Scoring the proliferative activity of haemangioma of infancy: the Haemangioma Activity Score (HAS).

Abstract:

BACKGROUND:Haemangioma of infancy (HOI) is the most frequently occurring benign tumour of infancy. A good, reliable and objective scoring system for haemangioma activity is not yet available. AIM:We have developed a simple system called the Haemangioma Activity Score (HAS) for scoring the (disease) proliferative activity of haemangiomas. The current study was undertaken to validate this system. METHODS:We validated the HAS in a comparative study of photographs taken during consultations from 2000 until 2008 (n = 78). Agreement between three observers was assessed at two different time points (t(0) and t(1)) with a minimum interval of 6 months between them, using interclass correlation coefficients (ICC). RESULTS:Agreement between observers was good. The average ICC of the HAS at t(0) and t(1) was 0.72 and 0.76, respectively. The average ICC of the HAS for the changes from baseline (HAS at t(0) minus HAS at t(1) ) was 0.69. CONCLUSIONS:We conclude that the HAS is a good system for scoring the proliferative activity of haemangiomas, and believe it to be useful in future investigations. The number of studies comparing different therapies for treating haemangiomas is steadily increasing, and the HAS (before and after treatment) may provide a valuable scoring system for evaluating such therapies.

journal_name

Clin Exp Dermatol

authors

Janmohamed SR,de Waard-van der Spek FB,Madern GC,de Laat PC,Hop WC,Oranje AP

doi

10.1111/j.1365-2230.2011.04080.x

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

715-23

issue

7

eissn

0307-6938

issn

1365-2230

journal_volume

36

pub_type

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