Optimization of percutaneous biopsy for diagnosis and pretreatment risk assessment of neuroblastoma.


BACKGROUND:Image-guided percutaneous core needle biopsy (PCNB) is increasingly utilized to diagnose solid tumors. The objective of this study is to determine whether PCNB is adequate for modern biologic characterization of neuroblastoma. PROCEDURE:A multi-institutional retrospective study was performed by the Pediatric Surgical Oncology Research Collaborative on children with neuroblastoma at 12 institutions over a 3-year period. Data collected included demographics, clinical details, biopsy technique, complications, and adequacy of biopsies for cytogenetic markers utilized by the Children's Oncology Group for risk stratification. RESULTS:A total of 243 children were identified with a diagnosis of neuroblastoma: 79 (32.5%) tumor excision at diagnosis, 94 (38.7%) open incisional biopsy (IB), and 70 (28.8%) PCNB. Compared to IB, there was no significant difference in ability to accurately obtain a primary diagnosis by PCNB (95.7% vs 98.9%, P = .314) or determine MYCN copy number (92.4% vs 97.8%, P = .111). The yield for loss of heterozygosity and tumor ploidy was lower with PCNB versus IB (56.1% vs 90.9%, P < .05; and 58.0% vs. 88.5%, P < .05). Complications did not differ between groups (2.9 % vs 3.3%, P = 1.000), though the PCNB group had fewer blood transfusions and lower opioid usage. Efficacy of PCNB was improved for loss of heterozygosity when a pediatric pathologist evaluated the fresh specimen for adequacy. CONCLUSIONS:PCNB is a less invasive alternative to open biopsy for primary diagnosis and MYCN oncogene status in patients with neuroblastoma. Our data suggest that PCNB could be optimized for complete genetic analysis by standardized protocols and real-time pathology assessment of specimen quality.


Pediatr Blood Cancer


Pediatric blood & cancer


Overman RE,Kartal TT,Cunningham AJ,Fialkowski EA,Naik-Mathuria BJ,Vasudevan SA,Malek MM,Kalsi R,Le HD,Stafford LC,Lautz TB,Many BT,Jones RE,Bütter A,Davidson J,Williams A,Dasgupta R,Lewis J,Troutt M,Aldrink JH,Man




Has Abstract


2020-05-01 00:00:00












  • Expression profiling reveals MSX1 and EphB2 expression correlates with the invasion capacity of Wilms tumors.

    abstract:BACKGROUND:Wilms tumor is the most common pediatric renal malignancy, but the parameters that are important to its invasion capacity are poorly understood. The aim of this study was to identify new proteins associated with the invasion capacity of Wilms tumor. PROCEDURE:Gene expression profiles for 15 primary Wilms tu...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Chetcuti A,Aktas S,Mackie N,Ulger C,Toruner G,Alkan M,Catchpoole D

    更新日期:2011-12-01 00:00:00

  • Thymic carcinoma in children.

    abstract::Thymic epithelial neoplasms consist of thymomas, thymic carcinoids, and thymic carcinomas. Carcinomas are malignant tumors of the thymus characterized by obvious cytological anaplasia. They constitute only 4%-14% of thymic epithelial neoplams. Thymic carcinoma rarely occurs in children. Research in the English literat...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,评审


    authors: Yaris N,Nas Y,Cobanoglu U,Yavuz MN

    更新日期:2006-08-01 00:00:00

  • Area deprivation is associated with poorer overall survival in children with acute lymphoblastic leukemia.

    abstract:BACKGROUND:Few studies have evaluated social determinants of outcomes disparities for children with acute lymphoblastic leukemia (ALL). We investigated the association of area deprivation index (ADI), a measure of neighborhood socioeconomic disadvantage, with overall survival (OS) among children and adolescents with AL...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Schraw JM,Peckham-Gregory EC,Rabin KR,Scheurer ME,Lupo PJ,Oluyomi A

    更新日期:2020-09-01 00:00:00

  • A survey of clinical productivity and current procedural terminology (CPT) coding patterns of pediatric hematologist/oncologists.

    abstract:BACKGROUND:Subspecialty-specific normative values for clinical productivity of practicing pediatric hematologist/oncologists have not been well established. This information could be a useful adjunct in administrative decision-making in areas such as necessary levels of physician staffing and development of compensatio...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Griffin TC,Hutter JJ,Johnson KK,Moscow JA

    更新日期:2004-08-01 00:00:00

  • Severe acute hypertriglyceridemia during acute lymphoblastic leukemia induction successfully treated with plasmapheresis.

    abstract::Children suffering from Acute Lymphoblastic Leukaemia (ALL) treated with asparaginase and corticosteroids are at risk of developing severe lipid abnormalities. The authors report the case of a 10-year-old male with extremely high plasma triglyceride concentrations (4,000 mg/dl) during the induction phase of ALL associ...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Ridola V,Buonuomo PS,Maurizi P,Putzulu R,Annunziata ML,Pietrini D,Riccardi R

    更新日期:2008-02-01 00:00:00

  • Feasibility of metronomic maintenance chemotherapy following high-dose chemotherapy for malignant central nervous system tumors.

    abstract:BACKGROUND:Children less than 5 years of age with malignant central nervous system (CNS) tumors, continue to have a high rate of morbidity and mortality following administration of conventional therapy. In an attempt to avoid the neurologic sequelae associated with craniospinal radiation, strategies such as high-dose c...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Choi LM,Rood B,Kamani N,La Fond D,Packer RJ,Santi MR,Macdonald TJ

    更新日期:2008-05-01 00:00:00

  • Health-related quality of life in children with sickle cell disease: a report from the Comprehensive Sickle Cell Centers Clinical Trial Consortium.

    abstract:BACKGROUND:Pediatric health-related quality of life (HRQOL) questionnaires have been validated in children with sickle cell disease (SCD), but small sample sizes in these studies have limited clinical comparisons. We used the baseline clinical data from the Collaborative Data (C-Data) Project of the Comprehensive Sickl...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,多中心研究


    authors: Dampier C,Lieff S,LeBeau P,Rhee S,McMurray M,Rogers Z,Smith-Whitley K,Wang W,Comprehensive Sickle Cell Centers (CSCC) Clinical Trial Consortium (CTC).

    更新日期:2010-09-01 00:00:00

  • Fournier's gangrene and scrotal ulcerations during all-trans-retinoic acid therapy for acute promyelocytic leukemia.

    abstract::Scrotal ulcers are a rare manifestation in patients with acute promyelocytic leukemia. Fournier's gangrene (FG) is even rarer. We describe three adolescents and young adults who developed scrotal ulcerations during induction with all-trans-retinoic acid. One patient developed FG. These lesions are predominantly seen i...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Naithani R,Kumar R,Mahapatra M

    更新日期:2008-08-01 00:00:00

  • Outcome of children and adolescents with Down syndrome treated on Dana-Farber Cancer Institute Acute Lymphoblastic Leukemia Consortium protocols 00-001 and 05-001.

    abstract:BACKGROUND:Children and adolescents with Down syndrome (DS) and acute lymphoblastic leukemia (ALL) are reported to have increased relapse rates and therapy-related mortality (TRM). Treatment regimens for DS-ALL patients often include therapy modifications. Dana-Farber Cancer Institute (DFCI) ALL Consortium protocols ha...

    journal_title:Pediatric blood & cancer

    pub_type: 临床试验,杂志文章


    authors: Athale UH,Puligandla M,Stevenson KE,Asselin B,Clavell LA,Cole PD,Kelly KM,Laverdiere C,Leclerc JM,Michon B,Schorin MA,Sulis ML,Welch JJG,Harris MH,Neuberg DS,Sallan SE,Silverman LB

    更新日期:2018-10-01 00:00:00

  • Communication, Documentation, and Training Standards in Pediatric Psychosocial Oncology.

    abstract::As part of a larger effort to create standards for psychosocial care of children with cancer, we document consensus and evidence-based data on interprofessional communication, documentation, and training for professionals providing psycho-oncology services. Six databases were searched. Sixty-five articles and six guid...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,评审


    authors: Patenaude AF,Pelletier W,Bingen K

    更新日期:2015-12-01 00:00:00

  • Rituximab as monotherapy and in addition to reduced CHOP in children with primary immunodeficiency and non-Hodgkin lymphoma.

    abstract::Children with primary immunodeficiency or chromosomal breakage syndromes are at increased risk of developing non-Hodgkin lymphomas; they cannot tolerate standard chemotherapy regimens. We report two children with diffuse, large, B-cell lymphoma; one had ataxia telangiectasia and one had common variable immunodeficienc...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Shabbat S,Aharoni J,Sarid L,Ben-Harush M,Kapelushnik J

    更新日期:2009-05-01 00:00:00

  • Metro-SMHOP 01: Metronomics combination with cyclophosphamide-etoposide and valproic acid for refractory and relapsing pediatric malignancies.

    abstract:BACKGROUND:In low- and middle-income countries, therapeutic options for advanced, refractory, or relapsing malignancies are limited due to local constraints such as cost of drugs, distance from oncology centers, and lack of availability of new anticancer drugs. Metronomics, which combines metronomic chemotherapy (MC) a...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: El Kababri M,Benmiloud S,Cherkaoui S,El Houdzi J,Maani K,Ansari N,Khoubila N,Kili A,El Khorassani M,Madani A,Tazi MA,Ahid S,Hessissen L,Quessar A,Harif M,Khattab M,André N

    更新日期:2020-09-01 00:00:00

  • Cancer surveillance and control in adolescents--similarities and contrasts between Canada and the United States.

    abstract::Opportunities for cancer prevention in adolescents range from limitation of sun exposure to the use of human papillomavirus vaccines. Those who develop malignant disease experience longer waiting times for diagnosis and treatment than do children, especially when referred to adult treatment centers, and they are less ...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,评审


    authors: Barr RD,Greenberg ML

    更新日期:2006-03-01 00:00:00

  • Bone marrow aspiration technique may have an impact on therapy stratification in children with acute lymphoblastic leukaemia.

    abstract:BACKGROUND:Morphological evaluation of early response to chemotherapy and measurement of minimal residual disease by flow cytometry or PCR are being used for evaluation of prognosis and treatment stratification in children with acute lymphoblastic leukaemia (ALL). PROCEDURE:In a series of 14 consecutive bone marrow in...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Helgestad J,Rosthøj S,Johansen P,Varming K,Østergaard E

    更新日期:2011-08-01 00:00:00

  • Concurrent radiation with irinotecan and carboplatin in intermediate- and high-risk rhabdomyosarcoma: a report on toxicity and efficacy from a prospective pilot phase II study.

    abstract:BACKGROUND:Irinotecan is highly active against rhabdomyosarcoma (RMS), yet its tolerability and efficacy in combination with radiation is unknown. We examined local control and toxicities in RMS patients treated with radiotherapy (RT) in combination with radiosensitizing agents irinotecan + carboplatin (I + C). PROCED...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Dharmarajan KV,Wexler LH,Wolden SL

    更新日期:2013-02-01 00:00:00

  • Absence of platelet recovery following Helicobacter pylori eradication in childhood chronic idiopathic thrombocytopenic purpura: a multi-center randomized controlled trial.

    abstract:OBJECTIVE:To investigate the effect of Helicobacter pylori eradication on platelet recovery in childhood chronic idiopathic thrombocytopenic purpura (ITP). PATIENTS AND METHODS:A multi-center randomized controlled trial was conducted. Patients aged 4-18 years, diagnosed with chronic ITP, defined by platelet count belo...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Treepongkaruna S,Sirachainan N,Kanjanapongkul S,Winaichatsak A,Sirithorn S,Sumritsopak R,Chuansumrit A

    更新日期:2009-07-01 00:00:00

  • If only I could turn back time-Regret in bereaved parents.

    abstract:INTRODUCTION:Regret about loss is one of the most intense types of regret experienced in life. Little is known about the bereavement regret of parents whose child has died of cancer. Although knowledge about parents' experiences after their child's death is vital for supporting these families, parents' regret is mostly...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Sim CW,Heuse S,Weigel D,Kendel F

    更新日期:2020-06-01 00:00:00

  • Screening for vitamin D insufficiency in pediatric cancer survivors.

    abstract:BACKGROUND:Corticosteroids increase risk for decreased bone mineral density, which can be worsened by vitamin D insufficiency (VDI) or deficiency (VDD). PROCEDURE:In the Vanderbilt cancer survivorship clinic, we obtained screening total 25-hydroxy vitamin D levels (VDL) in 171 cancer survivors <23 years old who were t...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Esbenshade AJ,Sopfe J,Zhao Z,Li Z,Campbell K,Simmons JH,Friedman DL

    更新日期:2014-04-01 00:00:00

  • A Prospective Cohort Quality Improvement Study to Reduce the Time to Antibiotics for New Fever in Neutropenic Pediatric Oncology Inpatients.

    abstract:BACKGROUND:Fever and neutropenia (F&N) is a pediatric oncology emergency due to the risk of disseminated infection. Quality improvement (QI) efforts to improve time to antibiotics for F&N in the emergency department have been documented, but the issue has not been studied in the established inpatient setting. PROCEDUR...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Green AL,Yi J,Bezler N,Pikman Y,Tubman VN,Obeng EA,O'Neil T,Mersereau R,Morrissey L,Billett AL

    更新日期:2016-01-01 00:00:00

  • Intravenous ferric carboxymaltose for iron deficiency anemia or iron deficiency without anemia after poor response to oral iron treatment: Benefits and risks in a cohort of 144 children and adolescents.

    abstract:OBJECTIVE:The objective of this single-center observational study was to determine the clinical and hematologic responses to intravenous ferric carboxymaltose (FCM) in a cohort of pediatric patients with poor response to oral iron therapy. The occurrence of adverse events was systematically recorded for up to 96 hours ...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Ozsahin H,Schaeppi M,Bernimoulin M,Allard M,Guidard C,van den Ouweland F

    更新日期:2020-10-01 00:00:00

  • Renal cell carcinoma harboring somatic TSC2 mutations in a child with methylmalonic acidemia.

    abstract::Pediatric renal cell carcinoma (RCC) is a rare cancer that can be associated with inherited diseases including tuberous sclerosis complex (TSC) caused by germline mutations in TSC1 or TSC2. Somatic mutations in TSC1 and TSC2 have also been reported in adult RCC, which predict response to mTOR inhibitors. Here, we pres...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Potter SL,Venkatramani R,Wenderfer S,Graham BH,Vasudevan SA,Sher A,Wu H,Wheeler DA,Yang Y,Eng CM,Gibbs RA,Roy A,Plon SE,Parsons DW

    更新日期:2017-05-01 00:00:00

  • Age dependency of primary tumor sites and metastases in patients with Ewing sarcoma.

    abstract:BACKGROUND:The median age of patients with Ewing sarcoma (EwS) at diagnosis is around 14-15 years. Older age is associated with a worse outcome. The correlation of age at diagnosis on sites of disease has not been fully described. OBJECTIVE:The goal of this study was to evaluate the differences in sites of primary tum...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Worch J,Ranft A,DuBois SG,Paulussen M,Juergens H,Dirksen U

    更新日期:2018-09-01 00:00:00

  • Improved outcome in childhood acute myeloid leukemia in Singapore with the MRC AML 10 protocol.

    abstract:BACKGROUND:The introduction of the United Kingdom Medical Research Council's 10th AML trial (MRC AML 10) protocol incorporating high-dose anthracycline therapy has improved outcome of children with acute myeloid leukemia (AML). In this study, we review the results of childhood AML therapy in a Singapore university hosp...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Tan RM,Quah TC,Aung L,Liang S,Kirk RC,Yeoh AE

    更新日期:2007-03-01 00:00:00

  • Brachiocephalic vein for percutaneous ultrasound-guided central line positioning in children: A 20-month preliminary experience with 109 procedures.

    abstract:BACKGROUND:Ultrasound-guided (USG) cannulation of the brachiocephalic vein (BCV) is gaining worldwide consensus for central venous access in children. This study reports a 20-month experience with this approach in children. METHODS:All patients who underwent percutaneous USG central venous catheter (CVC) positioning i...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Avanzini S,Mameli L,Disma N,Zanaboni C,Dato A,Montobbio G,Montagnini L,Bevilacqua M,Pierri F,Conte M,Amoroso L,Pala G,Pestarino S,Castagnola E,Molinari AC,Micalizzi C,Morreale G,Mattioli G,Pini Prato A

    更新日期:2017-02-01 00:00:00

  • Identifying relapses and stem cell transplants in pediatric acute lymphoblastic leukemia using administrative data: Capturing national outcomes irrespective of trial enrollment.

    abstract:INTRODUCTION:Our objectives were to design and validate methods to identify relapse and hematopoietic stem cell transplantation (HSCT) in children with acute lymphoblastic leukemia (ALL) using administrative data representing hospitalizations at US pediatric institutions. METHODS:We developed daily billing and ICD-9 c...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Cahen VC,Li Y,Getz KD,Elgarten CW,DiNofia AM,Wilkes JJ,Winestone LE,Huang YV,Miller TP,Gramatges MM,Rabin KR,Fisher BT,Aplenc R,Seif AE

    更新日期:2020-05-11 00:00:00

  • Outcome of childhood acute lymphoblastic leukemia with induction failure treated by the Japan Association of Childhood Leukemia study (JACLS) ALL F-protocol.

    abstract:BACKGROUND:Children with acute lymphoblastic leukemia (ALL) who fail to achieve complete remission (CR) after induction therapy (induction failure: IF) have a poor prognosis; however, there have been few prospective studies in patients with IF. PATIENTS AND METHODS:Between April 1997 and March 2005, 27 of 1,237 leukem...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Suzuki N,Yumura-Yagi K,Yoshida M,Hara J,Nishimura S,Kudoh T,Tawa A,Usami I,Tanizawa A,Hori H,Ito Y,Miyaji R,Oda M,Kato K,Hamamoto K,Osugi Y,Hashii Y,Nakahata T,Horibe K,Japan Association of Childhood Leukemia Study

    更新日期:2010-01-01 00:00:00

  • PedsQL™ Multidimensional Fatigue Scale in sickle cell disease: feasibility, reliability, and validity.

    abstract:BACKGROUND:Sickle cell disease (SCD) is an inherited blood disorder characterized by a chronic hemolytic anemia that can contribute to fatigue and global cognitive impairment in patients. The study objective was to report on the feasibility, reliability, and validity of the PedsQL™ Multidimensional Fatigue Scale in SCD...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,多中心研究


    authors: Panepinto JA,Torres S,Bendo CB,McCavit TL,Dinu B,Sherman-Bien S,Bemrich-Stolz C,Varni JW

    更新日期:2014-01-01 00:00:00

  • Paediatric and adolescent alveolar soft part sarcoma: A joint series from European cooperative groups.

    abstract:BACKGROUND:Alveolar soft part sarcomas (ASPS) are generally chemo- and radio-resistant mesenchymal tumours, with no standardized treatment guidelines. We describe the clinical behaviour of paediatric ASPS and compare these features to previously reported adult series. PATIENTS AND METHODS:The clinical data of 51 child...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Orbach D,Brennan B,Casanova M,Bergeron C,Mosseri V,Francotte N,Van Noesel M,Rey A,Bisogno G,Pierron G,Ferrari A

    更新日期:2013-11-01 00:00:00

  • Implementing the psychosocial standards in pediatric cancer: Current staffing and services available.

    abstract:BACKGROUND:Fifteen evidence-based Standards for Psychosocial Care for Children with Cancer and Their Families (Standards) were published in 2015. The Standards cover a broad range of topics and circumstances and require qualified multidisciplinary staff to be implemented. This paper presents data on the availability of...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Scialla MA,Canter KS,Chen FF,Kolb EA,Sandler E,Wiener L,Kazak AE

    更新日期:2017-11-01 00:00:00

  • Investigating the relationship between COMT polymorphisms and working memory performance among childhood brain tumor survivors.

    abstract:BACKGROUND:Survivors of childhood brain tumors are at increased risk for neurocognitive impairments, including deficits in abilities supported by frontal brain regions. Catechol-O-methyltransferase (COMT) metabolizes dopamine in the prefrontal cortex, with the Met allele resulting in greater dopamine availability and b...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Howarth RA,Adamson AM,Ashford JM,Merchant TE,Ogg RJ,Schulenberg SE,Ogg S,Li J,Wu S,Xiong X,Conklin HM

    更新日期:2014-01-01 00:00:00