Abstract:
:We report the case of a drug interaction between methotrexate (MTX) and chloral hydrate (CH) observed in a child treated for acute leukemia. Significantly slower MTX clearance and increased MTX exposure occurred on the first three courses of a high-dose chemotherapy when co-administered with CH despite normal renal function, adequate hydration, and alkalinization. Mean MTX area under the curve associated with CH administration was 1,134 µmol hours/L, compared to 608 µmol hours/L after discontinuation of CH. This interaction possibly resulted from a competition between anionic CH metabolites and MTX for renal tubular excretion.
journal_name
Pediatr Blood Cancerjournal_title
Pediatric blood & cancerauthors
Dao K,Ivanyuk A,Buclin T,Beck-Popovic M,Diezi Mdoi
10.1002/pbc.24393subject
Has Abstractpub_date
2013-03-01 00:00:00pages
518-20issue
3eissn
1545-5009issn
1545-5017journal_volume
60pub_type
杂志文章abstract::The commonly accepted definition of Fanconi anemia (FA) relying on DNA repair deficiency is submitted to a critical review starting from the early reports pointing to mitomycin C bioactivation and to the toxicity mechanisms of diepoxybutane and a group of nitrogen mustards causing DNA crosslinks in FA cells. A critica...
journal_title:Pediatric blood & cancer
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更新日期:2007-03-01 00:00:00
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journal_title:Pediatric blood & cancer
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