How radical should surgery be for early esophageal cancer?

Abstract:

BACKGROUND:We have compared the oncologic effectiveness of limited resection (LR) techniques such as transhiatal (TH) or limited resection of the esophagogastric junction with intestinal interposition (LREGJ) in the treatment of early esophageal carcinoma with that of the extended resection such as the classical thoracoabdominal (TA) en bloc esophagectomy. METHODS:We performed a retrospective analysis of prospectively collected data of 113 patients with T1 esophageal cancer (57 adeno- and 56 squamous cell carcinomas) who had surgical resection with systematic lymphadenectomy. Forty-one underwent extensive (TA) and 72 limited resection (51 TH and 21 LREGJ). RESULTS:Complete resection (R0) was achieved in all cases. Lymphatic metastases were seen in none of the mucosal but in 26.8% of the submucosal T1 cancers. The median lymph node yield was significantly higher in patients with extensive resection (24 vs. 15 lymph nodes; p=0.036), but this did not affect the overall survival (median=88 vs. 102 months, 5-year survival probability=57.8 vs. 67.7%; log rank=0.578). The median hospital stay and ICU stay were significantly shorter in the LR group (p=0.039 and p = 0.044, respectively). CONCLUSION:Limited resection leads to lower lymph node yield but similar oncologic effectiveness as the extensive surgery. It may represent a valuable alternative in the treatment of patients with early (submucosal) esophageal carcinoma.

journal_name

World J Surg

journal_title

World journal of surgery

authors

Bogoevski D,Bockhorn M,Koenig A,Reeh M,von Loga K,Sauter G,Rösch T,Izbicki JR

doi

10.1007/s00268-011-1069-8

subject

Has Abstract

pub_date

2011-06-01 00:00:00

pages

1311-20

issue

6

eissn

0364-2313

issn

1432-2323

journal_volume

35

pub_type

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