Abstract：
:Breast cancer is a common malignancy in women all over the world and novel therapeutic approaches are required for the treatment of patients who become refractory to conventional therapies. Thyroid cancer is being treated successfully with radioiodine since many years. The iodide is transported inside the thyroid epithelial cell via sodium iodide symporter (NIS) which is a trans-membrane protein. The present study was aimed to explore the uptake of radioiodide (RAI) and the expression of NIS in breast tissues of invasive ductal carcinoma patients. Breast tissues from tumor region (Tu-Br) as well as corresponding normal region (N-Br) were collected from patients of invasive ductal carcinoma. In vitro RAI uptake, its efflux and NIS expression were studied. The uptake of RAI (1.98+/-1.75 x 10(5) cpm/g) in Tu-Br was significantly higher as compared to that observed in N-Br (0.31+/-0.27 x 10(5) cpm/g) and fast efflux was observed in the tissue samples. NIS gene expression was positive in 41.66% (10/24) samples of Tu-Br. None of the N-Br samples expressed NIS gene. In 14 samples of Tu-Br, RAI uptake as well as NIS expression was studied. In 50% of these Tu-Br samples RAI uptake as well as of NIS gene expression was positive. The results indicate that RAI uptake is significantly higher in breast tumor tissues as compared to their normal counterpart and in future radioiodine may be an important agent for treatment of breast cancer.
journal_name
Indian J Exp Bioljournal_title
Indian journal of experimental biologyauthors
Damle AA,Narkar AA,Badwe RAsubject
Has Abstractpub_date
2011-06-01 00:00:00pages
416-22issue
6eissn
0019-5189issn
0975-1009journal_volume
49pub_type
杂志文章abstract：:Effects of sublethal doses of metal (Cu, Cd, Zn) mixtures on the activities of key respiratory enzymes (succinate dehydrogenase, SDH and glyceraldehyde dehydrogenase, GDH) and their recovery following withdrawal of treatments were studied in the freshwater fish O. mossambicus. On the basis of 96 hr LC50 Cu was highly ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1992-06-01 00:00:00
abstract：:Since aging is the most important risk factor for variety of diseases, the discovery of a wide range of chemical modulators of aging in model organisms encourages new strategies for targeting age associated diseases. Simple genetic manipulation leads to long-lived and healthy animals, so any compound which could have ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2013-07-01 00:00:00
abstract：:Thirteen strains of M. bovoculi, 6 from frozen bull-semen (3.5% of 168), 3 from neat bull-semen (3.0% of 100), one each from heart blood and stomach contents of aborted foetus of 85 (1.18%) bovine-abortions, one each from stomach contents and pooled internal organs of 9 (11.1%) stillborn calves, were isolated. All the...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2004-09-01 00:00:00
abstract：:The present study has been undertaken to observe the effect of aqueous extract of M. oleifera (MO) leaf (300mg/kg body weight) on mean ulcer index, enterochromaffin (EC) cells and serotonin (5-hydroxytryptamine; 5-HT) content of ulcerated gastric tissue. Ulceration was induced by using aspirin (500 mg/kg, po), cerebel...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2007-08-01 00:00:00
abstract：:The investigations on enzymes related to glutathione like glutathione-S-transferase (GST) and glutathione peroxidase (GSH-Px) have been carried out mostly in human and rat ovaries, however the studies on these enzymes in ruminants are relatively absent. In the present study the changes in the activity of these enzymes...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2001-11-01 00:00:00
abstract：:Activities of several drug metabolising enzymes in the small intestine were investigated in Swiss mice, Sprague Dawley rats and Syrian Golden Hamsters fed 10% masheri, a pyrolysed tobacco product, in diet, for 20 months. The basal levels of enzymes in proximal (PI), medium (MI) and distal (DI) parts of the intestine i...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1991-03-01 00:00:00
abstract：:Antinociceptive activity of methanolic extract of leaves of A. aspera was studied by peripheral/non-narcotic model of nociception like acetic acid induced writhing syndrome test and central/narcotic models like hot plate and tail flick tests. The methanolic extract of the plant, administered orally (@ 300, 600 and 900...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2010-08-01 00:00:00
abstract：:Administration of CCl4 to normal rats and consequent oral feeding with ellagic acid (50 mg/kg) provided a significant protection against the biochemical alterations in serum and liver produced by CCl4. In vitro experiments showed that liver microsomes from animals treated with ellagic acid and CCl4, decreased lipid pe...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1999-10-01 00:00:00
abstract：:Bacopa monniera, Linn. (Brahmi: Scrophulariaceae) an Ayurvedic medicine is clinically used for memory enhancing, epilepsy, insomnia and as mild sedative. For the first time the effect of alcohol and hexane fraction of Brahmi has been studied on FeSO4 and cumene hydroperoxide induced lipid peroxidation. Alcohol fractio...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1996-06-01 00:00:00
abstract：:The p38 mitogen activated protein kinase (p38MAPK) pathway is an important signaling cascade involved in cell growth, differentiation and apoptosis. High glucose activates p38MAPK pathway in different cells, including osteoblasts. In the present study, role of p38MAPK in high glucose induced osteoblast apoptosis and p...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2011-02-01 00:00:00
abstract：:The effects of air dried ginger powder (0.1g/kg body weight, po, for 75 days) were studied on experimentally induced atherosclerosis in rabbits by cholesterol feeding (0.3g/kg body weight, po). Cholesterol feeding for 75 days lead to distinct development of atheroma in the aorta and coronary arteriesof the rabbits and...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2004-07-01 00:00:00
abstract：:According to Ayurvedic literature of Sri Lanka, roasted seeds of Artocarpus heterophyllus Lam. (Family: Moraceae) has aphrodisiac activity. However, some reproductively active young men in rural areas of Sri Lanka claim that consumption of these seeds few hours prior to coitus disrupts sexual function. Because of thes...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2002-03-01 00:00:00
abstract：:Dose matched comparison between copper complex of tolmetin(Tol-Cu) and tolmetin(Tol) was carried out in male albino rats bearing either sutured incision, dead space or excision wounds. Results showed that Tol significantly decreased tesile strength of incision and dead space wound. This effect was totally reversed by ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1995-03-01 00:00:00
abstract：:We have found and synthesized a trapping ligand peptide H22-LP (the conservative sequence is NAHCALL) from a random phage library according to the broad-spectrum trapping receptor H22, which derived from the residue 14-35 near the N-terminal region of receptor US28 on HCMV. In this study, we will evaluate its potentia...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2012-05-01 00:00:00
abstract：:Influence of silymarin on UDP-glucuronic acid (UDPGA) and glucuronidation activity of freshly isolated rat hepatocytes in suspension and in rat liver in vivo was examined. Viability of the hepatocytes (> 85%) was not altered in Hank's balanced salt solution at least for 4 hr at 37 degrees C under oxygen. Silymarin at ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1997-03-01 00:00:00
abstract：:Effects of Indian red scorpion (M. tamulus concanesis; MBT) venom on the compound action potential (CAP) of sciatic nerve in vitro were examined. MBT venom (0.1-6.0 micrograms/ml) prolonged the repolarization time and refractory period of the CAP in a concentration-dependent manner with maximal potentiation occurring ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1998-11-01 00:00:00
abstract：:The present experiment was planned to study nephrotoxicity in experimental diabetic rats under sub-chronic exposure to arsenic. Alloxan induced diabetic and control rats were exposed to sodium arsenite (0 and 5.5 mg/kg, orally) for 30 days. More pronounced nephrotoxic effects were noted in arsenic exposed diabetic gro...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2010-07-01 00:00:00
abstract：:Ruminal fungal isolates (Orpinomyces sp.; C-14, Piromyces sp.; C-15, Orpinomyces sp.; B-13 and Anaeromyces sp.; B-6), were evaluated under anoxic conditions for their effect on in vitro dry matter digestibility, neutral detergent fibre, acid detergent fibre and acid detergent lignin using rice and wheat straw as subst...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2004-06-01 00:00:00
abstract：:The effects of sub-chronic doses of malathion exposure on humoral and cell-mediated immune (CMI) responses were studied in male albino mice, rats and rabbits using sheep red blood cells (SRBC), tetanus toxoid and ovalbumin as antigens. The humoral immune response was assessed by estimating serum immunoglobulin (IgM an...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1998-03-01 00:00:00
abstract：:A bench-scale biotrickling filter was operated in the laboratory for the treatment of dimethyl sulphide (DMS). The biotrickling filter was packed with pre-sterilized polyurethane foam and seeded with biomass developed from garden soil enriched with DMS. The biotrickling filter was operated for the generation of proces...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2013-11-01 00:00:00
abstract：:Sodium valproate (VPA) and flunarizine (FLU) administered individually and together were examined for their effects on behavioural, and EEG changes in the pentylenetetrazole (PTZ) induced rat model of absence seizures. PTZ, 20 mg/kg, i.p., produced behavioural staring and immobility with concomitant, repetitive 7 to 9...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1999-03-01 00:00:00
abstract：:Effect of chronic treatment with hydralazine (40 mg/kg/day) on isolated heart, anococcygeus muscle and myometrial preparations from rats has been studied. The treatment for 6 weeks caused a significant increase in isoprenaline induced positive inotropic response in rat heart. However, isoprenaline induced positive chr...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1996-03-01 00:00:00
abstract：:Effects of exogenous androgens (testosterone, testosterone propionate and dihydrotestosterone) and estradiol-17beta on the oviductal growth/hypertrophy were studied in young and bilaterally ovariectomized (BLO) adult frogs (Rana cyanophlyctis) during postbreeding phase of the reproductive cycle. Estradiol-17beta injec...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2001-09-01 00:00:00
abstract：:Growth rate of follicles and effects of administration of oestradiol valerate (EV), testosterone propionate (TP) and aminoglutethemide phosphate (AGP) on the development of ovarian follicles of the adult musk shrew were investigated. The follicular growth rate was estimated by mitotic index before and 2 hr after colch...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1993-11-01 00:00:00
abstract：:Cells and organisms exposed to detrimental and toxic substances show different responses in photon emission dependent on amount, kind and exposure time of toxin as well as on the organism investigated. Radical reaction-generating substances and dehydrating, lipid dissolving and protein denaturating toxins which do not...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2003-05-01 00:00:00
abstract：:Cyclophosphamide is a potent immunosuppressive agent and is being widely used in organ transplantation. The effects of this anti-rejection drug on lymphoid organs are poorly understood. Newborn Swiss mice injected with various doses of cyclophosphamide suffered from wasting disease at 4 weeks post treatment. The incid...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:A study was conducted of the effect of intravaginal instillation of 3 nonsteroidal oran antifertility agents in pregnant rats. The 3 compounds used were 2-phenyl-3-rho-beta-pyrrolidinoethoxyphenyl-6-methox y benzofuran hydrochoride (DBF), 20 mg/kg; 2-phenyl-3-rho-beta-pyrrolidi noethoxyphenyl-naptha (2:1,b furan (NF...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：1974-07-01 00:00:00
abstract：:FtsZ plays an important role in bacterial cell division by polymerizing to form the Z ring at the site of cytokinesis. Phytochemicals are known to disrupt bacterial cell division through inhibition of FtsZ assembly. In the present study phytochemicals like eugenol, trans-cinnamic acid, 4-formyl cinnamic acid, naringen...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2008-11-01 00:00:00
abstract：:This study evaluated the phytochemical and antimicrobial activities and also quantified bioactive nucleoside using high performance thin layer chromatography (HPTLC) of five extracts of Indian Himalayan Cordyceps sinensis prepared with different solvents employing accelerated solvent extraction (ASE) technique. The ph...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2015-01-01 00:00:00
abstract：:Leaf explants collected from flowering plants of Vanda spathulata were cultured in Mitra medium with combinations of 6-benzyladenine (BA; 13.2-88.8 microM) and indole-3-acetic acid (IAA; 0.0 -85.6 microM). Combination of BA (66.6 microM) and IAA (28.5 microM) induced maximum shoots (17.33) from foliar meristems (leaf ...
journal_title：Indian journal of experimental biology
pub_type： 杂志文章
doi：
更新日期：2003-08-01 00:00:00
