Breast Cancer and Non-Hodgkin Lymphoma in a Young Male with Cowden Syndrome.

abstract：BACKGROUND:SCH 727965 is a novel drug in clinical development that potently and selectively inhibits CDK1, CDK2, CDK5, and CDK9. The activity of SCH 727965 was evaluated against the PPTP's in vitro and in vivo panels. PROCEDURES:SCH 727965 was tested against the PPTP in vitro panel using 96 hours exposure at concentra...

journal_title：Pediatric blood & cancer

authors： Gorlick R,Kolb EA,Houghton PJ,Morton CL,Neale G,Keir ST,Carol H,Lock R,Phelps D,Kang MH,Reynolds CP,Maris JM,Billups C,Smith MA

更新日期：2012-12-15 00:00:00

abstract：:We describe a child with dyserythropoietic anemia, thrombocytosis, functional platelet defect, and megakaryocyte dysplasia. We show that (i) this constellation of hematopoietic abnormalities was due to a germline mutation within the 5' untranslated region (5'UTR) of globin transcription factor 1 (GATA1); (ii) the muta...

journal_title：Pediatric blood & cancer

authors： Zucker J,Temm C,Czader M,Nalepa G

更新日期：2016-05-01 00:00:00

abstract：:Hepatoblastoma (HB) and biliary atresia (BA) are both rare conditions that occurred in the patient described. This is the second such case in the literature. An explanation for this apparent coincidence could possibly be found in the existance of pluripotent liver stem cells. In humans, small epithelial cells (SEC) be...

journal_title：Pediatric blood & cancer

authors： Taat F,Bosman DK,Aronson DC

更新日期：2004-10-01 00:00:00

abstract：BACKGROUND:Children treated with cranial radiotherapy (CRT) for leukemia are at risk of developing central nervous system injuries. Magnetic resonance imaging (MRI) represents the examination method of choice for evaluating radiation-induced brain complications. The purpose of this report is to describe the spectrum of...

journal_title：Pediatric blood & cancer

authors： Faraci M,Morana G,Bagnasco F,Barra S,Polo P,Hanau G,Fioredda F,Caruso S,Rossi A,Spaziante R,Haupt R

更新日期：2011-08-01 00:00:00

abstract：:In HLH-94, the first prospective international treatment study for hemophagocytic lymphohistiocytosis (HLH), diagnosis was based on five criteria (fever, splenomegaly, bicytopenia, hypertriglyceridemia and/or hypofibrinogenemia, and hemophagocytosis). In HLH-2004 three additional criteria are introduced; low/absent NK...

journal_title：Pediatric blood & cancer

authors： Henter JI,Horne A,Aricó M,Egeler RM,Filipovich AH,Imashuku S,Ladisch S,McClain K,Webb D,Winiarski J,Janka G

更新日期：2007-02-01 00:00:00

abstract：INTRODUCTION:Major advances in the field of pediatric oncology have resulted from rigorous, prospective clinical oncology research trials. Optimizing access for all children and adolescents to clinical research trials is an important goal. Barriers to clinical trial enrollment are numerous, involving the health care sy...

journal_title：Pediatric blood & cancer

authors： Russo C,Stout L,House T,Santana VM

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:Anthracycline cardiomyopathy is of concern in children treated for acute myeloid leukaemia (AML), but there are few data on the incidence and natural history of cardiotoxicity after AML treatment in the United Kingdom, where regimens have included high anthracycline exposure. PROCEDURE:Prevalence and predic...

journal_title：Pediatric blood & cancer

authors： Temming P,Qureshi A,Hardt J,Leiper AD,Levitt G,Ancliff PJ,Webb DK

更新日期：2011-04-01 00:00:00

abstract：:Children with cancer are at risk of malnutrition, which can impair critical childhood processes of growth and development and contribute to poor health outcomes. Enteral nutrition can effectively ameliorate malnutrition or weight loss in children with cancer; however, published nutrition support algorithms contain min...

journal_title：Pediatric blood & cancer

authors： McGrath KH,Hardikar W

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Retinoblastoma occurs in approximately 4 per million children per year in the United States, usually before 2 years of age. In developed countries, 95% of children with tumor in one eye can be cured with enucleation, while children with tumor in both eyes require individualized therapy to preserve vision. Al...

journal_title：Pediatric blood & cancer

authors： Lambert MP,Shields C,Meadows AT

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:We have previously published data from 2001 to 2006 showing that adolescent and young adult (AYA) oncology patients have significantly lower therapeutic clinical trial enrollment rates than younger patients. Our objective was to determine if the enrollment of AYA patients on therapeutic studies at the same i...

journal_title：Pediatric blood & cancer

authors： Jacob SA,Shaw PH

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Medulloblastoma is an infratentorial primitive neuroectodermal tumour, diagnosed in paediatric population. The radiotherapy is an essential method of treatment for these tumours. The impact of technical quality of radiation therapy on survival was recently considered. In this study treatment-related variable...

journal_title：Pediatric blood & cancer

authors： Chojnacka M,Skowrońska-Gardas A

更新日期：2004-02-01 00:00:00

abstract：PURPOSE:About one-third of patients with rhabdomyosarcoma relapse despite appropriate treatment and experience a poor outcome. Little meaningful improvement in the outcome of this disease has been observed over the last 30 years. There is no clear international recommendation concerning the use of salvage chemotherapy ...

journal_title：Pediatric blood & cancer

authors： Winter S,Fasola S,Brisse H,Mosseri V,Orbach D

更新日期：2015-11-01 00:00:00

abstract：:Chronic myeloid leukemia (CML) is a rare disease in children. Different from that in adults, childhood CML involves transformative events occurring over a short time period. CML transformation to lymphoid blast phase (BP) is associated with copy number abnormalities, characteristic of BCR-ABL1 positive acute lymphobla...

journal_title：Pediatric blood & cancer

authors： Klumb CE,Barbosa TDC,Nestal de Moraes G,Schramm MT,Emerenciano M,Maia RC

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Survival for childhood acute lymphoblastic leukemia (ALL) has reached 80-90%. Future improvement in treatment success will involve new technologies and medication, adding to the pressure on limited financial resources. Therefore a retrospective cost-effectiveness analysis of ALL treatment with chemotherapy o...

journal_title：Pediatric blood & cancer

authors： van Litsenburg RR,Uyl-de Groot CA,Raat H,Kaspers GJ,Gemke RJ

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:Children with cancer may be at an increased risk of infection with hepatitis B virus (HBV) when levels of hepatitis B antibodies are reduced owing to chemotherapy-induced immunosuppression. This study evaluated the changes in HBV antibody status and HBV infections after chemotherapy in children with acute ly...

journal_title：Pediatric blood & cancer

authors： Choi YB,Lee NH,Yi ES,Kim YJ,Koo HH

更新日期：2019-12-01 00:00:00

abstract：:Family financial hardship has emerged as a burden of pediatric cancer treatment with negative implications for family well-being. As part of an extensive project to create evidence-based standards for the psychosocial care of children with cancer, we performed a literature review of pediatric cancer-associated financi...

journal_title：Pediatric blood & cancer

authors： Pelletier W,Bona K

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Although genetic and environmental factors are considered to be the main causes of acute lymphoblastic leukemia, the associations between maternal factors during pregnancy and the childhood ALL is still unclear. PROCEDURE:In this study, meta-analysis was used. Medline, PubMed, and Web of Science were search...

journal_title：Pediatric blood & cancer

authors： Yan K,Xu X,Liu X,Wang X,Hua S,Wang C,Liu X

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:To investigate the incidence, clinical characteristics and survival of malignant tumours of the gastrointestinal tract in children in the West Midlands in Britain over a 44-year span time, to identify any change over this period and to compare the data with the world literature. PROCEDURE:Retrospective popu...

journal_title：Pediatric blood & cancer

authors： Hameed R,Parkes S,Davies P,Morland BJ

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND:Clear cell sarcoma of the kidney (CCSK) is known for its propensity to metastasize to bone, but it also spreads to other sites including the brain. This study was undertaken to describe the treatment and outcomes of patients with recurrent CCSK involving the brain. METHODS:A retrospective records review was...

journal_title：Pediatric blood & cancer

authors： Radulescu VC,Gerrard M,Moertel C,Grundy PE,Mathias L,Feusner J,Diller L,Dome JS

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:The efficacy of combination chemotherapy with methotrexate (MTX) and asparaginase is not well known in relapsed and refractory acute leukemia after contemporary therapy. PROCEDURE:A retrospective study of pediatric patients with relapsed or refractory acute myeloid leukemia (AML) who received MTX and aspara...

journal_title：Pediatric blood & cancer

authors： Buaboonnam J,Cao X,Pauley JL,Pui CH,Ribeiro RC,Rubnitz JE,Inaba H

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Follicular variant of papillary thyroid carcinoma (FVPTC) has been shown to be an intermediate entity between papillary (PTC) and follicular/Hurtle cell (FTC) thyroid carcinoma in adults. However, the tumor characteristics and prognosis of FVPTCs has not been studied in the pediatric population and is the fo...

journal_title：Pediatric blood & cancer

authors： Lerner J,Goldfarb M

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:Cancer among infants (<1 year old) has unique epidemiologic, clinical, and genetic characteristics compared with cancer in older children. Nonetheless, data on secular trends in infant cancer incidence and survival in the United States is sparse. METHODS:Population-based data from nine areas of the Surveill...

journal_title：Pediatric blood & cancer

authors： Wang H,Mejia MC,Gonzalez SJ,Zoorob RJ,Chai W,Du XL

更新日期：2021-01-20 00:00:00

abstract：BACKGROUND:Childhood acute lymphoblastic leukemia (ALL) survivors' increased risk for adverse health outcomes could be mitigated through consuming a balanced diet. Nonetheless, >70% of adult survivors do not meet survivorship dietary recommendations. ALL treatment may amplify risk for restricted dietary preferences (pi...

journal_title：Pediatric blood & cancer

authors： Chardon ML,Pinto S,Slayton WB,Fisher RS,Janicke DM

更新日期：2020-12-31 00:00:00

abstract：BACKGROUND:Low expression of HLA class II antigens has been associated with more aggressive disease in several human malignancies including adult adrenocortical tumors (ACT), but their clinical relevance in pediatric ACT needs to be investigated. PROCEDURE:This study analyzed the expression profile of three class II h...

journal_title：Pediatric blood & cancer

authors： Leite FA,Lira RC,Fedatto PF,Antonini SR,Martinelli CE Jr,de Castro M,Neder L,Ramalho LN,Tucci S Jr,Mastelaro MJ,Seidinger AL,Cardinalli IA,Yunes JA,Brandalise SR,Tone LG,Scrideli CA

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:Survivors of childhood brain tumors are at increased risk for neurocognitive impairments, including deficits in abilities supported by frontal brain regions. Catechol-O-methyltransferase (COMT) metabolizes dopamine in the prefrontal cortex, with the Met allele resulting in greater dopamine availability and b...

journal_title：Pediatric blood & cancer

authors： Howarth RA,Adamson AM,Ashford JM,Merchant TE,Ogg RJ,Schulenberg SE,Ogg S,Li J,Wu S,Xiong X,Conklin HM

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:The presence of central nervous system (CNS) disease in pediatric acute myeloid leukemia (AML) is often thought to confer a worse prognosis. This study examined the outcome of children with AML who had CNS disease at diagnosis. METHODS:Patients enrolled on Children's Cancer Group protocols 2861, 2891, 2941,...

journal_title：Pediatric blood & cancer

authors： Johnston DL,Alonzo TA,Gerbing RB,Lange BJ,Woods WG

更新日期：2010-09-01 00:00:00

abstract：:For many children with cancer, participation in oncology camp programs is an important component of healing that offers opportunities for fun and can have substantial impacts on social and physical well-being. Optimal medical care and infectious screening for children attending oncology camp is critical to maximize sa...

journal_title：Pediatric blood & cancer

authors： Alexander S,Science M,Breakey V,Clarke A,Gibson P

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Patient transition readiness self-assessment tools and investigation into patient and parent perceptions of the transition process from pediatric to adult care models have informed recognition of gaps in care, particularly for those with chronic disease. Implementation of a longitudinal transition process wi...

journal_title：Pediatric blood & cancer

authors： Croteau SE,Padula M,Quint K,D'Angelo L,Neufeld EJ

更新日期：2016-03-01 00:00:00

abstract：INTRODUCTION:The National Heart, Lung, and Blood Institute guidelines for sickle cell disease (SCD) pain crisis management recommend opioids within 60 minutes of emergency department (ED) registration and every 30 minutes thereafter until acute pain is managed. These guidelines are based on expert opinion without publi...

journal_title：Pediatric blood & cancer

authors： Muslu CS,Kopetsky M,Nimmer M,Visotcky A,Fraser R,Brousseau DC

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Neuroblastoma (NB) is the most common solid extracranial tumor in childhood. Despite advances in therapy, the prognosis is poor and optimized therapies are urgently needed. Therefore, we investigated the antitumor potential of interleukin-15 (IL-15)-activated cytokine-induced killer (CIK) cells against diffe...

journal_title：Pediatric blood & cancer

authors： Cappel C,Huenecke S,Suemmerer A,Erben S,Rettinger E,Pfirrmann V,Heinze A,Zimmermann O,Klingebiel T,Ullrich E,Bader P,Bremm M

更新日期：2016-12-01 00:00:00