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Prevalence of airway obstruction assessed by lung function questionnaire.

Abstract：

OBJECTIVE:To estimate the prevalence of unidentified chronic obstructive pulmonary disease (COPD) and determine the screening accuracy of the Lung Function Questionnaire (LFQ). PATIENTS AND METHODS:Cigarette smokers who had a smoking history of 10 or more pack-years and were aged 30 years or older were recruited from 36 centers from February 18, 2009, to May 29, 2009. A total of 1575 patients completed a Web-based survey including the 5-item LFQ. Spirometry was performed on patients with an LFQ total score of 18 or less and on a subset scoring more than 18. The primary outcome was the proportion of patients at risk of airflow obstruction as measured by the LFQ (score, ≤ 18) in whom an airflow obstruction was confirmed by spirometry. RESULTS:Of the patients who completed the LFQ, 849 (54%) had standardized spirometry data available. On the basis of LFQ and spirometry results, the estimated prevalence of possible COPD was 17.9% (95% confidence interval, 15.3%-20.6%). At a cut point of 18 or less, sensitivity, specificity, positive predictive value, and negative predictive value of the LFQ were 88%, 25%, 21%, and 90%, respectively. Approximately 1 in 5 patients (21%) aged 30 years or older and 1 in 4 (26%) aged 50 years or older scored 18 or less on the LFQ and had a ratio of forced expiratory volume in the first second of expiration to forced vital capacity less than 0.70. CONCLUSION:On the basis of postbronchodilator spirometry results using weighted estimates, approximately 1 in 5 patients (21%) aged 30 years or older with a smoking history of 10 or more pack-years seen in a primary care setting is likely to have COPD. The LFQ could be a helpful COPD case-finding tool for clinicians to identify patients who need further evaluation. TRIAL REGISTRATION:clinicaltrials.gov Identifier: NCT01013948.

journal_name

Mayo Clin Proc

journal_title

Mayo Clinic proceedings

authors

Mintz ML,Yawn BP,Mannino DM,Donohue JF,Hanania NA,Grellet CA,Gilsenan AW,McLeod LD,Dalal AA,Raphiou IH,Prillaman BA,Crater GD,Cicale MJ,Mapel DW

doi

10.4065/mcp.2010.0787

subject

Has Abstract

pub_date

2011-05-01 00:00:00

pages

375-81

issue

eissn

0025-6196

issn

1942-5546

pii

S0025-6196(11)60026-8

journal_volume

pub_type

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Prevalence of airway obstruction assessed by lung function questionnaire.