Sustained remission with azacitidine monotherapy and an aberrant precursor B-lymphoblast population in juvenile myelomonocytic leukemia.

abstract：:Minimal residual disease (MRD) is an independent predictor of relapse risk in children with leukemia and is widely used for risk-adapted treatment. This article summarizes current evidence supporting the use of MRD, including clinical significance, current international clinical practice, impact statement, and recomme...

journal_title：Pediatric blood & cancer

authors： Athale UH,Gibson PJ,Bradley NM,Malkin DM,Hitzler J,POGO MRD Working Group.

更新日期：2016-06-01 00:00:00

abstract：:A teenage boy presented with a CD30-positive anaplastic large cell lymphoma (ALCL) affecting his scapula and was successfully treated with chemotherapy. His clinical features and outcome were compared with other cases described in the literature. A further review of 11 ALCL cases with bony involvement treated in the U...

journal_title：Pediatric blood & cancer

authors： Ng A,Hobson R,Williams D,Morland B

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND:Although screening for familial retinoblastoma has been shown to be beneficial we suspected that such screening programs may be less than optimal in developing countries (DC). METHODS:Retrospective cohort study comparing patients with familial retinoblastoma from five centers in DC (Argentina, Brazil, Turke...

journal_title：Pediatric blood & cancer

authors： Chantada GL,Dunkel IJ,Qaddoumi I,Antoneli CB,Totah A,Canturk S,Nawaiseh I,Fandiño A,Pífano I,Peksayar G,Ribeiro KB,Abramson DH

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:The prevalence of nausea and vomiting after receipt of intrathecal methotrexate (IT-MTX) in pediatric oncology patients is unknown. METHODS:Patients (4-18 years) about to receive IT-MTX were eligible to participate in this prospective, observational study. Patients received antiemetics as prescribed by thei...

journal_title：Pediatric blood & cancer

authors： Flank J,Nadeem K,Moledina S,Khanna M,Schindera C,Punnett A,Dupuis LL

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:The identification of tissue-specific differentially methylated regions (tDMRs) is key to our understanding of mammalian development. Research has indicated that tDMRs are aberrantly methylated in cancer and may affect the oncogenic process. PROCEDURE:We used the MassARRAY EpiTYPER system to determine the q...

journal_title：Pediatric blood & cancer

authors： Sugito K,Kawashima H,Uekusa S,Yoshizawa S,Hoshi R,Furuya T,Kaneda H,Hosoda T,Masuko T,Ohashi K,Ikeda T,Koshinaga T,Fujiwara K,Igarashi J,Ghosh S,Held WA,Nagase H

更新日期：2013-03-01 00:00:00

abstract：:Children with cancer and their families experience shifts in spiritual wellness from diagnosis through treatment and survivorship or bereavement. An interdisciplinary team conducted a systematic review of quantitative and qualitative research on spiritual assessments, interventions, and outcomes in childhood cancer fo...

journal_title：Pediatric blood & cancer

authors： Robert R,Stavinoha P,Jones BL,Robinson J,Larson K,Hicklen R,Smith B,Perko K,Koch K,Findley S,Weaver MS

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Coping with end-stage pediatric cancer patients and the related bereavement is a challenge for all the caregivers involved. PROCEDURE:Forty-seven cancer patients who died in 2006 were assessed as concerns the main place of care in the end stage of their disease, their symptoms, the palliative treatments rec...

journal_title：Pediatric blood & cancer

authors： Beretta S,Polastri D,Clerici CA,Casanova M,Cefalo G,Ferrari A,Luksch R,Massimino M,Meazza C,Podda MG,Spreafico F,Terenziani M,Bellani FF

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Cancer patients undergoing chemotherapy often develop anemia, which can increase the risk for transfusions and fatigue. The recombinant erythropoiesis-stimulating agent darbepoetin alfa can effectively treat chemotherapy-induced anemia (CIA) in adults, but limited data are available regarding its use in pedi...

journal_title：Pediatric blood & cancer

authors： Blumer J,Berg S,Adamson PC,Loew T,Rossi G,Hastings C

更新日期：2007-10-15 00:00:00

abstract：BACKGROUND:To analyze the impact of mediastinal irradiation on the incidence of cardiac late effects in long-term survivors of pediatric Hodgkin disease (HD). METHODS:The study cohort comprised 1,132 survivors of HD who received treatment before 18 years of age in consecutive trials between 1978 and 1995. They had mai...

journal_title：Pediatric blood & cancer

authors： Schellong G,Riepenhausen M,Bruch C,Kotthoff S,Vogt J,Bölling T,Dieckmann K,Pötter R,Heinecke A,Brämswig J,Dörffel W

更新日期：2010-12-01 00:00:00

abstract：:Diffuse intrinsic pontine glioma (DIPG) is characterized by a short history of brainstem symptoms and well-known magnetic resonance imaging features with a fatal outcome. However, we report three unusual cases of brainstem tumors with an initial indolent and protracted course, which subsequently developed the classica...

journal_title：Pediatric blood & cancer

authors： Baroni LV,Solano-Paez P,Nobre L,Michaeli O,Hawkins C,Laughlin S,Bartels U,Ramaswamy V,Bouffet E

更新日期：2020-03-01 00:00:00

abstract：:In this retrospective study of patients with overt orbital retinoblastoma, we evaluated minimally disseminated disease (MDD) in bone marrow and cerebrospinal fluid (CSF) using CRX and/or GD2 synthase as markers. Ten patients were evaluated-five (50%) at diagnosis and five upon relapse. MDD was detected in four cases (...

journal_title：Pediatric blood & cancer

authors： Aschero R,Torbidoni A,Sampor C,Laurent V,Zugbi S,Winter U,Lubieniecki F,Alonso D,Schaiquevich P,Chantada GL

更新日期：2019-06-01 00:00:00

abstract：PURPOSE:NWTS-5 was a multi-institutional clinical trial for patients less than 16 years of age at diagnosis with specific renal neoplasms who were diagnosed between August 1, 1995 and May 31, 2002. A uniform approach to the treatment of patients with relapse was employed. PATIENTS AND METHODS:Seventy-two patients who ...

journal_title：Pediatric blood & cancer

authors： Green DM,Cotton CA,Malogolowkin M,Breslow NE,Perlman E,Miser J,Ritchey ML,Thomas PR,Grundy PE,D'Angio GJ,Beckwith JB,Shamberger RC,Haase GM,Donaldson M,Weetman R,Coppes MJ,Shearer P,Coccia P,Kletzel M,Macklis R,To

更新日期：2007-05-01 00:00:00

abstract：:Primary cutaneous lymphomas are rare in children and mostly represented by mycosis fungoides and CD30(+) lymphoproliferative disorders. Most pediatric cutaneous lymphomas have similar clinical/pathological features as their adult counterparts, particularly the T-cell subtypes. With regard to outcome, adult cutaneous m...

journal_title：Pediatric blood & cancer

authors： Ceppi F,Pope E,Ngan B,Abla O

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:Specialized pediatric cancer centers (PCCs) are thought to be essential to obtain state-of-the-art care for children and adolescents. We determined the proportion of childhood cancer patients not treated in a PCC, and described their characteristics and place of treatment. PROCEDURE:The Swiss Childhood Canc...

journal_title：Pediatric blood & cancer

authors： Adam M,von der Weid N,Michel G,Zwahlen M,Lutz JM,Probst-Hensch N,Niggli F,Kuehni C,Swiss Pediatric Oncology Group (SPOG).,Swiss Association of Cancer Registries (ASRT).

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:Drug shortages require clinical teams to decide how to allocate drugs in limited supply among their patients. Ethical frameworks are invaluable for promoting rational approaches to drug distribution, but gaps remain between ethical theory and clinical application. The goal of this work was to explore how dec...

journal_title：Pediatric blood & cancer

authors： Russell HV,Bernhardt MB,Berg S

更新日期：2017-07-01 00:00:00

abstract：:Chronic granulomatous disease (CGD) is a primary immunodeficiency that affects the oxidative mechanism of microbial killing of phagocytic cells. The defect is characterized by a lack or severely reduced superoxide anion (O2-) production by phagocytes. Seventy percent of CGD cases are X-linked (X-CGD) and they are caus...

journal_title：Pediatric blood & cancer

authors： Barese CN,Copelli SB,De Matteo E,Zandomeni R,Salgueiro F,Di Giovanni D,Heyworth P,Rivas EM

更新日期：2005-04-01 00:00:00

abstract：INTRODUCTION:The rate of bacterial infections in children with sickle cell disease (SCD) has decreased in recent years, mainly due to penicillin prophylaxis and vaccination. OBJECTIVES:To determine the rate of severe bacterial infection (SBI) in a cohort of children with SCD and to describe low-risk factors for confir...

journal_title：Pediatric blood & cancer

authors： Rincón-López EM,Navarro Gómez ML,Hernández-Sampelayo Matos T,Saavedra-Lozano J,Aguilar de la Red Y,Hernández Rupérez B,Cela de Julián E,RETRO-DREP Study Group.

更新日期：2019-06-01 00:00:00

abstract：:Pediatric renal cell carcinoma (RCC) is a rare cancer that can be associated with inherited diseases including tuberous sclerosis complex (TSC) caused by germline mutations in TSC1 or TSC2. Somatic mutations in TSC1 and TSC2 have also been reported in adult RCC, which predict response to mTOR inhibitors. Here, we pres...

journal_title：Pediatric blood & cancer

authors： Potter SL,Venkatramani R,Wenderfer S,Graham BH,Vasudevan SA,Sher A,Wu H,Wheeler DA,Yang Y,Eng CM,Gibbs RA,Roy A,Plon SE,Parsons DW

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to evaluate a reduced irradiation dose strategy for newly diagnosed primary central nervous system (CNS) germinomas. METHODS:Twenty patients with histologically diagnosed localized pure germinoma (n = 19) or germinoma with a mature teratoma component (n = 1) received four cycle...

journal_title：Pediatric blood & cancer

authors： Khatua S,Dhall G,O'Neil S,Jubran R,Villablanca JG,Marachelian A,Nastia A,Lavey R,Olch AJ,Gonzalez I,Gilles F,Nelson M,Panigrahy A,McComb G,Krieger M,Fan J,Sposto R,Finlay JL

更新日期：2010-07-15 00:00:00

abstract：BACKGROUND:The aim of this study is to evaluate the relationship between the latency to diagnosis (LD) and the time to completion of chemotherapy (TCC) with clinical outcomes in children with osteosarcoma. METHODS:We performed a retrospective analysis of all patients who received treatment for osteosarcoma in two tert...

journal_title：Pediatric blood & cancer

authors： Vasquez L,Silva J,Chavez S,Zapata A,Diaz R,Tarrillo F,Maza I,Sialer L,García J

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:To evaluate efficacy, pharmacokinetics (PK) and pharmacodynamics of single-agent everolimus in pediatric patients with radiographically progressive low-grade glioma (LGG). METHODS:Everolimus was administered at 5 mg/m2 once daily as a tablet or liquid for a planned 48-week duration or until unacceptable tox...

journal_title：Pediatric blood & cancer

authors： Wright KD,Yao X,London WB,Kao PC,Gore L,Hunger S,Geyer R,Cohen KJ,Allen JC,Katzenstein HM,Smith A,Boklan J,Nazemi K,Trippett T,Karajannis M,Herzog C,Destefano J,Direnzo J,Pietrantonio J,Greenspan L,Cassidy D,Sch

更新日期：2021-02-01 00:00:00

abstract：BACKGROUND:Subspecialty-specific normative values for clinical productivity of practicing pediatric hematologist/oncologists have not been well established. This information could be a useful adjunct in administrative decision-making in areas such as necessary levels of physician staffing and development of compensatio...

journal_title：Pediatric blood & cancer

authors： Griffin TC,Hutter JJ,Johnson KK,Moscow JA

更新日期：2004-08-01 00:00:00

abstract：PURPOSE:Pediatric head and neck malignancies are managed with intensive multimodality therapy. Proton beam therapy (PBT) may reduce toxicity by limiting exposure of normal tissue to radiation. In this study, we report acute toxicities and early outcomes following PBT for pediatric head and neck malignancies. MATERIALS...

journal_title：Pediatric blood & cancer

authors： Vogel J,Both S,Kirk M,Chao HH,Bagatell R,Li Y,Womer R,Balamuth N,Reilly A,Kurtz G,Lustig R,Tochner Z,Hill-Kayser C

更新日期：2018-02-01 00:00:00

abstract：:High-risk (HR) acute lymphoblastic leukemia (ALL) remains one of the greatest challenges in pediatric oncology. Relapsed ALL is a leading cause of death in young people, and further improvements in outcome will required the development of therapeutic approaches directed against rational therapeutic targets, as escalat...

journal_title：Pediatric blood & cancer

authors： Hunger SP,Raetz EA,Loh ML,Mullighan CG

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:We report on the treatment of children and adolescents with acute lymphoblastic leukemia (ALL) in first relapse. The protocol focused on: (1) Intensive chemotherapy preceding allogeneic stem cell transplantation (SCT) in early bone marrow relapse; (2) Rotational chemotherapy in late relapse, without donor; (...

journal_title：Pediatric blood & cancer

authors： van den Berg H,de Groot-Kruseman HA,Damen-Korbijn CM,de Bont ES,Schouten-van Meeteren AY,Hoogerbrugge PM

更新日期：2011-08-01 00:00:00

abstract：:Sickle cell disease (SCD) is an inherited red blood cell disorder that occurs worldwide and results in significant morbidity and mortality. In addition to affected children who are born in the US, an increasing number of children with SCD are migrating to the US with their families or through international adoption. C...

journal_title：Pediatric blood & cancer

authors： Thornburg CD,Ware RE

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Although intra-retinal tumor has long been staged presurgically according to the Reese-Ellsworth (R-E) system, retinoblastoma differs from other pediatric neoplasms in never having had a widely accepted classification system that encompasses the entire spectrum of the disease. Comparisons among studies that ...

journal_title：Pediatric blood & cancer

authors： Chantada G,Doz F,Antoneli CB,Grundy R,Clare Stannard FF,Dunkel IJ,Grabowski E,Leal-Leal C,Rodríguez-Galindo C,Schvartzman E,Popovic MB,Kremens B,Meadows AT,Zucker JM

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:The presence of central nervous system (CNS) disease in pediatric acute myeloid leukemia (AML) is often thought to confer a worse prognosis. This study examined the outcome of children with AML who had CNS disease at diagnosis. METHODS:Patients enrolled on Children's Cancer Group protocols 2861, 2891, 2941,...

journal_title：Pediatric blood & cancer

authors： Johnston DL,Alonzo TA,Gerbing RB,Lange BJ,Woods WG

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:While pediatric low-grade glioma/glioneuronal tumors (LGG/LGGNTs) are considered slow-growing, indolent tumors with excellent long-term prognosis, mortality due to the disease is not unknown. Few studies have addressed the cause of death in this population. METHODS:Retrospective review of clinicopathologic ...

journal_title：Pediatric blood & cancer

authors： Upadhyaya SA,Ghazwani Y,Wu S,Broniscer A,Boop FA,Gajjar A,Qaddoumi I

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Posterior fossa syndrome (PFS) is defined as the temporary and complete loss of speech after posterior fossa surgery. The goal of this study was to identify incidence and risk factors for PFS and to determine accompanying neurobehavioral and psychologic problems. PROCEDURE:Between May 2007 and April 2009, c...

journal_title：Pediatric blood & cancer

authors： Küpeli S,Yalçın B,Bilginer B,Akalan N,Haksal P,Büyükpamukçu M

更新日期：2011-02-01 00:00:00