A novel nonsense mutation in the MPL gene in congenital amegakaryocytic thrombocytopenia.

abstract：BACKGROUND:Nephrogenic rests (NRs) are abnormally persistent foci of embryonal cells, thought to be the precursor lesion of Wilms tumors (WTs). To date, their presence has not been systematically examined in WTs treated with preoperative chemotherapy. METHODS:A systematic analysis of the data on NRs in WTs treated wit...

journal_title：Pediatric blood & cancer

authors： Vujanić GM,Apps JR,Moroz V,Ceroni F,Williams RD,Sebire NJ,Pritchard-Jones K

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Survival rates for patients with bone tumors have increased dramatically over the past few decades. Unfortunately, many patients face functional limitations resulting from disease management, but there is little evidence regarding physical functioning in adolescents with bone tumors. This lack is largely due...

journal_title：Pediatric blood & cancer

authors： Pakulis PJ,Young NL,Davis AM

更新日期：2005-10-15 00:00:00

abstract：:MIRAGE syndrome caused by mutations in SAMD9 is associated with potential loss of chromosome 7 (-7/7q-) and an increased risk to develop myelodysplastic syndrome (MDS). We report a case of MIRAGE syndrome, caused by a novel SAMD9 mutation p.Leu641Pro, leading to characteristic clinical features as well as to the coexi...

journal_title：Pediatric blood & cancer

authors： Csillag B,Ilencikova D,Meissl M,Webersinke G,Laccone F,Narumi S,Haas O,Duba HC

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Although intra-retinal tumor has long been staged presurgically according to the Reese-Ellsworth (R-E) system, retinoblastoma differs from other pediatric neoplasms in never having had a widely accepted classification system that encompasses the entire spectrum of the disease. Comparisons among studies that ...

journal_title：Pediatric blood & cancer

authors： Chantada G,Doz F,Antoneli CB,Grundy R,Clare Stannard FF,Dunkel IJ,Grabowski E,Leal-Leal C,Rodríguez-Galindo C,Schvartzman E,Popovic MB,Kremens B,Meadows AT,Zucker JM

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:Irinotecan is highly active against rhabdomyosarcoma (RMS), yet its tolerability and efficacy in combination with radiation is unknown. We examined local control and toxicities in RMS patients treated with radiotherapy (RT) in combination with radiosensitizing agents irinotecan + carboplatin (I + C). PROCED...

journal_title：Pediatric blood & cancer

authors： Dharmarajan KV,Wexler LH,Wolden SL

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND AND AIM:We reviewed the results and pattern of failure of the consensus HB/HCC 1996 treatment protocol for pediatric hepatoblastoma (HB) in Hong Kong. The role of SIOPEL and Children's Hepatic tumors International Collaboration (CHIC) risk stratification was evaluated. METHODS:Patients enrolled on the proto...

journal_title：Pediatric blood & cancer

authors： Liu APY,Ip JJK,Leung AWK,Luk CW,Li CH,Ho KKH,Lo R,Chan EKW,Chan ACY,Chung PHY,Chiang AKS

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:For children with juvenile myelomonocytic leukemia (JMML) who undergo stem cell transplantation (SCT), the role of immunological interventions including withdrawal of immunosuppressive therapy (IST) and donor lymphocyte infusion (DLI) for treatment of disease recurrence remains uncertain. PROCEDURE:We analy...

journal_title：Pediatric blood & cancer

authors： Inagaki J,Fukano R,Nishikawa T,Nakashima K,Sawa D,Ito N,Okamura J

更新日期：2013-01-01 00:00:00

abstract：:Male breast cancer (MBC) is unusual, especially in young adults. Most cases of MBC as a secondary malignancy relate to the previous treatment with ionizing radiation. MBC can be associated with mutations in hereditary cancer predisposition syndrome genes (i.e., BRCA2); however, no such association has been reported in...

journal_title：Pediatric blood & cancer

authors： Hagelstrom RT,Ford J,Reiser GM,Nelson M,Pickering DL,Althof PA,Sanger WG,Coccia PF

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Adolescents with cancer report a strong desire to be actively involved in personal healthcare decision making. The purpose of this study was to examine adolescent cancer patients' involvement in conversations about relapsed and refractory disease, to characterize the content of patient-clinician communicatio...

journal_title：Pediatric blood & cancer

authors： Frederick NN,Mack JW

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:The clinical impact of influenza in children undergoing therapy for cancer is not well-described in the literature. PROCEDURE:Laboratory-documented influenza infection in pediatric oncology patients cared for in a single regional pediatric medical center between July 2000 and June 2005 was identified by rev...

journal_title：Pediatric blood & cancer

authors： Tasian SK,Park JR,Martin ET,Englund JA

更新日期：2008-05-01 00:00:00

abstract：:Here, we present the case of a pediatric patient with newly diagnosed hepatocellular carcinoma causing central biliary obstruction and persistently elevated bilirubin of 3.0-4.3 mg/dl despite placement of bilateral internal-external biliary drains. The tumor was not resectable, and the patient was not a candidate for ...

journal_title：Pediatric blood & cancer

authors： Hiniker SM,Rangaswami A,Lungren MP,Thakor AS,Concepcion W,Balazy KE,Kovalchuk N,Donaldson SS

更新日期：2017-06-01 00:00:00

abstract：:Children with primary immunodeficiency or chromosomal breakage syndromes are at increased risk of developing non-Hodgkin lymphomas; they cannot tolerate standard chemotherapy regimens. We report two children with diffuse, large, B-cell lymphoma; one had ataxia telangiectasia and one had common variable immunodeficienc...

journal_title：Pediatric blood & cancer

authors： Shabbat S,Aharoni J,Sarid L,Ben-Harush M,Kapelushnik J

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:The awareness that adolescents can have cancer is probably insufficient, not only among teenagers and their families, but also among physicians, and adolescent patients are reportedly often referred to qualified cancer institutes after a considerable delay. PROCEDURE:A prospective series of 425 patients (28...

journal_title：Pediatric blood & cancer

authors： Veneroni L,Mariani L,Lo Vullo S,Favini F,Catania S,Vajna de Pava M,Massimino M,Ferrari A

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Subspecialty-specific normative values for clinical productivity of practicing pediatric hematologist/oncologists have not been well established. This information could be a useful adjunct in administrative decision-making in areas such as necessary levels of physician staffing and development of compensatio...

journal_title：Pediatric blood & cancer

authors： Griffin TC,Hutter JJ,Johnson KK,Moscow JA

更新日期：2004-08-01 00:00:00

abstract：:Dry eye disease is a well-known late complication of radiation therapy and is often difficult to treat. We evaluated the usefulness of cyclosporine 0.05% ophthalmic emulsion for the treatment of radiation-associated dry eye in children. Eleven children received cyclosporine 0.05% emulsion twice daily after failure of ...

journal_title：Pediatric blood & cancer

authors： Hoehn ME,Kelly SR,Wilson MW,Walton RC

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:To determine the maximum-tolerated duration and dose-limiting toxicity of a daily schedule of orally administered cyclophosphamide and topotecan in pediatric patients with recurrent or refractory malignant solid tumors. METHODS:Patients received oral cyclophosphamide (50 mg/m2/dose) in the morning followed ...

journal_title：Pediatric blood & cancer

authors： Bowers DC,Aquino VM,Leavey PJ,Bash RO,Journeycake JM,Tomlinson G,Mulne AF,Haynes HJ,Winick NJ

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Influenza is a health risk to children receiving chemotherapy for cancer. An absolute lymphocyte count (ALC) >1,000 cells/mm(3) has been associated with the ability to produce an immune response to influenza vaccine during chemotherapy. However, clinical efficacy of influenza vaccination during chemotherapy ...

journal_title：Pediatric blood & cancer

authors： Choi DK,Fuleihan RL,Walterhouse DO

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:Pediatric nonrhabdomyosarcoma soft tissue sarcomas (NRSTS) may rarely occur in visceral tissues, and little is known about their clinical history. The present study retrospectively analyzed a group of patients prospectively registered in Italian pediatric protocols conducted between 1979 and 2004. METHODS:I...

journal_title：Pediatric blood & cancer

authors： Ferrari A,Magni C,Bergamaschi L,Cecchetto G,Alaggio R,Milano GM,Bertolini P,Basso E,Manzitti C,Di Martino M,Giurici N,Melchionda F,Cecinati V,Chiaravalli S,Affinita MC,Scagnellato A,Casanova M,Bisogno G

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:Children with sickle cell disease (SCD) and moyamoya may benefit from indirect cerebral revascularization surgery in addition to chronic blood transfusion therapy for infarct prevention. We sought to compare overt and silent infarct recurrence rates in children with SCD undergoing revascularization. METHODS...

journal_title：Pediatric blood & cancer

authors： Hall EM,Leonard J,Smith JL,Guilliams KP,Binkley M,Fallon RJ,Hulbert ML

更新日期：2016-08-01 00:00:00

abstract：:The identification and referral of candidate patients for phase I trials relies heavily on pediatric oncologists who must balance their own perceptions of phase I trials with the desires of the patient and his/her family. A survey was sent to 419 physicians practicing pediatric oncology at 30 different institutions. R...

journal_title：Pediatric blood & cancer

authors： Gilliam MB,Madan-Swain A,Adams JM,Pressey JG

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Patients with cancer who receive intensive chemotherapeutic regimens are subject to profound immunosuppression and are susceptible to an extended array of pathogens. PROCEDURE:The infectious causes of symptomatic gastroenteritis as evidenced by diarrhea +/- fever, vomiting, and abdominal colic in children f...

journal_title：Pediatric blood & cancer

authors： El-Mahallawy HA,El-Din NH,Salah F,El-Arousy M,El-Naga SA

更新日期：2004-04-01 00:00:00

abstract：BACKGROUND:Dexamethasone is more efficacious than prednisone in the treatment of acute lymphoblastic leukemia (ALL), but has also been associated with greater toxicity. We compared neuropsychological outcomes for patients treated on DFCI ALL Consortium Protocol 00-01, which included a randomized comparison of the two s...

journal_title：Pediatric blood & cancer

authors： Waber DP,McCabe M,Sebree M,Forbes PW,Adams H,Alyman C,Sands SA,Robaey P,Romero I,Routhier MÈ,Girard JM,Sallan SE,Silverman LB

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Melanoma is a common cancer among adolescents and young adults (AYAs), yet adherence to recommended surveillance and factors related to adherence are not well understood in this population. This study assessed the prevalence and correlates of physician-conducted skin examination (PSE) and skin self-examinati...

journal_title：Pediatric blood & cancer

authors： Miller KA,Wojcik KY,Cockburn MG,In GK,Hamilton AS,Milam JE

更新日期：2020-03-01 00:00:00

abstract：:Acute bilineal leukemias are rare and are commonly associated with t(9;22) and MLL abnormalities. Herein, we report a pediatric case of bilineal T/myeloid acute leukemia associated with del (9q)(q13q22) and TLX3/BCL11B fusion due to the cryptic t(5;14)(q35;32). FISH studies confirmed the TLX3/BCL11B fusion in both the...

journal_title：Pediatric blood & cancer

authors： Oliveira JL,Kumar R,Khan SP,Law ME,Erickson-Johnson M,Oliveira AM,Ketterling RP,Dogan A

更新日期：2011-03-01 00:00:00

abstract：:Bridging the survival gap for children with cancer, between those (the great majority) in low and middle income countries (LMIC) and their economically advantaged counterparts, is a challenge that has been addressed by twinning institutions in high income countries with centers in LMIC. The long-established partnershi...

journal_title：Pediatric blood & cancer

authors： Barr RD,Antillón Klussmann F,Baez F,Bonilla M,Moreno B,Navarrete M,Nieves R,Peña A,Conter V,De Alarcón P,Howard SC,Ribeiro RC,Rodriguez-Galindo C,Valsecchi MG,Biondi A,Velez G,Tognoni G,Cavalli F,Masera G

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:Ewing sarcoma (EWS) is rarely diagnosed as a second malignancy. We sought to describe a cohort of patients with secondary EWS and investigate if patient characteristics and survival differ between patients with secondary and primary EWS. PROCEDURE:Patients with EWS or peripheral primitive neuroectodermal tu...

journal_title：Pediatric blood & cancer

authors： Applebaum MA,Goldsby R,Neuhaus J,DuBois SG

更新日期：2013-04-01 00:00:00

abstract：:High-risk (HR) acute lymphoblastic leukemia (ALL) remains one of the greatest challenges in pediatric oncology. Relapsed ALL is a leading cause of death in young people, and further improvements in outcome will required the development of therapeutic approaches directed against rational therapeutic targets, as escalat...

journal_title：Pediatric blood & cancer

authors： Hunger SP,Raetz EA,Loh ML,Mullighan CG

更新日期：2011-06-01 00:00:00

abstract：:Treatment recommendations for endemic Burkitt lymphoma (BL) in settings with only minimum requirements for curative treatment (PODC setting 1) are described. The reported cure rate for endemic BL is usually <50%. Facilities within setting 1 differ. Three treatment schedules are proposed based on: (1) when accurate sta...

journal_title：Pediatric blood & cancer

authors： Hesseling P,Israels T,Harif M,Chantada G,Molyneux E,Pediatric Oncology in Developing Countries.

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Compared to X-ray radiation therapy, proton therapy (PT) reduces the radiation dose to organs at risk, which is expected to translate into fewer second cancers and less cardiac morbidity decades after treatment. The Children's Oncology Group high-risk pediatric Hodgkin lymphoma (PHL) protocol, AHOD1331, allo...

journal_title：Pediatric blood & cancer

authors： Wray J,Flampouri S,Slayton W,Joyce M,Sandler E,Morris CG,Li Z,Indelicato DJ,Mendenhall NP,Hoppe BS

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Many pediatric oncology patients undergoing hematopoietic stem cell transplantation (HSCT) require nutritional support (NS) because of their inability to consume adequate caloric intake enough calories orally. Although NS can be provided either enteraly (EN) or parenteraly (PN), EN is the preferred method of...

journal_title：Pediatric blood & cancer

authors： Williams-Hooker R,Adams M,Havrilla DA,Leung W,Roach RR,Mosby TT

更新日期：2015-08-01 00:00:00