Barriers and facilitators of clinical trial enrollment in a network of community-based pediatric oncology clinics.

abstract：BACKGROUND AND AIM:We reviewed the results and pattern of failure of the consensus HB/HCC 1996 treatment protocol for pediatric hepatoblastoma (HB) in Hong Kong. The role of SIOPEL and Children's Hepatic tumors International Collaboration (CHIC) risk stratification was evaluated. METHODS:Patients enrolled on the proto...

journal_title：Pediatric blood & cancer

authors： Liu APY,Ip JJK,Leung AWK,Luk CW,Li CH,Ho KKH,Lo R,Chan EKW,Chan ACY,Chung PHY,Chiang AKS

更新日期：2019-01-01 00:00:00

abstract：:Squamous cell carcinoma of the anal canal in children is rare. To date, the etiology and outcome of this condition have been not fully understood. Here, we report an 11-year-old child with anal canal cancer who had concomitant disorders of sex development. Radiotherapy followed by salvage surgery achieved disease-free...

journal_title：Pediatric blood & cancer

authors： Watanabe T,Horikawa R,Masaki H,Yoshioka T,Matsumoto K,Kanamori Y

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Severe pandemic influenza A (H1N1) infection can lead to acute respiratory failure (ARF) with associated high mortality. Children with malignancy may be at higher risk of H1N1-associated ARF because of underlying primary disease or immunosuppression associated with chemotherapy. PROCEDURE:We describe the cl...

journal_title：Pediatric blood & cancer

authors： Elbahlawan L,Gaur AH,Furman W,Jeha S,Woods T,Norris A,Morrison RR

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:The role of the neutropenic diet in the development of infections in oncology and stem cell transplant (SCT) patients is controversial. There is no data on the use of the neutropenic diet among pediatric oncologists. METHODS:A self-administered electronic survey was sent to 1,639 pediatric oncologists at 19...

journal_title：Pediatric blood & cancer

authors： Braun LE,Chen H,Frangoul H

更新日期：2014-10-01 00:00:00

abstract：:Limited high-quality evidence supports the management of iron deficiency anemia (IDA). To assess our institutional performance in this area, we retrospectively reviewed IDA treatment practices in 195 consecutive children referred to our center from 2006 to mid-2010. The majority of children were ≤4 years old (64%) and...

journal_title：Pediatric blood & cancer

authors： Powers JM,Daniel CL,McCavit TL,Buchanan GR

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Dexamethasone is more efficacious than prednisone in the treatment of acute lymphoblastic leukemia (ALL), but has also been associated with greater toxicity. We compared neuropsychological outcomes for patients treated on DFCI ALL Consortium Protocol 00-01, which included a randomized comparison of the two s...

journal_title：Pediatric blood & cancer

authors： Waber DP,McCabe M,Sebree M,Forbes PW,Adams H,Alyman C,Sands SA,Robaey P,Romero I,Routhier MÈ,Girard JM,Sallan SE,Silverman LB

更新日期：2013-11-01 00:00:00

abstract：PURPOSE:To determine the safety, efficacy, and PK profile of intravenous busulfan (Bu) in the context of a Bu and cyclophosphamide (IVBuCy) preparative regimen in children undergoing allogeneic hematopoietic stem cell transplantation (HSCT). METHODS:Twenty-four children were enrolled in an open-label, multicenter tria...

journal_title：Pediatric blood & cancer

authors： Wall DA,Chan KW,Nieder ML,Hayashi RJ,Yeager AM,Kadota R,Przepiorka D,Mezzi K,Kletzel M,Pediatric Blood, Marrow Transplant Consortium.

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:Hematopoietic stem cell transplantation (HSCT) provides a curative therapy for children severely affected by sickle cell disease (SCD). Rejection-free survival after matched sibling donor (MSD) HSCT is very high, but adoption of HSCT as a curative SCD therapy has been slow. In this study, we assess providers...

journal_title：Pediatric blood & cancer

authors： Meier ER,Abraham AA,Ngwube A,Janson IA,Guilcher GMT,Horan J,Kasow KA

更新日期：2021-03-01 00:00:00

abstract：:Thymic epithelial neoplasms consist of thymomas, thymic carcinoids, and thymic carcinomas. Carcinomas are malignant tumors of the thymus characterized by obvious cytological anaplasia. They constitute only 4%-14% of thymic epithelial neoplams. Thymic carcinoma rarely occurs in children. Research in the English literat...

journal_title：Pediatric blood & cancer

authors： Yaris N,Nas Y,Cobanoglu U,Yavuz MN

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND:Although hematopoietic stem cell transplantation (HSCT) is offered as a curative therapy for pediatric myelodysplastic syndrome (MDS), it may cause severe complications and mortality. Several reports have shown the efficacy of immunosuppressive therapy (IST) in adult patients with refractory anemia (RA), but...

journal_title：Pediatric blood & cancer

authors： Hasegawa D,Manabe A,Yagasaki H,Ohtsuka Y,Inoue M,Kikuchi A,Ohara A,Tsuchida M,Kojima S,Nakahata T,Japanese Childhood MDS Study Group.

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:Pediatric nonrhabdomyosarcoma soft tissue sarcomas (NRSTS) may rarely occur in visceral tissues, and little is known about their clinical history. The present study retrospectively analyzed a group of patients prospectively registered in Italian pediatric protocols conducted between 1979 and 2004. METHODS:I...

journal_title：Pediatric blood & cancer

authors： Ferrari A,Magni C,Bergamaschi L,Cecchetto G,Alaggio R,Milano GM,Bertolini P,Basso E,Manzitti C,Di Martino M,Giurici N,Melchionda F,Cecinati V,Chiaravalli S,Affinita MC,Scagnellato A,Casanova M,Bisogno G

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:The aim of the study was to investigate factors affecting response to everolimus, a mammalian-target-of-rapamycin (mTOR) inhibitor, of subependymal giant cell astrocytomas (SEGA) in patients with tuberous sclerosis complex (TSC). METHODS:The study group consisted of 15 children with a diagnosis of TSC-relat...

journal_title：Pediatric blood & cancer

authors： Trelinska J,Dachowska I,Kotulska K,Baranska D,Fendler W,Jozwiak S,Mlynarski W

更新日期：2015-04-01 00:00:00

abstract：:Hemorrhagic cystitis (HC) is a common complication after stem cell transplantation (SCT) that occurs more frequently in patients with Fanconi anemia (FA) because of hypersensitivity of their cells to the agents used in the preparation for SCT (chemo and radiation). Many HC cases respond to therapy with hyperhydration ...

journal_title：Pediatric blood & cancer

authors： Al-Seraihi A,Ayas M

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND:Currently, there is no standardized treatment for adolescents, aged 15 years or older, with mature B-cell non-Hodgkin lymphoma (B-NHL), although this age group has been reported to have a poorer prognosis than younger patients. PROCEDURE:The present study analyzed the data of 321 patients with B-NHL, enroll...

journal_title：Pediatric blood & cancer

authors： Sekimizu M,Hashimoto H,Mori T,Kobayashi R,Horibe K,Tsurusawa M

更新日期：2018-08-01 00:00:00

abstract：:The incompatibility causing fetal and neonatal alloimmune thrombocytopenia (FNAIT) results from a fetus inheriting a paternal human platelet antigen (HPA), which is different from the maternal HPA. We present a unique case of FNAIT in a pregnancy involving an oocyte recipient mother with Turner syndrome. This is the f...

journal_title：Pediatric blood & cancer

authors： Barg AA,Ifrah AD,Strauss T,Simchen MJ,Orvieto R,Rosenberg N,Kenet G

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:A majority of Fanconi anemia (FA) patients will experience bone marrow failure (BMF) and androgen therapy (most often oxymetholone) may be utilized as a treatment to improve BMF-related cytopenias. However, oxymetholone is associated with toxicities making identification of other agents of interest. In this ...

journal_title：Pediatric blood & cancer

authors： Rose SR,Kim MO,Korbee L,Wilson KA,Ris MD,Eyal O,Sherafat-Kazemzadeh R,Bollepalli S,Harris R,Jeng MR,Williams DA,Smith FO

更新日期：2014-01-01 00:00:00

abstract：:Acute immune thrombocytopenic purpura (ITP) occurs most commonly in young children who present with severe isolated thrombocytopenia and purpura. A marrow examination is not required unless glucocorticoids are used, lest treatment mask incipient acute lymphoblastic leukemia, but controversy exists here. The recommenda...

journal_title：Pediatric blood & cancer

authors： Segel GB,Feig SA

更新日期：2009-09-01 00:00:00

abstract：:Guidelines for management of chronic idiopathic thrombocytopenic purpura (ITP) in childhood are still based on expert opinions and therefore remain controversial. Splenectomy is an established option for chronic ITP in adults, but splenectomy in childhood is complex, due to higher probability for spontaneous recovery ...

journal_title：Pediatric blood & cancer

authors： Minkov M

更新日期：2006-10-15 00:00:00

abstract：BACKGROUND:Treatment intensification was considered a suitable strategy to increase the cure rate of lymphoblastic lymphoma (LBL) in children. PROCEDURE:The AIEOP LNH-97 trial was run between 1997 and 2007 for newly diagnosed LBL in patients aged less than 18 years. Treatment schedule was based on the previous, LSA2-L...

journal_title：Pediatric blood & cancer

authors： Pillon M,Aricò M,Mussolin L,Carraro E,Conter V,Sala A,Buffardi S,Garaventa A,D'Angelo P,Lo Nigro L,Santoro N,Piglione M,Lombardi A,Porta F,Cesaro S,Moleti ML,Casale F,Mura R,d'Amore ES,Basso G,Rosolen A

更新日期：2015-08-01 00:00:00

abstract：:Chronic granulomatous disease (CGD) is an immune deficiency characterized by defective neutrophil function and increased risk of life-threatening infections. Allogeneic hematopoietic cell transplantation is curative for CGD, and conditioning regimen impacts transplant-related outcomes. We report a single-center prospe...

journal_title：Pediatric blood & cancer

authors： Bhatt ST,Schulz G,Hente M,Slater A,Murray L,Shenoy S,Bednarski JJ

更新日期：2020-01-01 00:00:00

abstract：:Granulocytic sarcoma (GS) is a localized tumor composed of immature myeloid cells. This extramedullary tumor can present before, concurrent with or after the diagnosis of acute myeloid leukemia. GS is extremely uncommon in acute promyelocytic leukemia (APL). As a proportion of patients never develop systemic disease, ...

journal_title：Pediatric blood & cancer

authors： Worch J,Ritter J,Frühwald MC

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND:Studies have shown that children with cancer globally lack access to palliative care. Little is known regarding physicians' perceptions of palliative care, treatment access, and self-reported competence in providing palliative care. PROCEDURE:Members of the Global Neuroblastoma Network (online tumor board) ...

journal_title：Pediatric blood & cancer

authors： Balkin EM,Thompson D,Colson KE,Lam CG,Matthay KK

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:The transition from the pediatric setting to adult care is a well-described period of morbidity and mortality for persons with sickle cell disease (SCD). We sought to measure the feasibility and effectiveness of providing skill-based educational handouts on improving self-management and transition readiness ...

journal_title：Pediatric blood & cancer

authors： Calhoun CL,Abel RA,Pham HA,Thompson S,King AA

更新日期：2019-07-01 00:00:00

abstract：:Hyperglycemia during induction chemotherapy for childhood acute lymphoblastic leukemia (ALL) has been inconsistently associated with risk of infection. We investigated the incidence of hyperglycemia during induction for childhood ALL in a retrospective cohort study of 144 patients treated on a single national protocol...

journal_title：Pediatric blood & cancer

authors： Dare JM,Moppett JP,Shield JP,Hunt LP,Stevens MC

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:We report a 13-year-old male with Diamond Blackfan anemia and short stature. He had a normal biochemical response to growth hormone (GH) stimulation, but his bone age was delayed, his insulin-like growth factor 1 (IGF-1) was low, and he had a poor growth velocity. He was started on daily GH injections. METH...

journal_title：Pediatric blood & cancer

authors： Scott EG,Haider A,Hord J

更新日期：2004-10-01 00:00:00

abstract：BACKGROUND:Children with cancer may be at an increased risk of infection with hepatitis B virus (HBV) when levels of hepatitis B antibodies are reduced owing to chemotherapy-induced immunosuppression. This study evaluated the changes in HBV antibody status and HBV infections after chemotherapy in children with acute ly...

journal_title：Pediatric blood & cancer

authors： Choi YB,Lee NH,Yi ES,Kim YJ,Koo HH

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:Stroke is a severe clinical disorder in sickle cell disease (SCD), and few studies have evaluated transcranial Doppler (TCD) flow velocities in hemoglobin SC disease (HbSC). The guidelines for stroke risk are based on evaluations in sickle cell anemia (SCA) or HbS/β thalassemia. PROCEDURE:In this study, we ...

journal_title：Pediatric blood & cancer

authors： Vieira C,de Oliveira CN,de Figueiredo LA,Santiago RP,Adanho CS,Santana SS,Burak CL,Lyra IM,Goncalves MS

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Previous studies of children with homozygous sickle cell anemia (SCA) show impaired growth and maturation. The correlation of this suboptimal growth with metabolic and hematological factors during puberty is poorly understood. PROCEDURE:We studied a group of pre-adolescent children with SCA (19 males, 14 fe...

journal_title：Pediatric blood & cancer

authors： Rhodes M,Akohoue SA,Shankar SM,Fleming I,Qi An A,Yu C,Acra S,Buchowski MS

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:This study was conducted to evaluate oral health and dental anomalies in children treated for acute lymphoblastic leukemia (ALL) and to compare results with those of a group of healthy children matched for sex and age. PROCEDURE:Fifty-six children treated for ALL and 56 healthy controls were examined for de...

journal_title：Pediatric blood & cancer

authors： Maciel JC,de Castro CG Jr,Brunetto AL,Di Leone LP,da Silveira HE

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:A pediatric Phase I trial was performed to determine the maximum-tolerated dose, dose-limiting toxicities (DLTs), and pharmacokinetics (PK) of vorinostat and bortezomib, in patients with solid tumors. PROCEDURE:Oral vorinostat was administered on days 1-5 and 8-12 of a 21-day cycle (starting dose 180 mg/m(2...

journal_title：Pediatric blood & cancer

authors： Muscal JA,Thompson PA,Horton TM,Ingle AM,Ahern CH,McGovern RM,Reid JM,Ames MM,Espinoza-Delgado I,Weigel BJ,Blaney SM

更新日期：2013-03-01 00:00:00