Use of RNA interference to elucidate the effect of MYCN on cell cycle in neuroblastoma.

abstract：:We report two survivors of Wilms tumor (WT) who developed inflammatory myofibroblastic tumor (IMT). The first patient had IMT in the mainstem bronchus 1 year after WT therapy that included vincristine, dactinomycin, doxorubicin (VDA) and whole lung radiation therapy (XRT). The second patient had IMT in the cecum 7 yea...

journal_title：Pediatric blood & cancer

authors： Ortiz MV,Rossi CT,Hill DA,Guzzetta PC,Qureshi F,Dome JS

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:We sought to determine the risk of bacteremia in a cohort of outpatient febrile nonneutropenic pediatric oncology patients and to assess clinical characteristics that may influence decisions regarding empiric antibiotic therapy. PROCEDURE:A single institution retrospective cohort study was performed of outp...

journal_title：Pediatric blood & cancer

authors： Kelly MJ,Vivier PM,Panken TM,Schwartz CL

更新日期：2010-01-01 00:00:00

abstract：:The majority of children with cancer live in low- and middle-income countries (LMICs) with little or no access to cancer treatment. The purpose of the paper is to describe the current status of childhood cancer treatment in Africa, as documented in publications, dedicated websites and information collected through sur...

journal_title：Pediatric blood & cancer

authors： Kruger M,Hendricks M,Davidson A,Stefan CD,van Eyssen AL,Uys R,van Zyl A,Hesseling P

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Neuroblastoma is the most common extracranial pediatric solid cancer. Lung metastasis is rarely detected in children with newly diagnosed neuroblastoma. We aimed to describe the incidence, clinical characteristics, and outcome of patients with lung metastasis at initial diagnosis using a large international ...

journal_title：Pediatric blood & cancer

authors： Dubois SG,London WB,Zhang Y,Matthay KK,Monclair T,Ambros PF,Cohn SL,Pearson A,Diller L

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND:Pain is the most common complication of sickle cell disease requiring emergency department (ED) visits and hospitalization. A Clinical Practice Guideline (CPG) to manage acute sickle cell pain offers clinicians a standardized approach for the provision of evidence-based, cost-effective care. After CPG implem...

journal_title：Pediatric blood & cancer

authors： Morrissey LK,Shea JO,Kalish LA,Weiner DL,Branowicki P,Heeney MM

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND:The role of local analgesics for lumbar punctures (LPs) in pediatric oncology patients has not been specifically studied. AIM:To compare the efficacy of eutectic mixture of local anesthetics (EMLA) cream to 1% lidocaine injection for LPs. METHOD:This was a retrospective observational study of all patients ...

journal_title：Pediatric blood & cancer

authors： Cruickshank A,Qeadan F,Kuttesch JF,Agarwal HS

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Pulmonary hypertension (PHTN) is a potentially life-threatening complication, detected by echocardiographic evidence of elevated tricuspid regurgitant velocity (TRV). This condition has been described in adults with sickle cell disease (SCD) and other hemolytic disorders; however, there is little information...

journal_title：Pediatric blood & cancer

authors： Ambrusko SJ,Gunawardena S,Sakara A,Windsor B,Lanford L,Michelson P,Krishnamurti L

更新日期：2006-12-01 00:00:00

abstract：AIM:Osteopontin (OPN) has been investigated as a biomarker for cancer and nonmalignant diseases during the last decades. Data about OPN as a potential biomarker in childhood diseases are still sparse, and reference values are not available in children. We aimed to establish reference values for children from birth to y...

journal_title：Pediatric blood & cancer

authors： Nourkami-Tutdibi N,Graf N,Beier R,Zemlin M,Tutdibi E

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:A total of 201 pediatric cases of acute lymphoblastic leukemia were treated with the ALL-96 protocol by the Kyushu-Yamaguchi Children's Cancer Study Group. PROCEDURE:Risk stratification was based on white cell counts, immunophenotype, the presence of central nervous system disease at diagnosis, organomegaly...

journal_title：Pediatric blood & cancer

authors： Nagatoshi Y,Matsuzaki A,Suminoe A,Inada H,Ueda K,Kawakami K,Yanai F,Nakayama H,Moritake H,Itonaga N,Hotta N,Fujita K,Hidaka Y,Yamanaka T,Kawano Y,Okamura J

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:The objective of this report was to estimate long-term outcome and prognostic factors in children and adolescents with osteosarcoma. A large group of osteosarcoma patients were analyzed at our national oncology center. PROCEDURE:To evaluate the efficacy of surgery and multiagent chemotherapy for treating os...

journal_title：Pediatric blood & cancer

authors： Hegyi M,Semsei AF,Jakab Z,Antal I,Kiss J,Szendroi M,Csoka M,Kovacs G

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:The histological response to neoadjuvant chemotherapy (NAC) in pediatric patients with Ewing sarcoma family of tumors (ESFT) can predict the disease-free survival. Therefore, a noninvasive method for response assessment is needed. Using the currently established imaging modalities, mass reduction does not al...

journal_title：Pediatric blood & cancer

authors： El-Hennawy G,Moustafa H,Omar W,Elkinaai N,Kamel A,Zaki I,Farid N,El-Kholy E

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Various projects dedicated specifically to adolescents and young adults (AYA) with cancer have been developed in recent years. A critical aspect of such programs is the ability to demonstrate its value, and therefore how to measure desired outcomes. METHODS:A list of metrics to consider for demonstrating th...

journal_title：Pediatric blood & cancer

authors： Ferrari A,Silva M,Veneroni L,Magni C,Clerici CA,Meazza C,Terenziani M,Spreafico F,Chiaravalli S,Casanova M,Luksch R,Catania S,Schiavello E,Biassoni V,Podda M,Bergamaschi L,Puma N,Indini A,Proserpio T,Massimino M

更新日期：2016-12-01 00:00:00

abstract：:Surgery plays an important role as part of the treatment plan in most children with malignant solid tumors in regards to initial biopsy, upfront resection, and delayed resection. Surgeons also play a critical role in the treatment of surgical complications that may arise during medical treatment. The pediatric surgica...

journal_title：Pediatric blood & cancer

authors： Fernandez-Pineda I,Sanders D,Rao BN,Shochat SJ,Davidoff AM

更新日期：2017-10-01 00:00:00

abstract：:Osteosarcoma is the most common bone tumor in children and young adults, with few advances in survival and treatment, especially for metastatic disease, in the last 30 years. Recently, immunotherapy has begun to show promise in various adult cancers, but the utility of this approach for osteosarcoma remains relatively...

journal_title：Pediatric blood & cancer

authors： Wedekind MF,Wagner LM,Cripe TP

更新日期：2018-09-01 00:00:00

abstract：:A newborn with unresectable kaposiform hemangioendothelioma associated with Kasabach Merritt phenomenon, unresponsive to vincristine and prednisone, received second-line treatment with propranolol at a dose of 2 mg/kg/day, starting at 2 months of life and continued for 13 months. There was only slight reduction in tum...

journal_title：Pediatric blood & cancer

authors： Filippi L,Tamburini A,Berti E,Perrone A,Defilippi C,Favre C,Calvani M,Della Bona ML,la Marca G,Donzelli G

更新日期：2016-07-01 00:00:00

abstract：:A 4-year-old male presented with rapid-onset cranial nerve palsy and ataxia. Brain magnetic resonance imaging (MRI) revealed a pontine mass lesion with discordant conventional and advanced imaging. A stereotactic core biopsy revealed glioblastoma with immunostaining suggestive of histone H3K27M and TP53 mutation, cons...

journal_title：Pediatric blood & cancer

authors： Tinkle CL,Orr BA,Lucas JT Jr,Klimo P,Patay Z,Baker SJ,Broniscer A,Qaddoumi I

更新日期：2017-08-01 00:00:00

abstract：PURPOSE:To evaluate the association of central nervous system (CNS) treatment intensity and the social functioning of children who have completed treatment for leukemia, lymphoma, and solid tumors outside the CNS. Furthermore, we expected that these associations would be moderated by child age at diagnosis and gender. ...

journal_title：Pediatric blood & cancer

authors： Vannatta K,Gerhardt CA,Wells RJ,Noll RB

更新日期：2007-10-15 00:00:00

abstract：BACKGROUND:High birth weight increases the risk of childhood acute lymphoid leukemia (ALL) through unknown mechanisms. Whether this risk is specific to ALL subtypes is unknown, and low case numbers have prevented investigation of the rarer leukemias. Here we address these associations using a large population-based dat...

journal_title：Pediatric blood & cancer

authors： O'Neill KA,Bunch KJ,Vincent TJ,Spector LG,Moorman AV,Murphy MF

更新日期：2012-01-01 00:00:00

abstract：:Paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired clonal stem cell disorder. Eculizumab and bone marrow transplantation are disease-modifying treatments for PNH but may not be readily available in resource-constrained settings. Of 52 pediatric patients with PNH, 20 had classical PNH and 32 had PNH/aplastic ...

journal_title：Pediatric blood & cancer

authors： Halder R,Mishra P,Aggarwal M,Mannivanan P,Dhawan R,Seth T,Tyagi S,Mahapatra M,Pati HP,Saxena R

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:Ultrasound-guided (USG) cannulation of the brachiocephalic vein (BCV) is gaining worldwide consensus for central venous access in children. This study reports a 20-month experience with this approach in children. METHODS:All patients who underwent percutaneous USG central venous catheter (CVC) positioning i...

journal_title：Pediatric blood & cancer

authors： Avanzini S,Mameli L,Disma N,Zanaboni C,Dato A,Montobbio G,Montagnini L,Bevilacqua M,Pierri F,Conte M,Amoroso L,Pala G,Pestarino S,Castagnola E,Molinari AC,Micalizzi C,Morreale G,Mattioli G,Pini Prato A

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Traditionally, physicians have believed that limb-salvage surgery has functional and cosmetic advantages over amputation, yet the literature is equivocal. Therefore, we sought to compare the psychosocial and functional outcomes in osteosarcoma survivors after limb-salvage surgery and amputation. We hypothesi...

journal_title：Pediatric blood & cancer

authors： Robert RS,Ottaviani G,Huh WW,Palla S,Jaffe N

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:Outcomes for patients with oncologic disease and/or after hematopoietic stem cell transplant (HSCT) requiring intensive care unit admission have improved, but indications for and outcomes after extracorporeal membrane oxygenation (ECMO) support in this population are poorly characterized. PROCEDURE:We analy...

journal_title：Pediatric blood & cancer

authors： Steppan DA,Coleman RD,Viamonte HK,Hanson SJ,Carroll MK,Klein OR,Cooke KR,Spinella PC,Steiner ME,Loftis LL,Bembea MM,Pediatric ECMO (PediECMO) subgroup of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network and

更新日期：2020-10-01 00:00:00

abstract：:We report two second malignant neoplasms (SMNs) of the parotid gland. Patient 1 was initially diagnosed with precursor B-cell lymphoblastic lymphoma of the scalp. Eight years after her initial diagnosis she presented with a small, painless mass in the region of her parotid gland. Patient 2 was diagnosed with pre-B-cel...

journal_title：Pediatric blood & cancer

authors： Savelli SL,Klopfenstein KJ,Termuhlen AM

更新日期：2005-12-01 00:00:00

abstract：:A major hallmark of NF1 is the development of benign tumors, including peripheral neurofibromas, plexiform neurofibromas, gliomas of the optic tract, other low grade gliomas, and pheochromocytomas. Hepatoblastoma have not been previously reported in patients with neurofibromatosis type 1. We present a case of a 9-mont...

journal_title：Pediatric blood & cancer

authors： Uçar C,Calişkan U,Toy H,Günel E

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:Recent studies suggest that SLCO1B1 c.521T > C variant decreases the clearance of methotrexate (MTX) and elevates its plasma concentration, hence leucovorin doses may need to be adjusted. However, high leucovorin doses may affect the cure rate in childhood acute lymphoblastic leukemia (ALL). Hitherto neither...

journal_title：Pediatric blood & cancer

authors： Zhang HN,He XL,Wang C,Wang Y,Chen YJ,Li JX,Niu CH,Gao P

更新日期：2014-12-01 00:00:00

abstract：:To assess safety and tolerability, we administered valacyclovir, an oral anti-viral medication that inhibits erythrocyte sickling in vitro, to 14 subjects with sickle-cell anemia for 1 week at a standard dose of 1,000 mg every 8 hr. No clinically significant adverse effects occurred. In 11 subjects in steady state, th...

journal_title：Pediatric blood & cancer

authors： Ender KL,DeBellis RH,Erlanger BF,Billote GB,Brittenham GM

更新日期：2011-05-01 00:00:00

abstract：:A 6-year-old female was admitted with abdominal pain and a mass in the right abdomen. Her lactose dehydrogenase level was 1,200 IU/L, and neuron specific enolase was 120 ng/ml. Computed tomography scan confirmed a large right renal mass with necrosis. A right radical nephrectomy was performed. The tumor was completely...

journal_title：Pediatric blood & cancer

authors： Maeda M,Tsuda A,Yamanishi S,Uchikoba Y,Fukunaga Y,Okita H,Hata J

更新日期：2008-01-01 00:00:00

abstract：:We describe 12 pediatric patients (8-16 years) with primary refractory (N = 6) or first relapse (N = 6) Hodgkin lymphoma (HL) treated with ifosfamide, gemcitabine, and vinorelbine (IGEV). The overall response rate to IGEV was 100%, with seven (58%) complete responses (CR) and five (42%) partial responses. Successful C...

journal_title：Pediatric blood & cancer

authors： Marr K,Ronsley R,Nadel H,Douglas K,Gershony S,Strahlendorf C,Davis JH,Deyell RJ

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:Primary stroke prevention programmes for children with sickle cell disease (SCD) have been shown to be feasible interventions in resource-poor countries. Different hydroxyurea (HU) regimens have been utilised in ameliorating the severity of SCD. OBJECTIVE:To determine the long-term outcomes of the stroke pr...

journal_title：Pediatric blood & cancer

authors： Lagunju IA,Labaeka A,Ibeh JN,Orimadegun AE,Brown BJ,Sodeinde OO

更新日期：2021-02-01 00:00:00

abstract：:The fundamental purposes underlying formal health care transition from the pediatric to adult setting for young adult survivors of childhood cancer are to facilitate the continuous, medically and developmentally appropriate implementation of risk-based guidelines for the monitoring and management of late effects of ch...

journal_title：Pediatric blood & cancer

authors： Freyer DR,Brugieres L

更新日期：2008-05-01 00:00:00