Abstract:
BACKGROUND:Primary percutaneous coronary intervention (PCI) is the best treatment of choice for acute ST segment elevation myocardial infarction (STEMI). This study aimed to determine the clinical outcomes of tirofiban combined with the low molecular weight heparin (LMWH), dalteparin, in primary PCI patients with acute STEMI. METHODS:From February 2006 to July 2006, a total of 120 patients with STEMI treated with primary PCI were randomised to 2 groups: unfractionated heparin (UFH) with tirofiban (group I: 60 patients, (61.2 ± 9.5) years), and dalteparin with tirofiban (group II: 60 patients, (60.5 ± 10.1) years). Major adverse cardiac events (MACE) during hospitalization and at 4 years after PCI were examined. Bleeding complications during hospitalization were also examined. RESULTS:There were no significant differences in sex, mean age, risk factors, past history, inflammatory marker, or echocardiography between the 2 groups. In terms of the target vessel and vascular complexity, there were no significant differences between the 2 groups. During the first 7 days, emergent revascularization occurred only in 1 patient (1.7%) in group I. Acute myocardial infarction (AMI) occurred in 1 (1.7%) patient in group I and in 1 (1.7%) in group II. Three (5.0%) patients in group I and 1 (1.7%) in group II died. Total in-hospital MACE during the first 7 days was 4 (6.7%) in group I and 2 (3.3%) in group II. Bleeding complications were observed in 10 patients (16.7%) in group I and in 4 patients (6.7%) in group II, however, the difference was not statistically significant. No significant intracranial bleeding was observed in either group. Four years after PCI, death occurred in 5 (8.3%) patients in group I and in 4 (6.7%) in group II. MACE occurred in 12 (20.0%) patients in group I and in 10 (16.7%) patients in group II. CONCLUSIONS:Dalteparin was effective and safe in primary PCI of STEMI patients and combined dalteparin with tirofiban was effective and safe without significant bleeding complications compared with UFH. Although there was no statistically significant difference, LMWH decreased the bleeding complications compared with UFH.
journal_name
Chin Med J (Engl)journal_title
Chinese medical journalauthors
Li WM,Yang XC,Wang LF,Ge YG,Wang HS,Xu L,Ni ZH,Zhang DPsubject
Has Abstractpub_date
2011-10-01 00:00:00pages
3275-80issue
20eissn
0366-6999issn
2542-5641journal_volume
124pub_type
杂志文章,随机对照试验abstract:OBJECTIVES:To formulate an equation for fine mapping of disease loci under complex conditions and determine the marker-disease distance in a specific case using this equation. METHODS:Lewontin's linkage disequilibrium (LD) measure D' was used to formulate an equation for mapping disease genes in the presence of phenoc...
journal_title:Chinese medical journal
pub_type: 杂志文章
doi:
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journal_title:Chinese medical journal
pub_type: 杂志文章,随机对照试验
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journal_title:Chinese medical journal
pub_type: 杂志文章
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journal_title:Chinese medical journal
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doi:
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journal_title:Chinese medical journal
pub_type: 杂志文章
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doi:
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doi:
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pub_type: 杂志文章
doi:
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journal_title:Chinese medical journal
pub_type: 杂志文章
doi:
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pub_type: 杂志文章,评审
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journal_title:Chinese medical journal
pub_type: 杂志文章
doi:
更新日期:1999-09-01 00:00:00
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journal_title:Chinese medical journal
pub_type: 杂志文章,多中心研究
doi:
更新日期:1995-04-01 00:00:00
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journal_title:Chinese medical journal
pub_type: 杂志文章
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pub_type: 杂志文章
doi:
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journal_title:Chinese medical journal
pub_type: 杂志文章
doi:
更新日期:2000-07-01 00:00:00
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journal_title:Chinese medical journal
pub_type: 杂志文章,meta分析
doi:
更新日期:2014-01-01 00:00:00
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journal_title:Chinese medical journal
pub_type: 杂志文章
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pub_type: 临床试验,杂志文章,随机对照试验
doi:
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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