Effect of added calcium phosphate on enamel remineralization by fluoride in a randomized controlled in situ trial.

Abstract:

UNLABELLED:Dental products containing calcium phosphate and fluoride are claimed to enhance enamel remineralization over fluoride products. OBJECTIVES:To compare remineralization of enamel subsurface lesions by dental products with added calcium phosphate in a double-blind, randomized, cross-over in situ study. METHODS:Human enamel specimens with subsurface lesions were prepared and inserted into intra-oral appliances worn by volunteers. A slurry (1g product plus 4 ml H(2)O) of each product was rinsed for 60s, 4 times per day for 10 days. Six products were tested (i) placebo, (ii) 1000 ppm F, (iii) 5000 ppm F, (iv) Tooth Mousse (TM), (v) TM plus 900 ppm F (TMP) and (vi) Clinpro with 950 ppm F. Calcium, inorganic phosphate and fluoride levels were measured in post-rinse/saliva samples using ion chromatography. Mineral content was measured using transverse microradiography. RESULTS:Only TM and TMP significantly increased salivary calcium and phosphate levels. The products produced remineralization in the following order from lowest to highest: placebo<1000 ppm F=Clinpro<5000 ppm F

journal_name

J Dent

journal_title

Journal of dentistry

authors

Shen P,Manton DJ,Cochrane NJ,Walker GD,Yuan Y,Reynolds C,Reynolds EC

doi

10.1016/j.jdent.2011.05.002

subject

Has Abstract

pub_date

2011-07-01 00:00:00

pages

518-25

issue

7

eissn

0300-5712

issn

1879-176X

pii

S0300-5712(11)00122-9

journal_volume

39

pub_type

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