Vitamin D: immunomodulation of asthma, allergic rhinitis, and chronic rhinosinusitis.

Abstract:

PURPOSE OF REVIEW:To discuss the role of vitamin D in asthma, allergic rhinitis, and chronic rhinosinusitis (CRS). RECENT FINDINGS:Over the last several years, the role of vitamin D in immunomodulation has been studied and shown to have a significant impact on immune function. A causal relationship exists between vitamin D function and innate and adaptive immunity to infections. The mechanisms underlying vitamin D immune actions could be attributed to a paracrine feedback loop that reduces inflammation as well as influencing the differentiation fate of activated CD4 T cells, or the enhancement of suppressor T-cell function; indeed, a combination of these factors may underlie the actions of vitamin D. SUMMARY:Recent findings on the function of vitamin D may explain aspects of the pathophysiology of allergic rhinitis and CRS and may help direct future interventions and treatment of these diseases.

authors

Akbar NA,Zacharek MA

doi

10.1097/MOO.0b013e3283465687

subject

Has Abstract

pub_date

2011-06-01 00:00:00

pages

224-8

issue

3

eissn

1068-9508

issn

1531-6998

journal_volume

19

pub_type

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