Simultaneous acute splenic sequestration and transient aplastic crisis in children with sickle cell disease.

Abstract:

:Acute splenic sequestration crisis (ASSC) is a hematological emergency in young children with sickle cell disease (SCD), characterized by worsening anemia and splenomegaly, usually with reticulocytosis and thrombocytopenia. Transient aplastic crisis (TAC) due to parvovirus B19 infection occurs in older children with SCD, and typically manifests as worsening anemia with reticulocytopenia and no splenomegaly. Five older children with SCD (4 HbSC, 1 HbSS on hydroxyurea) developed ASSC concurrent with TAC and had a severe clinical course. Our cases suggest that older children with SCD and acute parvovirus infection should be monitored closely for splenomegaly and multi-system dysfunction.

journal_name

Pediatr Blood Cancer

journal_title

Pediatric blood & cancer

authors

Yates AM,Hankins JS,Mortier NA,Aygun B,Ware RE

doi

10.1002/pbc.22035

subject

Has Abstract

pub_date

2009-09-01 00:00:00

pages

479-81

issue

3

eissn

1545-5009

issn

1545-5017

journal_volume

53

pub_type

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