[Diagnosis of prion diseases].

Abstract:

:Prion diseases are histologically characterized by a spongiform encephalopathy. The early symptoms of Creutzfeldt-Jakob disease (CJD) and variant Creutzfeldt-Jakob disease (vCJD) are unspecific. To date, the definite diagnosis can only be made by histological examination of central nervous tissue, i.e. brain biopsy or post mortem. Therefore, diagnostic tests are being elaborated that suffice with cerebrospinal fluid or blood. Unlike the sporadic form of Creutzfeldt-Jakob disease, that involves the central nervous system exclusively, in the variant of the Creutzfeldt-Jakob disease the lymphoreticular system including the tonsils is involved, too. Hence, a tonsillar biopsy can be performed instead of a brain biopsy. In particular, the diagnostic criteria of both CJD and vCJD are described.

journal_name

HNO

journal_title

HNO

authors

Federspil PA,Federspil P,Plinkert PK

doi

10.1007/s00106-002-0651-7

keywords:

subject

Has Abstract

pub_date

2002-04-01 00:00:00

pages

327-31

issue

4

eissn

0017-6192

issn

1433-0458

journal_volume

50

pub_type

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