Abstract:
BACKGROUND:Due to their comparatively low incidence, salivary gland carcinomas have only been the subject of isolated clinical studies in recent years. In addition, surgery with/without adjuvant radiotherapy is considered standard treatment. Systemic therapies have received little attention and are only used for advanced and distantly metastasized salivary gland malignancies. OBJECTIVE:The contributions with the highest relevance for this year's meeting of the American Society of Clinical Oncology (ASCO) were to be reviewed. MATERIALS AND METHODS:A total of 12 contributions pertaining to clinical studies on salivary gland malignancies were identified, eight of which were classified as relevant for future changes to the therapeutic landscape. RESULTS:Three studies dealt with different combinations of a checkpoint blockade, and each showed a low response rate. In addition, studies on targeted therapies depending on the results of a mutation analysis and expression of HER2 or the androgen receptor were presented. CONCLUSION:A favorable response of HER2-positive salivary gland carcinomas to an antibody-drug conjugate could be shown. Furthermore, no convincing data regarding response to programmed cell death protein 1 (PD1)/programmed death ligand 1 (PD-L1) inhibitors in advanced salivary gland cancer were presented. Further studies and ideas for new treatment approaches will be needed to improve the therapeutic options for patients with salivary gland carcinoma.
journal_name
HNOjournal_title
HNOauthors
Doescher J,Schuler PJ,Greve J,Meyer MF,Weissinger S,Hoffmann TK,Laban Sdoi
10.1007/s00106-019-00760-9subject
Has Abstractpub_date
2019-12-01 00:00:00pages
931-934issue
12eissn
0017-6192issn
1433-0458pii
10.1007/s00106-019-00760-9journal_volume
67pub_type
杂志文章,评审相关文献
HNO文献大全abstract::Malignancies of the nose, paranasal sinuses and anterior skull base are characterized by their hidden locations and late clinical manifestation. This explains why most of the patients at the University of Tübingen were diagnosed in an advanced tumor stage (15 T1/T2; 33 T3/T4). Surgical treatment was possible in 35 cas...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1996-04-01 00:00:00
abstract::Distorsion product otoacoustic emissions (DPOAE) are generated by a continuous bitonal stimulation of the cochlea. The resulting emissions are measurable in a definite mathematical function of the primaries (mf1 +/- nf2; f1 < f2). In humans sound emission at the frequency 2f1-f are usually detectable. To determine if ...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1993-07-01 00:00:00
abstract::Extensive tracheal defects after prolonged assisted ventilation, trauma or large resections in tumor surgery are a challenge in plastic and reconstructive surgery. Defects which cannot be satisfactorily repaired reguine near of an alloplastic tracheal replacement. Previous experimental and clinical experiences in the ...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1995-02-01 00:00:00
abstract::Fifty-one patients with inverted papillomas of the nose and paranasal sinuses underwent surgery, 35 by an intranasal endoscopic method and 16 by an extranasal approach. The recurrence rate after endoscopy surgery was 17% (6/35), compared with 19% (3/16) after an external approach. Endoscopic surgery proved to be succe...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1990-07-01 00:00:00
abstract::The incidence of human papillomavirus (HPV)-positive oropharyngeal carcinomas is increasing worldwide. Due to a markedly different response to treatment compared to HPV-negative oropharyngeal carcinomas, determining the ideal therapeutic approach can be challenging. Particularly in never-smokers, HPV-positive orophary...
journal_title:HNO
pub_type: 杂志文章,评审
doi:10.1007/s00106-020-00900-6
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:Digitalization has become a part of everyday life and digital applications offer an opportunity to promote health. In Germany, hearing rehabilitation after cochlear implantation (CI) typically takes place in specialized audiology centers. However, a variety of new auditory training programs have been develop...
journal_title:HNO
pub_type: 杂志文章,评审
doi:10.1007/s00106-020-00898-x
更新日期:2020-11-01 00:00:00
abstract::Several investigations prove that monaural acoustic deprivation induces detrimental changes in the auditory pathway. So far the major interest focused on degenerative processes on the deprived side, while effects on the contralateral untreated side were not taken into consideration. This ontogenetic study investigates...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s001060050032
更新日期:2000-03-01 00:00:00
abstract::Pyoderma gangrenosum belongs to the chronic, neutrophilic and necrotic dermatoses. These very painful, inflammable and purulent skin-ulcers often arise after injury or surgical intervention. About half of the patients suffer from systemic disease, for example hematological, gastrointestinal or rheumatic diseases.Our r...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s00106-002-0722-9
更新日期:2003-06-01 00:00:00
abstract::The protective effect of Ca2+ antagonists in acoustic trauma was evaluated by morphometric analysis of the guinea pig cochlea. Damage to the outer and inner hair cells was significantly reduced. Ca2+ antagonists may exert a beneficial influence on the cellular membrane of the sensory cell or on the cochlear vasculatur...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1987-05-01 00:00:00
abstract::Calcium phosphate ceramics have been proposed for obliteration of the mastoid cavity in middle ear surgery. To our knowledge no experimental data are available concerning the use of homologous fibrin glue associated with hydroxyapatite (HA) in animals. Obliteration of the epitympanic space and closure of defects in th...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1989-03-01 00:00:00
abstract::Statutory implementation of a universal newborn hearing screening requires a continuous quality assurance monitoring. Therefore, at the Annual Meeting in 2007, the members of the German Society of Phoniatrics and Pediatric Audiology passed a recommendation on measures of quality assurance applied to newborn hearing sc...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s00106-008-1878-8
更新日期:2009-01-01 00:00:00
abstract::Specific anosmia, the inability to perceive a specific odor, while olfactory perception is otherwise intact, is known as a rather seldom phenomenon. By testing the prevalence of specific anosmia to 20 different odors in a sample of 1600 people, we were able to estimate the general prevalence of anosmia. This revealed ...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s00106-016-0119-9
更新日期:2016-05-01 00:00:00
abstract::Failed intubation in three patients is reported. All three patients suffered sudden, extreme impaired of mask-ventilation. Twice a coniotomy with subsequent tracheostomy proved to be life saving and without permanent injury. In the other patient tracheostomy had been attempted without success, and subsequent, successf...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1987-10-01 00:00:00
abstract:INTRODUCTION:According to our audiological data, 90% of tinnitus patients have deficits in inner ear function as a generator of tinnitus, mainly in the outer hair cells (OHC). This can be verified by registration of distortion products of otoacoustic emissions (DPOAE). Thus, the main origin of tinnitus is peripheral, a...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s00106-008-1730-1
更新日期:2008-07-01 00:00:00
abstract::The increase in the incidence of thyroid cancer is accompanied by a mortality rate that is stable or perhaps even slightly decreasing. This phenomenon is due to the increased frequency of papillary microcarcinomas (thyroid tumors with a diameter of less than 1 cm), which is presumably attributable to the improved diag...
journal_title:HNO
pub_type: 杂志文章,评审
doi:10.1007/s00106-013-2679-2
更新日期:2013-04-01 00:00:00
abstract::A rare finding of primary cutaneous CD4+ small to medium-sized T‑cell lymphoma (SMPTCL) in a fifteen-year-old patient is reported. This is a rare tumor entity for which there is currently no standardized treatment recommendation. At the interdisciplinary tumor board, the decision was made to resect the tumor and recon...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s00106-020-00912-2
更新日期:2020-09-01 00:00:00
abstract::We present the case of a female patient suffering from recurrent vertigo and low-frequency hearing loss who was admitted for inpatient treatment with the diagnosis of Ménière's disease. After evaluation of all diagnostic examinations, including psychosomatic evaluation, a diagnosis of vestibular migraine with accompan...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s00106-011-2312-1
更新日期:2011-11-01 00:00:00
abstract::The two classic types of chronic otitis media--chronic suppurative disease and cholesteatoma--not only differ in their clinical course and prognosis, but they also require different therapeutic strategies. Benign chronic suppurative disease with its chronic irritating otorrhea can often be managed conservatively. Surg...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1994-09-01 00:00:00
abstract::In a series of 390 cases with suspicion of acoustic neurinomas 78 such tumors could be diagnosed, including 12 early stage neurinomas. This relatively high detection quote of small neurinomas is due to a special diagnostical programme: Every patient with unilateral and sensorineural hearing loss, independent of vertig...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1981-11-01 00:00:00
abstract::Telemedicine includes all medical activities involved in diagnosis, therapeutics or social medicine undertaken by an electronic transfer medium. This technique requires the transmission of visual and acoustic information over long distances and does not require the specialist to be personally present at the requested ...
journal_title:HNO
pub_type: 杂志文章,评审
doi:10.1007/s001060050632
更新日期:2000-09-01 00:00:00
abstract::Electrical stimulation of the human olfactory mucosa was performed by means of an electrode, which was attached to a rhinoscope. Stimulations of the nasal mucosa did not evoke the sensation of smell, but suppressed smell sensations of presented odorants. When electrical stimulation followed the exposure to an odorant ...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1985-07-01 00:00:00
abstract:BACKGROUND:Girls tend to acquire language skills faster than boys do. Furthermore, specific language impairment and dyslexia are diagnosed more often in males than in females. We investigated whether auditory verbal learning skills in boys are inferior to those of girls as a possible cause for gender dependency in lang...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s00106-009-1996-y
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:The Oldenburg children's rhyme test (OlKi) was designed and optimized for speech intelligibility measurements for primary school pupils in silence [8, 3]. In the optimization, the intelligibility of the particular test words was equalized. METHODS:The evaluation of the test with 147 primary school pupils wi...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s00106-005-1304-4
更新日期:2006-03-01 00:00:00
abstract::Comorbidity is the presence of one or more disorders in addition to the main disorder. Comorbidities negatively influence the development of the main disease. For patients with tinnitus a comorbidity is an additional component complicating the habituation of ear noise and patients with decompensated tinnitus often hav...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s00106-009-2050-9
更新日期:2010-07-01 00:00:00
abstract::Menière's disease is recognized as the idiopathic form of recurrent inner ear disease with the trias of hearing loss, tinnitus and vertigo with aural fullness and Menière's syndrome as the non-idiopathic form. Subentities with unknown pathogenesis are Lermoyez' s syndrome and Tumarkin crises. A common pathogenetic fac...
journal_title:HNO
pub_type: 杂志文章,评审
doi:10.1007/s00106-009-1915-2
更新日期:2009-05-01 00:00:00
abstract::Four low-vacuum systems and 6 high-vacuum systems were examined concerning their pressure-volume relationships. For each type the maximum filling volume for sufficient drainage of wound secretions was determined. The use of a wound fluid substitute instead of water resulted in a lower aspiration volume. Enlargement of...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1993-12-01 00:00:00
abstract::Three keloids harvested during surgery were prepared for histology and scanning electron microscopy (SEM) of vascular corrosion casts. One well-filled keloid (12 cm x 7 cm) was examined by SEM. This specimen revealed a conspicuous increase in subepidermal venous vessels as well as prominent luminal bulging of the endo...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1990-06-01 00:00:00
abstract:BACKGROUND:Apart from allergen avoidance and pharmacotreatment, specific immunotherapy (SIT) is the most important therapeutic option offered to allergic patients. Clinical efficacy of SIT depends on the specific allergen extract used, the quality and total cumulative amount of allergen applied and the treatment schedu...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s00106-009-1946-8
更新日期:2009-11-01 00:00:00
abstract::Wullstein, the founder of modern microscopic ear surgery, already used an oto-endoscope intraoperatively. However, it is only after the recent development of modern video-endoscopy with high-definition, 4K, and 3‑dimensional imaging that endoscopically guided surgery of the middle ear is gaining some importance. Key v...
journal_title:HNO
pub_type: 杂志文章,评审
doi:10.1007/s00106-016-0268-x
更新日期:2017-01-01 00:00:00
abstract::The various stages of tumor growth are characterized by typical epithelial, vascular, and secondary connective tissue changes. Narrow Band Imaging (NBI) endoscopy is a minimally invasive imaging technique that presents vascular structures in particular at a higher contrast than white light endoscopy alone. In combinat...
journal_title:HNO
pub_type: 杂志文章,评审
doi:10.1007/s00106-016-0284-x
更新日期:2017-01-01 00:00:00