Metastatic malignant melanoma presenting as pancytopenia in a three-year-old boy.

abstract：BACKGROUND:The identification of tissue-specific differentially methylated regions (tDMRs) is key to our understanding of mammalian development. Research has indicated that tDMRs are aberrantly methylated in cancer and may affect the oncogenic process. PROCEDURE:We used the MassARRAY EpiTYPER system to determine the q...

journal_title：Pediatric blood & cancer

authors： Sugito K,Kawashima H,Uekusa S,Yoshizawa S,Hoshi R,Furuya T,Kaneda H,Hosoda T,Masuko T,Ohashi K,Ikeda T,Koshinaga T,Fujiwara K,Igarashi J,Ghosh S,Held WA,Nagase H

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:The aim of the study was to investigate factors affecting response to everolimus, a mammalian-target-of-rapamycin (mTOR) inhibitor, of subependymal giant cell astrocytomas (SEGA) in patients with tuberous sclerosis complex (TSC). METHODS:The study group consisted of 15 children with a diagnosis of TSC-relat...

journal_title：Pediatric blood & cancer

authors： Trelinska J,Dachowska I,Kotulska K,Baranska D,Fendler W,Jozwiak S,Mlynarski W

更新日期：2015-04-01 00:00:00

abstract：INTRODUCTION:The National Heart, Lung, and Blood Institute guidelines for sickle cell disease (SCD) pain crisis management recommend opioids within 60 minutes of emergency department (ED) registration and every 30 minutes thereafter until acute pain is managed. These guidelines are based on expert opinion without publi...

journal_title：Pediatric blood & cancer

authors： Muslu CS,Kopetsky M,Nimmer M,Visotcky A,Fraser R,Brousseau DC

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Image-guided percutaneous core needle biopsy (PCNB) is increasingly utilized to diagnose solid tumors. The objective of this study is to determine whether PCNB is adequate for modern biologic characterization of neuroblastoma. PROCEDURE:A multi-institutional retrospective study was performed by the Pediatri...

journal_title：Pediatric blood & cancer

authors： Overman RE,Kartal TT,Cunningham AJ,Fialkowski EA,Naik-Mathuria BJ,Vasudevan SA,Malek MM,Kalsi R,Le HD,Stafford LC,Lautz TB,Many BT,Jones RE,Bütter A,Davidson J,Williams A,Dasgupta R,Lewis J,Troutt M,Aldrink JH,Man

更新日期：2020-05-01 00:00:00

abstract：:Paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired clonal stem cell disorder. Eculizumab and bone marrow transplantation are disease-modifying treatments for PNH but may not be readily available in resource-constrained settings. Of 52 pediatric patients with PNH, 20 had classical PNH and 32 had PNH/aplastic ...

journal_title：Pediatric blood & cancer

authors： Halder R,Mishra P,Aggarwal M,Mannivanan P,Dhawan R,Seth T,Tyagi S,Mahapatra M,Pati HP,Saxena R

更新日期：2020-04-01 00:00:00

abstract：INTRODUCTION:Major advances in the field of pediatric oncology have resulted from rigorous, prospective clinical oncology research trials. Optimizing access for all children and adolescents to clinical research trials is an important goal. Barriers to clinical trial enrollment are numerous, involving the health care sy...

journal_title：Pediatric blood & cancer

authors： Russo C,Stout L,House T,Santana VM

更新日期：2020-04-01 00:00:00

abstract：INTRODUCTION:To describe the quality of life (QOL) of pediatric brain tumor survivors (PBTSs) prospectively and to identify potential medical, personal and family contextual factors associated with QOL. METHODS:Ninety-one PBTSs (8-16 years) who were off treatment and attending a regular classroom participated. Self- a...

journal_title：Pediatric blood & cancer

authors： Barrera M,Atenafu EG,Schulte F,Bartels U,Sung L,Janzen L,Chung J,Cataudella D,Hancock K,Saleh A,Strother D,McConnell D,Downie A,Hukin J,Zelcer S

更新日期：2017-09-01 00:00:00

abstract：:In this retrospective study of patients with overt orbital retinoblastoma, we evaluated minimally disseminated disease (MDD) in bone marrow and cerebrospinal fluid (CSF) using CRX and/or GD2 synthase as markers. Ten patients were evaluated-five (50%) at diagnosis and five upon relapse. MDD was detected in four cases (...

journal_title：Pediatric blood & cancer

authors： Aschero R,Torbidoni A,Sampor C,Laurent V,Zugbi S,Winter U,Lubieniecki F,Alonso D,Schaiquevich P,Chantada GL

更新日期：2019-06-01 00:00:00

abstract：:We aimed to provide recommendations on the infusion duration of anthracycline chemotherapy agents in children with cancer. This study also serves as a practice example of the essential steps that need to be taken when using a previously published systematic review to develop a high-quality clinical practice guideline....

journal_title：Pediatric blood & cancer

authors： Loeffen EAH,van Dalen EC,Mulder RL,van de Wetering MD,Kremer LCM,Tissing WJE,Anthracycline Cardiotoxicity Working Group.

更新日期：2018-02-01 00:00:00

abstract：:This report compares a traditional full-dose ifosfamide administration modality (24-hr hyperhydration and mesna infusion) with a simplified 9-hr hyperhydration and mesna infusion for use in outpatients. Acute ifosfamide toxicity was the same, suggesting that ifosfamide could be safely administered to outpatients, redu...

journal_title：Pediatric blood & cancer

authors： Meazza C,Bisogno G,Casanova M,Zanetti I,Carli M,Ferrari A

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:Despite the increasing cure rates for children with acute lymphoblastic leukemia (ALL), patients who relapse continue to have poor prognosis. The Children's Oncology Group (COG) conducted a limited institution Phase II trial of Campath-1H, a monoclonal antibody that targets CD52 on leukemic cells, in childre...

journal_title：Pediatric blood & cancer

authors： Angiolillo AL,Yu AL,Reaman G,Ingle AM,Secola R,Adamson PC

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:Children treated with cranial radiotherapy (CRT) for leukemia are at risk of developing central nervous system injuries. Magnetic resonance imaging (MRI) represents the examination method of choice for evaluating radiation-induced brain complications. The purpose of this report is to describe the spectrum of...

journal_title：Pediatric blood & cancer

authors： Faraci M,Morana G,Bagnasco F,Barra S,Polo P,Hanau G,Fioredda F,Caruso S,Rossi A,Spaziante R,Haupt R

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Primary hemophagocytic lymphohistiocytosis (HLH) represents a group of inherited hyperinflammatory immunodeficiencies, including familial HLH (FHL), Griscelli syndrome type 2 (GS2), and X-linked lymphoproliferative syndrome (XLP). We previously reported an annual incidence of suspected primary HLH in Sweden ...

journal_title：Pediatric blood & cancer

authors： Meeths M,Horne A,Sabel M,Bryceson YT,Henter JI

更新日期：2015-02-01 00:00:00

abstract：:Pediatric cancer programs in low-income countries (LIC) can improve outcomes. However, treatment must be tailored to the patient's living conditions and the availability of supportive care. In some cases, a more intense regimen will decrease survival since the increase in death from toxicity may exceed any decrease in...

journal_title：Pediatric blood & cancer

authors： Howard SC,Ortiz R,Baez LF,Cabanas R,Barrantes J,Fu L,Peña A,Samudio A,Vizcaino M,Rodríguez-Galindo C,Barr RD,Conter V,Biondi A,Masera G,MISPHO Consortium Writing Committee.

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND:Neonatal leukemia characterized by early stem cell origin and extramedullary infiltration in the first 4 weeks of life is rare. We analyzed the features and outcome of neonatal leukemia in Japan to establish an appropriate treatment strategy for this rare disorder. PROCEDURE:Patients with infant leukemia re...

journal_title：Pediatric blood & cancer

authors： Ishii E,Oda M,Kinugawa N,Oda T,Takimoto T,Suzuki N,Kosaka Y,Ohara A,Ogawa A,Ishii M,Sakata N,Okamura T,Koike K,Kojima S,Horibe K,Mizutani S

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:The use of carboplatin for the treatment of pediatric low grade gliomas (PLGG) is often limited by the development of carboplatin hypersensitivity. Reported rates of carboplatin hypersensitivity reactions vary between 6% and 32% in these patients. Here we report the frequency of carboplatin hypersensitivity ...

journal_title：Pediatric blood & cancer

authors： Dodgshun AJ,Hansford JR,Cole T,Choo S,Sullivan MJ

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:SCH 727965 is a novel drug in clinical development that potently and selectively inhibits CDK1, CDK2, CDK5, and CDK9. The activity of SCH 727965 was evaluated against the PPTP's in vitro and in vivo panels. PROCEDURES:SCH 727965 was tested against the PPTP in vitro panel using 96 hours exposure at concentra...

journal_title：Pediatric blood & cancer

authors： Gorlick R,Kolb EA,Houghton PJ,Morton CL,Neale G,Keir ST,Carol H,Lock R,Phelps D,Kang MH,Reynolds CP,Maris JM,Billups C,Smith MA

更新日期：2012-12-15 00:00:00

abstract：BACKGROUND:Silent cerebral infarcts are both morbid and progressive in children with sickle cell disease (SCD). While blood transfusion therapy is effective primary and secondary stroke prevention, the efficacy and acceptance of blood transfusion therapy for children with silent cerebral infarcts is unknown. The overal...

journal_title：Pediatric blood & cancer

authors： King AA,Noetzel M,White DA,McKinstry RC,Debaun MR

更新日期：2008-03-01 00:00:00

abstract：:Germline or acquired mutations involving the GATA-binding protein gene (GATA2) have been linked to a variety of clinical conditions. In addition, patients harboring GATA2 mutations have a striking predisposition to develop myeloid malignancies, such as myelodysplastic syndrome or acute myeloid leukemia, but not acute ...

journal_title：Pediatric blood & cancer

authors： Esparza O,Xavier AC,Atkinson TP,Hill BC,Whelan K

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:The histological response to neoadjuvant chemotherapy (NAC) in pediatric patients with Ewing sarcoma family of tumors (ESFT) can predict the disease-free survival. Therefore, a noninvasive method for response assessment is needed. Using the currently established imaging modalities, mass reduction does not al...

journal_title：Pediatric blood & cancer

authors： El-Hennawy G,Moustafa H,Omar W,Elkinaai N,Kamel A,Zaki I,Farid N,El-Kholy E

更新日期：2020-11-01 00:00:00

abstract：:Although investigators have been engaged in the study of human energy metabolism for over 100 years, there remain unanswered questions regarding the role that energy expenditure plays in human health and disease. A critical examination of available methods for measurement of the various components of daily energy expe...

journal_title：Pediatric blood & cancer

authors： DeLany JP

更新日期：2012-01-01 00:00:00

abstract：:We report the case of a drug interaction between methotrexate (MTX) and chloral hydrate (CH) observed in a child treated for acute leukemia. Significantly slower MTX clearance and increased MTX exposure occurred on the first three courses of a high-dose chemotherapy when co-administered with CH despite normal renal fu...

journal_title：Pediatric blood & cancer

authors： Dao K,Ivanyuk A,Buclin T,Beck-Popovic M,Diezi M

更新日期：2013-03-01 00:00:00

abstract：:Children with sickle cell anemia (SCA) have low bone mass though bone turnover has not been well described. In this study, growth and pubertal development were assessed twice, 1 year apart, in 80 young subjects with type-SS SCA, while whole body bone mineral content (BMC) and density where measured in a subset (n = 46...

journal_title：Pediatric blood & cancer

authors： Fung EB,Kawchak DA,Zemel BS,Rovner AJ,Ohene-Frempong K,Stallings VA

更新日期：2008-03-01 00:00:00

abstract：:Acute splenic sequestration crisis (ASSC) is a hematological emergency in young children with sickle cell disease (SCD), characterized by worsening anemia and splenomegaly, usually with reticulocytosis and thrombocytopenia. Transient aplastic crisis (TAC) due to parvovirus B19 infection occurs in older children with S...

journal_title：Pediatric blood & cancer

authors： Yates AM,Hankins JS,Mortier NA,Aygun B,Ware RE

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:Right hemicolectomy (RHC) in patients with neuroendocrine tumors (NET) of the appendix has been advocated for tumors more than 2 cm, or with mesoappendix/vessel invasion, or with raised mitotic activity. No study demonstrated prolonged survival with RHC over appendectomy alone. The aim of this study was to c...

journal_title：Pediatric blood & cancer

authors： de Lambert G,Lardy H,Martelli H,Orbach D,Gauthier F,Guérin F

更新日期：2016-04-01 00:00:00

abstract：:Ovarian tumors have a low incidence in childhood, accounting for 1% of malignancies within the ages of 0-17 years. Small cell carcinoma of the ovary is a rare histology and historically has a poor prognosis. We report a case of an 11-year-old female diagnosed with small cell carcinoma of the ovary and hypercalcemia (S...

journal_title：Pediatric blood & cancer

authors： Martinez-Borges AR,Petty JK,Hurt G,Stribling JT,Press JZ,Castellino SM

更新日期：2009-12-15 00:00:00

abstract：BACKGROUND:Infection in neutropenic children is a major cause of morbidity and mortality in children treated for cancer. In developing countries, children with cancer are often malnourished at diagnosis. In Blantyre, Malawi, children with Burkitt lymphoma are treated with a local protocol with limited toxicity. The aim...

journal_title：Pediatric blood & cancer

authors： Israëls T,van de Wetering MD,Hesseling P,van Geloven N,Caron HN,Molyneux EM

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:Insomnia is common among adolescent and young adult (AYA) cancer survivors. Cognitive-behavioral therapy for insomnia (CBT-I) is considered the gold standard treatment. Standard CBT-I was designed for adults and not adapted to the unique medical, psychosocial, and developmental needs of AYA cancer survivors,...

journal_title：Pediatric blood & cancer

authors： Zhou ES,Recklitis CJ

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Kaposi sarcoma (KS) is the most common HIV-associated malignancy in sub-Saharan Africa. The presentation and outcomes of pediatric KS are not well understood. PROCEDURE:We performed a retrospective cohort analysis of 81 HIV-infected children with KS at the Baylor Children's Clinical Centres of Excellence in...

journal_title：Pediatric blood & cancer

authors： Cox CM,El-Mallawany NK,Kabue M,Kovarik C,Schutze GE,Kazembe PN,Mehta PS

更新日期：2013-08-01 00:00:00

abstract：:We report on an acute myeloid leukemia in a neonate whose mother was exposed to diethylstilboestrol in utero. The newborn presented with leukemia cutis, hemorrhagic skin lesions, hyperleucocytosis and disseminated intravascular coagulation. A bone marrow examination confirmed the diagnosis of acute monocytic leukemia ...

journal_title：Pediatric blood & cancer

authors： Chantrain CF,Sauvage D,Brichard B,Dupont S,Poirel HA,Ameye G,De Weer A,Vandenberghe P,Detaille T,Anslot C,de Cléty SC,Vermylen C

更新日期：2009-08-01 00:00:00