Abstract:
:Many children in the USA are prescribed psychotropic drugs that have not been fully investigated in paediatric clinical trials. The common practice of prescribing psychotropic drugs off-label poses unknown and potentially serious short- and long-term consequences for these children. This paper briefly reviews the factors associated with the lack of paediatric clinical trials. We advocate a shift toward increasing paediatric trials with psychotropic drugs through a combination of adequate safety controls, additional reimbursement/compensation, a more organised and large-scale effort to collate results and outcomes across researchers and studies and additional public education about the importance of this research. In addition, we encourage the re-examination of the ethical standards for children's participation in phase 1 clinical trials as well as argue for longitudinal developmental studies on children who are prescribed off-label psychotropic drugs.
journal_name
J Med Ethicsjournal_title
Journal of medical ethicsauthors
Tishler CL,Reiss NSdoi
10.1136/medethics-2011-100003subject
Has Abstractpub_date
2012-04-01 00:00:00pages
250-2issue
4eissn
0306-6800issn
1473-4257pii
medethics-2011-100003journal_volume
38pub_type
杂志文章,评审abstract::A National Committee for the Ethics of Research could consider new questions arising from innovations in research or practice, deal with multi-centre trials, adjudicate when separate local committees give conflicting advice about similar projects, or oversee the work of district committees. The value of each of these ...
journal_title:Journal of medical ethics
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abstract::Towers reviews Joan Robinson: One Woman's Story, an American documentary film about a terminal cancer patient that was first broadcast by the Public Broadcasting Service on 21 January 1980. The film was made at the instigation of Robinson, a writer and editor, and covers the last twenty-two months of her life from th...
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abstract::Kovacs argues that honorary authorship and regarding each co-author of multi-authored papers as if they were sole authors when the performance of researchers is being evaluated by their publications mean that we should require authors to identify what proportion of each publication should be attributed to each co-auth...
journal_title:Journal of medical ethics
pub_type: 评论,杂志文章
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abstract::Many healthcare goods, such as surgical instruments, textiles and gloves, are manufactured in unregulated factories and sweatshops where, amongst other labour rights violations, workers are subject to considerable occupational health risks. In this paper we undertake an ethical analysis of the supply of sweatshop-prod...
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abstract:BACKGROUND:More and more quantitative information is becoming available about the risks of complications arising from medical treatment. In everyday practice, this raises the question whether each and every risk, however low, should be disclosed to patients. What could be good reasons for doing or not doing so? This wi...
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doi:10.1136/jme.2005.014936
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journal_title:Journal of medical ethics
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journal_title:Journal of medical ethics
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abstract:OBJECTIVE:To determine the views of people with multiple sclerosis (MS) and professionals in relation to confidentiality, consent and access to data within a proposed MS register in the UK. DESIGN:Qualitative study using focus groups (10) and interviews (13). SETTING:England and Northern Ireland. PARTICIPANTS:68 peo...
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journal_title:Journal of medical ethics
pub_type: 杂志文章
doi:10.1136/jme.2006.019661
更新日期:2008-01-01 00:00:00
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journal_title:Journal of medical ethics
pub_type: 杂志文章
doi:10.1136/medethics-2018-105069
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVES:To compare the perceptions of physician executives and clinicians regarding ethical issues in Saudi Arabian hospitals and the attributes that might lead to the existence of these ethical issues. DESIGN:Self-completion questionnaire administered from February to July 1997. SETTING:Different health regions i...
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doi:10.1136/jme.25.1.51
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journal_title:Journal of medical ethics
pub_type: 杂志文章
doi:10.1136/medethics-2013-101578
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVES:A statute enacted in 2005 modified the legislative framework of the rights of terminally ill persons in France. Ten years after the EURONIC study, which described the self-reported practices of neonatal caregivers towards ethical decision-making, a new study was conducted to assess the impact of the new law ...
journal_title:Journal of medical ethics
pub_type: 杂志文章
doi:10.1136/jme.2010.038356
更新日期:2011-04-01 00:00:00
abstract::With so much attention being paid to the development and refinement of appropriate criteria and tests for death, little attention has been given to the broader conceptual issues having to do with its definition or with the relation of a definition to its criterion. The task of selecting the correct criterion is, howev...
journal_title:Journal of medical ethics
pub_type: 杂志文章
doi:10.1136/jme.21.5.270
更新日期:1995-10-01 00:00:00
abstract::It is argued that the current policy of the British Medical Association (BMA) on conscientious objection is not aligned with recent human rights developments. These grant a right to conscientious objection to doctors in many more circumstances than the very few recognised by the BMA. However, this wide-ranging right m...
journal_title:Journal of medical ethics
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doi:10.1136/medethics-2015-103222
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journal_title:Journal of medical ethics
pub_type: 评论,杂志文章
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更新日期:1997-04-01 00:00:00
abstract::Psychotropic and other drugs can alter brain mechanisms regulating the formation, storage, and retrieval of different types of memory. These include "off label" uses of existing drugs and new drugs designed specifically to target the neural bases of memory. This paper discusses the use of beta-adrenergic antagonists t...
journal_title:Journal of medical ethics
pub_type: 杂志文章,评审
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更新日期:2006-02-01 00:00:00
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journal_title:Journal of medical ethics
pub_type: 杂志文章,多中心研究
doi:10.1136/medethics-2012-100546
更新日期:2012-10-01 00:00:00
abstract::One theme of London University lawyer Ian Kennedy's 1980 Reith Lectures on medical ethics was the need to change the emphasis in physician patient relations from paternalism on the part of doctors to self determination on the part of patients. Bamford, a specialist in obstetrics and gynecology, demonstrates how reali...
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更新日期:1981-12-01 00:00:00
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更新日期:1984-09-01 00:00:00
abstract::Recently, new developments took place in the Dutch debate on the legislation of euthanasia. After a brief account of that debate, the article discusses a new government proposal for legislation in this field, which was submitted to the Dutch parliament in November 1991. This proposal relates not only to euthanasia but...
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更新日期:1992-09-01 00:00:00
abstract::Dental tourism is patients travelling across international borders with the intention of receiving dental care. It is a growing phenomenon that raises many ethical issues, particularly regarding the dentist-patient relationship. We discuss various issues related to this phenomenon, including patient autonomy over prac...
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更新日期:2014-03-01 00:00:00
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更新日期:2019-02-01 00:00:00