Abstract：
:The relationship between endogenous LH concentrations and ongoing pregnancy rates among normogonadotrophic patients undergoing ovarian stimulation in a gonadotrophin-releasing hormone antagonist protocol were examined. In the Engage trial, 1506 patients received corifollitropin alfa (150 μg) or daily recombinant FSH (rFSH) (200 IU) for the first 7 days of stimulation with 0.25mg ganirelix from stimulation day 5. Patients were retrospectively stratified by serum LH percentiles (< 25th, 25th-75th and >75th) on stimulation day 8 and day of human chorionic gonadotrophin administration. Odds ratios (OR) with and without adjustment for predictive factors for ongoing pregnancy were estimated. LH concentration was not associated with pregnancy rates in either treatment arm, in contrast to ovarian response and serum progesterone. With adjustment for these predictors and age, OR (95% confidence interval) for ongoing pregnancy on stimulation day 8 for LH categories < P25 versus ≥ P25, >P75 versus ≤ P75 and < P25 versus >P75 were 0.75 (0.53-1.06), 1.26 (0.87-1.83) and 0.70 (0.46-1.09) in the corifollitropin alfa arm and 0.80 (0.54-1.17), 1.28 (0.87-1.87) and 0.73 (0.46-1.16) in the rFSH arm respectively. There was also no significant difference in pregnancy rates between LH categories on day of human chorionic gonadotrophin administration with either treatment.
journal_name
Reprod Biomed Onlinejournal_title
Reproductive biomedicine onlineauthors
Doody KJ,Devroey P,Leader A,Witjes H,Mannaerts BMdoi
10.1016/j.rbmo.2011.06.015subject
Has Abstractpub_date
2011-10-01 00:00:00pages
449-56issue
4eissn
1472-6483issn
1472-6491pii
S1472-6483(11)00359-2journal_volume
23pub_type
杂志文章,随机对照试验abstract：RESEARCH QUESTION:Can serum oestradiol concentrations on the day of progesterone initiation predict live birth rates in single, autologous vitrified-warmed blastocyst transfers following artificial endometrial preparation? DESIGN:This retrospective study included the first transfers of 468 patients with unexplained or...
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journal_title：Reproductive biomedicine online
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journal_title：Reproductive biomedicine online
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journal_title：Reproductive biomedicine online
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journal_title：Reproductive biomedicine online
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journal_title：Reproductive biomedicine online
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journal_title：Reproductive biomedicine online
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journal_title：Reproductive biomedicine online
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journal_title：Reproductive biomedicine online
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journal_title：Reproductive biomedicine online
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journal_title：Reproductive biomedicine online
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journal_title：Reproductive biomedicine online
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journal_title：Reproductive biomedicine online
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journal_title：Reproductive biomedicine online
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