Abstract：
BACKGROUND:Pediatric venous thromboembolism (VTE) is an increasingly common problem. We hypothesized that VTE occurs most commonly in tertiary care settings and that the pattern of associated illnesses may have changed from earlier reports. METHODS:The Kids' Inpatient Database 2006 was utilized to identify children ≤ 18 years old with in-hospital VTE. Children were identified by the presence of thrombosis specific ICD-9-CM diagnosis or procedure codes. Remaining ICD-9-CM codes were utilized to categorize patients by acute or chronic illness. The incidence of in-hospital VTE by hospital type, age, gender, race, and disposition were estimated. RESULTS:Over 4,500 children met the inclusion criteria (188/100,000 discharges). Most VTE discharges (67.5%) were from children's hospitals (RR 5.09; 95% CI 4.76; 5.44). Underlying chronic illnesses were associated with most VTE (76.2%), most commonly: cardiovascular (18.4%), malignancy (15.7%), and neuromuscular disease (9.9%). VTE not associated with chronic illness were most often idiopathic (12.6%), followed by infections (9.5%), and trauma (9.1%). The greatest proportions of children with VTE were infants (23.1%) and adolescents (37.8%). However, when standardized against the entire database of discharges, infants were least likely to develop VTE (RR 0.48; 95% CI 0.43; 0.52), while adolescents were at highest risk (RR 1.89; 95% CI 1.73; 2.07). Hospitalizations ending with death were more likely to include VTE (RR 6.16; 95% CI 5.32; 7.13). CONCLUSIONS:Pediatric VTE is most commonly seen in tertiary care. Adolescents are at greatest risk to develop in-hospital VTE. Patients whose hospitalization ended with death are at much greater risk to develop VTE.
journal_name
Pediatr Blood Cancerjournal_title
Pediatric blood & cancerauthors
Setty BA,O'Brien SH,Kerlin BAdoi
10.1002/pbc.23388subject
Has Abstractpub_date
2012-08-01 00:00:00pages
258-64issue
2eissn
1545-5009issn
1545-5017journal_volume
59pub_type
杂志文章abstract：BACKGROUND:Prophylactic use of cranial radiation therapy (CRT) in young children with acute lymphoblastic leukemia (ALL) is associated with significant long-term morbidity. Therefore, current treatment protocols for pediatric B-precursor ALL have abandoned prophylactic CRT in favor of intrathecal chemotherapy, combined...
journal_title：Pediatric blood & cancer
pub_type： 杂志文章
doi：10.1002/pbc.10392
更新日期：2004-01-01 00:00:00
abstract：:Undifferentiated embryonal sarcoma of the liver (UESL) is a rare aggressive mesenchymal pediatric tumor. Previously, reported outcomes have been very poor. Here, we report a single-center experience of five patients with UESL treated with upfront gross total resection and adjuvant chemotherapy. We have a median follow...
journal_title：Pediatric blood & cancer
pub_type： 杂志文章
doi：10.1002/pbc.26154
更新日期：2016-12-01 00:00:00
abstract：:Acute splenic sequestration crisis (ASSC) is a hematological emergency in young children with sickle cell disease (SCD), characterized by worsening anemia and splenomegaly, usually with reticulocytosis and thrombocytopenia. Transient aplastic crisis (TAC) due to parvovirus B19 infection occurs in older children with S...
journal_title：Pediatric blood & cancer
pub_type： 杂志文章
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更新日期：2009-09-01 00:00:00
abstract：BACKGROUND:Children with terminal cancer and their families describe a preference for home-based end-of-life care. Inadequate support outside of the hospital is a limiting factor in home location feasibility, particularly in rural regions lacking pediatric-trained hospice providers. METHODS:The purpose of this longitu...
journal_title：Pediatric blood & cancer
pub_type： 杂志文章
doi：10.1002/pbc.28921
更新日期：2021-02-01 00:00:00
abstract：BACKGROUND:The role of local analgesics for lumbar punctures (LPs) in pediatric oncology patients has not been specifically studied. AIM:To compare the efficacy of eutectic mixture of local anesthetics (EMLA) cream to 1% lidocaine injection for LPs. METHOD:This was a retrospective observational study of all patients ...
journal_title：Pediatric blood & cancer
pub_type： 杂志文章
doi：10.1002/pbc.27957
更新日期：2019-11-01 00:00:00
abstract：:This is the case report of a 14-year young female who was diagnosed with solitary bone plasmacytoma (SBP) of proximal tibia and was treated by local involved field radiotherapy. We present the clinical, radiological and pathological findings of the case and review of the available treatment options and prognosis of th...
journal_title：Pediatric blood & cancer
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doi：10.1002/pbc.22687
更新日期：2011-01-01 00:00:00
abstract：:Childhood, adolescent, and young adult (CAYA) cancer survivors may be at risk for a severe course of COVID-19. Little is known about the clinical course of COVID-19 in CAYA cancer survivors, or if additional preventive measures are warranted. We established a working group within the International Late Effects of Chil...
journal_title：Pediatric blood & cancer
pub_type： 杂志文章,多中心研究
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更新日期：2020-12-01 00:00:00
abstract：BACKGROUND:Central nervous system (CNS) malignancies are the most common solid tumors among children, and novel therapies are needed to help improve survival. Pomalidomide is an immunomodulatory agent that displays antiangiogenic and cytotoxic activity, making it an appropriate candidate to explore in pediatric CNS tum...
journal_title：Pediatric blood & cancer
pub_type： 杂志文章
doi：10.1002/pbc.28756
更新日期：2021-02-01 00:00:00
abstract：:Juvenile myelomonocytic leukemia (JMML) has a poor prognosis in general, with hematopoietic stem cell transplant (HSCT) remaining the standard of care for cure. The hypomethylating agent, azacitidine, has been used as a bridging therapy to transplant. However, no patients have been treated with azacitidine without an ...
journal_title：Pediatric blood & cancer
pub_type： 杂志文章
doi：10.1002/pbc.27905
更新日期：2019-10-01 00:00:00
abstract：BACKGROUND:Childhood cancer is relatively rare and tends to present specific age distribution, as a prognostic factor for some of these diseases. Information on how young age affects prognosis, response to chemotherapy, and local control options in children versus AYA with osteosarcoma (OST) is minimal. METHODS:In ord...
journal_title：Pediatric blood & cancer
pub_type： 杂志文章
doi：10.1002/pbc.25459
更新日期：2015-07-01 00:00:00
abstract：:A teenage boy presented with a CD30-positive anaplastic large cell lymphoma (ALCL) affecting his scapula and was successfully treated with chemotherapy. His clinical features and outcome were compared with other cases described in the literature. A further review of 11 ALCL cases with bony involvement treated in the U...
journal_title：Pediatric blood & cancer
pub_type： 杂志文章,评审
doi：10.1002/pbc.20542
更新日期：2007-04-01 00:00:00
abstract：:Hepatoblastoma (HB) and biliary atresia (BA) are both rare conditions that occurred in the patient described. This is the second such case in the literature. An explanation for this apparent coincidence could possibly be found in the existance of pluripotent liver stem cells. In humans, small epithelial cells (SEC) be...
journal_title：Pediatric blood & cancer
pub_type： 杂志文章
doi：10.1002/pbc.20115
更新日期：2004-10-01 00:00:00
abstract：PURPOSE:The Children's Oncology Group conducted a phase II trial of 21-day continuous infusion topotecan to determine the response rate in pediatric patients with recurrent or refractory malignant solid tumors. PROCEDURE:Patients with Ewing sarcoma family of tumors (ESFT), osteosarcoma (OS), soft tissue sarcomas (STS)...
journal_title：Pediatric blood & cancer
pub_type： 杂志文章
doi：10.1002/pbc.20739
更新日期：2006-11-01 00:00:00
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journal_title：Pediatric blood & cancer
pub_type： 杂志文章,评审
doi：10.1002/pbc.26308
更新日期：2017-04-01 00:00:00
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journal_title：Pediatric blood & cancer
pub_type： 临床试验,杂志文章
doi：10.1002/pbc.27735
更新日期：2019-07-01 00:00:00
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journal_title：Pediatric blood & cancer
pub_type： 杂志文章
doi：10.1002/pbc.21190
更新日期：2008-03-01 00:00:00
abstract：:Malignant melanoma is rare in childhood and has never been reported to cause pancytopenia due to bone marrow metastases in a child. We report a 3-year-old boy with a large congenital melanocytic nevus who presented with bone pain and pancytopenia due to diffuse bone and bone marrow infiltration with metastatic melanom...
journal_title：Pediatric blood & cancer
pub_type： 杂志文章,评审
doi：10.1002/pbc.20200
更新日期：2005-07-01 00:00:00
abstract：BACKGROUND:Adolescents with cancer report a strong desire to be actively involved in personal healthcare decision making. The purpose of this study was to examine adolescent cancer patients' involvement in conversations about relapsed and refractory disease, to characterize the content of patient-clinician communicatio...
journal_title：Pediatric blood & cancer
pub_type： 杂志文章
doi：10.1002/pbc.26918
更新日期：2018-04-01 00:00:00
abstract：BACKGROUND:Sickle cell disease (SCD) is an autosomal recessive hemoglobinopathy associated with morbidity and mortality. We sought to understand family planning intentions of parents of young children with SCD including the awareness of three reproductive options (adoption, in vitro fertilization with egg/sperm donatio...
journal_title：Pediatric blood & cancer
pub_type： 杂志文章
doi：10.1002/pbc.28227
更新日期：2020-05-01 00:00:00
abstract：:Wiskott-Aldrich syndrome (WAS) is characterized by primary immunodeficiency, thrombocytopenia and eczema. Patients with WAS have an increased risk to develop tumors. Non-Hodgkin lymphoma (NHL) represents the most common malignancy occurring in WAS-affected patients, diffuse-large-B-cell lymphoma is the most frequently...
journal_title：Pediatric blood & cancer
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doi：10.1002/pbc.23393
更新日期：2012-08-01 00:00:00
abstract：:Natural killer (NK) cell lymphoma of lung is very rare. We report a case of NK cell lymphoma presented in a 17-year-old male with bilateral pleural effusions and hemophagocytic lymphohistocytosis. Morphologic and immunohistochemical tests revealed an association of NK cell lymphoma with Epstein-Barr virus. A literatur...
journal_title：Pediatric blood & cancer
pub_type： 杂志文章
doi：10.1002/pbc.21943
更新日期：2009-05-01 00:00:00
abstract：PURPOSE:This study compared the relative incidence of treatment-related toxicities and the event-free and overall survival between Hispanic and non-Hispanic children undergoing therapy for acute lymphoblastic leukemia (ALL) on Dana-Farber Cancer Institute ALL Consortium protocol 05-001. PATIENTS AND METHODS:Secondary ...
journal_title：Pediatric blood & cancer
pub_type： 临床试验,杂志文章,多中心研究
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更新日期：2018-03-01 00:00:00
abstract：BACKGROUND:Although weight loss and lack of linear growth occur in children with cancer, growth history is not included in research that aims to determine nutritional status in children newly diagnosed with cancer. Therefore, this study aimed to determine weight loss and lack of linear growth in this patient group. PR...
journal_title：Pediatric blood & cancer
pub_type： 杂志文章,评审
doi：10.1002/pbc.25301
更新日期：2015-02-01 00:00:00
abstract：OBJECTIVES:Palliative radiation therapy (pRT) is often used to improve quality of life for pediatric patients. Though palliative doses are generally lower than those for cure, pRT may still introduce undesirable effects. The decision to pursue additional therapy for a child may be challenging and depends on parents' kn...
journal_title：Pediatric blood & cancer
pub_type： 杂志文章
doi：10.1002/pbc.28003
更新日期：2020-01-01 00:00:00
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journal_title：Pediatric blood & cancer
pub_type： 杂志文章
doi：10.1002/pbc.23007
更新日期：2011-08-01 00:00:00
abstract：:Increasingly young people survive cancer in childhood and as a result complications of its treatment are becoming more common and important. Premature ovarian failure is recognized as a complication of radiotherapy to a field that includes the pelvis and alkylating-agent-based chemotherapy. Young pre-pubertal girls ar...
journal_title：Pediatric blood & cancer
pub_type： 杂志文章,评审
doi：10.1002/pbc.22012
更新日期：2009-08-01 00:00:00
abstract：:Hepatoblastoma is a malignant pediatric liver tumor. The currently used diagnostic serum marker for hepatoblastoma, α-fetoprotein (AFP), is not always reliable in infants with hepatoblastoma, due to the physiologically elevated levels of AFP in this age group. In this report, we show that Delta-like 1 homolog (DLK1), ...
journal_title：Pediatric blood & cancer
pub_type： 杂志文章
doi：10.1002/pbc.24024
更新日期：2012-10-01 00:00:00
abstract：:Opsoclonus, myoclonus, ataxia syndrome (OMA) is a severe neurologic disorder often associated with neuroblastoma. It is challenging to treat and can have long-term neurologic sequelae. Current recommended therapies include intravenous immunoglobulin, corticosteroids, rituximab, and chemotherapy (cyclophosphamide). We ...
journal_title：Pediatric blood & cancer
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更新日期：2018-08-01 00:00:00
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journal_title：Pediatric blood & cancer
pub_type： 杂志文章
doi：10.1002/pbc.20531
更新日期：2006-10-15 00:00:00
abstract：:Pediatric cancer survivors have increased risk of obesity, hypertension, dyslipidemia, and type 2 diabetes, leading to premature cardiovascular disease (CVD). Multiple tissues that are involved in glucose homeostasis and lipid metabolism are adversely affected by chemotherapy. This review highlights the relevant tissu...
journal_title：Pediatric blood & cancer
pub_type： 杂志文章,评审
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更新日期：2013-12-01 00:00:00
