Preliminary study on the evaluation of olfactory neuroblastoma using PET/CT.

Abstract:

PURPOSE:Because of paucity of data available regarding the utility of PET/CT in the diagnosis and staging of patients with olfactory neuroblastoma (ONB), we retrospectively analyzed the efficacy of PET/CT in 9 patients with ONB. MATERIALS AND METHODS:Whole-body F-18 FDG PET/CT was performed in 7 patients with newly diagnosed ONB, as well as in 1 patient with recurrence and in 1 patient with remnant tumor. Regional C-11 choline (C-11 CHO) PET/CT was performed in 2 patients with negative F-18 FDG scans. The lesion with intense radiotracer uptake was suggested as positive for tumor and the results of PET/CT were compared with conventional staging examinations. RESULTS:F-18 FDG PET/CT was positive in 7/9 (77.7%) patients with ONB. In 2 patients with negative F-18 FDG, the lesions were C-11CHO avid. Both the primary tumors and its invasions were clearly delineated by F-18 FDG or C-11 CHO PET/CT. SUVmax of F-18 FDG in the primary tumor was 6.37 ± 4.22 and did not correlate with lesion size (F-18 FDG/size: r = 0.097, P = 0.820). Whole-body F-18 FDG PET/CT detected parapharyngeal and cervical lymph node metastases in 2 patients, lung metastases in 1 patient, liver metastases in 1 patients, and bone metastases in 2 patients. PET/CT altered the stages of 3 of 9 patients with upstaging in 2 patients and downstaging in 1 patient. CONCLUSIONS:PET/CT may be useful for the diagnosis and staging of ONB.

journal_name

Clin Nucl Med

authors

Wu HB,Wang QS,Zhong JM,Zhou WL,Li HS,Qiao-yu W

doi

10.1097/RLU.0b013e31821a2711

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

894-8

issue

10

eissn

0363-9762

issn

1536-0229

pii

00003072-201110000-00010

journal_volume

36

pub_type

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