Reproductive intentions in mothers of young children with sickle cell disease.


BACKGROUND:Sickle cell disease (SCD) is an autosomal recessive hemoglobinopathy associated with morbidity and mortality. We sought to understand family planning intentions of parents of young children with SCD including the awareness of three reproductive options (adoption, in vitro fertilization with egg/sperm donation [IVFD], in vitro fertilization [IVF] with preimplantation genetic testing [IVF/PGT]) to decrease the risk of having a child with SCD. PROCEDURE:Qualitative, semistructured, one-on-one interviews with 18 female parents of young children with SCD at an urban, tertiary care pediatric hospital. RESULTS:Half of the parents knew their hemoglobinopathy status or their partner's status before pregnancy. Eight parents chose to have no further children because of fear of SCD in another child. Awareness of reproductive options prior to study enrollment was limited. After brief introduction, 7 parents would consider adoption, 2 IVFD, and 10 IVF/PGT. Desire for a biological child, fear of parental jealousy, ethical or religious considerations, and cost affected the acceptability of these options. Participants universally wanted information about reproductive options available to others prior to pregnancy. CONCLUSIONS:There is limited awareness and variable acceptability of alternative reproductive options available to decrease the risk of a future child having SCD. Participants universally endorsed the need for education regarding hemoglobinopathy status, SCD, and reproductive options prior to pregnancy because for many participants having a child with SCD affected their reproductive intentions. Educational interventions to ensure informed reproductive decision making should be sensitive to desires for a biological child, and ethical and financial considerations.


Pediatr Blood Cancer


Pediatric blood & cancer


Schultz CL,Tchume-Johnson T,Jackson T,Enninful-Eghan H,Schapira MM,Smith-Whitley K




Has Abstract


2020-05-01 00:00:00












  • Late valvular and other cardiac diseases after different doses of mediastinal radiotherapy for Hodgkin disease in children and adolescents: report from the longitudinal GPOH follow-up project of the German-Austrian DAL-HD studies.

    abstract:BACKGROUND:To analyze the impact of mediastinal irradiation on the incidence of cardiac late effects in long-term survivors of pediatric Hodgkin disease (HD). METHODS:The study cohort comprised 1,132 survivors of HD who received treatment before 18 years of age in consecutive trials between 1978 and 1995. They had mai...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Schellong G,Riepenhausen M,Bruch C,Kotthoff S,Vogt J,Bölling T,Dieckmann K,Pötter R,Heinecke A,Brämswig J,Dörffel W

    更新日期:2010-12-01 00:00:00

  • The strange case of the lost NRAS mutation in a child with juvenile myelomonocytic leukemia.

    abstract::Juvenile myelomonocytic leukemia (JMML) is a rare myelodysplastic/myeloproliferative disorder of early childhood characterized by mutations of the RAS-RAF-MAP kinase signaling pathway. We report the case of a child with a diagnosis of JMML carrying two mutations of NRAS gene (c.37G>C and c.38G>A) independently occurri...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: De Filippi P,Zecca M,Novara F,Lisini D,Maserati E,Pasquali F,Rosti V,Carlo-Stella C,Zavras N,Cagioni C,Zuffardi O,Pagliara D,Danesino C,Locatelli F

    更新日期:2012-09-01 00:00:00

  • Serologic response and clinical efficacy of influenza vaccination in children and young adults on chemotherapy for cancer.

    abstract:BACKGROUND:Influenza is a health risk to children receiving chemotherapy for cancer. An absolute lymphocyte count (ALC) >1,000 cells/mm(3) has been associated with the ability to produce an immune response to influenza vaccine during chemotherapy. However, clinical efficacy of influenza vaccination during chemotherapy ...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Choi DK,Fuleihan RL,Walterhouse DO

    更新日期:2016-11-01 00:00:00

  • Successful antifungal combination therapy with voriconazole and caspofungin.

    abstract::A 12-year-old boy in third remission of an acute lymphoblastic leukaemia developed infection of lung and paranasal sinuses with Aspergillus flavus in neutropenia. Because of the high risk of leukaemia-relapse bone marrow transplantation (BMT) from a matched unrelated donor was carried out despite invasive pulmonary as...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Schuster F,Moelter C,Schmid I,Graubner UB,Kammer B,Belohradsky BH,Führer M

    更新日期:2005-06-15 00:00:00

  • Reversible Fanconi syndrome in a pediatric patient on deferasirox.

    abstract::Deferasirox (Exjade®, Novartis) is a widely used oral iron chelator for the treatment of patients with iron overload due to chronic transfusion therapy for diseases such as β-thalassemia and sickle cell disease. Renal side effects of deferasirox are common and include non-progressive increases in serum creatinine, how...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Rheault MN,Bechtel H,Neglia JP,Kashtan CE

    更新日期:2011-04-01 00:00:00

  • Access to specialized pediatric cancer care in Switzerland.

    abstract:BACKGROUND:Specialized pediatric cancer centers (PCCs) are thought to be essential to obtain state-of-the-art care for children and adolescents. We determined the proportion of childhood cancer patients not treated in a PCC, and described their characteristics and place of treatment. PROCEDURE:The Swiss Childhood Canc...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,多中心研究


    authors: Adam M,von der Weid N,Michel G,Zwahlen M,Lutz JM,Probst-Hensch N,Niggli F,Kuehni C,Swiss Pediatric Oncology Group (SPOG).,Swiss Association of Cancer Registries (ASRT).

    更新日期:2010-05-01 00:00:00

  • Late effects in childhood cancer survivors: a review with a framing effect bias?

    abstract::Most publications report the adverse (negative) health issues in childhood cancer survivors. Presenting information to the newly diagnosed patient in a positive manner is advocated, while noting that recurrence is the most likely adverse event. Re-analysis of population-based studies on life-threatening toxicities fro...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,评审


    authors: Fryer C

    更新日期:2011-12-15 00:00:00

  • Patient-reported health status during pediatric cancer treatment.

    abstract:BACKGROUND:Changes in patient function and factors affecting pediatric patients with cancer during treatment are largely unknown. The purpose of this study was to measure patient-reported outcomes (PROs) in children during the initial 6 months of therapy to characterize function and explore factors associated with func...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Dobrozsi S,Yan K,Hoffmann R,Panepinto J

    更新日期:2017-04-01 00:00:00

  • Stereotactic body radiotherapy for pediatric hepatocellular carcinoma with central biliary obstruction.

    abstract::Here, we present the case of a pediatric patient with newly diagnosed hepatocellular carcinoma causing central biliary obstruction and persistently elevated bilirubin of 3.0-4.3 mg/dl despite placement of bilateral internal-external biliary drains. The tumor was not resectable, and the patient was not a candidate for ...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Hiniker SM,Rangaswami A,Lungren MP,Thakor AS,Concepcion W,Balazy KE,Kovalchuk N,Donaldson SS

    更新日期:2017-06-01 00:00:00

  • Cardiac liposarcoma and bilateral ovarian mature teratoma in a patient with congenital heart disease and f-anisosplenia.

    abstract::A 10-year-old female with atrial septal defect presented with bilateral ovarian mature cystic teratomas. Three spleniculi adjacent to the main spleen were noticed while the endoscopic surgery. Two years later a heart tumor was discovered which led to death. Pathologic examination of samples of the mass proved it to be...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Pollono DG,Drut R

    更新日期:2008-08-01 00:00:00

  • Carboplatin Hypersensitivity Reactions in Pediatric Low Grade Glioma Are Protocol Specific and Desensitization Shows Poor Efficacy.

    abstract:BACKGROUND:The use of carboplatin for the treatment of pediatric low grade gliomas (PLGG) is often limited by the development of carboplatin hypersensitivity. Reported rates of carboplatin hypersensitivity reactions vary between 6% and 32% in these patients. Here we report the frequency of carboplatin hypersensitivity ...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Dodgshun AJ,Hansford JR,Cole T,Choo S,Sullivan MJ

    更新日期:2016-01-01 00:00:00

  • Choroid plexus tumors; management, outcome, and association with the Li-Fraumeni syndrome: the Children's Hospital Los Angeles (CHLA) experience, 1991-2010.

    abstract:BACKGROUND:Choroid plexus tumors (CPT) are rare, and predominate in early childhood. An association with the Li-Fraumeni syndrome (LFS) has been reported, but the biological and clinical implications of this association remain poorly defined. We have investigated the clinical features and overall survival of all CPT pa...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Gozali AE,Britt B,Shane L,Gonzalez I,Gilles F,McComb JG,Krieger MD,Lavey RS,Shlien A,Villablanca JG,Erdreich-Epstein A,Dhall G,Jubran R,Tabori U,Malkin D,Finlay JL

    更新日期:2012-06-01 00:00:00

  • Long-term survivors of childhood cancer report quality of life and health status in parity with a comparison group.

    abstract:BACKGROUND:There is a need for more knowledge about how survivors of childhood cancer perceive their lives and what influence current health status has on their quality of life. The purpose was to describe this among a group of long-term survivors and among a comparison group. PROCEDURE:Telephone interviews were perfo...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Sundberg KK,Doukkali E,Lampic C,Eriksson LE,Arvidson J,Wettergren L

    更新日期:2010-08-01 00:00:00

  • Successful treatment of a patient with mixed warm and cold antibody mediated Evans syndrome and glucose intolerance.

    abstract::Thrombocytopenia and autoimmune hemolytic anemia (Evans syndrome) with the presence of both warm and cold autoantibodies (mixed type) are rare in the pediatric age group. This condition may be associated with other autoimmune disorders and is notoriously difficult to treat. This case describes an adolescent male who p...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Jubinsky PT,Rashid N

    更新日期:2005-09-01 00:00:00

  • Safety of short-term valacyclovir as an anti-sickling agent in sickle-cell anemia.

    abstract::To assess safety and tolerability, we administered valacyclovir, an oral anti-viral medication that inhibits erythrocyte sickling in vitro, to 14 subjects with sickle-cell anemia for 1 week at a standard dose of 1,000 mg every 8 hr. No clinically significant adverse effects occurred. In 11 subjects in steady state, th...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Ender KL,DeBellis RH,Erlanger BF,Billote GB,Brittenham GM

    更新日期:2011-05-01 00:00:00

  • Outcomes of pediatric patients with oncologic disease or following hematopoietic stem cell transplant supported on extracorporeal membrane oxygenation: The PEDECOR experience.

    abstract:BACKGROUND:Outcomes for patients with oncologic disease and/or after hematopoietic stem cell transplant (HSCT) requiring intensive care unit admission have improved, but indications for and outcomes after extracorporeal membrane oxygenation (ECMO) support in this population are poorly characterized. PROCEDURE:We analy...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,多中心研究


    authors: Steppan DA,Coleman RD,Viamonte HK,Hanson SJ,Carroll MK,Klein OR,Cooke KR,Spinella PC,Steiner ME,Loftis LL,Bembea MM,Pediatric ECMO (PediECMO) subgroup of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network and

    更新日期:2020-10-01 00:00:00

  • Information provision and information needs in adult survivors of childhood cancer.

    abstract:BACKGROUND:Knowledge about their past medical history is central for childhood cancer survivors to ensure informed decisions in their health management. Knowledge about information provision and information needs in this population is still scarce. We thus aimed to assess: (1) the information survivors reported to have...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Gianinazzi ME,Essig S,Rueegg CS,von der Weid NX,Brazzola P,Kuehni CE,Michel G,Swiss Paediatric Oncology Group (SPOG).

    更新日期:2014-02-01 00:00:00

  • Outcome of children with primary resistant or relapsed non-Hodgkin lymphoma and mature B-cell leukemia after intensive first-line treatment: a population-based analysis of the Austrian Cooperative Study Group.

    abstract:BACKGROUND:Children and adolescents with Non-Hodgkin lymphoma (NHL) and mature B-cell leukemia (B-ALL) have an excellent prognosis with contemporary chemotherapy stratified according to the histologic subtype and clinical stage of disease. However, a small subset of patients does not respond to front-line therapy or su...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,多中心研究


    authors: Attarbaschi A,Dworzak M,Steiner M,Urban C,Fink FM,Reiter A,Gadner H,Mann G

    更新日期:2005-01-01 00:00:00

  • Pulmonary function abnormalities in childhood cancer survivors treated with bleomycin.

    abstract:BACKGROUND:Bleomycin is associated with pulmonary toxic side effects including pneumonitis and pulmonary fibrosis. We evaluated the prevalence of long-term pulmonary function abnormalities in children receiving bleomycin therapy in the context of current chemotherapeutic regimens. METHODS:A retrospective review of pat...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: De A,Guryev I,LaRiviere A,Kato R,Wee CP,Mascarenhas L,Keens TG,Venkatramani R

    更新日期:2014-09-01 00:00:00

  • Central nervous system disease in pediatric acute myeloid leukemia: A report from the Children's Oncology Group.

    abstract:BACKGROUND:The prognostic impact of central nervous system (CNS) involvement in children with acute myeloid leukemia (AML) has varied in past trials, and controversy exists over the degree of involvement requiring intensified CNS therapy. Two recent Children's Oncology Group protocols, AAML03P1 and AAML0531, directed a...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Johnston DL,Alonzo TA,Gerbing RB,Aplenc R,Woods WG,Meshinchi S,Gamis AS

    更新日期:2017-12-01 00:00:00

  • The role of myeloablative chemotherapy with autologous hematopoietic cell rescue in central nervous system germ cell tumors.

    abstract::This review of the experience of high dose chemotherapy in patients with recurrent or refractory intracranial germ cell tumor confirms that sustained tumor control can be achieved with this modality both in germinoma and non-germinomatous germ cell tumors. Data from cooperative groups in Europe and North America sugge...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,评审


    authors: Bouffet E

    更新日期:2010-04-01 00:00:00

  • Variation in hospital admission from the emergency department for children with cancer: A Pediatric Health Information System study.

    abstract:BACKGROUND:Children with cancer experience a wide range of conditions that require urgent evaluation in the emergency department (ED), yet variation in admission rates is poorly documented. PROCEDURE:We performed a retrospective cohort study using the Pediatric Health Information System of ED encounters by children wi...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Mueller EL,Jacob SA,Cochrane AR,Carroll AE,Bennett WE Jr

    更新日期:2020-06-01 00:00:00

  • Testicular stem cells for fertility preservation: preclinical studies on male germ cell transplantation and testicular grafting.

    abstract::Spermatogonial stem cells open novel strategies for preservation of testicular tissue and fertility preservation in boys and men exposed to gonadotoxic therapies. This review provides an update on the physiology of spermatogonial stem cells in rodent and primate testes. Species-specific differences must be considered ...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,评审


    authors: Schlatt S,Ehmcke J,Jahnukainen K

    更新日期:2009-08-01 00:00:00

  • Metastatic malignant melanoma presenting as pancytopenia in a three-year-old boy.

    abstract::Malignant melanoma is rare in childhood and has never been reported to cause pancytopenia due to bone marrow metastases in a child. We report a 3-year-old boy with a large congenital melanocytic nevus who presented with bone pain and pancytopenia due to diffuse bone and bone marrow infiltration with metastatic melanom...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,评审


    authors: Spiller SE,Hawkins DS,Finn LS,Sze RW,Sybert V

    更新日期:2005-07-01 00:00:00

  • Intermittent oral trimethoprim/sulfamethoxazole on two non-consecutive days per week is effective as Pneumocystis jiroveci pneumonia prophylaxis in pediatric patients receiving chemotherapy or hematopoietic stem cell transplantation.

    abstract::Pneumocystis jiroveci pneumonia (PCP) is a serious complication in patients receiving chemotherapy or hematopoietic stem cell transplantation. Current recommendations for trimethoprim-sulfamethoxazole (TMP-SMZ) dosing as PCP prophylaxis in immunocompromised patients are based on either daily dosing or dosing three con...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Ohata Y,Ohta H,Hashii Y,Tokimasa S,Ozono K,Hara J

    更新日期:2009-01-01 00:00:00

  • Implementation of an educational intervention to optimize self-management and transition readiness in young adults with sickle cell disease.

    abstract:BACKGROUND:The transition from the pediatric setting to adult care is a well-described period of morbidity and mortality for persons with sickle cell disease (SCD). We sought to measure the feasibility and effectiveness of providing skill-based educational handouts on improving self-management and transition readiness ...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Calhoun CL,Abel RA,Pham HA,Thompson S,King AA

    更新日期:2019-07-01 00:00:00

  • Thymic carcinoma in children.

    abstract::Thymic epithelial neoplasms consist of thymomas, thymic carcinoids, and thymic carcinomas. Carcinomas are malignant tumors of the thymus characterized by obvious cytological anaplasia. They constitute only 4%-14% of thymic epithelial neoplams. Thymic carcinoma rarely occurs in children. Research in the English literat...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,评审


    authors: Yaris N,Nas Y,Cobanoglu U,Yavuz MN

    更新日期:2006-08-01 00:00:00

  • Folate pathway polymorphisms predict deficits in attention and processing speed after childhood leukemia therapy.

    abstract:BACKGROUND:Neurocognitive impairment occurs in 20-40% of childhood acute lymphoblastic leukemia (ALL) survivors, possibly mediated by folate depletion and homocysteine elevation following methotrexate treatment. We evaluated the relationship between folate pathway polymorphisms and neurocognitive impairment after child...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Kamdar KY,Krull KR,El-Zein RA,Brouwers P,Potter BS,Harris LL,Holm S,Dreyer Z,Scaglia F,Etzel CJ,Bondy M,Okcu MF

    更新日期:2011-09-01 00:00:00

  • Pediatric laryngeal carcinoma in a heterozygous carrier of Fanconi anemia.

    abstract::A case of invasive, keratinizing squamous cell carcinoma of the larynx in an 8-year-old female treated with laryngectomy is presented. Perinatal exposure to human papilloma virus and constitutional heterozygosity for a FANCC mutation were identified, though FANCC heterozygosity is not known to be cancer predisposing. ...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: D'Souza AM,Mark J,Demarcantonio M,Leino D,Sisson R,Geller JI

    更新日期:2017-08-01 00:00:00

  • Phase II study of cixutumumab in combination with temsirolimus in pediatric patients and young adults with recurrent or refractory sarcoma: a report from the Children's Oncology Group.

    abstract:BACKGROUND:The combined inhibition of insulin-growth factor type 1 receptor (IGF-1R) and the mammalian target of rapamycin (mTOR) has shown activity in preclinical models of pediatric sarcoma and in adult sarcoma patients. We evaluated the activity of the anti-IGF-1R antibody cixutumumab with the mTOR inhibitor temsiro...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,多中心研究


    authors: Wagner LM,Fouladi M,Ahmed A,Krailo MD,Weigel B,DuBois SG,Doyle LA,Chen H,Blaney SM

    更新日期:2015-03-01 00:00:00