Metabolic syndrome in pediatric cancer survivors: a mechanistic review.

abstract：:Ependymoblastoma (EBL) is a rare malignant CNS tumor of early childhood, listed as a subgroup of primitive neuroectodermal tumors (PNET) in the 2007 WHO Classification of Tumours of the Central Nervous System. Histologically, EBL can be defined by multilayered, mitotically active "ependymoblastic" rosettes with centra...

journal_title：Pediatric blood & cancer

authors： Nowak J,Seidel C,Pietsch T,Friedrich C,von Hoff K,Rutkowski S,Warmuth-Metz M

更新日期：2014-06-01 00:00:00

abstract：:Children suffering from Acute Lymphoblastic Leukaemia (ALL) treated with asparaginase and corticosteroids are at risk of developing severe lipid abnormalities. The authors report the case of a 10-year-old male with extremely high plasma triglyceride concentrations (4,000 mg/dl) during the induction phase of ALL associ...

journal_title：Pediatric blood & cancer

authors： Ridola V,Buonuomo PS,Maurizi P,Putzulu R,Annunziata ML,Pietrini D,Riccardi R

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:Juvenile xanthogranuloma (JXG) is the most common non-Langerhans cell histiocytosis in children. The mortality and morbidity of JXG with extracutaneous lesions remain unclear. METHODS:Data of patients aged < 18 years who were diagnosed with JXG between 2001 and 2010 were retrospectively collected through a ...

journal_title：Pediatric blood & cancer

authors： Maeda M,Morimoto A,Shioda Y,Asano T,Koga Y,Nakazawa Y,Kanegane H,Kudo K,Ohga S,Ishii E,Histiocytosis Study Group of the Japanese Society of Pediatric Hematology\/Oncology.

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Sickle cell disease (SCD) is an inherited blood disorder characterized by a chronic hemolytic anemia that can contribute to fatigue and global cognitive impairment in patients. The study objective was to report on the feasibility, reliability, and validity of the PedsQL™ Multidimensional Fatigue Scale in SCD...

journal_title：Pediatric blood & cancer

authors： Panepinto JA,Torres S,Bendo CB,McCavit TL,Dinu B,Sherman-Bien S,Bemrich-Stolz C,Varni JW

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:The prevalence of nausea and vomiting after receipt of intrathecal methotrexate (IT-MTX) in pediatric oncology patients is unknown. METHODS:Patients (4-18 years) about to receive IT-MTX were eligible to participate in this prospective, observational study. Patients received antiemetics as prescribed by thei...

journal_title：Pediatric blood & cancer

authors： Flank J,Nadeem K,Moledina S,Khanna M,Schindera C,Punnett A,Dupuis LL

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:We sought to better define the role of hematopoietic cell transplantation (HCT) in first remission (CR1) for high-risk pediatric acute myeloid leukemia (AML). PROCEDURES:Outcomes were compared among patients aged less than 21 years with cytogenetically defined poor-risk AML treated with chemotherapy, matche...

journal_title：Pediatric blood & cancer

authors： Kelly MJ,Horan JT,Alonzo TA,Eapen M,Gerbing RB,He W,Lange BJ,Parsons SK,Woods WG

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:The objectives of this study were to determine the maximum tolerated dose (MTD), dose-limiting toxicities (DLTs), pharmacokinetics, and anti-tumor effect of irinotecan in pediatric patients with recurrent or refractory malignancies. PROCEDURE:Twenty-three patients between 1 and 21 years of age, with a solid...

journal_title：Pediatric blood & cancer

authors： Bomgaars L,Kerr J,Berg S,Kuttesch J,Klenke R,Blaney SM

更新日期：2006-01-01 00:00:00

abstract：:The BRAF V600E missense mutation is known to be present in a subset of central nervous system tumors. We report a patient with a BRAF V600E mutated pilomyxoid astrocytoma who failed multiple conventional chemotherapy regimens. Treatment with vemurafenib, a molecularly targeted therapy against the mutant BRAF V600E kin...

journal_title：Pediatric blood & cancer

authors： Skrypek M,Foreman N,Guillaume D,Moertel C

更新日期：2014-11-01 00:00:00

abstract：:We describe here the outcomes of reduced-toxicity alternate-donor stem cell transplant (SCT) with posttransplant cyclophosphamide (PTCy) for primary immunodeficiency disorders (PIDs) in eight children (haploidentical-seven and matched unrelated donor-one). The conditioning was with serotherapy (alemtuzumab-3/rabbit-an...

journal_title：Pediatric blood & cancer

authors： Rastogi N,Katewa S,Thakkar D,Kohli S,Nivargi S,Yadav SP

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Medulloblastoma is an infratentorial primitive neuroectodermal tumour, diagnosed in paediatric population. The radiotherapy is an essential method of treatment for these tumours. The impact of technical quality of radiation therapy on survival was recently considered. In this study treatment-related variable...

journal_title：Pediatric blood & cancer

authors： Chojnacka M,Skowrońska-Gardas A

更新日期：2004-02-01 00:00:00

abstract：:Childhood, adolescent, and young adult (CAYA) cancer survivors may be at risk for a severe course of COVID-19. Little is known about the clinical course of COVID-19 in CAYA cancer survivors, or if additional preventive measures are warranted. We established a working group within the International Late Effects of Chil...

journal_title：Pediatric blood & cancer

authors： Verbruggen LC,Wang Y,Armenian SH,Ehrhardt MJ,van der Pal HJH,van Dalen EC,van As JW,Bardi E,Baust K,Berger C,Castagnola E,Devine KA,Gebauer J,Marchak JG,Glaser AW,Groll AH,Haeusler GM,den Hartogh J,Haupt R,Hjorth L

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:There is little information about factors modulating bone mineral density (BMD) in survivors of childhood acute lymphoblastic leukemia (ALL). PROCEDURE:We analyzed data from 57 survivors (26 male, 52 Caucasian) who underwent two serial quantitative computed tomography (QCT) studies of BMD. Using multiple li...

journal_title：Pediatric blood & cancer

authors： Kaste SC,Rai SN,Fleming K,McCammon EA,Tylavsky FA,Danish RK,Rose SR,Sitter CD,Pui CH,Hudson MM

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Over the past decade, PET-CT has been used to assess rhabdomyosarcoma (RMS) in children. However, the role of PET-CT in staging RMS is unknown. PROCEDURE:Thirty subjects with RMS, median age 7.3 years, underwent PET-CT before therapy. PET-CTs and conventional imaging (CI) were independently reviewed by two ...

journal_title：Pediatric blood & cancer

authors： Federico SM,Spunt SL,Krasin MJ,Billup CA,Wu J,Shulkin B,Mandell G,McCarville MB

更新日期：2013-07-01 00:00:00

abstract：:Phytosterolemia is a rare autosomal recessive sterol storage disease caused by mutations in ABCG5 and ABCG8 genes. A 9-year-old Turkish boy who was presented with exclusively hematologic abnormalities had elevated plant sterol levels. Sequencing of ABCG5 and ABCG8 genes revealed a novel homozygous IVS10-1 G>T mutation...

journal_title：Pediatric blood & cancer

authors： Kaya Z,Niu DM,Yorulmaz A,Tekin A,Gürsel T

更新日期：2014-08-01 00:00:00

abstract：OBJECTIVES:Palliative radiation therapy (pRT) is often used to improve quality of life for pediatric patients. Though palliative doses are generally lower than those for cure, pRT may still introduce undesirable effects. The decision to pursue additional therapy for a child may be challenging and depends on parents' kn...

journal_title：Pediatric blood & cancer

authors： Lee BK,Boyle PJ,Zaslowe-Dude C,Wolfe J,Marcus KJ

更新日期：2020-01-01 00:00:00

abstract：:A 17-year-old girl with B-cell precursor acute lymphoblastic leukemia (BCP-ALL) with persistent minimal residual disease (MRD) who underwent standard chemotherapy was found to have a BCR-ABL1-like gene expression pattern. Genome sequencing revealed a JAK2 mutation not previously described in BCP-ALL and a potential th...

journal_title：Pediatric blood & cancer

authors： Mayfield JR,Czuchlewski DR,Gale JM,Matlawska-Wasowska K,Vasef MA,Nickl C,Pickett G,Ness SA,Winter SS

更新日期：2017-05-01 00:00:00

abstract：INTRODUCTION:Thalassemia major (TM) is an inherited disorder caused by ineffective erythropoiesis. At the present time, allogeneic stem cell transplantation (allo-SCT) is a curative option. Conventional busulfan and cyclophosphamide based myeloablative conditioning regimens are limited by increased toxicity, especially...

journal_title：Pediatric blood & cancer

authors： Sheth V,Grisariu S,Avni B,Stepensky P,Ashkenazi M,Shapira MY,Or R

更新日期：2018-11-01 00:00:00

abstract：:Wilms tumor (WT) is the most common primary renal tumor in childhood. The occurrence of WT in patients with growth retardation, mental retardation and central nervous system abnormalities in association with premature chromatid separation (PCS) and mosaic variegated aneuploidy has been previously described in only 10 ...

journal_title：Pediatric blood & cancer

authors： Sari N,Akyuz C,Aktas D,Gumruk F,Orhan D,Alikasifoglu M,Aydin B,Alanay Y,Buyukpamukcu M

更新日期：2009-08-01 00:00:00

abstract：:Diffuse intrinsic pontine glioma (DIPG) is characterized by a short history of brainstem symptoms and well-known magnetic resonance imaging features with a fatal outcome. However, we report three unusual cases of brainstem tumors with an initial indolent and protracted course, which subsequently developed the classica...

journal_title：Pediatric blood & cancer

authors： Baroni LV,Solano-Paez P,Nobre L,Michaeli O,Hawkins C,Laughlin S,Bartels U,Ramaswamy V,Bouffet E

更新日期：2020-03-01 00:00:00

abstract：:Here, we present the case of a pediatric patient with newly diagnosed hepatocellular carcinoma causing central biliary obstruction and persistently elevated bilirubin of 3.0-4.3 mg/dl despite placement of bilateral internal-external biliary drains. The tumor was not resectable, and the patient was not a candidate for ...

journal_title：Pediatric blood & cancer

authors： Hiniker SM,Rangaswami A,Lungren MP,Thakor AS,Concepcion W,Balazy KE,Kovalchuk N,Donaldson SS

更新日期：2017-06-01 00:00:00

abstract：:Congenital hypotransferrinemia (OMIM 209300) is an extremely rare disorder of inherited iron metabolism. Since its description in 1961, only 16 cases have been reported. The defective gene and molecular defect causing this disorder and clinicolaboratory findings seen in the homozygous and heterozygous states have been...

journal_title：Pediatric blood & cancer

authors： Aslan D

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:A desperate need for novel therapies in pediatric ependymoma (EPN) exists, as chemotherapy remains ineffective and radiotherapy often fails. EPN have significant infiltration of immune cells, which correlates with outcome. Immune checkpoint inhibitors provide an avenue for new treatments. This study characte...

journal_title：Pediatric blood & cancer

authors： Witt DA,Donson AM,Amani V,Moreira DC,Sanford B,Hoffman LM,Handler MH,Levy JMM,Jones KL,Nellan A,Foreman NK,Griesinger AM

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:Although weight loss and lack of linear growth occur in children with cancer, growth history is not included in research that aims to determine nutritional status in children newly diagnosed with cancer. Therefore, this study aimed to determine weight loss and lack of linear growth in this patient group. PR...

journal_title：Pediatric blood & cancer

authors： Brinksma A,Roodbol PF,Sulkers E,Hooimeijer HL,Sauer PJ,van Sonderen E,de Bont ES,Tissing WJ

更新日期：2015-02-01 00:00:00

abstract：:Bridging the survival gap for children with cancer, between those (the great majority) in low and middle income countries (LMIC) and their economically advantaged counterparts, is a challenge that has been addressed by twinning institutions in high income countries with centers in LMIC. The long-established partnershi...

journal_title：Pediatric blood & cancer

authors： Barr RD,Antillón Klussmann F,Baez F,Bonilla M,Moreno B,Navarrete M,Nieves R,Peña A,Conter V,De Alarcón P,Howard SC,Ribeiro RC,Rodriguez-Galindo C,Valsecchi MG,Biondi A,Velez G,Tognoni G,Cavalli F,Masera G

更新日期：2014-02-01 00:00:00

abstract：:Non-Hodgkin lymphoma (NHL) is a heterogeneous group of lymphoid malignancies with high incidence in adolescents and young adults (AYAs). The most common diseases include diffuse large B-cell lymphoma, anaplastic large cell lymphoma, Burkitt lymphoma, lymphoblastic lymphoma, and primary mediastinal large B-cell lymphom...

journal_title：Pediatric blood & cancer

authors： Hochberg J,Flower A,Brugieres L,Cairo MS

更新日期：2018-08-01 00:00:00

abstract：:Wiskott-Aldrich syndrome (WAS) is characterized by primary immunodeficiency, thrombocytopenia and eczema. Patients with WAS have an increased risk to develop tumors. Non-Hodgkin lymphoma (NHL) represents the most common malignancy occurring in WAS-affected patients, diffuse-large-B-cell lymphoma is the most frequently...

journal_title：Pediatric blood & cancer

authors： Coccia P,Mastrangelo S,Ruggiero A,Scalzone M,Rosolen A,Maurizi P,Riccardi R

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:Ultrasound-guided (USG) cannulation of the brachiocephalic vein (BCV) is gaining worldwide consensus for central venous access in children. This study reports a 20-month experience with this approach in children. METHODS:All patients who underwent percutaneous USG central venous catheter (CVC) positioning i...

journal_title：Pediatric blood & cancer

authors： Avanzini S,Mameli L,Disma N,Zanaboni C,Dato A,Montobbio G,Montagnini L,Bevilacqua M,Pierri F,Conte M,Amoroso L,Pala G,Pestarino S,Castagnola E,Molinari AC,Micalizzi C,Morreale G,Mattioli G,Pini Prato A

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:MYCN amplification marks poor prognosis in neuroblastoma (NB) tumors. In evaluating the mechanisms by which retinoic acid (RA) or nerve growth factor (NGF) decrease cell number in MYCN amplified NB cells, we have identified a number of proteins whose expression either decreases (E2F, CDC2, CDK6, cyclin depen...

journal_title：Pediatric blood & cancer

authors： Woo CW,Tan F,Cassano H,Lee J,Lee KC,Thiele CJ

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:Iron overload is well documented in patients with β-thalassemia major, and patients who have undergone hematopoietic stem cell transplantation (HSCT) remain at risk as a result of pre- and immediate post-HSCT transfusions. PROCEDURE:This is a prospective, randomized, 1-year clinical trial that compares the ...

journal_title：Pediatric blood & cancer

authors： Inati A,Kahale M,Sbeiti N,Cappellini MD,Taher AT,Koussa S,Nasr TA,Musallam KM,Abbas HA,Porter JB

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Patients with cancer who receive intensive chemotherapeutic regimens are subject to profound immunosuppression and are susceptible to an extended array of pathogens. PROCEDURE:The infectious causes of symptomatic gastroenteritis as evidenced by diarrhea +/- fever, vomiting, and abdominal colic in children f...

journal_title：Pediatric blood & cancer

authors： El-Mahallawy HA,El-Din NH,Salah F,El-Arousy M,El-Naga SA

更新日期：2004-04-01 00:00:00