Abstract：
:Translational research in head and neck oncology is subject to the same laws as all other solid tumors. It is based on the one hand on a solid framework of well prepared clinical studies and / or workflows according to consensus criteria with comparable documentation of clinical outcomes, while on the other on methodolgically solid and reproducible laboratory research within an effeciently interacting network. Translationally applicable single molecular markers from basic research [with the exception of p16(INK4a) as a surrogate marker for human papillomavirus (HPV)] have not found their way into clinical routine in head and neck squamous cell carcinoma (HNSCC). "Correlated gene sets" and "metagenes", including genetic profiling (omics) within clinically characterized patient groups, play an increasing role in the translational research of HNSCC. Although methodological problems currently hinder clinical oncological research, increasing focus on translational research can be observed.
journal_name
HNOjournal_title
HNOauthors
Dietz A,Wichmann Gdoi
10.1007/s00106-011-2361-5subject
Has Abstractpub_date
2011-09-01 00:00:00pages
874-84issue
9eissn
0017-6192issn
1433-0458journal_volume
59pub_type
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