LH concentrations do not correlate with pregnancy in rFSH/GnRH antagonist cycles.

Abstract:

:The possible relationship between endogenous LH concentrations and clinical outcome was evaluated in 750 patients treated with a standardized gonadotrophin-releasing hormone (GnRH) antagonist and recombinant FSH (rFSH)-only protocol. Serum LH concentrations were measured during stimulation by a central laboratory and patients were stratified into quantiles of P75. The P25 values were 3.38 IU/l, 0.93 IU/l, and 0.91 IU/l on stimulation days 1, 5, and 8, respectively. The ongoing pregnancy rates per started cycle of patients within the P75 subsets and ranged in the various subsets between 35.0% and 39.5%. In keeping with previous, smaller studies, these findings demonstrate that in good prognosis, non-obese patients endogenous LH in a GnRH antagonist protocol is able to support treatment with rFSH only.

journal_name

Reprod Biomed Online

authors

Doody K,Devroey P,Gordon K,Witjes H,Mannaerts B

doi

10.1016/j.rbmo.2009.12.019

subject

Has Abstract

pub_date

2010-04-01 00:00:00

pages

565-7

issue

4

eissn

1472-6483

issn

1472-6491

pii

S1472-6483(09)00303-4

journal_volume

20

pub_type

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