NHL in adolescents and young adults: A unique population.

Abstract:

:Non-Hodgkin lymphoma (NHL) is a heterogeneous group of lymphoid malignancies with high incidence in adolescents and young adults (AYAs). The most common diseases include diffuse large B-cell lymphoma, anaplastic large cell lymphoma, Burkitt lymphoma, lymphoblastic lymphoma, and primary mediastinal large B-cell lymphoma. In comparison to younger children and adults, AYAs (15-39 years) with NHL present a specific set of challenges including variations in tumor biology, inconsistent treatment, pharmacodynamics, and psychosocial barriers. While survival of AYAs with NHL has improved, cure rates remain suboptimal. Incorporation of novel agents into pediatric-inspired treatment regimens specifically designed for NHL in AYAs has led to improved outcomes. Consideration of AYAs as a distinct population in the diagnosis and treatment of NHL is encouraged.

journal_name

Pediatr Blood Cancer

journal_title

Pediatric blood & cancer

authors

Hochberg J,Flower A,Brugieres L,Cairo MS

doi

10.1002/pbc.27073

subject

Has Abstract

pub_date

2018-08-01 00:00:00

pages

e27073

issue

8

eissn

1545-5009

issn

1545-5017

journal_volume

65

pub_type

杂志文章,评审
  • Simultaneous acute splenic sequestration and transient aplastic crisis in children with sickle cell disease.

    abstract::Acute splenic sequestration crisis (ASSC) is a hematological emergency in young children with sickle cell disease (SCD), characterized by worsening anemia and splenomegaly, usually with reticulocytosis and thrombocytopenia. Transient aplastic crisis (TAC) due to parvovirus B19 infection occurs in older children with S...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.22035

    authors: Yates AM,Hankins JS,Mortier NA,Aygun B,Ware RE

    更新日期:2009-09-01 00:00:00

  • Children's views on their involvement in clinical research.

    abstract:OBJECTIVE:To examine the level of children's understanding of informed consent in clinical trials and factors that may influence these processes. DESIGN:Twenty nine children who were included in clinical trials for treatment of cancer or HIV, were offered the possibility to complete a semidirective interview, with par...

    journal_title:Pediatric blood & cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/pbc.21359

    authors: Chappuy H,Doz F,Blanche S,Gentet JC,Tréluyer JM

    更新日期:2008-05-01 00:00:00

  • Outcome after first relapse in children with acute lymphoblastic leukemia: a report based on the Dutch Childhood Oncology Group (DCOG) relapse all 98 protocol.

    abstract:BACKGROUND:We report on the treatment of children and adolescents with acute lymphoblastic leukemia (ALL) in first relapse. The protocol focused on: (1) Intensive chemotherapy preceding allogeneic stem cell transplantation (SCT) in early bone marrow relapse; (2) Rotational chemotherapy in late relapse, without donor; (...

    journal_title:Pediatric blood & cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/pbc.22946

    authors: van den Berg H,de Groot-Kruseman HA,Damen-Korbijn CM,de Bont ES,Schouten-van Meeteren AY,Hoogerbrugge PM

    更新日期:2011-08-01 00:00:00

  • Sex ratio among childhood cancers by single year of age.

    abstract:BACKGROUND:The male excess in childhood cancer incidence is well-established; however, the underlying biologic mechanisms remain unknown. Examining the association between male sex and childhood cancer by single year of age and tumor type may highlight important periods of risk such as variation in growth and hormonal ...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.27620

    authors: Williams LA,Richardson M,Marcotte EL,Poynter JN,Spector LG

    更新日期:2019-06-01 00:00:00

  • Neuropsychological outcomes of a randomized trial of prednisone versus dexamethasone in acute lymphoblastic leukemia: findings from Dana-Farber Cancer Institute All Consortium Protocol 00-01.

    abstract:BACKGROUND:Dexamethasone is more efficacious than prednisone in the treatment of acute lymphoblastic leukemia (ALL), but has also been associated with greater toxicity. We compared neuropsychological outcomes for patients treated on DFCI ALL Consortium Protocol 00-01, which included a randomized comparison of the two s...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/pbc.24666

    authors: Waber DP,McCabe M,Sebree M,Forbes PW,Adams H,Alyman C,Sands SA,Robaey P,Romero I,Routhier MÈ,Girard JM,Sallan SE,Silverman LB

    更新日期:2013-11-01 00:00:00

  • A case of natural killer cell lymphoma presenting with bilateral pleural effusions and hemophagocytic lymphohistocytosis.

    abstract::Natural killer (NK) cell lymphoma of lung is very rare. We report a case of NK cell lymphoma presented in a 17-year-old male with bilateral pleural effusions and hemophagocytic lymphohistocytosis. Morphologic and immunohistochemical tests revealed an association of NK cell lymphoma with Epstein-Barr virus. A literatur...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.21943

    authors: Tai CF,Chang LY,Lin DT,Lin KH,Jou ST,Yang YL

    更新日期:2009-05-01 00:00:00

  • A novel nonsense mutation in the MPL gene in congenital amegakaryocytic thrombocytopenia.

    abstract::Congenital amegakaryocytic thrombocytopenia (CAMT) is a rare autosomal recessive disorder characterized by thrombocytopenia from failure of megakaryopoiesis. CAMT is one of the bone marrow failure syndromes, and the disease progression may involve other lineages leading to pancytopenia. The genetic background of CAMT ...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.22842

    authors: Chung HS,Koh KN,Kim HJ,Kim HJ,Lee KO,Park CJ,Chi HS,Kim SH,Seo JJ,Im HJ

    更新日期:2011-02-01 00:00:00

  • A meta-analysis of MTHFR C677T and A1298C polymorphisms and risk of acute lymphoblastic leukemia in children.

    abstract:BACKGROUND:Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms have been implicated in childhood acute lymphoblastic leukemia (ALL) risk, but previously published studies were inconsistent and recent meta-analyses were not adequate. PROCEDURES:In a meta-analysis of 21 publications with 4,706 cas...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/pbc.23137

    authors: Yan J,Yin M,Dreyer ZE,Scheurer ME,Kamdar K,Wei Q,Okcu MF

    更新日期:2012-04-01 00:00:00

  • Modifying bone mineral density, physical function, and quality of life in children with acute lymphoblastic leukemia.

    abstract:BACKGROUND:The early effects of childhood acute lymphoblastic leukemia (ALL) include decreased physical function, bone mineral density (BMD/g/cm2 ), and health-related quality of life (HRQL). We assessed the capacity of a physical therapy and motivation-based intervention, beginning after diagnosis and continuing throu...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1002/pbc.26929

    authors: Cox CL,Zhu L,Kaste SC,Srivastava K,Barnes L,Nathan PC,Wells RJ,Ness KK

    更新日期:2018-04-01 00:00:00

  • Feasibility of metronomic maintenance chemotherapy following high-dose chemotherapy for malignant central nervous system tumors.

    abstract:BACKGROUND:Children less than 5 years of age with malignant central nervous system (CNS) tumors, continue to have a high rate of morbidity and mortality following administration of conventional therapy. In an attempt to avoid the neurologic sequelae associated with craniospinal radiation, strategies such as high-dose c...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.21381

    authors: Choi LM,Rood B,Kamani N,La Fond D,Packer RJ,Santi MR,Macdonald TJ

    更新日期:2008-05-01 00:00:00

  • Thrombophilia testing in children: a 7 year experience.

    abstract:BACKGROUND:Incidence of venous thromboembolism (VTE) in children is reported to be increasing. We examined thrombophilia testing results in children with VTE that presented in inpatient and outpatient settings to explore patterns of thrombophilia testing. PROCEDURE: PATIENTS/METHODS:Children, ages 0-20 years with VTE...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.24846

    authors: Mahajerin A,Obasaju P,Eckert G,Vik TA,Mehta R,Heiny M

    更新日期:2014-03-01 00:00:00

  • Hospital-based home care for children with cancer.

    abstract::Hospital-based home care (HBHC) is widely applied in Pediatric Oncology. We reviewed the potential effect of HBHC on children's physical health and risk of adverse events, parental and child satisfaction, quality of life of children and their parents, and costs. A search of PubMed, CINAHL, and EMBASE led to identifica...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,评审

    doi:10.1002/pbc.23047

    authors: Hansson H,Hallström I,Kjaergaard H,Johansen C,Schmiegelow K

    更新日期:2011-09-01 00:00:00

  • The Italian consensus conference on the role of rehabilitation for children and adolescents with leukemia, central nervous system, and bone tumors, part 1: Review of the conference and presentation of consensus statements on rehabilitative evaluation of m

    abstract::Because of increasing survival rates in pediatric oncology, attention is focusing on cancer and its treatment-related side effects. Rehabilitation may reduce their impact. However, the literature does not provide strong evidence regarding rehabilitation pathways. Therefore, the Italian Association of Pediatric Hematol...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,评审

    doi:10.1002/pbc.28681

    authors: Rossi F,Ricci F,Botti S,Bertin D,Breggiè S,Casalaz R,Cervo M,Ciullini P,Coppo M,Cornelli A,Esposito M,Ferrarese M,Ghetti M,Longo L,Morri M,Naretto G,Orsini N,Fagioli F,AIEOP Rehabilitation Working Group Members.

    更新日期:2020-12-01 00:00:00

  • Breast Cancer and Non-Hodgkin Lymphoma in a Young Male with Cowden Syndrome.

    abstract::Male breast cancer (MBC) is unusual, especially in young adults. Most cases of MBC as a secondary malignancy relate to the previous treatment with ionizing radiation. MBC can be associated with mutations in hereditary cancer predisposition syndrome genes (i.e., BRCA2); however, no such association has been reported in...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.25796

    authors: Hagelstrom RT,Ford J,Reiser GM,Nelson M,Pickering DL,Althof PA,Sanger WG,Coccia PF

    更新日期:2016-03-01 00:00:00

  • Treatment of pediatric non-Hodgkin lymphomas in a country with limited resources: results of the first national protocol in Nicaragua.

    abstract::We report the results of a protocol for the diagnosis and treatment of pediatric non-Hodgkin lymphomas (NHL) conducted in Nicaragua in the context of an international collaborative program. Fifty-three children with NHL treated between 1996 and 2003 were retrospectively evaluated. Therapy was designed based on local d...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.21046

    authors: Baez F,Pillon M,Manfredini L,Ocampo E,Mendez G,Ortiz R,Palacios R,Gutierrez T,Tridello G,Conter V,Valsecchi M,Fossati Bellani F,Cavalli F,Masera G,Rosolen A

    更新日期:2008-01-01 00:00:00

  • Natural course of low risk neuroblastoma.

    abstract:BACKGROUND:Neuroblastoma is characterized by heterogeneity of histology, biology, and clinical behavior. Most epidemiology studies are based on Western and Japanese populations; there are very few studies on neuroblastoma from Southeast Asia. PROCEDURE:Cases of Thai children with neuroblastoma were retrospectively rev...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.23325

    authors: Shuangshoti S,Shuangshoti S,Nuchprayoon I,Kanjanapongkul S,Marrano P,Irwin MS,Thorner PS

    更新日期:2012-05-01 00:00:00

  • Autologous stem cell transplantation for refractory opsoclonus myoclonus ataxia syndrome.

    abstract::Opsoclonus, myoclonus, ataxia syndrome (OMA) is a severe neurologic disorder often associated with neuroblastoma. It is challenging to treat and can have long-term neurologic sequelae. Current recommended therapies include intravenous immunoglobulin, corticosteroids, rituximab, and chemotherapy (cyclophosphamide). We ...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.27110

    authors: Johnston DL,Murray S,Irwin MS,Doyle J,Schechter T

    更新日期:2018-08-01 00:00:00

  • The relationship between ventricular volume and whole-brain irradiation dose in central nervous system germ cell tumors.

    abstract:BACKGROUND:Advanced irradiation techniques, including intensity-modulated radiation therapy (IMRT), aim to limit irradiation to adjoining tissues by conforming beams to a well-defined volume. In intracranial germinomas, whole-ventricular IMRT decreases the volume of irradiation to surrounding parenchyma. This study exa...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.28005

    authors: Toll SA,Jones MT,Yoshida EJ,Dhall G,Olch AJ,Wong KK

    更新日期:2019-12-01 00:00:00

  • Intravenous ferric carboxymaltose for iron deficiency anemia or iron deficiency without anemia after poor response to oral iron treatment: Benefits and risks in a cohort of 144 children and adolescents.

    abstract:OBJECTIVE:The objective of this single-center observational study was to determine the clinical and hematologic responses to intravenous ferric carboxymaltose (FCM) in a cohort of pediatric patients with poor response to oral iron therapy. The occurrence of adverse events was systematically recorded for up to 96 hours ...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.28614

    authors: Ozsahin H,Schaeppi M,Bernimoulin M,Allard M,Guidard C,van den Ouweland F

    更新日期:2020-10-01 00:00:00

  • Prevention and management of central venous catheter occlusion and thrombosis in children with cancer.

    abstract:BACKGROUND:The views and clinical practice of children's cancer units were surveyed regarding management of central venous catheter (CVC) occlusion (CVC-occlusion), CVC-related thrombosis (CVC-thrombosis) and thromboembolism (CVC-thromboembolism). PROCEDURE:A questionnaire was sent to all 22 United Kingdom Children's ...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,多中心研究

    doi:10.1002/pbc.21332

    authors: Skinner R,Koller K,McIntosh N,McCarthy A,Pizer B,United Kingdom Children's Cancer Study Group (UKCCSG).,Paediatric Oncology Nursing Forum (PONF) Supportive Care Group.

    更新日期:2008-04-01 00:00:00

  • Treatment of infantile choriocarcinoma of the liver.

    abstract::Primary choriocarcinoma of the liver is an extremely rare childhood malignancy frequently associated with clinical instability at initial presentation. It often mimics other benign and malignant childhood liver tumors. Prompt diagnosis and initiation of treatment are necessary to attain a successful outcome. We descri...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.20623

    authors: Yoon JM,Burns RC,Malogolowkin MH,Mascarenhas L

    更新日期:2007-07-01 00:00:00

  • Dose response and local control using radiotherapy in non-metastatic Ewing sarcoma.

    abstract:BACKGROUND:To determine prognostic factors for local control in the radiotherapeutic management of non-metastatic Ewing sarcoma. PROCEDURE:Forty patients with localized Ewing sarcoma (ES) were treated with primary site RT at one institution. Median RT dose was 55.8 Gy (range, 25.5-76 Gy). Chemotherapy was given to 34 ...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.20904

    authors: Paulino AC,Nguyen TX,Mai WY,Teh BS,Wen BC

    更新日期:2007-08-01 00:00:00

  • Insights on neoplastic stem cells from gel-based proteomics of childhood germ cell tumors.

    abstract:BACKGROUND:Childhood germ cell tumors (cGCTs), believed to arise from transformed primordial germ cells by an unknown mechanism, provide a unique model system for investigating cell signaling, pluripotency, and the microenvironment of neoplastic stem cells (NSCs) in vivo. This is the first report of proteomics of cGCTs...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.23282

    authors: Haskins WE,Eedala S,Jadhav YL,Labhan MS,Pericherla VC,Perlman EJ

    更新日期:2012-05-01 00:00:00

  • Outcome of childhood acute lymphoblastic leukemia with induction failure treated by the Japan Association of Childhood Leukemia study (JACLS) ALL F-protocol.

    abstract:BACKGROUND:Children with acute lymphoblastic leukemia (ALL) who fail to achieve complete remission (CR) after induction therapy (induction failure: IF) have a poor prognosis; however, there have been few prospective studies in patients with IF. PATIENTS AND METHODS:Between April 1997 and March 2005, 27 of 1,237 leukem...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.22217

    authors: Suzuki N,Yumura-Yagi K,Yoshida M,Hara J,Nishimura S,Kudoh T,Tawa A,Usami I,Tanizawa A,Hori H,Ito Y,Miyaji R,Oda M,Kato K,Hamamoto K,Osugi Y,Hashii Y,Nakahata T,Horibe K,Japan Association of Childhood Leukemia Study

    更新日期:2010-01-01 00:00:00

  • Influenza-associated morbidity in children with cancer.

    abstract:BACKGROUND:The clinical impact of influenza in children undergoing therapy for cancer is not well-described in the literature. PROCEDURE:Laboratory-documented influenza infection in pediatric oncology patients cared for in a single regional pediatric medical center between July 2000 and June 2005 was identified by rev...

    journal_title:Pediatric blood & cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/pbc.21472

    authors: Tasian SK,Park JR,Martin ET,Englund JA

    更新日期:2008-05-01 00:00:00

  • Hematopoietic stem cell transplant referral patterns for children with sickle cell disease vary among pediatric hematologist/oncologists' practice focus: A Sickle Cell Transplant Advocacy and Research Alliance (STAR) study.

    abstract:BACKGROUND:Hematopoietic stem cell transplantation (HSCT) provides a curative therapy for children severely affected by sickle cell disease (SCD). Rejection-free survival after matched sibling donor (MSD) HSCT is very high, but adoption of HSCT as a curative SCD therapy has been slow. In this study, we assess providers...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.28861

    authors: Meier ER,Abraham AA,Ngwube A,Janson IA,Guilcher GMT,Horan J,Kasow KA

    更新日期:2021-03-01 00:00:00

  • Successful treatment of a patient with mixed warm and cold antibody mediated Evans syndrome and glucose intolerance.

    abstract::Thrombocytopenia and autoimmune hemolytic anemia (Evans syndrome) with the presence of both warm and cold autoantibodies (mixed type) are rare in the pediatric age group. This condition may be associated with other autoimmune disorders and is notoriously difficult to treat. This case describes an adolescent male who p...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.20312

    authors: Jubinsky PT,Rashid N

    更新日期:2005-09-01 00:00:00

  • Intravenous pentamidine is effective as second line Pneumocystis pneumonia prophylaxis in pediatric oncology patients.

    abstract:BACKGROUND:Pneumocystis jirovecii, formerly carinii, pneumonia (PCP) poses a life-threatening risk to oncology patients. The use of trimethoprim-sulfamethoxazole (TMP-SMZ) prophylaxis virtually eliminates the risk of infection; however, many patients cannot tolerate TMP-SMZ. We performed a retrospective analysis to det...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.21287

    authors: Kim SY,Dabb AA,Glenn DJ,Snyder KM,Chuk MK,Loeb DM

    更新日期:2008-04-01 00:00:00

  • Clinical advances in hemophilia management.

    abstract::Hemophilia is an excellent example in medicine where clinical translation of basic science discoveries has transformed the gloomy outlook of the disease. This review provides an overview of clinical advances in hemophilia management with a specific focus on the molecular heterogeneity of the disease and progress in ma...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,评审

    doi:10.1002/pbc.23193

    authors: Sharathkumar AA,Carcao M

    更新日期:2011-12-01 00:00:00

  • Local lymph node involvement in pediatric renal cell carcinoma: a report from the Italian TREP project.

    abstract:BACKGROUND:One of the most important adverse prognostic factors for adult renal cell carcinoma (RCC) is the retroperitoneal lymph node involvement. The aim of this article is to study the prognostic significance of local lymph node involvement in pediatric RCC and the role of retroperitoneal lymph node dissection (RLND...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.21652

    authors: Indolfi P,Bisogno G,Cecchetto G,Spreafico F,De Salvo GL,Collini P,Jenkner A,Inserra A,Schiavetti A,di Martino M,Casale F

    更新日期:2008-10-01 00:00:00