Optimization of percutaneous biopsy for diagnosis and pretreatment risk assessment of neuroblastoma.


BACKGROUND:Image-guided percutaneous core needle biopsy (PCNB) is increasingly utilized to diagnose solid tumors. The objective of this study is to determine whether PCNB is adequate for modern biologic characterization of neuroblastoma. PROCEDURE:A multi-institutional retrospective study was performed by the Pediatric Surgical Oncology Research Collaborative on children with neuroblastoma at 12 institutions over a 3-year period. Data collected included demographics, clinical details, biopsy technique, complications, and adequacy of biopsies for cytogenetic markers utilized by the Children's Oncology Group for risk stratification. RESULTS:A total of 243 children were identified with a diagnosis of neuroblastoma: 79 (32.5%) tumor excision at diagnosis, 94 (38.7%) open incisional biopsy (IB), and 70 (28.8%) PCNB. Compared to IB, there was no significant difference in ability to accurately obtain a primary diagnosis by PCNB (95.7% vs 98.9%, P = .314) or determine MYCN copy number (92.4% vs 97.8%, P = .111). The yield for loss of heterozygosity and tumor ploidy was lower with PCNB versus IB (56.1% vs 90.9%, P < .05; and 58.0% vs. 88.5%, P < .05). Complications did not differ between groups (2.9 % vs 3.3%, P = 1.000), though the PCNB group had fewer blood transfusions and lower opioid usage. Efficacy of PCNB was improved for loss of heterozygosity when a pediatric pathologist evaluated the fresh specimen for adequacy. CONCLUSIONS:PCNB is a less invasive alternative to open biopsy for primary diagnosis and MYCN oncogene status in patients with neuroblastoma. Our data suggest that PCNB could be optimized for complete genetic analysis by standardized protocols and real-time pathology assessment of specimen quality.


Pediatr Blood Cancer


Pediatric blood & cancer


Overman RE,Kartal TT,Cunningham AJ,Fialkowski EA,Naik-Mathuria BJ,Vasudevan SA,Malek MM,Kalsi R,Le HD,Stafford LC,Lautz TB,Many BT,Jones RE,Bütter A,Davidson J,Williams A,Dasgupta R,Lewis J,Troutt M,Aldrink JH,Man




Has Abstract


2020-05-01 00:00:00












  • Aprepitant in adolescent patients for prevention of chemotherapy-induced nausea and vomiting: a randomized, double-blind, placebo-controlled study of efficacy and tolerability.

    abstract:BACKGROUND:The neurokinin-1 receptor antagonist aprepitant, plus a 5HT3 antagonist and corticosteroid is well-tolerated and effective in preventing chemotherapy-induced nausea and vomiting in adults but has not been formally assessed in adolescents. PROCEDURE:Patients age 11-19 years old receiving emetogenic chemother...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,随机对照试验


    authors: Gore L,Chawla S,Petrilli A,Hemenway M,Schissel D,Chua V,Carides AD,Taylor A,Devandry S,Valentine J,Evans JK,Oxenius B,Adolescent Aprepitant in Cancer Study Group.

    更新日期:2009-02-01 00:00:00

  • Intra-Arterial Platelet Infusion for Intractable Hemorrhage and Refractory Thrombocytopenia in Children With Gastrointestinal Graft-Versus-Host Disease.

    abstract::Acute gastrointestinal graft-versus-host disease (GVHD) refractory to first-line treatment with systemic corticosteroids results in increased morbidity and potential mortality. We retrospectively assessed the feasibility and efficacy of catheter-directed intra-arterial platelet infusion (IAPI) in two pediatric patient...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,评审


    authors: Kably IM,Ziga ED,Andreansky M

    更新日期:2015-12-01 00:00:00

  • Pilomyxoid astrocytoma treated successfully with vemurafenib.

    abstract::The BRAF V600E missense mutation is known to be present in a subset of central nervous system tumors. We report a patient with a BRAF V600E mutated pilomyxoid astrocytoma who failed multiple conventional chemotherapy regimens. Treatment with vemurafenib, a molecularly targeted therapy against the mutant BRAF V600E kin...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Skrypek M,Foreman N,Guillaume D,Moertel C

    更新日期:2014-11-01 00:00:00

  • Immunophenotype and cytogenetic characteristics in the relationship between birth weight and childhood leukemia.

    abstract:BACKGROUND:High birth weight increases the risk of childhood acute lymphoid leukemia (ALL) through unknown mechanisms. Whether this risk is specific to ALL subtypes is unknown, and low case numbers have prevented investigation of the rarer leukemias. Here we address these associations using a large population-based dat...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: O'Neill KA,Bunch KJ,Vincent TJ,Spector LG,Moorman AV,Murphy MF

    更新日期:2012-01-01 00:00:00

  • Histology, fusion status, and outcome in metastatic rhabdomyosarcoma: A report from the Children's Oncology Group.

    abstract:BACKGROUND:Distinguishing alveolar rhabdomyosarcoma (ARMS) from embryonal rhabdomyosarcoma (ERMS) has historically been of prognostic and therapeutic importance. However, classification has been complicated by shifting histologic criteria required for an ARMS diagnosis. Children's Oncology Group (COG) studies after IRS...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Rudzinski ER,Anderson JR,Chi YY,Gastier-Foster JM,Astbury C,Barr FG,Skapek SX,Hawkins DS,Weigel BJ,Pappo A,Meyer WH,Arnold MA,Teot LA,Parham DM

    更新日期:2017-12-01 00:00:00

  • Hyperbaric oxygen should not be used in the management of hemorrhagic cystitis in patients with Fanconi anemia.

    abstract::Hemorrhagic cystitis (HC) is a common complication after stem cell transplantation (SCT) that occurs more frequently in patients with Fanconi anemia (FA) because of hypersensitivity of their cells to the agents used in the preparation for SCT (chemo and radiation). Many HC cases respond to therapy with hyperhydration ...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Al-Seraihi A,Ayas M

    更新日期:2007-11-01 00:00:00

  • Treatment of infantile choriocarcinoma of the liver.

    abstract::Primary choriocarcinoma of the liver is an extremely rare childhood malignancy frequently associated with clinical instability at initial presentation. It often mimics other benign and malignant childhood liver tumors. Prompt diagnosis and initiation of treatment are necessary to attain a successful outcome. We descri...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Yoon JM,Burns RC,Malogolowkin MH,Mascarenhas L

    更新日期:2007-07-01 00:00:00

  • Presentation of acute promyelocytic leukemia as granulocytic sarcoma.

    abstract::Granulocytic sarcoma (GS) is a localized tumor composed of immature myeloid cells. This extramedullary tumor can present before, concurrent with or after the diagnosis of acute myeloid leukemia. GS is extremely uncommon in acute promyelocytic leukemia (APL). As a proportion of patients never develop systemic disease, ...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Worch J,Ritter J,Frühwald MC

    更新日期:2008-03-01 00:00:00

  • Prognostic impact of diagnostic and treatment delays in children with osteosarcoma.

    abstract:BACKGROUND:The aim of this study is to evaluate the relationship between the latency to diagnosis (LD) and the time to completion of chemotherapy (TCC) with clinical outcomes in children with osteosarcoma. METHODS:We performed a retrospective analysis of all patients who received treatment for osteosarcoma in two tert...

    journal_title:Pediatric blood & cancer

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Vasquez L,Silva J,Chavez S,Zapata A,Diaz R,Tarrillo F,Maza I,Sialer L,García J

    更新日期:2020-04-01 00:00:00

  • Influence of pediatric cancer-related financial burden on parent distress and other stress-related symptoms.

    abstract:BACKGROUND:Pediatric cancer-induced financial burden is source of stress for parents, particularly mothers, single parents, and parents with lower incomes. This financial burden has been linked to poorer family quality of life (QOL) in terms of new onset material hardships, and could also affect individual QOL in terms...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Santacroce SJ,Kneipp SM

    更新日期:2020-03-01 00:00:00

  • Chickenpox in varicella IgG positive patients: experience of a regional paediatric oncology centre.

    abstract::Aciclovir prophylaxis was previously given to all immunocompromised patients treated by our unit, following contact with varicella zoster. In 2003, we changed practice according to National Guidelines, giving prophylaxis only to patients without serum varicella zoster immunoglobulin G antibody (VZ IgG) at diagnosis of...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Manley S,Mallinson H,Caswell M,Keenan R,Pizer B

    更新日期:2008-10-01 00:00:00

  • Successful treatment of refractory donor lymphocyte infusion-induced immune-mediated pancytopenia with rituximab.

    abstract::A 6-year-old male with chronic granulomatous disease, who was transplanted with bone marrow and exhibited increasing mixed chimerism, subsequently received two donor lymphocyte infusions (DLI). Two weeks after the second DLI, the patient developed acute graft-versus-host disease (GVHD) and progressive pancytopenia tha...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Kato I,Umeda K,Awaya T,Yui Y,Niwa A,Fujino H,Matsubara H,Watanabe K,Heike T,Adachi N,Endo F,Mizukami T,Nunoi H,Nakahata T,Adachi S

    更新日期:2010-02-01 00:00:00

  • Successful treatment of severe myasthenia gravis developed after allogeneic hematopoietic stem cell transplantation with plasma exchange and rituximab.

    abstract::Myasthenia gravis is among the rare complications after allogeneic hematopoietic stem cell transplantation and is usually associated with chronic GVHD. Herein, we report a 2-year and 10 months of age female with Griscelli syndrome, who developed severe myasthenia gravis at post-transplant +22nd month and required resp...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Unal S,Sag E,Kuskonmaz B,Kesici S,Bayrakci B,Ayvaz DC,Tezcan I,Yalnızoglu D,Uckan D

    更新日期:2014-05-01 00:00:00

  • Fludarabine-based reduced toxicity yet myeloablative conditioning is effective and safe particularly in patients with high-risk thalassemia undergoing allogeneic transplantation.

    abstract:INTRODUCTION:Thalassemia major (TM) is an inherited disorder caused by ineffective erythropoiesis. At the present time, allogeneic stem cell transplantation (allo-SCT) is a curative option. Conventional busulfan and cyclophosphamide based myeloablative conditioning regimens are limited by increased toxicity, especially...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Sheth V,Grisariu S,Avni B,Stepensky P,Ashkenazi M,Shapira MY,Or R

    更新日期:2018-11-01 00:00:00

  • Identifying patient- and family-centered outcomes relevant to inpatient versus at-home management of neutropenia in children with acute myeloid leukemia.

    abstract::Efficacy of therapeutic strategies relative to patient- and family-centered outcomes in pediatric oncology must be assessed. We sought to identify outcomes important to children with acute myeloid leukemia and their families related to inpatient versus at-home management of neutropenia. We conducted qualitative interv...

    journal_title:Pediatric blood & cancer

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Szymczak JE,Getz KD,Madding R,Fisher B,Raetz E,Hijiya N,Gramatges MM,Henry M,Mian A,Arnold SD,Aftandilian C,Collier AB,Aplenc R

    更新日期:2018-04-01 00:00:00

  • Predictors of treatment abandonment for patients with pediatric cancer at Indus Children Cancer Hospital, Karachi, Pakistan.

    abstract:BACKGROUND:Abandonment of treatment is one of the toughest challenges to deal with in pediatric oncology. It leads to unnecessary mortality and morbidity in patients from low- and middle-income countries. PROCEDURE:The objective of our retrospective study was to determine the prevalence and predictors for abandonment ...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Siddiqui DE,Ashraf MS,Iftikhar S,Belgaumi AF

    更新日期:2018-02-01 00:00:00

  • Sirolimus therapy in the treatment of pseudomyogenic hemangioendothelioma.

    abstract::Pseudomyogenic hemangioendothelioma (PMH) is a rare, mostly indolent vascular tumor. Extensive cases are treated with amputation as chemotherapy seems to be ineffective. Recently, promising results were published using mammalian target of rapamycin (mTOR) inhibitors in tumors of vascular origin. Here, we present a cas...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Gabor KM,Sapi Z,Tiszlavicz LG,Fige A,Bereczki C,Bartyik K

    更新日期:2018-02-01 00:00:00

  • Successful treatment of refractory immune hemolysis following unrelated cord blood transplant with Campath-1H.

    abstract::Immune-mediated hemolytic anemia is a well-recognized complication of hematopoietic stem cell transplantation. We report on a 6-year-old boy with X-linked adrenoleukodystrophy who developed severe delayed alloimmune hemolytic anemia associated with immune-mediated neutropenia and thrombocytopenia following major ABO i...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Chao MM,Levine JE,Ferrara JL,Cooling L,Cooke KR,Hutchinson RJ,Yanik GA

    更新日期:2008-04-01 00:00:00

  • Safety, efficacy, and pharmacokinetics of intravenous busulfan in children undergoing allogeneic hematopoietic stem cell transplantation.

    abstract:PURPOSE:To determine the safety, efficacy, and PK profile of intravenous busulfan (Bu) in the context of a Bu and cyclophosphamide (IVBuCy) preparative regimen in children undergoing allogeneic hematopoietic stem cell transplantation (HSCT). METHODS:Twenty-four children were enrolled in an open-label, multicenter tria...

    journal_title:Pediatric blood & cancer

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Wall DA,Chan KW,Nieder ML,Hayashi RJ,Yeager AM,Kadota R,Przepiorka D,Mezzi K,Kletzel M,Pediatric Blood, Marrow Transplant Consortium.

    更新日期:2010-02-01 00:00:00

  • Long-term follow-up of the thyroid gland after treatment with 131I-Metaiodobenzylguanidine in children with neuroblastoma: importance of continuous surveillance.

    abstract:BACKGROUND:Thyroid dysfunction has been reported in up to 52% of patients 1.4 years after treatment with (131) I-Metaiodobenzylguanidine (MIBG) in children with neuroblastoma (NBL), despite the use of potassium-iodide (KI). Our aim was to investigate if the incidence and severity of thyroid damage increases in time. M...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Clement SC,van Eck-Smit BL,van Trotsenburg AS,Kremer LC,Tytgat GA,van Santen HM

    更新日期:2013-11-01 00:00:00

  • Female reproductive function after treatment of childhood acute lymphoblastic leukemia.

    abstract:BACKGROUND:The aim was to evaluate self-reported reproductive characteristics and markers of ovarian function in a nationwide cohort of female survivors of childhood acute lymphoblastic leukemia (ALL), because prior investigations have produced conflicting data. PROCEDURE:Self-reported reproductive characteristics wer...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Roshandel R,van Dijk M,Overbeek A,Kaspers G,Lambalk C,Beerendonk C,Bresters D,van der Heiden-van der Loo M,van den Heuvel-Eibrink M,Kremer L,Loonen J,van der Pal H,Ronckers C,Tissing W,Versluys B,van Leeuwen F,van den Ber

    更新日期:2021-01-18 00:00:00

  • Efficacy and toxicity of plerixafor for peripheral blood stem cell mobilization in children with high-risk neuroblastoma.

    abstract::Six patients with high-risk neuroblastoma underwent the second stem cell collection round with G-CSF (5 μg/kg/day) + plerixafor (0.24 mg/kg/day) because the amount of CD34(+) cells collected during the first collection round with G-CSF alone was insufficient. The number of CD34(+) cells collected in the second collect...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Son MH,Kang ES,Kim DH,Lee SH,Yoo KH,Sung KW,Koo HH,Kim DW,Kim JY,Cho EJ

    更新日期:2013-08-01 00:00:00

  • Reproductive intentions in mothers of young children with sickle cell disease.

    abstract:BACKGROUND:Sickle cell disease (SCD) is an autosomal recessive hemoglobinopathy associated with morbidity and mortality. We sought to understand family planning intentions of parents of young children with SCD including the awareness of three reproductive options (adoption, in vitro fertilization with egg/sperm donatio...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Schultz CL,Tchume-Johnson T,Jackson T,Enninful-Eghan H,Schapira MM,Smith-Whitley K

    更新日期:2020-05-01 00:00:00

  • Comparison of allergic reactions to pegasparaginase given intravenously versus intramuscularly.

    abstract:BACKGROUND:Pegasparaginase (PEG) is important for treatment of Acute Lymphoblastic Leukemia (ALL). Despite conjugation to polyethylene glycol to reduce immunogenicity, allergic reactions still occur and may be severe. Traditionally, PEG is given via intramuscular (IM) injection but recent protocols have shown it can be...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Pidaparti M,Bostrom B

    更新日期:2012-09-01 00:00:00

  • Area deprivation is associated with poorer overall survival in children with acute lymphoblastic leukemia.

    abstract:BACKGROUND:Few studies have evaluated social determinants of outcomes disparities for children with acute lymphoblastic leukemia (ALL). We investigated the association of area deprivation index (ADI), a measure of neighborhood socioeconomic disadvantage, with overall survival (OS) among children and adolescents with AL...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Schraw JM,Peckham-Gregory EC,Rabin KR,Scheurer ME,Lupo PJ,Oluyomi A

    更新日期:2020-09-01 00:00:00

  • Expression profiling reveals MSX1 and EphB2 expression correlates with the invasion capacity of Wilms tumors.

    abstract:BACKGROUND:Wilms tumor is the most common pediatric renal malignancy, but the parameters that are important to its invasion capacity are poorly understood. The aim of this study was to identify new proteins associated with the invasion capacity of Wilms tumor. PROCEDURE:Gene expression profiles for 15 primary Wilms tu...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Chetcuti A,Aktas S,Mackie N,Ulger C,Toruner G,Alkan M,Catchpoole D

    更新日期:2011-12-01 00:00:00

  • Measuring the efficacy of a project for adolescents and young adults with cancer: A study from the Milan Youth Project.

    abstract:BACKGROUND:Various projects dedicated specifically to adolescents and young adults (AYA) with cancer have been developed in recent years. A critical aspect of such programs is the ability to demonstrate its value, and therefore how to measure desired outcomes. METHODS:A list of metrics to consider for demonstrating th...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Ferrari A,Silva M,Veneroni L,Magni C,Clerici CA,Meazza C,Terenziani M,Spreafico F,Chiaravalli S,Casanova M,Luksch R,Catania S,Schiavello E,Biassoni V,Podda M,Bergamaschi L,Puma N,Indini A,Proserpio T,Massimino M

    更新日期:2016-12-01 00:00:00

  • Minimal Residual Disease and Childhood Leukemia: Standard of Care Recommendations From the Pediatric Oncology Group of Ontario MRD Working Group.

    abstract::Minimal residual disease (MRD) is an independent predictor of relapse risk in children with leukemia and is widely used for risk-adapted treatment. This article summarizes current evidence supporting the use of MRD, including clinical significance, current international clinical practice, impact statement, and recomme...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,实务指引,评审


    authors: Athale UH,Gibson PJ,Bradley NM,Malkin DM,Hitzler J,POGO MRD Working Group.

    更新日期:2016-06-01 00:00:00

  • A man-made disease: Fetal neonatal alloimmune thrombocytopenia due to incompatibility between oocyte donor and gestational mother.

    abstract::The incompatibility causing fetal and neonatal alloimmune thrombocytopenia (FNAIT) results from a fetus inheriting a paternal human platelet antigen (HPA), which is different from the maternal HPA. We present a unique case of FNAIT in a pregnancy involving an oocyte recipient mother with Turner syndrome. This is the f...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Barg AA,Ifrah AD,Strauss T,Simchen MJ,Orvieto R,Rosenberg N,Kenet G

    更新日期:2017-08-01 00:00:00

  • Palliative radiotherapy for pediatric patients: Parental perceptions of indication, intent, and outcomes.

    abstract:OBJECTIVES:Palliative radiation therapy (pRT) is often used to improve quality of life for pediatric patients. Though palliative doses are generally lower than those for cure, pRT may still introduce undesirable effects. The decision to pursue additional therapy for a child may be challenging and depends on parents' kn...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Lee BK,Boyle PJ,Zaslowe-Dude C,Wolfe J,Marcus KJ

    更新日期:2020-01-01 00:00:00