Pilomyxoid astrocytoma treated successfully with vemurafenib.

Abstract:

:The BRAF V600E missense mutation is known to be present in a subset of central nervous system tumors. We report a patient with a BRAF V600E mutated pilomyxoid astrocytoma who failed multiple conventional chemotherapy regimens. Treatment with vemurafenib, a molecularly targeted therapy against the mutant BRAF V600E kinase, combined with vinblastine resulted in tumor regression. Furthermore, this patient experienced almost immediate progression of disease after holding vemurafenib for only 2-3 weeks, suggesting that the tumor response is vemurafenib dependent. This population of patients may benefit from targeted therapy and testing of individual tumors for BRAF mutations is justified.

journal_name

Pediatr Blood Cancer

journal_title

Pediatric blood & cancer

authors

Skrypek M,Foreman N,Guillaume D,Moertel C

doi

10.1002/pbc.25084

subject

Has Abstract

pub_date

2014-11-01 00:00:00

pages

2099-100

issue

11

eissn

1545-5009

issn

1545-5017

journal_volume

61

pub_type

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