Fipronil (active ingredient of acaricide Frontline®) acting on the mice thyroid.

Abstract:

:Fipronil, active ingredient of Frontline® acaricide, is a phenyl-pyrazolic derivative, and its efficacy in the elimination of several plagues, even in lower concentrations, has already been demonstrated; however, its effect on nontarget organisms has not been thoroughly explained. In this sense, the present study had the objective to evaluate the effects of different doses of fipronil in mice and determine its cytotoxic potential and possible compromises on nontarget organisms in artificial conditions. The results showed that animals exposed to fipronil presented significant alterations in the thyroidean tissue with evident follicular disorganization, decreased in the size of most follicles culminating with the rupture of smaller follicles and still with posterior fusion in a big and irregular "follicle" filled with colloid. The present study also revealed that the action of fipronil not only causes disorganization in the thyroidean tissue but alsoalters the chemical composition of the colloid itself (prehormone), modifying its proteic basis, which was confirmed by histochemical test for protein detection, making it clear that, in thyroids exposed to fipronil, the colloid was weakly positive or even negative for the presence of proteins in its constitution.

journal_name

Microsc Res Tech

authors

Ferreira M,De Oliveira PR,Denardi SE,Bechara GH,Mathias MI

doi

10.1002/jemt.21053

subject

Has Abstract

pub_date

2012-03-01 00:00:00

pages

265-70

issue

3

eissn

1059-910X

issn

1097-0029

journal_volume

75

pub_type

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