perioperative care protocols have been tested in patients undergoing pancreaticoduodenectomy (PD), with controversial results on morbidity. Incomp...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-014-2653-5
更新日期：2014-11-01 00:00:00
abstract：BACKGROUND:This study is intended to ascertain if outcome of acute abdominal surgery among elderly patients with acute abdominal pain have improved. METHODS:Altogether 456 patients aged >65 years underwent emergency abdominal surgery between the years 2007 and 2009 in our hospital. After excluding emergency reoperatio...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-015-3207-1
更新日期：2015-12-01 00:00:00
abstract：INTRODUCTION:Percutaneous needle biopsy (PNB) is the standard of care for diagnosis of breast lesions. Rates of excisional biopsy for breast diagnosis in North America have been reported at approximately 35 %, although significant regional variation exists. A target rate of PNB for diagnosis of breast abnormalities is ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-015-3293-0
更新日期：2016-07-01 00:00:00
abstract：BACKGROUND:A majority of patients with end-stage renal disease suffer from secondary hyperparathyroidism, which is associated with osteoporosis and cardiovascular disease. Parathyroidectomy (PTX) is often necessary despite medical treatment. However, the effect of PTX on cardio- and cerebrovascular events (CVE) remains...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-019-05020-z
更新日期：2019-08-01 00:00:00
abstract：:Octenidine HCl is new topical antiseptic solution for wounds and abdominal washing that has been found to be highly effective for inactivating scolices in an in vitro study. However, the effects of octenidine HCl on the liver are not yet known. The aim of this study was to determine if there are any histopathologic ch...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-007-9022-6
更新日期：2007-06-01 00:00:00
abstract：:Tamoxifen is being used successfully in breast cancer patients as adjuvant hormonal therapy. The aim of this retrospective cohort study is to evaluate the impact of tamoxifen on gallstone formation in postmenopausal breast cancer patients. A total of 3165 patients who were treated for invasive breast cancer between 19...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-002-6468-4
更新日期：2003-04-01 00:00:00
abstract：:A total of 143 patients who underwent hepatic resection for hepatocellular carcinoma in our department were reviewed. The review was conducted for two periods: 1970-1982 (early period) and 1983-1990 (late period), that is, the periods before and after introduction of the hepatic surgical technique involving the use of...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF01659138
更新日期：1993-09-01 00:00:00
abstract：BACKGROUND:Construction of a gastric tube that is well perfused with blood during esophagectomy is the most important factor in avoiding anastomotic leakage. We clarified the hemodynamics of the reconstructed gastric tube with indocyanine green (ICG) fluorescence. METHODS:In 20 patients undergoing gastric tube reconst...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-013-2237-9
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND:We have compared the oncologic effectiveness of limited resection (LR) techniques such as transhiatal (TH) or limited resection of the esophagogastric junction with intestinal interposition (LREGJ) in the treatment of early esophageal carcinoma with that of the extended resection such as the classical thorac...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-011-1069-8
更新日期：2011-06-01 00:00:00
abstract：BACKGROUND:Laparoscopic reoperative anti-reflux surgery (ARS) has a significantly higher morbidity than laparoscopic primary ARS; however, it is not known whether the same pattern exists within the robotic approach. We aimed to evaluate the safety and efficacy of robotic reoperative ARS in comparison with primary robot...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-018-4708-5
更新日期：2018-12-01 00:00:00
abstract：BACKGROUND:Hepatic resection for hepatocellular carcinoma (HCC) patients with liver cirrhosis and severe hypersplenic thrombocytopenia is risky and controversial. METHODS:From 1989 to 2005, 341 patients underwent hepatic resection for HCC in our hospital. Of these, 15 patients were concomitant with severe thrombocytop...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-007-9442-3
更新日期：2008-06-01 00:00:00
abstract：:Nuss described a minimally invasive technique for correcting pectus excavatum in children. A curved stainless-steel bar is inserted behind the sternum through the chest cavity with the convex surface face down, then rotated 180 degrees to elevate the sternum and correct the deformity. The procedure gained wide accepta...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-002-6519-x
更新日期：2002-10-01 00:00:00
abstract：:A group of 105 consecutive patients with venographically proved major acute deep vein thrombosis (DVT) were randomized in an open prospective study to evaluate the comparative efficacy and safety of a fixed dose of subcutaneous low-molecular-weight heparin (LMWH) and warfarin for the prevention of recurrent venous thr...
journal_title：World journal of surgery
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s002689900081
更新日期：1996-06-01 00:00:00
abstract：BACKGROUND:In gastric cancer, the recurrence rate is high even after curative surgery. A relevant issue is the identification of independent prognostic factors to select high-risk patients; such features can be used as predictive factors for tailored therapies. In this study we have investigated the role of epidermal g...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-007-9016-4
更新日期：2007-07-01 00:00:00
abstract：INTRODUCTION:Covid-19 has had a significant impact on all aspects of health care. We aimed to characterise the trends in emergency general surgery at a district general hospital in Scotland. METHODS:A prospective cohort study was performed from 23/03/20 to 07/05/20. All emergency general surgery patients were included...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-020-05760-3
更新日期：2020-11-01 00:00:00
abstract：:Percutaneous dilatational tracheostomy (PDT) is being increasingly used. Concerns have been raised as to its safety, especially when it is done at the bedside. A prospective evaluation was conducted of 100 consecutive, unselected critically ill patients with PDT. The mean intensive care unit (ICU) stay before PDT was ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s002680010180
更新日期：2000-09-01 00:00:00
abstract：:Despite a slow decline in the incidence of gastric cancer over the last 90 years, we can still expect to see over 100,000 patients die of this disease each decade in England and Wales. The 5-year survival rate has not improved during this century, which is largely due to the stage at diagnosis being unchanged. There a...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/BF00294709
更新日期：1995-07-01 00:00:00
abstract：:Innovation is responsible for most advances in the field of surgery. Innovative approaches to solving clinical problems have significantly decreased morbidity and mortality for many surgical procedures, and have led to improved patient outcomes. While innovation is motivated by the surgeon's expectation that the new a...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-014-2568-1
更新日期：2014-07-01 00:00:00
abstract：:A new endoprosthesis designed for surgical intubation of neoplastic strictures of the proximal biliary tract has been developed. The technical aspects of intubation by this endoprosthesis are discussed, and the results in the first 25 patients are given. The results suggest that this device was well tolerated. Mortali...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF01671165
更新日期：1989-01-01 00:00:00
